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Volumn 25, Issue 8, 2015, Pages 1380-1391

Morbidly “Healthy” Obese Are Not Metabolically Healthy but Less Metabolically Imbalanced Than Those with Type 2 Diabetes or Dyslipidemia

Author keywords

Bariatric surgery; Diabetes; Dyslipidemia; Healthy obese; Inflammation; Obesity

Indexed keywords

ADIPONECTIN; FATTY ACID; GLUCORECEPTOR; GLUCOSE; GLUCOSE RECEPTOR 4; INSULIN; INSULIN RECEPTOR; INTERLEUKIN 6; LEPTIN; LIPID; PHOSPHOLIPID; PLASMINOGEN ACTIVATOR INHIBITOR 1; UNCLASSIFIED DRUG; ADIPOQ PROTEIN, HUMAN; GLUCOSE TRANSPORTER 4; IL6 PROTEIN, HUMAN; SERPINE1 PROTEIN, HUMAN;

EID: 84938149748     PISSN: 09608923     EISSN: 17080428     Source Type: Journal    
DOI: 10.1007/s11695-014-1528-z     Document Type: Article
Times cited : (14)

References (37)
  • 1
    • 78650128005 scopus 로고    scopus 로고
    • Open questions about metabolically normal obesity
    • Pataky Z, Bobbioni-Harsch E, Golay A. Open questions about metabolically normal obesity. Int J Obes (Lond). 2010;34 Suppl 2:S18–23.
    • (2010) Int J Obes (Lond) , vol.34 , pp. S18-S23
    • Pataky, Z.1    Bobbioni-Harsch, E.2    Golay, A.3
  • 2
    • 79954992126 scopus 로고    scopus 로고
    • What is the evolution of metabolically normal obesity?
    • COI: 1:STN:280:DC%2BC3MvovVWmsA%3D%3D, PID: 21545017
    • Pataky Z, Bobbioni-Harsch E, Makoundou V, et al. What is the evolution of metabolically normal obesity? Rev Med Suisse. 2011;7(288):692–4.
    • (2011) Rev Med Suisse , vol.7 , Issue.288 , pp. 692-694
    • Pataky, Z.1    Bobbioni-Harsch, E.2    Makoundou, V.3
  • 3
    • 77955494890 scopus 로고    scopus 로고
    • The obese healthy paradox: is inflammation the answer?
    • COI: 1:CAS:528:DC%2BC3cXptlylt7k%3D, PID: 20522023
    • Barbarroja N, Lopez-Pedrera R, Mayas MD, et al. The obese healthy paradox: is inflammation the answer? Biochem J. 2010;430(1):141–9.
    • (2010) Biochem J , vol.430 , Issue.1 , pp. 141-149
    • Barbarroja, N.1    Lopez-Pedrera, R.2    Mayas, M.D.3
  • 4
    • 80052776606 scopus 로고    scopus 로고
    • Metabolic normality in overweight and obese subjects. Which parameters? Which risks?
    • COI: 1:CAS:528:DC%2BC3MXhtFyntbbI
    • Pataky Z, Makoundou V, Nilsson P, et al. Metabolic normality in overweight and obese subjects. Which parameters? Which risks? Int J Obes (Lond). 2011;35:1208–15.
    • (2011) Int J Obes (Lond) , vol.35 , pp. 1208-1215
    • Pataky, Z.1    Makoundou, V.2    Nilsson, P.3
  • 5
    • 67349268828 scopus 로고    scopus 로고
    • Increased expression and activity of hepatic lipase in the liver of morbidly obese adult patients in relation to lipid content
    • PID: 18972174
    • Pardina E, Baena-Fustegueras JA, Catalan R, et al. Increased expression and activity of hepatic lipase in the liver of morbidly obese adult patients in relation to lipid content. Obes Surg. 2009;19(7):894–904.
    • (2009) Obes Surg , vol.19 , Issue.7 , pp. 894-904
    • Pardina, E.1    Baena-Fustegueras, J.A.2    Catalan, R.3
  • 6
    • 77953292318 scopus 로고    scopus 로고
    • The relationships between IGF-1 and CRP, NO, leptin, and adiponectin during weight loss in the morbidly obese
    • PID: 20195789
    • Pardina E, Ferrer R, Baena-Fustegueras JA, et al. The relationships between IGF-1 and CRP, NO, leptin, and adiponectin during weight loss in the morbidly obese. Obes Surg. 2010;20(5):623–32.
    • (2010) Obes Surg , vol.20 , Issue.5 , pp. 623-632
    • Pardina, E.1    Ferrer, R.2    Baena-Fustegueras, J.A.3
  • 7
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III)
    • NCEP. Executive summary of the third report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001;285:2486–97.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 8
    • 34250350040 scopus 로고    scopus 로고
    • Task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    • ESH and ESC. Task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25:1105–87.
    • (2007) J Hypertens , vol.25 , pp. 1105-1187
    • ESH and ESC, E.S.C.1
  • 10
    • 84938147146 scopus 로고    scopus 로고
    • Lohman T, Roche A, Martorel R, eds.Champaign
    • Standardization of anthropometric measurements. In: Lohman T, Roche A, Martorel R, eds.Champaign, IL: Human Kinetics Publishers. 1988;39–80.
    • IL: Human Kinetics Publishers , vol.1988 , pp. 39-80
  • 11
    • 84857370660 scopus 로고    scopus 로고
    • Only C-reactive protein, but not TNF-α or IL6, reflects the improvement in inflammation after bariatric surgery
    • PID: 22038572
    • Pardina E, Ferrer R, Baena-Fustegueras JA, et al. Only C-reactive protein, but not TNF-α or IL6, reflects the improvement in inflammation after bariatric surgery. Obes Surg. 2012;22(1):131–9.
    • (2012) Obes Surg , vol.22 , Issue.1 , pp. 131-139
    • Pardina, E.1    Ferrer, R.2    Baena-Fustegueras, J.A.3
  • 12
    • 0025253262 scopus 로고
    • Apolipoprotein assays: standardization and quality control
    • COI: 1:CAS:528:DyaK3MXitValtLg%3D
    • Marcovina SM, Albers JJ. Apolipoprotein assays: standardization and quality control. Scand J Clin Lab Invest. 1990;50(198):58–65.
    • (1990) Scand J Clin Lab Invest , vol.50 , Issue.198 , pp. 58-65
    • Marcovina, S.M.1    Albers, J.J.2
  • 13
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • COI: 1:CAS:528:DyaL2MXlslKnu7k%3D, PID: 3899825
    • Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–9.
    • (1985) Diabetologia , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3
  • 14
    • 53249149870 scopus 로고    scopus 로고
    • High adiponectin concentrations are associated with the metabolically healthy obese phenotype
    • COI: 1:CAS:528:DC%2BD1cXht1GmurvO, PID: 18682512
    • Aguilar-Salinas CA, Garcia EG, Robles L, et al. High adiponectin concentrations are associated with the metabolically healthy obese phenotype. J Clin Endocrinol Metab. 2008;93(10):4075–9.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.10 , pp. 4075-4079
    • Aguilar-Salinas, C.A.1    Garcia, E.G.2    Robles, L.3
  • 15
    • 23044454515 scopus 로고    scopus 로고
    • The metabolically healthy but obese individual presents a favorable inflammation profile
    • COI: 1:CAS:528:DC%2BD2MXmtlCitbY%3D, PID: 15855252
    • Karelis AD, Faraj M, Bastard JP, et al. The metabolically healthy but obese individual presents a favorable inflammation profile. J Clin Endocrinol Metab. 2005;90(7):4145–50.
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.7 , pp. 4145-4150
    • Karelis, A.D.1    Faraj, M.2    Bastard, J.P.3
  • 16
    • 33747739430 scopus 로고    scopus 로고
    • Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease
    • COI: 1:CAS:528:DC%2BD28XosFGhs7s%3D, PID: 16735483
    • Meigs JB, Wilson PW, Fox CS, et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab. 2006;91(8):2906–12.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.8 , pp. 2906-2912
    • Meigs, J.B.1    Wilson, P.W.2    Fox, C.S.3
  • 17
    • 79959637527 scopus 로고    scopus 로고
    • Body size phenotypes and inflammation in the women’s health initiative observational study
    • COI: 1:CAS:528:DC%2BC3MXotVylsro%3D
    • Wildman RP, Kaplan R, Manson JE, et al. Body size phenotypes and inflammation in the women’s health initiative observational study. Obesity (Silver Spring). 2011;19(7):1482–91.
    • (2011) Obesity (Silver Spring) , vol.19 , Issue.7 , pp. 1482-1491
    • Wildman, R.P.1    Kaplan, R.2    Manson, J.E.3
  • 18
    • 84885206610 scopus 로고    scopus 로고
    • Does inflammation determine metabolic health status in obese and nonobese adults?
    • COI: 1:CAS:528:DC%2BC3sXhs1elsLnJ, PID: 23979951
    • Phillips CM, Perry IJ. Does inflammation determine metabolic health status in obese and nonobese adults? J Clin Endocrinol Metab. 2013;98(10):E1610–9.
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.10 , pp. E1610-E1619
    • Phillips, C.M.1    Perry, I.J.2
  • 19
    • 84872327440 scopus 로고    scopus 로고
    • Pathophysiology of human visceral obesity: an update
    • COI: 1:CAS:528:DC%2BC3sXhvFKns7c%3D, PID: 23303913
    • Tchernof A, Despres JP. Pathophysiology of human visceral obesity: an update. Physiol Rev. 2013;93(1):359–404.
    • (2013) Physiol Rev , vol.93 , Issue.1 , pp. 359-404
    • Tchernof, A.1    Despres, J.P.2
  • 20
    • 0035052940 scopus 로고    scopus 로고
    • What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women?
    • COI: 1:CAS:528:DC%2BD3MXitFWnsL8%3D, PID: 11238480
    • Brochu M, Tchernof A, Dionne IJ, et al. What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? J Clin Endocrinol Metab. 2001;86(3):1020–5.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.3 , pp. 1020-1025
    • Brochu, M.1    Tchernof, A.2    Dionne, I.J.3
  • 21
    • 33749126980 scopus 로고    scopus 로고
    • Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women
    • COI: 1:CAS:528:DC%2BD28XhtVSnsrbF
    • Shin MJ, Hyun YJ, Kim OY, et al. Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women. Int J Obes (Lond). 2006;30(10):1529–34.
    • (2006) Int J Obes (Lond) , vol.30 , Issue.10 , pp. 1529-1534
    • Shin, M.J.1    Hyun, Y.J.2    Kim, O.Y.3
  • 22
    • 84868122221 scopus 로고    scopus 로고
    • Progression from high insulin resistance to type 2 diabetes does not entail additional visceral adipose tissue inflammation
    • Barbarroja N, Lopez-Pedrera C, Garrido-Sanchez L, et al. Progression from high insulin resistance to type 2 diabetes does not entail additional visceral adipose tissue inflammation. PLoS One. 2012;7:e48155. doi:10.1371/journal.pone.0048155.
    • (2012) PLoS One , vol.e48155 , pp. 7
    • Barbarroja, N.1    Lopez-Pedrera, C.2    Garrido-Sanchez, L.3
  • 23
    • 51849164091 scopus 로고    scopus 로고
    • Adiponectina: una adipocitoquina con múltiples funciones protectoras
    • COI: 1:CAS:528:DC%2BD1MXislSrtL4%3D
    • Elissondo N, Gómez Rosso L, Maidana P, et al. Adiponectina: una adipocitoquina con múltiples funciones protectoras. Acta Bioquim Clin Latinoam. 2008;42(1):17–33.
    • (2008) Acta Bioquim Clin Latinoam , vol.42 , Issue.1 , pp. 17-33
    • Elissondo, N.1    Gómez Rosso, L.2    Maidana, P.3
  • 24
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • COI: 1:CAS:528:DC%2BD28XmvV2ltL0%3D, PID: 16823476
    • Kadowaki T, Yamauchi T, Kubota N, et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006;116(7):1784–92.
    • (2006) J Clin Invest , vol.116 , Issue.7 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3
  • 25
    • 24044451713 scopus 로고    scopus 로고
    • Regulation of adiponectin expression in human adipocytes: effects of adiposity, glucocorticoids, and tumor necrosis factor alpha
    • COI: 1:CAS:528:DC%2BD2MXlsFSkurc%3D, PID: 15897474
    • Degawa-Yamauchi M, Moss KA, Bovenkerk JE, et al. Regulation of adiponectin expression in human adipocytes: effects of adiposity, glucocorticoids, and tumor necrosis factor alpha. Obes Res. 2005;13(4):662–9.
    • (2005) Obes Res , vol.13 , Issue.4 , pp. 662-669
    • Degawa-Yamauchi, M.1    Moss, K.A.2    Bovenkerk, J.E.3
  • 26
    • 77951912134 scopus 로고    scopus 로고
    • Establishment of a concept of visceral fat syndrome and discovery of adiponectin
    • COI: 1:CAS:528:DC%2BC3cXjtFOgtro%3D, PID: 20154470
    • Matsuzawa Y. Establishment of a concept of visceral fat syndrome and discovery of adiponectin. Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(2):131–41.
    • (2010) Proc Jpn Acad Ser B Phys Biol Sci , vol.86 , Issue.2 , pp. 131-141
    • Matsuzawa, Y.1
  • 27
    • 77953286661 scopus 로고    scopus 로고
    • A review of weight loss following Roux-en-Y gastric bypass vs restrictive bariatric surgery: impact on adiponectin and insulin
    • PID: 20177811
    • Butner KL, Nickols-Richardson SM, Clark SF, et al. A review of weight loss following Roux-en-Y gastric bypass vs restrictive bariatric surgery: impact on adiponectin and insulin. Obes Surg. 2010;20(5):559–68.
    • (2010) Obes Surg , vol.20 , Issue.5 , pp. 559-568
    • Butner, K.L.1    Nickols-Richardson, S.M.2    Clark, S.F.3
  • 28
    • 0041665074 scopus 로고    scopus 로고
    • Adiponectin mRNA levels in the abdominal adipose depots of nondiabetic women
    • COI: 1:CAS:528:DC%2BD3sXltl2ksrk%3D, PID: 12861229
    • Yang WS, Chen MH, Lee WJ, et al. Adiponectin mRNA levels in the abdominal adipose depots of nondiabetic women. Int J Obes Relat Metab Disord. 2003;27:896–900.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 896-900
    • Yang, W.S.1    Chen, M.H.2    Lee, W.J.3
  • 29
    • 0042888597 scopus 로고    scopus 로고
    • Fat depot-specific expression of adiponectin is impaired in Zucker fatty rats
    • COI: 1:CAS:528:DC%2BD3sXlvVGqu78%3D, PID: 12898458
    • Altomonte J, Harbaran S, Richter A, et al. Fat depot-specific expression of adiponectin is impaired in Zucker fatty rats. Metab Clin Exp. 2003;52:958–63.
    • (2003) Metab Clin Exp , vol.52 , pp. 958-963
    • Altomonte, J.1    Harbaran, S.2    Richter, A.3
  • 30
    • 48749104020 scopus 로고    scopus 로고
    • Analysis of adiponectin gene and comparison of its expression in two different pig breeds
    • COI: 1:CAS:528:DC%2BD1cXptFOrur4%3D, PID: 18535556
    • Daniele A, Cammarata R, Masullo M, et al. Analysis of adiponectin gene and comparison of its expression in two different pig breeds. Obesity. 2008;16:1869–74.
    • (2008) Obesity , vol.16 , pp. 1869-1874
    • Daniele, A.1    Cammarata, R.2    Masullo, M.3
  • 31
    • 84879989100 scopus 로고    scopus 로고
    • Adiponectin oligomers as potential indicators of adipose tissue improvement in obese subjects
    • PID: 23612446
    • De Rosa A, Monaco ML, Capasso M, et al. Adiponectin oligomers as potential indicators of adipose tissue improvement in obese subjects. Eur J Endocrinol. 2013;169:37–43.
    • (2013) Eur J Endocrinol , vol.169 , pp. 37-43
    • De Rosa, A.1    Monaco, M.L.2    Capasso, M.3
  • 33
    • 0031054698 scopus 로고    scopus 로고
    • Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution
    • COI: 1:CAS:528:DyaK2sXhsVGnu74%3D, PID: 9032087
    • Montague CT, Prins JB, Sanders L, et al. Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes. 1997;46(3):342–7.
    • (1997) Diabetes , vol.46 , Issue.3 , pp. 342-347
    • Montague, C.T.1    Prins, J.B.2    Sanders, L.3
  • 34
    • 0036875928 scopus 로고    scopus 로고
    • Differences in adiponectin protein expression: effect of fat depots and type 2 diabetic status
    • COI: 1:CAS:528:DC%2BD3sXis1altLg%3D, PID: 12660876
    • Fisher FM, McTernan PG, Valsamakis G, et al. Differences in adiponectin protein expression: effect of fat depots and type 2 diabetic status. Horm Metab Res. 2002;34(11–12):650–4.
    • (2002) Horm Metab Res , vol.34 , Issue.11-12 , pp. 650-654
    • Fisher, F.M.1    McTernan, P.G.2    Valsamakis, G.3
  • 35
    • 34447560040 scopus 로고    scopus 로고
    • Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome?
    • PID: 17627548
    • Rodríguez A, Catalán V, Gómez-Ambrosi J, et al. Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome? Curr Pharm Des. 2007;13(21):2169–75.
    • (2007) Curr Pharm Des , vol.13 , Issue.21 , pp. 2169-2175
    • Rodríguez, A.1    Catalán, V.2    Gómez-Ambrosi, J.3
  • 36
    • 33745896155 scopus 로고    scopus 로고
    • Recent advances in the relationship between obesity, inflammation, and insulin resistance
    • COI: 1:CAS:528:DC%2BD28XksVWktrw%3D, PID: 16613757
    • Bastard JP, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006;17(1):4–12.
    • (2006) Eur Cytokine Netw , vol.17 , Issue.1 , pp. 4-12
    • Bastard, J.P.1    Maachi, M.2    Lagathu, C.3
  • 37
    • 84855702675 scopus 로고    scopus 로고
    • Response to ‘Metabolically normal obesity’ a misnomer?
    • Pataky Z, Bobbioni-Harsch E, Golay A. Response to ‘Metabolically normal obesity’ a misnomer? Int J Obes (Lond). 2011;36:165.
    • (2011) Int J Obes (Lond) , vol.36 , pp. 165
    • Pataky, Z.1    Bobbioni-Harsch, E.2    Golay, A.3


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