Divalent folate modification on PEG: An effective strategy for improving the cellular uptake and targetability of pegylated polyamidoamine-polyethylenimine copolymer

Molecular Pharmaceutics

Volumn 12, Issue 1, 2015, Pages 240-252

  Cao, Duanwen ^a   Tian, Shouqin ^b   Huang, Huan ^b,c   Chen, Jianhai ^a   Pan, Shirong ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c BEIJING HOSPITAL   (China)

Author keywords

cellular uptake; divalent folate; gene vector; PEG; targeting delivery

Indexed keywords

CATION; CLATHRIN; COPOLYMER; DNA; FOLATE RECEPTOR; FOLIC ACID; NANOCARRIER; POLYAMIDOAMINE; POLYETHYLENEIMINE; POLYMER; MACROGOL DERIVATIVE; POLY(ETHYLENE GLYCOL)-FOLATE; POLYAMINE;

ARTICLE; CANCER THERAPY; CAVEOLA; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; DRUG UPTAKE; ENDOCYTOSIS; FEMALE; GENE TARGETING; GENE VECTOR; GENETIC TRANSFECTION; HEMOLYSIS; HUMAN; HUMAN CELL; LYSOSOME; MOLECULE; MULTICELLULAR SPHEROID; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PHYSICAL CHEMISTRY; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; ENDOSOME; GENE TRANSFER; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; RABBIT;

ANIMALS; DNA; ENDOCYTOSIS; ENDOSOMES; FOLIC ACID; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEK293 CELLS; HELA CELLS; HEMOLYSIS; HUMANS; LYSOSOMES; MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; POLYAMINES; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYMERS; RABBITS; SPHEROIDS, CELLULAR;

EID: 84920498571     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500572v     Document Type: Article

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