Semisynthetic Lipopeptides Derived from Nisin Display Antibacterial Activity and Lipid II Binding on Par with That of the Parent Compound

Journal of the American Chemical Society

Volumn 137, Issue 29, 2015, Pages 9382-9389

  Koopmans, Timo ^a   Wood, Thomas M ^a   'T Hart, Peter ^a   Kleijn, Laurens H J ^a   Hendrickx, Antoni P A ^b   Willems, Rob J L ^b   Breukink, Eefjan ^c   Martin, Nathaniel I ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

SYNTHESIS (CHEMICAL);

ANTI-BACTERIAL ACTIVITY; BACTERIAL GROWTH; BACTERIAL STRAINS; MECHANISM OF ACTION; MEMBRANE MODELS; PARENT COMPOUNDS; PORE FORMATION; POTENT INHIBITION;

ANTIBIOTICS;

LANTIBIOTIC; LIPID; LIPOPEPTIDE; NISIN; ANTIINFECTIVE AGENT; LIPOSOME; MURAMYL-NAC-(PENTAPEPTIDE)PYROPHOSPHORYL-UNDECAPRENOL; URIDINE DIPHOSPHATE N ACETYLMURAMIC ACID;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM CULTURE; CHANNEL GATING; MEMBRANE MODEL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; SYNTHESIS; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; DRUG STABILITY; ENTEROCOCCUS FAECIUM; HUMAN; METABOLISM; PROTEIN DEGRADATION;

ANTI-BACTERIAL AGENTS; DRUG STABILITY; ENTEROCOCCUS FAECIUM; HUMANS; LIPOPEPTIDES; NISIN; PROTEOLYSIS; UNILAMELLAR LIPOSOMES; URIDINE DIPHOSPHATE N-ACETYLMURAMIC ACID;

EID: 84938294812     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b04501     Document Type: Article

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