Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure

Redox Biology

Volumn 6, Issue , 2015, Pages 169-173

  Akkafa, Feridun ^a   Halil Altiparmak, Ibrahim ^a   Erkus, Musluhittin Emre ^a   Aksoy, Nurten ^a   Kaya, Caner ^b   Ozer, Ahmet ^a   Sezen, Hatice ^a   Oztuzcu, Serdar ^c   Koyuncu, Ismail ^a   Umurhan, Berrin ^a  

^a HARRAN UNIVERSITY   (Turkey)

^b Mehmet Akif Inan Training and Research Hospital   (Turkey)

^c GAZIANTEP UNIVERSITY   (Turkey)

Author keywords

HDL; OSI; RT qPCR; Sirtuin; TAS; TOS

Indexed keywords

SIRTUIN 1; ANTIOXIDANT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; SIRT1 PROTEIN, HUMAN; TRIACYLGLYCEROL;

ADULT; ARTICLE; COLORIMETRY; COMPENSATED HEART FAILURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DECOMPENSATED HEART FAILURE; DOWN REGULATION; FEMALE; GENDER; HEART EJECTION FRACTION; HEART FAILURE; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; WAIST CIRCUMFERENCE; AGED; BLOOD; BODY MASS; CASE CONTROL STUDY; ENZYMOLOGY; GENE EXPRESSION; GENETICS; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; PATHOLOGY; SEVERITY OF ILLNESS INDEX;

MAMMALIA; TOSCANA VIRUS;

AGED; ANTIOXIDANTS; BODY MASS INDEX; CASE-CONTROL STUDIES; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FEMALE; GENE EXPRESSION; HEART FAILURE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; OXIDATIVE STRESS; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SIRTUIN 1; TRIGLYCERIDES; WAIST CIRCUMFERENCE;

EID: 84938364123     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2015.07.011     Document Type: Article

References (30)

1. McBurney M.W., Yang X., Jardine K., Hixon M., Boekelheide K., Webb J.R., et al. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol. Cell. Biol. 2003, 23:38-54.
2. Gasser S.M., Cockell M.M. The molecular biology of the SIR proteins. Gene 2001, 279:1-16.
3. Alcendor R.R., Gao S., Zhai P., Zablocki D., Holle E., Yu X., et al. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ. Res. 2007, 100:1512-1521. 10.1161/01.RES.0000267723.65696.4a.
4. Pillai J.B., Isbatan A., Imai S., Gupta M.P. Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. J. Biol. Chem. 2005, 280:43121-43130. 10.1074/jbc.M506162200.
5. Khan R.S., Fonseca-Kelly Z., Callinan C., Zuo L., Sachdeva M.M., Shindler K.S. SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells. Front. Cell. Neurosci. 2012, 6:63. 10.3389/fncel.2012.00063.
6. Motta M.C., Divecha N., Lemieux M., Kamel C., Chen D., Gu W., et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 2004, 116:551-563.
7. Braunwald E. Heart failure. JACC: Heart Fail. 2013, 1:1-20. 10.1016/j.jchf.2012.10.002.
8. Tomaselli G.F., Barth A.S. Sudden cardio arrest: oxidative stress irritates the heart. Nat. Med. 2010, 16:648-649. 10.1038/nm0610-648.
9. Tsutsui H., Kinugawa S., Matsushima S. Oxidative stress and heart failure. Am. J. Physiol. Heart Circ. Physiol. 2011, 301:H2181-H2190. 10.1152/ajpheart.00554.2011.
10. Uttara B., Singh A.V., Zamboni P., Mahajan R.T. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr. Neuropharmacol. 2009, 7:65-74. 10.2174/157015909787602823.
11. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262.
12. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin. Biochem. 2004, 37:277-285. 10.1016/j.clinbiochem.2003.11.015.
13. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin. Biochem. 2005, 38:1103-1111. 10.1016/j.clinbiochem.2005.08.008.
14. Harma M., Harma M., Erel O. Oxidative stress in women with preeclampsia. Am. J. Obstet. Gynecol. 2005, 192:656-657. (author reply 657). 10.1016/j.ajog.2004.07.094.
15. Aycicek A., Erel O. Total oxidant/antioxidant status in jaundiced newborns before and after phototherapy. J. Pediatr. (Rio. J) 2007, 83:319-322. 10.2223/JPED.1645.
16. Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev. 2000, 14:1021-1026. 10.1101/gad.14.9.1021.
17. Mattagajasingh I., Kim C.-S., Naqvi A., Yamamori T., Hoffman T.A., Jung S.-B., et al. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:14855-14860. 10.1073/pnas.0704329104.
18. Planavila A., Iglesias R., Giralt M., Villarroya F. Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation. Cardiovasc. Res. 2011, 90:276-284. 10.1093/cvr/cvq376.
19. Lu T.-M., Tsai J.-Y., Chen Y.-C., Huang C.-Y., Hsu H.-L., Weng C.-F., et al. Downregulation of Sirt1 as aging change in advanced heart failure. J. Biomed. Sci. 2014, 21:57. 10.1186/1423-0127-21-57.
20. Breitenstein A., Wyss C.A., Spescha R.D., Franzeck F.C., Hof D., Riwanto M., et al. Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease. PLoS One 2013, 8:e53106. 10.1371/journal.pone.0053106.
21. Hill M.F., Singal P.K. Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rats. Am. J. Pathol. 1996, 148:291-300.
22. Hill M.F., Palace V.P., Kaur K., Kumar D., Khaper N., Singal P.K. Reduction in oxidative stress and modulation of heart failure subsequent to myocardial infarction in rats. Exp. Clin. Cardiol. 2005, 10:146-153.
23. Freeman L.M., Rush J.E., Milbury P.E., Blumberg J.B. Antioxidant status and biomarkers of oxidative stress in dogs with congestive heart failure. J. Vet. Intern. Med. 2005, 19:537-541. (accessed October 28, 2014). http://www.ncbi.nlm.nih.gov/pubmed/16095171.
24. Ellidag H.Y., Eren E., Yilmaz N., Cekin Y. Oxidative stress and ischemia-modified albumin in chronic ischemic heart failure. Redox Rep. 2014, 19(3):118-123.
25. White M., Ducharme A., Ibrahim R., Whittom L., Lavoie J., Guertin M.-C., et al. Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support. Clin. Sci. (Lond) 2006, 110:483-489. 10.1042/CS20050317.
26. Keith M., Geranmayegan A., Sole M.J., Kurian R., Robinson A., Omran A.S., et al. Increased oxidative stress in patients with congestive heart failure. J. Am. Coll. Cardiol. 1998, 31:1352-1356.
27. Tanno M., Kuno A., Yano T., Miura T., Hisahara S., Ishikawa S., et al. Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J. Biol. Chem. 2010, 285:8375-8382. 10.1074/jbc.M109.090266.
28. Kilic U., Gok O., Bacaksiz A., Izmirli M., Elibol-Can B., Uysal O. SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases. PLoS One 2014, 9:e90428. 10.1371/journal.pone.0090428.
29. Inamori T., Goda T., Kasezawa N., Yamakawa-Kobayashi K. The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels: a population based study. Lipids Health Dis. 2013, 12:4. 10.1186/1476-511X-12-4.
30. Han J., Atzmon G., Barzilai N., Suh Y. Genetic variation in Sirtuin 1 (SIRT1) is associated with lipid profiles but not with longevity in Ashkenazi Jews. Transl Res. 2015, 165(4):480-481.