LRIG1, a 3p tumor suppressor, represses EGFR signaling and is a novel epigenetic silenced gene in colorectal cancer

Biochemical and Biophysical Research Communications

Volumn 464, Issue 2, 2015, Pages 519-525

  Kou, Changhua ^a   Zhou, Tian ^a   Han, Xilin ^a   Zhuang, Huijie ^a   Qian, Haixin ^b  

^a XUZHOU CENTRAL HOSPITAL   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

Colorectal cancer; EGFR signaling; LRIG1; Methylation; Proliferation

Indexed keywords

COMPLEMENTARY DNA; DECITABINE; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; PROTEIN; PROTEIN KINASE B; SHORT HAIRPIN RNA; TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN LRIG1; UNCLASSIFIED DRUG; LRIG1 PROTEIN, HUMAN; MEMBRANE PROTEIN;

ARTICLE; CACO 2 CELL LINE; CANCER GROWTH; CANCER TISSUE; CELL PROLIFERATION; COLONY FORMATION; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; EPIGENETIC REPRESSION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC CORRELATION; GENETIC TRANSFECTION; HCT116 CELL LINE; HT 29 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; LOVO CELL LINE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SW480 CELL LINE; UPREGULATION; CHROMOSOME 3; COLORECTAL TUMOR; GENETIC EPIGENESIS; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 3; COLORECTAL NEOPLASMS; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; MEMBRANE GLYCOPROTEINS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 84938292875     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.06.173     Document Type: Article

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