Uric acid, indoxyl sulfate, and methylguanidine activate bulbospinal neurons in the RVLM via their specific transporters and by producing oxidative stress

Neuroscience

Volumn 304, Issue , 2015, Pages 133-145

  Oshima, N ^a   Onimaru, H ^b   Matsubara, H ^a   Uchida, T ^a   Watanabe, A ^a   Takechi, H ^a   Nishida, Y ^a   Kumagai, H ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Nox4; OAT3; RVLM neurons; URAT1; Uremic toxins

Indexed keywords

INDICAN; METHYLGUANIDINE; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; ORGANIC CATION TRANSPORTER 3; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; URATE TRANSPORTER; URIC ACID; 3-BENZYL-7-(2-BENZOXAZOLYL)THIO-1,2,3-TRIAZOLO(4,5-D)PYRIMIDINE; ANION TRANSPORT PROTEIN; BENZOXAZOLE DERIVATIVE; CYBB PROTEIN, RAT; ENZYME INHIBITOR; MEMBRANE PROTEIN; NEUROPROTECTIVE AGENT; NEUROTOXIN; NOX4 PROTEIN, RAT; ORGANIC ANION TRANSPORTER; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SLC22A6 PROTEIN, RAT; TRIAZOLE DERIVATIVE; URAT1 PROTEIN, RAT;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVITY; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; ELECTRODE; HISTOPATHOLOGY; HYPERPOLARIZATION; HYPERTENSION; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; KENNEDY DISEASE; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PATCH CLAMP TECHNIQUE; PERFUSION AND SUPERFUSION; PRIORITY JOURNAL; RAT; ROSTRAL VENTROLATERAL MEDULLA; SPINAL CORD NERVE CELL; ADRENERGIC SYSTEM; ANIMAL; ANTAGONISTS AND INHIBITORS; CHRONIC KIDNEY FAILURE; DRUG EFFECTS; MEDULLA OBLONGATA; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; WISTAR RAT;

ANIMALS; ANION TRANSPORT PROTEINS; BENZOXAZOLES; ENZYME INHIBITORS; INDICAN; MEDULLA OBLONGATA; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIALS; METHYLGUANIDINE; NADPH OXIDASE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; OXIDATIVE STRESS; PATCH-CLAMP TECHNIQUES; RATS, WISTAR; RENAL INSUFFICIENCY, CHRONIC; SYMPATHETIC NERVOUS SYSTEM; TRIAZOLES; URIC ACID;

EID: 84938300254     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.07.055     Document Type: Article

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