Indoxyl sulphate inhibits osteoclast differentiation and function

Nephrology Dialysis Transplantation

Volumn 27, Issue 6, 2012, Pages 2176-2181

  Mozar, Anaïs ^a,b   Louvet, Loïc ^a,b   Godin, Corinne ^a,b   Mentaverri, Romuald ^a,b   Brazier, Michel ^a,b   Kamel, Saïd ^a,b   Massy, Ziad A ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^c AMIENS UNIVERSITY HOSPITAL   (France)

Author keywords

Adynamic bone disease; Chronic kidney disease; Indoxyl sulphate; Osteoclast

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDICAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATE; PROBENECID; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION;

ANIMALS; BONE RESORPTION; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN TYPE I; HUMANS; INDICAN; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MAP KINASE KINASE 4; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MONOCYTES; OSTEOCLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; TRANSCRIPTION FACTOR AP-1;

EID: 84861884567     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr647     Document Type: Article

References (14)

1. Niwa T, Takeda N, Tatematsu A et al. Accumulation of indoxyl sulfate, an inhibitor of drug-binding, in uremic serum as demonstrated by internal-surface reversed-phase liquid chromatography. Clin Chem 1988; 34: 2264-2267
2. Dou L, Jourde-Chiche N, Faure V et al. The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells. J Thromb Haemost 2007; 5: 1302-1308
3. Motojima M, Hosokawa A, Yamato H et al. Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NFkappaB and free radical in proximal tubular cells. Kidney Int 2003; 63: 1671-1680
4. Shimoishi K, Anraku M, Kitamura K et al. An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure. Pharm Res 2007; 24: 1283-1289
5. Iwasaki Y, Yamato H, Nii-Kono T et al. Administration of oral charcoal adsorbent (AST-120) suppresses low-turnover bone progression in uraemic rats. Nephrol Dial Transplant 2006; 21: 2768-2774
6. Nii-Kono T, Iwasaki Y, Uchida M et al. Indoxyl sulfate induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells. Kidney Int 2007; 71: 738-743
7. Somerville PJ, Kaye M. Evidence that resistance to the calcemic action of parathyroid hormone in rats with acute uremia is caused by phosphate retention. Kidney Int 1979; 16: 552-560
8. Mozar A, Haren N, Chasseraud M et al. High extracellular inorganic phosphate concentration inhibits RANK-RANKL signaling in osteoclastlike cells. J Cell Physiol 2008; 215: 47-54
9. Vanholder R, De Smet R, Glorieux G et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 2003; 63: 1934-1943
10. Menaa C, Esser E, Sprague SM. Beta2-microglobulin stimulates osteoclast formation. Kidney Int 2008; 73: 1275-1281
11. Chillon JM, Mozar A, Six I et al. Pathophysiological mechanisms and consequences of cardiovascular calcifications: role of cardiovascular and bone remodeling. Ann Pharm Fr 2009; 67: 234-240
12. Moe S, Drueke T, Cunningham J et al. Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2006; 69: 1945-1953
13. Stubbs JR, Liu S, Tang W et al. Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice. J Am Soc Nephrol 2007; 18: 2116-2124
14. Goto S, Fujii H, Hamada Y et al. Association between indoxyl sulfate and skeletal resistance in hemodialysis patients. Ther Apher Dial 2010; 14: 417-423