Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the kidneys

International Journal of Molecular Medicine

Volumn 36, Issue 3, 2015, Pages 712-724

  Watanabe, Yuko ^a,b   Yoshida, Momoko ^a,b   Yamanishi, Kyosuke ^c   Yamamoto, Hideyuki ^c   Okuzaki, Daisuke ^b   Nojima, Hiroshi ^b   Yasunaga, Teruo ^b   Okamura, Haruki ^c   Matsunaga, Hisato ^c   Yamanishi, Hiromichi ^a  

^a Hirakata General Hospital for Developmental Disorders   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Attention deficit hyperactivity disorder; Gene expression profiles; Hypertension; Kidney; Spontaneously hypertensive rats; Stroke prone spontaneously hypertensive rats

Indexed keywords

ACYL COENZYME A OXIDASE; ACYL COENZYME A OXIDASE 2; ANGIOTENSIN II RECEPTOR ASSOCIATED PROTEIN; ANGIOTENSINOGEN; BETA2 GLYCOPROTEIN 1; COLECALCIFEROL 24 HYDROXYLASE; CONNECTIVE TISSUE GROWTH FACTOR; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOCHROME P450 2C11; DEIODINASE; DIMETHYLANILINE MONOOXYGENASE; DIPEPTIDYL CARBOXYPEPTIDASE; FIN BUD INITIATION FACTOR; FLAVIN CONTAINING MONOOXYGENASE 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; INDOLETHYL AMINE N METHYLTRANSFERASE; INITIATION FACTOR; IODOTHYRONINE; MYOSIN; MYOSIN XVI; OXIDOREDUCTASE; PROTEIN BCL 6; RECEPTOR PROTEIN; RETINOID X RECEPTOR GAMMA; RYANODINE RECEPTOR 1; SERINE PROTEINASE INHIBITOR; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; VASCULOTROPIN B; ZINC FINGER AND BTB DOMAIN CONTAINING 16; ZINC FINGER PROTEIN; TRANSCRIPTOME;

ADRENAL GLAND; ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENTION DEFICIT DISORDER; BRAIN; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; GENE EXPRESSION; GENE ONTOLOGY; GENETIC ANALYSIS; HUNTINGTON CHOREA; HYPERTENSION; KIDNEY; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPONTANEOUSLY HYPERTENSIVE RAT; ANIMAL; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; METABOLISM; WISTAR KYOTO RAT;

ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HYPERTENSION; KIDNEY; RATS, INBRED SHR; RATS, INBRED WKY; STROKE; TRANSCRIPTOME;

EID: 84938094630     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2281     Document Type: Article

References (53)

1. Okamoto K and Aoki K: Development of a strain of spontaneously hypertensive rats. Jpn Circ J 27: 282-293, 1963.
2. Okamoto K, Yamori Y and Nagaoka A: Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res 34-35 (Suppl I): I-143-I-153, 1974.
3. Ueno KI, Togashi H, Mori K, Matsumoto M, Ohashi S, Hoshino A, Fujita T, Saito H, Minami M and Yoshioka M: Behavioural and pharmacological relevance of stroke-prone spontaneously hypertensive rats as an animal model of a developmental disorder. Behav Pharmacol 13: 1-13, 2002.
4. Yamamoto H, Okuzaki D, Yamanishi K, Xu Y, Watanabe Y, Yoshida M, Yamashita A, Goto N, Nishiguchi S, Shimada K, et al: Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats. Int J Mol Med 31: 1057-1065, 2013.
5. Yoshida M, Watanabe Y, Yamanishi K, Yamashita A, Yamamoto H, Okuzaki D, Shimada K, Nojima H, Yasunaga T, Okamura H, et al: Analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: gene expression profiles in the brain. Int J Mol Med 33: 887-896, 2014.
6. Guyton AC: Abnormal renal function and autoregulation in essential hypertension. Hypertension 18 (Suppl): III49-III53, 1991.
7. Huang W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57, 2009.
8. Huang DW, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37: 1-13, 2009.
9. Daniel JM and Reynolds AB: The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol 19: 3614-3623, 1999.
10. Dhordain P, Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The HD, Zelent A and Koken MH: Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF. Oncogene 19: 6240-6250, 2000.
11. Miles RR, Crockett DK, Lim MS and Elenitoba-Johnson KS: Analysis of BCL6-interacting proteins by tandem mass spectrometry. Mol Cell Proteomics 4: 1898-1909, 2005.
12. Wei F, Zaprazna K, Wang J and Atchison ML: PU.1 can recruit BCL6 to DNA to repress gene expression in germinal center B cells. Mol Cell Biol 29: 4612-4622, 2009.
13. Vasanwala FH, Kusam S, Toney LM and Dent AL: Repression of AP-1 function: A mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. J Immunol 169: 1922-1929, 2002.
14. Cox JL, Wilder PJ, Gilmore JM, Wuebben EL, Washburn MP and Rizzino A: The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. PLoS One 8: e62857, 2013.
15. Mansukhani A, Ambrosetti D, Holmes G, Cornivelli L and Basilico C: Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J Cell Biol 168: 1065-1076, 2005.
16. Fukuyama K, Ichiki T, Takeda K, Tokunou T, Iino N, Masuda S, Ishibashi M, Egashira K, Shimokawa H, Hirano K, et al: Downregulation of vascular angiotensin II type 1 receptor by thyroid hormone. Hypertension 41: 598-603, 2003.
17. Azuma K, Tamura K, Shigenaga A, Wakui H, Masuda S, Tsurumi-Ikeya Y, Tanaka Y, Sakai M, Matsuda M, Hashimoto T, et al: Novel regulatory effect of angiotensin II type 1 receptor-interacting molecule on vascular smooth muscle cells. Hypertension 50: 926-932, 2007.
18. Liu Q, Wang G, Zhou G, Tan Y, Wang X, Wei W, Liu L, Xue W, Feng W and Cai L: Angiotensin II-induced p53-dependent cardiac apoptotic cell death: its prevention by metallothionein. Toxicol Lett 191: 314-320, 2009.
19. Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D and He F: Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. J Proteome Res 7: 3879-3889, 2008.
20. Scotet V, De Braekeleer M, Audrézet MP, Lodé L, Verlingue C, Quéré I, Mercier B, Duguépéroux I, Codet JP, Moineau MP, et al: Prevalence of CFTR mutations in hypertrypsinaemia detected through neonatal screening for cystic fibrosis. Clin Genet 59: 42-47, 2001.
21. Lempinen M, Paju A, Kemppainen E, Smura T, Kylänpää ML, Nevanlinna H, Stenman J and Stenman UH: Mutations N34S and P55S of the SPINK1 gene in patients with chronic pancreatitis or pancreatic cancer and in healthy subjects: a report from Finland. Scand J Gastroenterol 40: 225-230, 2005.
22. Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, et al: The absence of intrarenal ACE protects against hypertension. J Clin Invest 123: 2011-2023, 2013.
23. Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA and Williams GH: Ala92 type 2 deiodinase allele increases risk for the development of hypertension. Hypertension 49: 461-466, 2007.
24. L?set M, Mundal SB, Johnson MP, Fenstad MH, Freed KA, Lian IA, Eide IP, Bj?rge L, Blangero J, Moses EK and Austgulen R: A transcriptional profile of the decidua in preeclampsia. Am J Obstet Gynecol 204: 84.e1-84.e27, 2011.
25. Delbosc S, Cristol JP, Descomps B, Mimran A and Jover B: Simvastatin prevents angiotensin II-induced cardiac alteration and oxidative stress. Hypertension 40: 142-147, 2002.
26. Sakai T, Balasubramanian K, Maiti S, Halder JB and Schroit AJ: Plasmin-cleaved beta-2-glycoprotein 1 is an inhibitor of angiogenesis. Am J Pathol 171: 1659-1669, 2007.
27. Simpkins AN, Rudic RD, Schreihofer DA, Roy S, Manhiani M, Tsai HJ, Hammock BD and Imig JD: Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection. Am J Pathol 174: 2086-2095, 2009.
28. Thulin A, Ringvall M, Dimberg A, Karehed K, Väisänen T, Väisänen MR, Hamad O, Wang J, Bjerkvig R, Nilsson B, et al: Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein. Mol Cancer Res 7: 1792-1802, 2009.
29. O-Uchi J, Jhun BS, Hurst S, Bisetto S, Gross P, Chen M, Kettlewell S, Park J, Oyamada H, Smith GL, et al: Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts. Am J Physiol Heart Circ Physiol 305: H1736-H1751, 2013.
30. Bellomo D, Headrick JP, Silins GU, Paterson CA, Thomas PS, Gartside M, Mould A, Cahill MM, Tonks ID, Grimmond SM, et al: Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ Res 86: E29-E35, 2000.
31. Strand AD, Aragaki AK, Shaw D, Bird T, Holton J, Turner C, Tapscott SJ, Tabrizi SJ, Schapira AH, Kooperberg C and Olson JM: Gene expression in Huntington's disease skeletal muscle: a potential biomarker. Hum Mol Genet 14: 1863-1876, 2005.
32. Hodges A, Strand AD, Aragaki AK, Kuhn A, Sengstag T, Hughes G, Elliston LA, Hartog C, Goldstein DR, Thu D, et al: Regional and cellular gene expression changes in human Huntington's disease brain. Hum Mol Genet 15: 965-977, 2006.
33. Thomas EA: Striatal specificity of gene expression dysregulation in Huntington's disease. J Neurosci Res 84: 1151-1164, 2006.
34. Kephart DD, Walfish PG, DeLuca H and Butt TR: Retinoid X receptor isotype identity directs human vitamin D receptor heterodimer transactivation from the 24-hydroxylase vitamin D response elements in yeast. Mol Endocrinol 10: 408-419, 1996.
35. Zella LA, Shevde NK, Hollis BW, Cooke NE and Pike JW: Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo. Endocrinology 149: 3656-3667, 2008.
36. Norkina O, Kaur S, Ziemer D and De Lisle RC: Inflammation of the cystic fibrosis mouse small intestine. Am J Physiol Gastrointest Liver Physiol 286: G1032-G1041, 2004.
37. Fontemaggi G, Kela I, Amariglio N, Rechavi G, Krishnamurthy J, Strano S, Sacchi A, Givol D and Blandino G: Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses. J Biol Chem 277: 43359-43368, 2002.
38. Seo E, Basu-Roy U, Zavadil J, Basilico C and Mansukhani A: Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage. Mol Cell Biol 31: 4593-4608, 2011.
39. Senbonmatsu T, Saito T, Landon EJ, Watanabe O, Price E Jr, Roberts RL, Imboden H, Fitzgerald TG, Gaffney FA and Inagami T: A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. EMBO J 22: 6471-6482, 2003.
40. El-Shewy HM, Sohn M, Wilson P, Lee MH, Hammad SM, Luttrell LM and Jaffa AA: Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells. Mol Endocrinol 26: 833-845, 2012.
41. Kyriakis JM and Avruch J: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81: 807-869, 2001.
42. Horisawa K, Tateyama S, Ishizaka M, Matsumura N, Takashima H, Miyamoto-Sato E, Doi N and Yanagawa H: In vitro selection of Jun-associated proteins using mRNA display. Nucleic Acids Res 32: e169, 2004.
43. Rao S, Matsumura A, Yoon J and Simon MC: SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. J Biol Chem 274: 11115-11124, 1999.
44. Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy JY and Zhu Y: Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci USA 104: 9018-9023, 2007.
45. Toh WH, Siddique MM, Boominathan L, Lin KW and Sabapathy K: c-Jun regulates the stability and activity of the p53 homologue, p73. J Biol Chem 279: 44713-44722, 2004.
46. Canettieri G, Franchi A, Guardia MD, Morantte I, Santaguida MG, Harney JW, Larsen PR and Centanni M: Activation of thyroid hormone is transcriptionally regulated by epidermal growth factor in human placenta-derived JEG3 cells. Endocrinology 149: 695-702, 2008.
47. Jahan A and Chiang JY: Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene. Am J Physiol Gastrointest Liver Physiol 288: G685-G695, 2005.
48. Morris JB, Pham TM, Kenney B, Sheppard KE and Woodcock EA: UTP transactivates epidermal growth factor receptors and promotes cardiomyocyte hypertrophy despite inhibiting transcription of the hypertrophic marker gene, atrial natriuretic peptide. J Biol Chem 279: 8740-8746, 2004.
49. Fontana X, Hristova M, Da Costa C, Patodia S, Thei L, Makwana M, Spencer-Dene B, Latouche M, Mirsky R, Jessen KR, et al: c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling. J Cell Biol 198: 127-141, 2012.
50. Kinoshita I, Leaner V, Katabami M, Manzano RG, Dent P, Sabichi A and Birrer MJ: Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: Increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth. Oncogene 22: 2710-2722, 2003.
51. Sinha S, Malonia SK, Mittal SP, Singh K, Kadreppa S, Kamat R, Mukhopadhyaya R, Pal JK and Chattopadhyay S: Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element. EMBO J 29: 830-842, 2010.
52. Izzotti A, Cartiglia C, Longobardi M, Bagnasco M, Merello A, You M, Lubet RA and De Flora S: Gene expression in the lung of p53 mutant mice exposed to cigarette smoke. Cancer Res 64: 8566-8572, 2004.
53. Steffan JS, Kazantsev A, Spasic-Boskovic O, Greenwald M, Zhu YZ, Gohler H, Wanker EE, Bates GP, Housman DE and Thompson LM: The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci USA 97: 6763-6768, 2000.