Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat, a spontaneous type 2 diabetic animal model

Chinese Journal of Natural Medicines

Volumn 13, Issue 7, 2015, Pages 529-534

  Wang, Xue ^a   Lu, Qian ^a   Yu, Dong Sheng ^a   Chen, Yu Peng ^a   Shang, Jing ^a   Zhang, Lu Yong ^a   Sun, Hong Bin ^a   Liu, Jun ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Asiatic acid; Diabetes mellitus; Goto Kakizaki (GK) rats; Hyperglycemia; Islet fibrosis; Pancreas

Indexed keywords

ASIATIC ACID; CARBOXYMETHYLCELLULOSE; FIBRONECTIN; GLUCOSE; INSULIN; GLUCOSE BLOOD LEVEL; PENTACYCLIC TRITERPENE; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; FIBROSIS; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; GOTO KAKIZAKI RAT; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT DURATION; WISTAR RAT; ANIMAL; BLOOD; CENTELLA; CHEMISTRY; DIABETES MELLITUS, TYPE 2; DISEASE MODEL; DRUG EFFECTS; GLUCOSE TOLERANCE TEST; INBRED RAT STRAIN; METABOLISM; PANCREATIC DISEASES; PATHOLOGY; PHYTOTHERAPY;

ANIMALS; BLOOD GLUCOSE; CENTELLA; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FIBRONECTINS; FIBROSIS; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; PANCREATIC DISEASES; PENTACYCLIC TRITERPENES; PHYTOTHERAPY; PLANT EXTRACTS; RATS, INBRED STRAINS;

EID: 84938367940     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(15)30047-9     Document Type: Article

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