A novel method for measuring cellular antibody uptake using imaging flow cytometry reveals distinct uptake rates for two different monoclonal antibodies targeting L1

Journal of Immunological Methods

Volumn 423, Issue , 2015, Pages 70-77

  Hazin, John ^a,b   Moldenhauer, Gerhard ^a   Altevogt, Peter ^a   Brady, Nathan R ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Antibody internalization; Endocytosis; EpCAM; Imaging flow cytometry; L1; L1CAM

Indexed keywords

CELL ANTIBODY; EPITHELIAL CELL ADHESION MOLECULE; MONCOLONAL ANTIBODY L1 OV52.24; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY L1 9.3; NERVE CELL ADHESION MOLECULE L1; UNCLASSIFIED DRUG; CADM1 PROTEIN, HUMAN; CELL ADHESION MOLECULE; EPCAM PROTEIN, HUMAN; IMMUNOGLOBULIN; TUMOR ANTIGEN;

ACCURACY; ANALYTIC METHOD; ARTICLE; CELL KILLING; CELL MEMBRANE; CELL SUBPOPULATION; ENDOCYTOSIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMUNOGENICITY; INTERNALIZATION; MEASUREMENT; PRIORITY JOURNAL; TUMOR CELL; CARCINOMA; FEMALE; IMAGE CYTOMETRY; METABOLISM; OVARY TUMOR; PHYSIOLOGY; PROCEDURES; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; BIOLOGICAL TRANSPORT; CARCINOMA; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL MEMBRANE; FEMALE; FLOW CYTOMETRY; HUMANS; IMAGE CYTOMETRY; IMMUNOGLOBULINS; OVARIAN NEOPLASMS;

EID: 84938197029     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2015.04.024     Document Type: Article

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