Women at extreme risk for obesity-related carcinogenesis: Baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life

Gynecologic Oncology

Volumn 138, Issue 2, 2015, Pages 238-245

  Modesitt, Susan C ^a   Hallowell, Peter T ^b   Slack Davis, Jill K ^b   Michalek, Ryan D ^c   Atkins, Kristen A ^b   Kelley, Sarah L ^d   Arapovic, Sanja ^a   Shupnik, Margaret A ^b   Hoehn, Kyle ^b,e  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c METABOLON INC   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Bariatric surgery; Endometrial hyperplasia; Metabolomics; Morbid obesity; QOL

Indexed keywords

FATTY ACID; GLUCOSE; HEME; INSULIN; PHENYLALANINE; PRASTERONE SULFATE; TRYPTOPHAN;

ADULT; AGED; AMINO ACID METABOLISM; ARTICLE; BARIATRIC SURGERY; BODY MASS; BODY WEIGHT; CARCINOGENESIS; CONTROLLED STUDY; ENDOMETRIUM BIOPSY; ENDOMETRIUM HYPERPLASIA; FEMALE; GLUCOSE HOMEOSTASIS; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MENSTRUAL IRREGULARITY; METABOLIC PARAMETERS; METABOLOMICS; MICROBIOME; OBESITY; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; QUALITY OF LIFE; STUDENT T TEST; WEIGHT REDUCTION; CLINICAL TRIAL; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; LIPID METABOLISM; METABOLISM; MIDDLE AGED; PATHOLOGY; YOUNG ADULT;

ADULT; AGED; BARIATRIC SURGERY; BODY WEIGHT; CARCINOGENESIS; ENDOMETRIAL HYPERPLASIA; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; GLUCOSE; HUMANS; LIPID METABOLISM; MIDDLE AGED; OBESITY; QUALITY OF LIFE; YOUNG ADULT;

EID: 84938196834     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2015.05.015     Document Type: Article

References (26)

1. S. Modesitt, and J. Walker Obesity crisis in cancer care: gynecologic cancer prevention, treatment, and survivorship in obese women in the United States Gynecol. Oncol. 133 2014 1 3
2. K.M. Flegal, M.D. Carroll, B.K. Kit, and C.L. Ogden Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010 JAMA 307 2012 491 497
3. G.K. Reeves, K. Pirie, V. Beral, J. Green, E. Spencer, and D. Bull Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study BMJ 335 2007 1134
4. P.G. Rose Endometrial carcinoma N. Engl. J. Med. 335 1996 640 649
5. G. Lane Obesity and gynaecological cancer Menopause Int. 14 2008 33 37
6. K. Bhaskaran, I. Douglas, H. Forbes, I. dos-Santos-Silva, D.A. Leon, and L. Smeeth Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults Lancet 384 2014 755 765
7. G.M. McCawley, J.S. Ferriss, D. Geffel, C.J. Northup, and S.C. Modesitt Cancer in obese women: potential protective impact of bariatric surgery J. Am. Coll. Surg. 208 2009 1093 1098
8. P.A. Argenta, M. Kassing, A.M. Truskinovsky, and C.A. Svendsen Bariatric surgery and endometrial pathology in asymptomatic morbidly obese women: a prospective, pilot study BJOG 120 2013 795 800
9. N. Puzziferri, T.B. Roshek III, H.G. Mayo, R. Gallagher, S.H. Belle, and E.H. Livingston Long-term follow-up after bariatric surgery: a systematic review JAMA 312 2014 934 942
10. L. Sjostrom, A. Gummesson, C.D. Sjostrom, K. Narbro, M. Peltonen, H. Wedel, C. Bengtsson, C. Bouchard, B. Carlsson, S. Dahlgren, P. Jacobson, K. Karason, J. Karlsson, B. Larsson, A.K. Lindroos, H. Lonroth, I. Naslund, T. Olbers, K. Stenlof, J. Torgerson, and L.M. Carlsson Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial Lancet Oncol. 10 2009 653 662
11. A.M. Evans, C.D. DeHaven, T. Barrett, M. Mitchell, and E. Milgram Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems Anal. Chem. 81 2009 6656 6667
12. W. Sha, K.A. da Costa, L.M. Fischer, M.V. Milburn, K.A. Lawton, A. Berger, W. Jia, and S.H. Zeisel Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline FASEB J. 24 2010 2962 2975
13. C.D. Dehaven, A.M. Evans, H. Dai, and K.A. Lawton Organization of GC/MS and LC/MS metabolomics data into chemical libraries J. Cheminf. 2 2010 9
14. J. Larner, D.L. Brautigan, and M.O. Thorner D-chiro-inositol glycans in insulin signaling and insulin resistance Mol. Med. 16 2010 543 552
15. C.B. Newgard, J. An, J.R. Bain, M.J. Muehlbauer, R.D. Stevens, L.F. Lien, A.M. Haqq, S.H. Shah, M. Arlotto, C.A. Slentz, J. Rochon, D. Gallup, O. Ilkayeva, B.R. Wenner, W.S. Yancy Jr., H. Eisenson, G. Musante, R.S. Surwit, D.S. Millington, M.D. Butler, and L.P. Svetkey A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance Cell Metab. 9 2009 311 326
16. S.C. Modesitt, and J.R. van Nagell Jr. The impact of obesity on the incidence and treatment of gynecologic cancers: a review Obstet. Gynecol. Surv. 60 2005 683 692
17. S.C. Modesitt, D.L. Geffel, J. Via, and A LW Morbidly obese women with and without endometrial cancer: are there differences in measured physical fitness, body composition, or hormones? Gynecol. Oncol. 124 2012 431 436
18. N. Potischman, R.N. Hoover, L.A. Brinton, P. Siiteri, J.F. Dorgan, C.A. Swanson, M.L. Berman, R. Mortel, L.B. Twiggs, R.J. Barrett, G.D. Wilbanks, V. Persky, and J.R. Lurain Case-control study of endogenous steroid hormones and endometrial cancer J. Natl. Cancer Inst. 88 1996 1127 1135
19. J. Larner Inositol, glycogen, insulin, and six nobelists J. Biol. Chem. 288 2013 12313 12324
20. J.E. Nestler, D.J. Jakubowicz, P. Reamer, R.D. Gunn, and G. Allan Ovulatory and metabolic effects of d-chiro-inositol in the polycystic ovary syndrome N. Engl. J. Med. 340 1999 1314 1320
21. F.L. Byrne, I.K. Poon, S.C. Modesitt, J.L. Tomsig, J.D. Chow, M.E. Healy, W.D. Baker, K.A. Atkins, J.M. Lancaster, D.C. Marchion, K.H. Moley, K.S. Ravichandran, J.K. Slack-Davis, and K.L. Hoehn Metabolic vulnerabilities in endometrial cancer Cancer Res. 74 2014 5832 5845
22. M.A. Lips, J.B. Van Klinken, V. van Harmelen, H.K. Dharuri, P.A. t Hoen, J.F. Laros, G.J. van Ommen, I.M. Janssen, B. Van Ramshorst, B.A. Van Wagensveld, D.J. Swank, F. Van Dielen, A. Dane, A. Harms, R. Vreeken, T. Hankemeier, J.W. Smit, H. Pijl, and K. Willems van Dijk Roux-en-Y gastric bypass surgery, but not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the presence of type 2 diabetes Diabetes Care 37 2014 3150 3156
23. J. Graessler, Y. Qin, H. Zhong, J. Zhang, J. Licinio, M.L. Wong, A. Xu, T. Chavakis, A.B. Bornstein, M. Ehrhart-Bornstein, V. Lamounier-Zepter, T. Lohmann, T. Wolf, and S.R. Bornstein Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters Pharmacogenomics J. 13 2013 514 522
24. T.E. Sweeney, and J.M. Morton The human gut microbiome: a review of the effect of obesity and surgically induced weight loss JAMA Surg. 148 2013 563 569
25. S. Bae, C.M. Ulrich, M.L. Neuhouser, O. Malysheva, L.B. Bailey, L. Xiao, E.C. Brown, K.L. Cushing-Haugen, Y. Zheng, T.Y. Cheng, J.W. Miller, R. Green, D.S. Lane, S.A. Beresford, and M.A. Caudill Plasma choline metabolites and colorectal cancer risk in the Women's Health Initiative Observational Study Cancer Res. 74 2014 7442 7452
26. K.B. Kim, J.Y. Yang, S.J. Kwack, K.L. Park, H.S. Kim, H. Ryu do, Y.J. Kim, G.S. Hwang, and B.M. Lee Toxicometabolomics of urinary biomarkers for human gastric cancer in a mouse model J. Toxicol. Environ. Health A 73 2010 1420 1430