Carotid baroreflex activation therapy for resistant hypertension

Nature Reviews Cardiology

Volumn 12, Issue 8, 2015, Pages 451-463

  Victor, Ronald G ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAROTID BAROREFLEX ACTIVATION THERAPY; CAROTID SINUS MASSAGE; CAROTID SINUS PRESSORECEPTOR REFLEX; ELECTROSTIMULATION THERAPY; HEART FAILURE; HUMAN; IMPLANTABLE CAROTID SINUS STIMULATOR; NERVE CONDUCTION; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRESSORECEPTOR; PRIORITY JOURNAL; RESISTANT HYPERTENSION; REVIEW; SENSORY NERVE CONDUCTION; SYMPATHETIC NERVE; ADRENERGIC SYSTEM; CAROTID ARTERY; CLINICAL TRIAL (TOPIC); DEVICES; DRUG RESISTANCE; EFFERENT NERVE; ELECTRODE; EQUIPMENT DESIGN; HEART RATE; HYPERTENSION; INNERVATION; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESSORECEPTOR REFLEX; PROCEDURES; SKELETAL MUSCLE;

ANTIHYPERTENSIVE AGENT; DIURETIC AGENT;

ANTIHYPERTENSIVE AGENTS; BAROREFLEX; CAROTID ARTERIES; CLINICAL TRIALS AS TOPIC; DIURETICS; DRUG RESISTANCE; EFFERENT PATHWAYS; ELECTRIC STIMULATION THERAPY; ELECTRODES; EQUIPMENT DESIGN; HEART RATE; HUMANS; HYPERTENSION; MUSCLE, SKELETAL; SYMPATHETIC NERVOUS SYSTEM;

EID: 84938197796     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2015.96     Document Type: Review

References (125)

1. Mancia, G., & Mark, A. L. Arterial baroreflexes in humans. Comprehensive Physiology [online], http://www.comprehensivephysiology.com/WileyCDA/CompPhysArticle/refId-cp020320.html (2011
2. Martin, E. A., & Victor, R. G. Premise, promise, and potential limitations of invasive devices to treat hypertension. Curr. Cardiol. Rep. 13, 86-92 (2011
3. Bakris, G. L. Interventional cardiology: Indications for renal denervation: a balanced approach?. Nat. Rev. Cardiol. 10, 434-436 (2013
4. Bohm, M., Linz, D., Urban, D., Mahfoud, F., & Ukena, C. Renal sympathetic denervation: applications in hypertension and beyond. Nat. Rev. Cardiol. 10, 465-476 (2013
5. Mearns, B. M. Hypertension: further EnligHTNment on renal sympathetic denervation. Nat. Rev. Cardiol. 10, 490 (2013
6. Wang, Y. Ethnicity and sympathetic tone: predictors of the blood pressure response to renal denervation?. Nat. Rev. Cardiol. 11, 638 (2014
7. Bronk, D. W., & Stella, G. The response to steady pressures of single end organs in the isolated carotid sinus. Am. J. Physiol. 110, 708-714 (1935
8. Brown, A. M. Receptors under pressure. An update on baroreceptors. Circ. Res. 46, 1-10 (1980
9. Heymans, C., & van den Heuvel-Heymans, G. New aspects of blood pressure regulation. Circulation 4, 581-586 (1951
10. Hajduczok, G., Chapleau, M. W., Ferlic, R. J., Mao, H. Z., & Abboud, F. M. Gadolinium inhibits mechanoelectrical transduction in rabbit carotid baroreceptors. Implication of stretch-Activated channels. J. Clin. Invest. 94, 2392-2396 (1994
11. Chen, H. I., Chapleau, M. W., McDowell, T. S., & Abboud, F. M. Prostaglandins contribute to activation of baroreceptors in rabbits. Possible paracrine influence of endothelium. Circ. Res. 67, 1394-1404 (1990
12. Snitsarev, V., Whiteis, C. A., Chapleau, M. W., & Abboud, F. M. Neuronal prostacyclin is an autocrine regulator of arterial baroreceptor activity. Hypertension 46, 540-546 (2005
13. Aljadhey, H., et al. Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension. BMC Cardiovasc. Disord. 12, 93 (2012
14. Li, Z., et al. Nitric oxide as an autocrine regulator of sodium currents in baroreceptor neurons. Neuron 20, 1039-1049 (1998
15. Andresen, M. C., Doyle, M. W., Jin, Y. H., & Bailey, T. W. Cellular mechanisms of baroreceptor integration at the nucleus tractus solitarius. Ann. N. Y. Acad. Sci. 940, 132-141 (2001
16. Reis, D. J. The brain and hypertension: reflections on 35 years of inquiry into the neurobiology of the circulation. Circulation 70, III31-III45 (1984
17. Ohta, H., Li, X., & Talman, W. T. Release of glutamate in the nucleus tractus solitarii in response to baroreflex activation in rats. Neuroscience 74, 29-37 (1996
18. Ohta, H., & Talman, W. T. Both NMDA and non-NMDA receptors in the NTS participate in the baroreceptor reflex in rats. Am. J. Physiol. 267, R1065-R1070 (1994
19. Yin, M., Lee, C. C., Ohta, H., & Talman, W. T. Hemodynamic effects elicited by stimulation of the nucleus tractus solitarii. Hypertension 23, I73-I77 (1994
20. Lin, L. H., & Talman, W. T. Vesicular glutamate transporters and neuronal nitric oxide synthase colocalize in aortic depressor afferent neurons. J. Chem. Neuroanat. 32, 54-64 (2006
21. Talman, W. T., & Dragon, D. N. Transmission of arterial baroreflex signals depends on neuronal nitric oxide synthase. Hypertension 43, 820-824 (2004
22. Madden, C. J., & Sved, A. F. Rostral ventrolateral medulla C1 neurons and cardiovascular regulation. Cell. Mol. Neurobiol. 23, 739-749 (2003
23. Bristow, J. D., Honour, A. J., Pickering, T. G., & Sleight, P. Cardiovascular and respiratory changes during sleep in normal and hypertensive subjects. Cardiovasc. Res. 3, 476-485 (1969
24. Eckberg, D. L., Drabinsky, M., & Braunwald, E. Defective cardiac parasympathetic control in patients with heart disease. N. Engl. J. Med. 285, 877-883 (1971
25. Korner, P. I., West, M. J., Shaw, J., & Uther, J. B. Steady-state properties of the baroreceptor-heart rate reflex in essential hypertension in man. Clin. Exp. Pharmacol. Physiol. 1, 65-76 (1974
26. Mancia, G., et al. Circulatory reflexes from carotid and extracarotid baroreceptor areas in man. Circ. Res. 41, 309-315 (1977
27. Sundlof, G., & Wallin, B. G. Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age. J. Physiol. 274, 621-637 (1978
28. Aksamit, T. R., Floras, J. S., Victor, R. G., & Aylward. P. E. Paroxysmal hypertension due to sinoaortic baroreceptor denervation in humans. Hypertension 9, 309-314 (1987
29. Heusser, K., Tank, J., Luft, F. C., & Jordan, J. Baroreflex failure. Hypertension 45, 834-839 (2005
30. Jacobsen, T. N., et al. Relative contributions of cardiopulmonary and sinoaortic baroreflexes in causing sympathetic activation in the human skeletal muscle circulation during orthostatic stress. Circ. Res. 73, 367-378 (1993
31. Norcliffe-Kaufmann, L., Axelrod, F., & Kaufmann, H. Afferent baroreflex failure in familial dysautonomia. Neurology 75, 1904-1911 (2010
32. Anderson, S. L., et al. Familial dysautonomia is caused by mutations of the IKAP gene. Am. J. Hum. Genet. 68, 753-758 (2001
33. Abashidze, A., Gold, V., Anavi, Y., Greenspan, H., & Weil, M. Involvement of IKAP in peripheral target innervation and in specific JNK and NGF signaling in developing PNS neurons. PLoS ONE 9, e113428 (2014
34. Sanders, J. S., Ferguson, D. W., & Mark, A. L. Arterial baroreflex control of sympathetic nerve activity during elevation of blood pressure in normal man: dominance of aortic baroreflexes. Circulation 77, 279-288 (1988
35. Sanders, J. S., Mark, A. L., & Ferguson, D. W. Importance of aortic baroreflex in regulation of sympathetic responses during hypotension. Evidence from direct sympathetic nerve recordings in humans. Circulation 79, 83-92 (1989
36. Kaplan, N. M., & Victor, R. G. Kaplan's Clinical Hypertension, 11th edn (Wolters Kluwer, 2014
37. Mancia, G., et al. 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur. Heart J. 34, 2159-2219 (2013
38. Fontil, V., et al. Physician underutilization of effective medications for resistant hypertension at office visits in the United States: NAMCS 2006-2010. J. Gen. Intern. Med. 29, 468-476 (2014
39. Khanna, R. R., Victor, R. G., Bibbins-Domingo, K., Shapiro, M. F., & Pletcher, M. J. Missed opportunities for treatment of uncontrolled hypertension at physician office visits in the United States, 2005-2009. Arch. Intern. Med. 172, 1344-1345 (2012
40. Jaffe, M. G., Lee, G. A., Young, J. D., Sidney, S., & Go, A. S. Improved blood pressure control associated with a large-scale hypertension program. JAMA 310, 699-705 (2013
41. Egan, B. M., Zhao, Y., Axon, R. N., Brzezinski, W. A., & Ferdinand, K. C. Uncontrolled and apparent treatment resistant hypertension in the United States, 1988 to 2008. Circulation 124, 1046-1058 (2011
42. Egan, B. M., et al. Prevalence of optimal treatment regimens in patients with apparent treatment-resistant hypertension based on office blood pressure in a community-based practice network. Hypertension 62, 691-697 (2013
43. Weitzman, D., Chodick, G., Shalev, V., Grossman, C., & Grossman, E. Prevalence and factors associated with resistant hypertension in a large health maintenance organization in Israel. Hypertension 64, 501-507 (2014
44. Calhoun, D. A., et al. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension 51, 1403-1419 (2008
45. Vongpatanasin, W. Resistant hypertension: a review of diagnosis and management. JAMA 311, 2216-2224 (2014
46. Vongpatanasin, W., Kario, K., Atlas, S. A., & Victor, R. G. Central sympatholytic drugs. J. Clin. Hypertens. (Greenwich) 13, 658-661 (2011
47. Guyenet, P. G. The sympathetic control of blood pressure. Nat. Rev. Neurosci. 7, 335-346 (2006
48. Harrison, D. G. The immune system in hypertension. Trans. Am. Clin. Climatol. Assoc. 125, 130-138 (2014
49. Sander, M., Hansen, J., & Victor, R. G. The sympathetic nervous system is involved in the maintenance but not initiation of the hypertension induced by N? nitro L-Arginine methyl ester. Hypertension 30, 64-70 (1997
50. Grimson, K. S., Orgain, E. S. Anderson, B., Broome, R. A., & Longino, F. H. Results of treatment of patients with hypertension by total thoracic and partial to total lumbar sympathectomy, splanchnicectomy and celiac ganglionectomy. Ann. Surg. 129, 850-871 (1949
51. Darr, R., et al. Pheochromocytoma-update on disease management. Ther. Adv. Endocrinol. Metab. 3, 11-26 (2012
52. Guyton, A. C. Blood pressure control-special role of the kidneys and body fluids. Science 252, 1813-1816 (1991
53. Lifton, R. P., Wilson, F. H., Choate, K. A., & Geller, D. S. Salt and blood pressure: new insight from human genetic studies. Cold Spring Harb. Symp. Quant. Biol. 67, 445-450 (2002
54. Schlaich, M. P., et al. Sympathetic augmentation in hypertension: role of nerve firing, norepinephrine reuptake, and Angiotensin neuromodulation. Hypertension 43, 169-175 (2004
55. Esler, M. Sympathetic nervous system moves toward center stage in cardiovascular medicine: from Thomas Willis to resistant hypertension. Hypertension 63, e25-e32 (2014
56. DiBona, G. F. Physiology in perspective: the wisdom of the body. Neural control of the kidney. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289, R633-R641 (2005
57. Grassi, G., et al. Sympathetic and baroreflex cardiovascular control in hypertension-related left ventricular dysfunction. Hypertension 53, 205-209 (2009
58. Grassi, G., et al. Marked sympathetic activation and baroreflex dysfunction in true resistant hypertension. Int. J. Cardiol. 177, 1020-1025 (2014
59. Mancia, G., & Grassi, G. The autonomic nervous system and hypertension. Circ. Res. 114, 1804-1814 (2014
60. Esler, M. Renal denervation for treatment of drug-resistant hypertension. Trends Cardiovasc. Med. 25, 107-115 (2015
61. Mancia, G., Ludbrook, J., Ferrari, A., Gregorini, L., & Zanchetti, A. Baroreceptor reflexes in human hypertension. Circ. Res. 43, 170-177 (1978
62. Guo, G. B., Thames, M. D., & Abboud, F. M. Arterial baroreflexes in renal hypertensive rabbits. Selectivity and redundancy of baroreceptor influence on heart rate, vascular resistance, and lumbar sympathetic nerve activity. Circ. Res. 53, 223-234 (1983
63. Thrasher, T. N. Unloading arterial baroreceptors causes neurogenic hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282, R1044-R1053 (2002
64. Thrasher, T. N. Effects of chronic baroreceptor unloading on blood pressure in the dog. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R863-R871 (2005
65. Thrasher, T. N. Arterial baroreceptor input contributes to long-Term control of blood pressure. Curr. Hypertens. Rep. 8, 249-254 (2006
66. Carlsten, A., Folkow, B., Grimby, G., Hamberger, C. A., & Thulesius, O. Cardiovascular effects of direct stimulation of the carotid sinus nerve in man. Acta Physiol. Scand. 44, 138-145 (1958
67. Bilgutay, A. M., Bigultay, I., & Lillehei, C. W. In Baroreceptors and Hypertension (ed. Kedzi, P.) 425-437 (Pergamon, 1967
68. Bilgutay, A. M., & Lillehei, C. W. Surgical treatment of hypertension with reference to baropacing. Am. J. Cardiol. 17, 663-667 (1966
69. Scheffers, I. J., Kroon, A. A., & de Leeuw, P. W. Carotid baroreflex activation: past, present, and future. Curr. Hypertens. Rep. 12, 61-66 (2010
70. Braunwald, E., & Sobel, B. E. Braunwald NS: treatment of paroxysmal supraventricular trachycardia by electrical stimulation of the carotid-sinus nerves. N. Engl. J. Med. 281, 885-887 (1969
71. Braunwald, E., Epstein, S. E., Glick, G., Wechsler, A. S., & Braunwald, N. S. Relief of angina pectoris by electrical stimulation of the carotid-sinus nerves. N. Engl. J. Med. 277, 1278-1283 (1967
72. No authors listed] Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA 202, 1028-1034 (1967
73. Cowley, A. W. Jr, Liard, J. F., & Guyton, A. C. Role of baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circ. Res. 32, 564-576 (1973
74. Lohmeier, T. E., Irwin, E. D., Rossing, M. A., Serdar, D. J., & Kieval, R. S. Prolonged activation of the baroreflex produces sustained hypotension. Hypertension 43, 306-311 (2004
75. Tordoir, J. H., et al. An implantable carotid sinus baroreflex activating system: surgical technique and short-Term outcome from a multi-center feasibility trial for the treatment of resistant hypertension. Eur. J. Vasc. Endovasc. Surg. 33, 414-421 (2007
76. Brest, A. N., Wiener, L., & Bachrach, B. Bilateral carotid sinus nerve stimulation in the treatment of hypertension. Am. J. Cardiol. 29, 821-825 (1972
77. Parsonnet, V., Rothfeld, E. L., Raman, K. V., & Myers, G. H. Electrical stimulation of the carotid sinus nerve. Surg. Clin. North Am. 49, 589-596 (1969
78. Schmidli, J., et al. Acute device-based blood pressure reduction: electrical activation of the carotid baroreflex in patients undergoing elective carotid surgery. Vascular 15, 63-69 (2007
79. Mohaupt, M. G., Schmidli, J., & Luft, F. C. Management of uncontrollable hypertension with a carotid sinus stimulation device. Hypertension 50, 825-828 (2007
80. Wustmann, K., et al. Effects of chronic baroreceptor stimulation on the autonomic cardiovascular regulation in patients with drug-resistant arterial hypertension. Hypertension 54, 530-536 (2009
81. Goldstein, D. S., Bentho, O., Park, M. Y., & Sharabi, Y. Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes. Exp. Physiol. 96, 1255-1261 (2011
82. Vongpatanasin, W., Taylor, J. A., & Victor, R. G. Effects of cocaine on heart rate variability in healthy subjects. Am. J. Cardiol. 93, 385-388 (2004
83. Heusser, K., et al. Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients. Hypertension 55, 619-626 (2010
84. Scheffers, I. J., et al. Novel baroreflex activation therapy in resistant hypertension: results of a European multi-center feasibility study. J. Am. Coll. Cardiol. 56, 1254-1258 (2010
85. Bisognano, J. D., Kaufman, C. L., Bach, D. S., Lovett, E. G., & de Leeuw, P. Improved cardiac structure and function with chronic treatment using an implantable device in resistant hypertension: results from European and United States trials of the Rheos system. J. Am. Coll. Cardiol. 57, 1787-1788 (2011
86. Bisognano, J. D., et al. Baroreflex activation therapy lowers blood pressure in patients with resistant hypertension: results from the double-blind, randomized, placebo-controlled Rheos Pivotal Trial. J. Am. Coll. Cardiol. 58, 765-773 (2011
87. Alnima, T., de Leeuw, P. W., Tan, F. E., & Kroon, A. A. Renal responses to long-Term carotid baroreflex activation therapy in patients with drug-resistant hypertension. Hypertension 61, 1334-1339 (2013
88. Bakris, G. L., et al. Baroreflex activation therapy provides durable benefit in patients with resistant hypertension: results of long-Term follow-up in the Rheos Pivotal Trial. J. Am. Soc. Hypertens. 6, 152-158 (2012
89. Bakris, G., Nadim, M., Haller, H., Lovett, E., & Bisognano, J. Baroreflex activation therapy safely reduces blood pressure for at least five years in a large resistant hypertension cohort [abstract]. J. Am. Soc. Hypertens. 8, e9 (2014
90. Patel, H. C., et al. Magnitude of blood pressure reduction in the placebo arms of modern hypertension trials: implications for trials of renal denervation. Hypertension 65, 401-406 (2015
91. Chapman, N., et al. Effect of spironolactone on blood pressure in subjects with resistant hypertension. Hypertension 49, 839-845 (2007
92. de Leeuw, P. W., et al. Bilateral or unilateral stimulation for baroreflex activation therapy. Hypertension 65, 187-192 (2015
93. Sagawa, K., & Watanabe, K. Summation of bilateral carotid sinus signals in the barostatic reflex. Am. J. Physiol. 209, 1278-1286 (1965
94. Diedrich, A., et al. Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation. Am. J. Physiol. Heart Circ. Physiol. 296, H1758-H1765 (2009
95. Furlan, R., et al. Effects of unilateral and bilateral carotid baroreflex stimulation on cardiac and neural sympathetic discharge oscillatory patterns. Circulation 108, 717-723 (2003
96. Tafil-Klawe, M., Raschke, F., & Hildebrandt, G. Functional asymmetry in carotid sinus cardiac reflexes in humans. Eur. J. Appl. Physiol. Occup. Physiol. 60, 402-405 (1990
97. Alnima, T., de Leeuw, P. W., & Kroon, A. A. Baroreflex activation therapy for the treatment of drug-resistant hypertension: new developments. Cardiol. Res. Pract. 12, 1-7 (2012
98. Hoppe, U. C., et al. Minimally invasive system for baroreflex activation therapy chronically lowers blood pressure with pacemaker-like safety profile: results from the Barostim neo trial. J. Am. Soc. Hypertens. 6, 270-276 (2012
99. Borisenko, O., Beige, J., Lovett, E. G., Hoppe, U. C., & Bjessmo, S. Cost-effectiveness of Barostim therapy for the treatment of resistant hypertension in European settings. J. Hypertens. 32, 681-692 (2014
100. US National Library of Medicine. ClinicalTrials.gov [online], https://www.clinicaltrials.gov/ct2/show/NCT01679132 (2015
101. CVRx®. CVRx® receives CE mark approval and introduces new implantable device for hypertension, the Barostim neo™ [online], http://www.cvrx.com/intl-news/cvrx-receives-ce-mark-Approval-And-introduces-new-implantable-device-for-hypertension-The-barostim-neo/(2011
102. CVRx®. CVRx® granted CE marking of the Barostim neo System™ for conditional MRI compatibility [online], http://www.cvrx.com/usa-news/cvrxgranted-ce-marking-barostim-neo-system-conditional-mri-compatibility/(2014
103. CVRx®. CVRx® granted humanitarian device exemption approval from FDA for Barostim neo legacy™ hypertension therapy device [online], http://www.cvrx.com/usa-news/cvrx-granted-humanitarian-device-exemption-Approval-fda-barostim-neo-legacy-hypertension-Therapy-device/(2014
104. CVRx®. CVRx® receives CE mark approval of the Barostim neo System™ for the treatment of heart failure [online], http://www.cvrx.com/usa-news/cvrx-receives-ce-mark-Approval-barostim-neo-system-Treatment-heart-failure/(2014
105. Halbach, M., Hickethier, T., Madershahian, N., & Muller-Ehmsen, J. Baroreflex activation therapy: a new treatment option for heart failure with reduced ejection fraction. Expert Rev. Cardiovasc. Ther. 12, 1465-1469 (2014
106. Madershahian, N., et al. Baroreflex activation therapy in patients with pre-existing implantable cardioverter-defibrillator: compatible, complementary therapies. Europace 16, 861-865 (2014
107. Gronda, E., et al. Chronic baroreflex activation effects on sympathetic nerve traffic, baroreflex function, and cardiac haemodynamics in heart failure: a proof of concept study. Eur. J. Heart Fail. 16, 977-983 (2014
108. Barrett, E. J., Wang, H., Upchurch, C. T., & Liu, Z. Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature. Am. J. Physiol. Endocrinol. Metab. 301, E252-E263 (2011
109. Jamerson, K. A., Julius, S., Gudbrandsson, T., Andersson, O., & Brant, D. O. Reflex sympathetic activation induces acute insulin resistance in the human forearm. Hypertension 21, 618-623 (1993
110. Haenni, A., & Lithell, H. Moxonidine improves insulin sensitivity in insulin-resistant hypertensives. J. Hypertens. Suppl. 17, S29-S35 (1999
111. May, M., et al. Limited acute influences of electrical baroreceptor activation on insulin sensitivity and glucose delivery: a randomized, double-blind, crossover clinical study. Diabetes 63, 2833-2837 (2014
112. Converse, R. L. Jr, et al. Sympathetic overactivity in patients with chronic renal failure. N. Engl. J. Med. 327, 1912-1918 (1992
113. Ligtenberg, G., et al. Reduction of sympathetic hyperactivity by enalapril in patients with chronic renal failure. N. Engl. J. Med. 340, 1321-1328 (1999
114. Wallbach, M., et al. Impact of baroreflex activation therapy on renal function-A pilot study. Am. J. Nephrol. 40, 371-380 (2014
115. Page, I. H. A syndrome simulating diencephalic stimulation occurring in patients with essential hypertension. Am. J. Med. Sci. 190, 9-14 (1935
116. Eisenhofer, G., Sharabi, Y., & Pacak, K. Unexplained symptomatic paroxysmal hypertension in pseudopheochromocytoma: a stress response disorder?. Ann. N. Y. Acad. Sci. 1148, 469-478 (2008
117. Kuchel, O., Buu, N. T., Larochelle, P., Hamet, P., & Genest, Jr. J. Episodic dopamine discharge in paroxysmal hypertension. Page's syndrome revisited. Arch. Intern. Med. 146, 1315-1320 (1986
118. Pickering, T. G., & Clemow, L. Paroxysmal hypertension: the role of stress and psychological factors. J. Clin. Hypertens. (Greenwich) 10, 575-581 (2008
119. Hering, H E. Die Karotissinus Reflex auf Herz und Gefasse [German] 1-150 (Steinkopff, 1927
120. Koch, E., & Mies, H Chronischer arterieller hochdruck durch experimentelle dauerausschaltung der blutdruckzügler [German]. Krankheitsforschung 7, 241-256 (1929
121. Volhard, F. On the pathogenesis of essential hypertension and hypertrophy [German]. Schweiz Med. Wochenschr. 78, 1189 (1948
122. Lown, B., & Levine, S. A. The carotid sinus. Clinical value of its stimulation. Circulation 23, 766-789 (1961
123. Solti, F., et al. Baropacing of the carotid sinus nerve for treatment of intractable hypertension. Z. Kardiol. 64, 368-374 (1975
124. Bristow, J. D., Honour, A. J., Pickering, G. W., Sleight, P., & Smyth, H. S. Diminished baroreflex sensitivity in high blood pressure. Circulation 39, 48-54 (1969
125. Lu, Y., et al. The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. Neuron 64, 885-897 (2009