Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway

Biochemical Pharmacology

Volumn 96, Issue 4, 2015, Pages 323-336

  Wu, Xin ^a   Dou, Yannong ^a   Yang, Yan ^a,b   Bian, Difei ^a   Luo, Jinque ^a   Tong, Bei ^a   Xia, Yufeng ^a   Dai, Yue ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Third People's Hospital of Chengdu   (China)

Author keywords

Arctigenin; Colitis; Differentiation; mTORC1 pathway; T cells

Indexed keywords

ARCTIGENIN; DEXTRAN SULFATE; GAMMA INTERFERON; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 21; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 4; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STAT3 PROTEIN; STAT4 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR RORGAMMAT; TRANSCRIPTION FACTOR T BET; TUBERIN; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; FURAN DERIVATIVE; LIGNAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCTIUM LAPPA; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CLINICAL EFFECTIVENESS; COLITIS; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; IMMUNOSTIMULATION; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; HUMAN; JURKAT CELL LINE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL DIFFERENTIATION; COLITIS; DEXTRAN SULFATE; FURANS; HUMANS; JURKAT CELLS; LIGNANS; MALE; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; SIGNAL TRANSDUCTION; TH1 CELLS; TH17 CELLS; TOR SERINE-THREONINE KINASES;

EID: 84938294113     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.06.008     Document Type: Article

References (33)

1. I. Ordás, L. Eckmann, M. Talamini, D.C. Baumgart, and W.J. Sandborn Ulcerative colitis Lancet 380 2012 1606 1619
2. P.V. Khanna, D.Q. Shih, T. Haritunians, D.P. McGovern, and S. Targan Use of animal models in elucidating disease pathogenesis in IBD Semin. Immunopathol. 36 2014 541 551
3. M. Boirivant, and A. Cossu Inflammatory bowel disease Oral Dis. 18 2012 1 15
4. T. Kobayashi, S. Okamoto, T. Hisamatsu, N. Kamada, H. Chinen, R. Saito, and et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease Gut 57 2008 1682 1689
5. N. Eastaff-Leung, N. Mabarrack, A. Barbour, A. Cummins, and S. Barry Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease Clin. Immunol. 30 2009 80 89
6. M.F. Neurath New targets for mucosal healing and therapy in inflammatory bowel diseases Mucosal Immunol. 7 2014 6 19
7. T. Olsen, R. Rismo, G. Cui, R. Goll, I. Christiansen, and J. Florholmen Th1 and Th17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation Cytokine 56 2011 633 640
8. G. Monteleone, R. Caruso, and F. Pallone Targets for new immunomodulation strategies in inflammatory bowel disease Autoimmun. Rev. 13 2014 11 14
9. L. Rovedatti, T. Kudo, P. Biancheri, M. Sarra, C.H. Knowles, D.S. Rampton, and et al. Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease Gut 58 2009 1629 1636
10. J.B. Brown, P. Cheresh, Z. Zhang, H. Ryu, E. Managlia, and T.A. Barrett P-selectin glycoprotein ligand-1 is needed for sequential recruitment of T-helper 1 (Th1) and local generation of Th17 T cells in dextran sodium sulfate (DSS) colitis Inflamm. Bowel Dis. 18 2012 323 332
11. J. Xu, Y. Yang, G. Qiu, G. Lal, N. Yin, Z. Wu, and et al. Stat4 is critical for the balance between Th17 cells and regulatory T cells in colitis J. Immunol. 186 2011 6597 6606
12. J. Li, B. Wei, A. Guo, C. Liu, S. Huang, F. Du, and et al. Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired Th17 cell differentiation Proc. Natl. Acad. Sci. U. S. A. 110 2013 7395 7400
13. K.W. Kalim, M. Basler, C.J. Kirk, and M. Groettrup Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation J. Immunol. 189 2012 4182 4193
14. M.J. McGeachy, Y. Chen, C.M. Tato, A. Laurence, B. Joyce-Shaikh, W.M. Blumenschein, and et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo Nat. Immunol. 10 2009 314 324
15. M. Yang, X. Xu, C. Xie, Z. Xie, J. Huang, and D. Yang Separation and purification of arctiin, arctigenin, matairesinol, and lappaol F from Fructus Arctii by high-speed counter-current chromatography Separ. Sci. Technol. 48 2013 1738 1744
16. S.Y. Park, S.S. Hong, X.H. Han, J.S. Hwang, D. Lee, J.S. Ro, and et al. Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production Chem. Pharm. Bull. (Tokyo) 55 2007 150 152
17. X. Wu, Y. Yang, Y. Dou, J. Ye, D. Bian, Z. Wei, and et al. Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice Int. Immunopharmacol. 23 2014 505 515
18. Y. Zhang, S. Xu, J. Lin, G. Yao, Z. Han, B. Liang, and et al. mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo Breast Cancer Res. Treat. 136 2012 379 388
19. M. Liu, S.A. Wilk, A. Wang, L. Zhou, R.H. Wang, W. Ogawa, and et al. Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR J. Biol. Chem. 285 2010 36387 36394
20. G.M. Delgoffe, K.N. Pollizzi, A.T. Waickman, E. Heikamp, D.J. Meyers, M.R. Horton, and et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2 Nat. Immunol. 12 2011 295 303
21. Y. Kurebayashi, S. Nagai, A. Ikejiri, M. Ohtani, K. Ichiyama, Y. Baba, and et al. PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORgamma Cell Rep. 1 2012 360 373
22. C.S. Beevers, L. Chen, L. Liu, Y. Luo, N.J.G. Webster, and S. Huang Curcumin disrupts the mammalian target of rapamycin-raptor complex Cancer Res. 69 2009 1000 1008
23. G.-T. Ho, C. Lees, and J. Satsangi Ulcerative colitis Medicine 35 2007 277 282
24. A. Di Sabatino, P. Biancheri, L. Rovedatti, T.T. MacDonald, and G.R. Corazza New pathogenic paradigms in inflammatory bowel disease Inflamm. Bowel Dis. 18 2012 368 371
25. P. Alex, N.C. Zachos, T. Nguyen, L. Gonzales, T.E. Chen, L.S. Conklin, and et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis Inflamm. Bowel Dis. 15 2009 341 352
26. M. Leppkes, C. Becker, I.I. Ivanov, S. Hirth, S. Wirtz, C. Neufert, and et al. RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F Gastroenterology 136 2009 257 267
27. Y.S. Kim, M.H. Lee, A.S. Ju, and K.J. Rhee Th17 responses are not induced in dextran sodium sulfate model of acute colitis Immune Netw. 11 2011 416 419
28. I.I. Ivanov, B.S. McKenzie, L. Zhou, C.E. Tadokoro, A. Lepelley, J.J. Lafaille, and et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells Cell 126 2006 1121 1133
29. J. Wang, M. Pae, S.N. Meydani, and D. Wu Green tea epigallocatechin-3-gallate modulates differentiation of naive CD4(+) T cells into specific lineage effector cells J. Mol. Med. (Berl.) 91 2013 485 495
30. M.F. Gulen, K. Bulek, H. Xiao, M. Yu, J. Gao, L. Sun, and et al. Inactivation of the enzyme GSK3alpha by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance Immunity 37 2012 800 812
31. G.M. Delgoffe, T.P. Kole, Y. Zheng, P.E. Zarek, K.L. Matthews, B. Xiao, and et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment Immunity 30 2009 832 844
32. Y.G. Zhao, Y. Wang, Z. Guo, Gu Ad, H.C. Dan, A.S. Baldwin, and et al. Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway J. Immunol. 189 2012 4417 4425
33. K. Lee, P. Gudapati, S. Dragovic, C. Spencer, S. Joyce, N. Killeen, and et al. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways Immunity 32 2010 743 753