메뉴 건너뛰기




Volumn 10, Issue 8, 2014, Pages

Virus-Specific Regulatory T Cells Ameliorate Encephalitis by Repressing Effector T Cell Functions from Priming to Effector Stages

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; CHEMOKINE RECEPTOR CXCR3; EPITOPE; FINGOLIMOD; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

EID: 84938107770     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004279     Document Type: Article
Times cited : (34)

References (41)
  • 2
    • 45849153869 scopus 로고    scopus 로고
    • Coordination of early protective immunity to viral infection by regulatory T cells
    • Lund JM, Hsing L, Pham TT, Rudensky AY, (2008) Coordination of early protective immunity to viral infection by regulatory T cells. Science 320: 1220–1224.
    • (2008) Science , vol.320 , pp. 1220-1224
    • Lund, J.M.1    Hsing, L.2    Pham, T.T.3    Rudensky, A.Y.4
  • 3
    • 63149132590 scopus 로고    scopus 로고
    • Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities
    • Ruckwardt TJ, Bonaparte KL, Nason MC, Graham BS, (2009) Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities. J Virol 83: 3019–3028.
    • (2009) J Virol , vol.83 , pp. 3019-3028
    • Ruckwardt, T.J.1    Bonaparte, K.L.2    Nason, M.C.3    Graham, B.S.4
  • 4
    • 84881635553 scopus 로고    scopus 로고
    • Role of regulatory T cells during virus infection
    • Veiga-Parga T, Sehrawat S, Rouse BT, (2013) Role of regulatory T cells during virus infection. Immunol Rev 255: 182–196.
    • (2013) Immunol Rev , vol.255 , pp. 182-196
    • Veiga-Parga, T.1    Sehrawat, S.2    Rouse, B.T.3
  • 5
    • 70449377991 scopus 로고    scopus 로고
    • Tregs control the development of symptomatic West Nile virus infection in humans and mice
    • Lanteri MC, O'Brien KM, Purtha WE, Cameron MJ, Lund JM, et al. (2009) Tregs control the development of symptomatic West Nile virus infection in humans and mice. J Clin Invest 119: 3266–3277.
    • (2009) J Clin Invest , vol.119 , pp. 3266-3277
    • Lanteri, M.C.1    O'Brien, K.M.2    Purtha, W.E.3    Cameron, M.J.4    Lund, J.M.5
  • 6
    • 1642305619 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions
    • Suvas S, Azkur AK, Kim BS, Kumaraguru U, Rouse BT, (2004) CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J Immunol 172: 4123–4132.
    • (2004) J Immunol , vol.172 , pp. 4123-4132
    • Suvas, S.1    Azkur, A.K.2    Kim, B.S.3    Kumaraguru, U.4    Rouse, B.T.5
  • 7
    • 77952746516 scopus 로고    scopus 로고
    • Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus
    • Trandem K, Anghelina D, Zhao J, Perlman S, (2010) Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus. J Immunol 184: 4391–4400.
    • (2010) J Immunol , vol.184 , pp. 4391-4400
    • Trandem, K.1    Anghelina, D.2    Zhao, J.3    Perlman, S.4
  • 8
    • 60649110015 scopus 로고    scopus 로고
    • Role of regulatory T cells in coronavirus-induced acute encephalitis
    • Anghelina D, Zhao J, Trandem K, Perlman S, (2009) Role of regulatory T cells in coronavirus-induced acute encephalitis. Virology 385: 358–367.
    • (2009) Virology , vol.385 , pp. 358-367
    • Anghelina, D.1    Zhao, J.2    Trandem, K.3    Perlman, S.4
  • 9
    • 84871161596 scopus 로고    scopus 로고
    • On the role of regulatory T cells during viral-induced inflammatory lesions
    • Veiga-Parga T, Suryawanshi A, Mulik S, Gimenez F, Sharma S, et al. (2012) On the role of regulatory T cells during viral-induced inflammatory lesions. J Immunol 189: 5924–5933.
    • (2012) J Immunol , vol.189 , pp. 5924-5933
    • Veiga-Parga, T.1    Suryawanshi, A.2    Mulik, S.3    Gimenez, F.4    Sharma, S.5
  • 10
    • 84879101749 scopus 로고    scopus 로고
    • Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice
    • Bedoya F, Cheng GS, Leibow A, Zakhary N, Weissler K, et al. (2013) Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice. J Immunol 190: 6115–6125.
    • (2013) J Immunol , vol.190 , pp. 6115-6125
    • Bedoya, F.1    Cheng, G.S.2    Leibow, A.3    Zakhary, N.4    Weissler, K.5
  • 11
    • 33645077332 scopus 로고    scopus 로고
    • Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens
    • Suffia IJ, Reckling SK, Piccirillo CA, Goldszmid RS, Belkaid Y, (2006) Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. J Exp Med 203: 777–788.
    • (2006) J Exp Med , vol.203 , pp. 777-788
    • Suffia, I.J.1    Reckling, S.K.2    Piccirillo, C.A.3    Goldszmid, R.S.4    Belkaid, Y.5
  • 12
    • 79961139920 scopus 로고    scopus 로고
    • IFN-gamma- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis
    • Zhao J, Zhao J, Fett C, Trandem K, Fleming E, et al. (2011) IFN-gamma- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis. J Exp Med 208: 1571–1577.
    • (2011) J Exp Med , vol.208 , pp. 1571-1577
    • Zhao, J.1    Zhao, J.2    Fett, C.3    Trandem, K.4    Fleming, E.5
  • 13
    • 84879604666 scopus 로고    scopus 로고
    • Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12
    • Shafiani S, Dinh C, Ertelt JM, Moguche AO, Siddiqui I, et al. (2013) Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. Immunity 38: 1261–1270.
    • (2013) Immunity , vol.38 , pp. 1261-1270
    • Shafiani, S.1    Dinh, C.2    Ertelt, J.M.3    Moguche, A.O.4    Siddiqui, I.5
  • 14
    • 77958132478 scopus 로고    scopus 로고
    • Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection
    • Johanns TM, Ertelt JM, Rowe JH, Way SS, (2010) Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection. PLoS Pathog 6: e1001043.
    • (2010) PLoS Pathog , vol.6 , pp. 1001043
    • Johanns, T.M.1    Ertelt, J.M.2    Rowe, J.H.3    Way, S.S.4
  • 15
    • 80052294339 scopus 로고    scopus 로고
    • Quantitative impact of thymic selection on Foxp3+ and Foxp3− subsets of self-peptide/MHC class II-specific CD4+ T cells
    • Moon JJ, Dash P, Oguin TH, 3rdMcClaren JL, Chu HH, et al. (2011) Quantitative impact of thymic selection on Foxp3+ and Foxp3− subsets of self-peptide/MHC class II-specific CD4+ T cells. Proc Natl Acad Sci U S A 108: 14602–14607.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 14602-14607
    • Moon, J.J.1    Dash, P.2    Oguin, T.H.3    McClaren, J.L.4    Chu, H.H.5
  • 16
    • 51349095960 scopus 로고    scopus 로고
    • Tuning microenvironments: induction of regulatory T cells by dendritic cells
    • Belkaid Y, Oldenhove G, (2008) Tuning microenvironments: induction of regulatory T cells by dendritic cells. Immunity 29: 362–371.
    • (2008) Immunity , vol.29 , pp. 362-371
    • Belkaid, Y.1    Oldenhove, G.2
  • 17
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, et al. (2004) In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199: 1455–1465.
    • (2004) J Exp Med , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3    Finger, E.B.4    Szot, G.5
  • 18
    • 33846410255 scopus 로고    scopus 로고
    • Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice
    • Tarbell KV, Petit L, Zuo X, Toy P, Luo X, et al. (2007) Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med 204: 191–201.
    • (2007) J Exp Med , vol.204 , pp. 191-201
    • Tarbell, K.V.1    Petit, L.2    Zuo, X.3    Toy, P.4    Luo, X.5
  • 19
    • 77954390239 scopus 로고    scopus 로고
    • Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis
    • Shafiani S, Tucker-Heard G, Kariyone A, Takatsu K, Urdahl KB, (2010) Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis. J Exp Med 207: 1409–1420.
    • (2010) J Exp Med , vol.207 , pp. 1409-1420
    • Shafiani, S.1    Tucker-Heard, G.2    Kariyone, A.3    Takatsu, K.4    Urdahl, K.B.5
  • 20
    • 31544476315 scopus 로고    scopus 로고
    • Coronavirus infection of the central nervous system: host-virus stand-off
    • Bergmann CC, Lane TE, Stohlman SA, (2006) Coronavirus infection of the central nervous system: host-virus stand-off. Nat Rev Microbiol 4: 121–132.
    • (2006) Nat Rev Microbiol , vol.4 , pp. 121-132
    • Bergmann, C.C.1    Lane, T.E.2    Stohlman, S.A.3
  • 21
    • 79251500661 scopus 로고    scopus 로고
    • Phenotypical and functional specialization of FOXP3+ regulatory T cells
    • Campbell DJ, Koch MA, (2011) Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat Rev Immunol 11: 119–130.
    • (2011) Nat Rev Immunol , vol.11 , pp. 119-130
    • Campbell, D.J.1    Koch, M.A.2
  • 22
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, et al. (2009) The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 10: 595–602.
    • (2009) Nat Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5
  • 23
    • 84884349852 scopus 로고    scopus 로고
    • Development of transgenic mice expressing a coronavirus-specific public CD4 T cell receptor
    • Zhao J, Fett C, Pewe L, Zhao J, Perlman S, (2013) Development of transgenic mice expressing a coronavirus-specific public CD4 T cell receptor. J Immunol Methods 396: 56–64.
    • (2013) J Immunol Methods , vol.396 , pp. 56-64
    • Zhao, J.1    Fett, C.2    Pewe, L.3    Zhao, J.4    Perlman, S.5
  • 24
    • 0034266098 scopus 로고    scopus 로고
    • The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease
    • Liu MT, Chen BP, Oertel P, Buchmeier MJ, Armstrong D, et al. (2000) The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease. J Immunol 165: 2327–2330.
    • (2000) J Immunol , vol.165 , pp. 2327-2330
    • Liu, M.T.1    Chen, B.P.2    Oertel, P.3    Buchmeier, M.J.4    Armstrong, D.5
  • 25
    • 78049480679 scopus 로고    scopus 로고
    • Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
    • Brinkmann V, Billich A, Baumruker T, Heining P, Schmouder R, et al. (2010) Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat Rev Drug Discov 9: 883–897.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 883-897
    • Brinkmann, V.1    Billich, A.2    Baumruker, T.3    Heining, P.4    Schmouder, R.5
  • 26
    • 33646805064 scopus 로고    scopus 로고
    • T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects
    • Beima KM, Miazgowicz MM, Lewis MD, Yan PS, Huang TH, et al. (2006) T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects. J Biol Chem 281: 11992–12000.
    • (2006) J Biol Chem , vol.281 , pp. 11992-12000
    • Beima, K.M.1    Miazgowicz, M.M.2    Lewis, M.D.3    Yan, P.S.4    Huang, T.H.5
  • 27
    • 84866893829 scopus 로고    scopus 로고
    • Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-gamma, IL-2 and IL-2R
    • Zhao J, Zhao J, Perlman S, (2012) Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-gamma, IL-2 and IL-2R. PLoS ONE 7: e46241.
    • (2012) PLoS ONE , vol.7 , pp. 46241
    • Zhao, J.1    Zhao, J.2    Perlman, S.3
  • 28
    • 33746369415 scopus 로고    scopus 로고
    • Regulatory T-cell physiology and application to treat autoimmunity
    • Tang Q, Bluestone JA, (2006) Regulatory T-cell physiology and application to treat autoimmunity. Immunol Rev 212: 217–237.
    • (2006) Immunol Rev , vol.212 , pp. 217-237
    • Tang, Q.1    Bluestone, J.A.2
  • 29
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • Shevach EM, (2009) Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 30: 636–645.
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 30
    • 4344657757 scopus 로고    scopus 로고
    • CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion
    • Sarween N, Chodos A, Raykundalia C, Khan M, Abbas AK, et al. (2004) CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion. J Immunol 173: 2942–2951.
    • (2004) J Immunol , vol.173 , pp. 2942-2951
    • Sarween, N.1    Chodos, A.2    Raykundalia, C.3    Khan, M.4    Abbas, A.K.5
  • 31
    • 84866183753 scopus 로고    scopus 로고
    • IFN-gamma production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease
    • Koenecke C, Lee CW, Thamm K, Fohse L, Schafferus M, et al. (2012) IFN-gamma production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease. J Immunol 189: 2890–2896.
    • (2012) J Immunol , vol.189 , pp. 2890-2896
    • Koenecke, C.1    Lee, C.W.2    Thamm, K.3    Fohse, L.4    Schafferus, M.5
  • 32
    • 70449532980 scopus 로고    scopus 로고
    • Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection
    • Oldenhove G, Bouladoux N, Wohlfert EA, Hall JA, Chou D, et al. (2009) Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity 31: 772–786.
    • (2009) Immunity , vol.31 , pp. 772-786
    • Oldenhove, G.1    Bouladoux, N.2    Wohlfert, E.A.3    Hall, J.A.4    Chou, D.5
  • 33
    • 34147128572 scopus 로고    scopus 로고
    • Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
    • Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, et al. (2007) Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med 13: 423–431.
    • (2007) Nat Med , vol.13 , pp. 423-431
    • Korn, T.1    Reddy, J.2    Gao, W.3    Bettelli, E.4    Awasthi, A.5
  • 34
    • 0028826296 scopus 로고
    • Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus
    • Sun N, Grzybicki D, Castro R, Murphy S, Perlman S, (1995) Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus. Virology 213: 482–493.
    • (1995) Virology , vol.213 , pp. 482-493
    • Sun, N.1    Grzybicki, D.2    Castro, R.3    Murphy, S.4    Perlman, S.5
  • 35
    • 84865483192 scopus 로고    scopus 로고
    • Administration of CD4+CD25highCD127- regulatory T cells preserves beta-cell function in type 1 diabetes in children
    • Marek-Trzonkowska N, Mysliwiec M, Dobyszuk A, Grabowska M, Techmanska I, et al. (2012) Administration of CD4+CD25highCD127- regulatory T cells preserves beta-cell function in type 1 diabetes in children. Diabetes Care 35: 1817–1820.
    • (2012) Diabetes Care , vol.35 , pp. 1817-1820
    • Marek-Trzonkowska, N.1    Mysliwiec, M.2    Dobyszuk, A.3    Grabowska, M.4    Techmanska, I.5
  • 36
    • 84863840517 scopus 로고    scopus 로고
    • Regulatory T-cell therapy for transplantation: how many cells do we need?
    • Tang Q, Lee K, (2012) Regulatory T-cell therapy for transplantation: how many cells do we need? Curr Opin Organ Transplant 17: 349–354.
    • (2012) Curr Opin Organ Transplant , vol.17 , pp. 349-354
    • Tang, Q.1    Lee, K.2
  • 37
    • 0022446017 scopus 로고
    • Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies
    • Fleming JO, Trousdale MD, El-Zaatari F, Stohlman SA, Weiner LP, (1986) Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies. J Virol 58: 869–875.
    • (1986) J Virol , vol.58 , pp. 869-875
    • Fleming, J.O.1    Trousdale, M.D.2    El-Zaatari, F.3    Stohlman, S.A.4    Weiner, L.P.5
  • 38
    • 33745714786 scopus 로고    scopus 로고
    • Pathogenic role for virus-specific CD4 T cells in mice with coronavirus-induced acute encephalitis
    • Anghelina D, Pewe L, Perlman S, (2006) Pathogenic role for virus-specific CD4 T cells in mice with coronavirus-induced acute encephalitis. Am J Pathol 169: 209–222.
    • (2006) Am J Pathol , vol.169 , pp. 209-222
    • Anghelina, D.1    Pewe, L.2    Perlman, S.3
  • 39
    • 23844554435 scopus 로고    scopus 로고
    • A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus
    • Pewe L, Zhou H, Netland J, Tangadu C, Olivares H, et al. (2005) A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus. J Virol 79: 11335–11342.
    • (2005) J Virol , vol.79 , pp. 11335-11342
    • Pewe, L.1    Zhou, H.2    Netland, J.3    Tangadu, C.4    Olivares, H.5
  • 40
    • 0028824901 scopus 로고
    • CD8+ T cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity
    • Castro RF, Perlman S, (1995) CD8+ T cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity. J Virol 69: 8127–8131.
    • (1995) J Virol , vol.69 , pp. 8127-8131
    • Castro, R.F.1    Perlman, S.2
  • 41
    • 0035124174 scopus 로고    scopus 로고
    • High-magnitude, virus-specific CD4 T-cell response in the central nervous system of coronavirus-infected mice
    • Haring JS, Pewe LL, Perlman S, (2001) High-magnitude, virus-specific CD4 T-cell response in the central nervous system of coronavirus-infected mice. J Virol 75: 3043–3047.
    • (2001) J Virol , vol.75 , pp. 3043-3047
    • Haring, J.S.1    Pewe, L.L.2    Perlman, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.