Profiling of chiral and achiral carboxylic acid metabolomics: Synthesis and evaluation of triazine-type chiral derivatization reagents for carboxylic acids by LC-ESI-MS/MS and the application to saliva of healthy volunteers and diabetic patients

Analytical and Bioanalytical Chemistry

Volumn 407, Issue 3, 2015, Pages 1003-1014

  Takayama, Takahiro ^a   Kuwabara, Tomohiro ^a   Maeda, Toshio ^a   Noge, Ichiro ^b   Kitagawa, Yutaka ^b   Inoue, Koichi ^a   Todoroki, Kenichiro ^a   Min, Jun Zhe ^a   Toyo'oka, Toshimasa ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b Numazu City Hospital   (Japan)

Author keywords

Carboxylic acids; Chiral derivatization reagent; Chiral metabolomics; Diabetic patients; Enantiomer separation; Saliva analysis; UPLC MS MS

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHY; DIAGNOSIS; ENANTIOMERS; LACTIC ACID; SEPARATION;

DERIVATIZATION REAGENT; DIABETIC PATIENT; ENANTIOMER SEPARATION; METABOLOMICS; SALIVA ANALYSIS; UPLC-MS/MS;

CARBOXYLIC ACIDS;

1-(4,6-DIMETHOXY-1,3,5-TRIAZIN-2-YL)PYRROLIDIN-3-AMINE; CARBOXYLIC ACID; LACTIC ACID; PYRROLIDINE DERIVATIVE; TRIAZINE DERIVATIVE;

ADULT; CHEMISTRY; DIABETES MELLITUS; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MALE; METABOLISM; METABOLOMICS; MIDDLE AGED; NORMAL HUMAN; PROCEDURES; REVERSED PHASE LIQUID CHROMATOGRAPHY; SALIVA; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

ADULT; CARBOXYLIC ACIDS; CHROMATOGRAPHY, LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DIABETES MELLITUS; FEMALE; HEALTHY VOLUNTEERS; HUMANS; LACTIC ACID; LIMIT OF DETECTION; MALE; METABOLOMICS; MIDDLE AGED; PYRROLIDINES; SALIVA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; TRIAZINES;

EID: 84938261791     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-014-8275-9     Document Type: Article

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