Epigenetic regulation of REG1A and chemosensitivity of cutaneous melanoma

Epigenetics

Volumn 8, Issue 10, 2013, Pages 1043-1052

  Sato, Yusuke ^a   Marzese, Diego M ^a   Ohta, Katsuya ^a   Huang, Sharon K ^a   Sim, Myung Shin ^a   Chong, Kelly ^a   Hoon, Dave S B ^a  

^a JOHN WAYNE CANCER INSTITUTE   (United States)

Author keywords

Chemosensitivity; Melanoma; Metastasis; Methylation; REG1A

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CISPLATIN; DACARBAZINE; MESSENGER RNA;

ADJUVANT CHEMOTHERAPY; ADULT; ARTICLE; CELL LINE; CELL PROLIFERATION; CHEMOSENSITIVITY; CHEMOTHERAPY; CONTROLLED STUDY; CUTANEOUS MELANOMA; DEMETHYLATION; DISEASE FREE SURVIVAL; DISEASE SPECIFIC SURVIVAL; EPIGENETICS; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MELANOMA METASTASIS; PROGNOSIS; PROTEIN EXPRESSION; REGENERATING GENE 1A; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; TISSUE REGENERATION; UPREGULATION;

CHEMOSENSITIVITY; MELANOMA; METASTASIS; METHYLATION; REG1A;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CISPLATIN; DACARBAZINE; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION; HUMANS; LITHOSTATHINE; LYMPHATIC METASTASIS; MALE; MELANOMA; PROGNOSIS; PROMOTER REGIONS, GENETIC; SKIN NEOPLASMS;

EID: 84884915253     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.25810     Document Type: Article

References (37)

1. Mocellin S, Pasquali S, Rossi CR, Nitti D. Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-analysis. J Natl Cancer Inst 2010; 102: 493-501; PMID: 20179267; http://dx. doi. org/10. 1093/jnci/djq009
2. Morton DL, Thompson JF, Cochran AJ, Mozzillo N, Elashoff R, Essner R, et al.; MSLT Group. Sentinelnode biopsy or nodal observation in melanoma. N Engl J Med 2006; 355: 1307-17; PMID: 17005948; http://dx. doi. org/10. 1056/NEJMoa060992
3. Kirkwood JM, Moschos S, Wang W. Strategies for the development of more effective adjuvant therapy of melanoma: current and future explorations of antibodies, cytokines, vaccines, and combinations. Clin Cancer Res 2006; 12: 2331s-6s; PMID: 16609054; http://dx. doi. org/10. 1158/1078-0432. CCR-05-2538
4. Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010; 363: 809-19; PMID: 20818844; http://dx. doi. org/10. 1056/NEJMoa1002011
5. Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010; 363: 711-23; PMID: 20525992; http://dx. doi. org/10. 1056/NEJMoa1003466
6. Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y, et al. A novel gene activated in regenerating islets. J Biol Chem 1988; 263: 2111-4; PMID: 2963000
7. Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem 1990; 265: 7432-9; PMID: 2332435
8. Miyaoka Y, Kadowaki Y, Ishihara S, Ose T, Fukuhara H, Kazumori H, et al. Transgenic overexpression of Reg protein caused gastric cell proliferation and differentiation along parietal cell and chief cell lineages. Oncogene 2004; 23: 3572-9; PMID: 15116092; http://dx. doi. org/10. 1038/sj. onc. 1207333
9. Unno M, Itoh T, Watanabe T, Miyashita H, Moriizumi S, Teraoka H, et al. Islet beta-cell regeneration and reg genes. Adv Exp Med Biol 1992; 321: 61-6, discussion 67-9; PMID: 1449083; http://dx. doi. org/10. 1007/978-1-4615-3448-8_8
10. Hayashi K, Motoyama S, Sugiyama T, Izumi J, Anbai A, Nanjo H, et al. REG Ialpha is a reliable marker of chemoradiosensitivity in squamous cell esophageal cancer patients. Ann Surg Oncol 2008; 15: 1224-31; PMID: 18259819; http://dx. doi. org/10. 1245/s10434-008-9810-8
11. Motoyama S, Sugiyama T, Ueno Y, Okamoto H, Takasawa S, Nanjo H, et al. REG I expression predicts long-term survival among locally advanced thoracic squamous cell esophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by esophagectomy. Ann Surg Oncol 2006; 13: 1724-31; PMID: 17009160; http://dx. doi. org/10. 1245/s10434-006-9075-z
12. Sekikawa A, Fukui H, Fujii S, Ichikawa K, Tomita S, Imura J, et al. REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. Carcinogenesis 2008; 29: 76-83; PMID: 18024479; http://dx. doi. org/10. 1093/carcin/bgm250
13. Yoshino N, Ishihara S, Rumi MA, Ortega-Cava CF, Yuki T, Kazumori H, et al. Interleukin-8 regulates expression of Reg protein in Helicobacter pyloriinfected gastric mucosa. Am J Gastroenterol 2005; 100: 2157-66; PMID: 16181363; http://dx. doi. org/10. 1111/j. 1572-0241. 2005. 41915. x
14. Astrosini C, Roeefzaad C, Dai YY, Dieckgraefe BK, Jöns T, Kemmner W. REG1A expression is a prognostic marker in colorectal cancer and associated with peritoneal carcinomatosis. Int J Cancer 2008; 123: 409-13; PMID: 18452172; http://dx. doi. org/10. 1002/ijc. 23466
15. Lee WS, Seo G, Shin HJ, Yun SH, Yun H, Choi N, et al. Identification of differentially expressed genes in microsatellite stable HNPCC and sporadic colon cancer. J Surg Res 2008; 144: 29-35; PMID: 17950328; http://dx. doi. org/10. 1016/j. jss. 2007. 02. 005
16. Kimura N, Yonekura H, Okamoto H, Nagura H. Expression of human regenerating gene mRNA and its product in normal and neoplastic human pancreas. Cancer 1992; 70: 1857-63; PMID: 1525759; http://dx. doi. org/10. 1002/1097-0142(19921001)70: 7<1857: AIDCNCR2820700708> 3. 0. CO; 2-8
17. Cavard C, Terris B, Grimber G, Christa L, Audard V, Radenen-Bussiere B, et al. Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with beta-catenin mutations. Oncogene 2006; 25: 599-608; PMID: 16314847; http://dx. doi. org/10. 1038/sj. onc. 1208860
18. Minamiya Y, Kawai H, Saito H, Ito M, Hosono Y, Motoyama S, et al. REG1A expression is an independent factor predictive of poor prognosis in patients with non-small cell lung cancer. Lung Cancer 2008; 60: 98-104; PMID: 17964685; http://dx. doi. org/10. 1016/j. lungcan. 2007. 09. 012
19. Sasaki Y, Minamiya Y, Takahashi N, Nakagawa T, Katayose Y, Ito A, et al. REG1A expression is an independent factor predictive of poor prognosis in patients with breast cancer. Ann Surg Oncol 2008; 15: 3244-51; PMID: 18781363; http://dx. doi. org/10. 1245/s10434-008-0137-2
20. Geng J, Fan J, Wang P, Fang ZJ, Xia GW, Jiang HW, et al. REG1A predicts recurrence in stage Ta/T1 bladder cancer. Eur J Surg Oncol 2009; 35: 852-7; PMID: 19167858; http://dx. doi. org/10. 1016/j. ejso. 2008. 12. 007
21. Sato Y, Motoyama S, Nanjo H, Ito S, Yoshino K, Sasaki T, et al. REG1A expression status suggests chemosensitivity among advanced thoracic esophageal squamous cell carcinoma patients treated with esophagectomy followed by adjuvant chemotherapy. [Epub Ahead of Print]. Ann Surg Oncol 2013; PMID: 23645481; http://dx. doi. org/10. 1245/s10434-013-2983-9
22. Greenberg ES, Chong KK, Huynh KT, Tanaka R, Hoon DS. Epigenetic biomarkers in skin cancer. Cancer Lett 2012; PMID: 22289720; http://dx. doi. org/10. 1016/j. canlet. 2012. 01. 020
23. Rodenhiser D, Mann M. Epigenetics and human disease: translating basic biology into clinical applications. CMAJ 2006; 174: 341-8; PMID: 16446478; http://dx. doi. org/10. 1503/cmaj. 050774
24. Hoon DS, Spugnardi M, Kuo C, Huang SK, Morton DL, Taback B. Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients. Oncogene 2004; 23: 4014-22; PMID: 15064737; http://dx. doi. org/10. 1038/sj. onc. 1207505
25. Kitago M, Martinez SR, Nakamura T, Sim MS, Hoon DS. Regulation of RUNX3 tumor suppressor gene expression in cutaneous melanoma. Clin Cancer Res 2009; 15: 2988-94; PMID: 19336521; http://dx. doi. org/10. 1158/1078-0432. CCR-08-3172
26. Nguyen T, Kuo C, Nicholl MB, Sim MS, Turner RR, Morton DL, et al. Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma. Epigenetics 2011; 6: 388-94; PMID: 21081840; http://dx. doi. org/10. 4161/epi. 6. 3. 14056
27. Tanemura A, Terando AM, Sim MS, van Hoesel AQ, de Maat MF, Morton DL, et al. CpG island methylator phenotype predicts progression of malignant melanoma. Clin Cancer Res 2009; 15: 1801-7; PMID: 19223509; http://dx. doi. org/10. 1158/1078-0432. CCR-08-1361
28. Yoshimura T, Nagahara M, Kuo C, Turner RR, Soon-Shiong P, Hoon DS. Lymphovascular invasion of colorectal cancer is correlated to SPARC expression in the tumor stromal microenvironment. Epigenetics 2011; 6: 1001-11; PMID: 21725199; http://dx. doi. org/10. 4161/epi. 6. 8. 16063
29. Kagara N, Huynh KT, Kuo C, Okano H, Sim MS, Elashoff D, et al. Epigenetic regulation of cancer stem cell genes in triple-negative breast cancer. Am J Pathol 2012; 181: 257-67; PMID: 22626806; http://dx. doi. org/10. 1016/j. ajpath. 2012. 03. 019
30. Galluzzi L, Senovilla L, Vitale I, Michels J, Martins I, Kepp O, et al. Molecular mechanisms of cisplatin resistance. Oncogene 2012; 31: 1869-83; PMID: 21892204; http://dx. doi. org/10. 1038/onc. 2011. 384
31. Neyns B, Tosoni A, Hwu WJ, Reardon DA. Dosedense temozolomide regimens: antitumor activity, toxicity, and immunomodulatory effects. Cancer 2010; 116: 2868-77; PMID: 20564393; http://dx. doi. org/10. 1002/cncr. 25035
32. Miyata H, Doki Y, Shiozaki H, Inoue M, Yano M, Fujiwara Y, et al. CDC25B and p53 are independently implicated in radiation sensitivity for human esophageal cancers. Clin Cancer Res 2000; 6: 4859-65; PMID: 11156245
33. Takasawa S, Ikeda T, Akiyama T, Nata K, Nakagawa K, Shervani NJ, et al. Cyclin D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration. FEBS Lett 2006; 580: 585-91; PMID: 16405968; http://dx. doi. org/10. 1016/j. febslet. 2005. 12. 070
34. Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, et al. The MIQE guidelines: minimum information for publication of quantitative realtime PCR experiments. Clin Chem 2009; 55: 611-22; PMID: 19246619; http://dx. doi. org/10. 1373/clinchem. 2008. 112797
35. Narita N, Tanemura A, Murali R, Scolyer RA, Huang S, Arigami T, et al. Functional RET G691S polymorphism in cutaneous malignant melanoma. Oncogene 2009; 28: 3058-68; PMID: 19561646; http://dx. doi. org/10. 1038/onc. 2009. 164
36. Triche TJ Jr., Weisenberger DJ, Van Den Berg D, Laird PW, Siegmund KD. Low-level processing of Illumina Infinium DNA Methylation BeadArrays. Nucleic Acids Res 2013; 41: e90; PMID: 23476028; http://dx. doi. org/10. 1093/nar/gkt090
37. McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM; Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics. REporting recommendations for tumour MARKer prognostic studies (REMARK). Eur J Cancer 2005; 41: 1690-6; PMID: 16043346; http://dx. doi. org/10. 1016/j. ejca. 2005. 03. 032