The gene pair PRR11 and SKA2 shares a NF-Y-regulated bidirectional promoter and contributes to lung cancer development

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1849, Issue 9, 2015, Pages 1133-1144

  Wang, Yitao ^a   Zhang, Ying ^a   Zhang, Chundong ^a   Weng, Huali ^a   Li, Yi ^a   Cai, Wei ^a   Xie, Mengyu ^a   Long, Yinjiang ^a   Ai, Qing ^a   Liu, Zhu ^a   Du, Gang ^a   Wang, Sen ^a   Niu, Yulong ^a   Song, Fangzhou ^a   Ozaki, Toshinori ^b   Bu, Youquan ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b CHIBA CANCER CENTER   (Japan)

Author keywords

Bidirectional promoter; Cell cycle; Lung cancer; NF Y; PRR11; SKA2

Indexed keywords

NUCLEAR FACTOR Y; SMALL INTERFERING RNA; SPACER DNA; TRANSCRIPTION FACTOR; CCAAT BINDING FACTOR; CHROMATIN; DNA; NONHISTONE PROTEIN; PROLINE-RICH PROTEIN 11, HUMAN; PROTEIN; SKA2 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; BIOINFORMATICS; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE LOCUS; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; LUNG CANCER; LUNG CARCINOGENESIS; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; PRR11 GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SKA2 GENE; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; UPREGULATION; ANIMAL; CHROMATIN; GENETIC TRANSCRIPTION; GENETICS; LUNG TUMOR; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; TUMOR CELL LINE;

EUKARYOTA;

ANIMALS; BASE SEQUENCE; CCAAT-BINDING FACTOR; CELL LINE, TUMOR; CHROMATIN; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA; GENE EXPRESSION REGULATION; HUMANS; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PROTEINS; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION, GENETIC;

EID: 84938091717     PISSN: 18749399     EISSN: 18764320     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2015.07.002     Document Type: Article

References (40)

1. Blattner F.R., Plunkett G., Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. The complete genome sequence of Escherichia coli K-12. Science 1997, 277:1453-1462.
2. Venter J.C., Adams M.D., Myers E.W., et al. The sequence of the human genome. Science 2001, 291:1304-1351.
3. Adachi N., Lieber M.R. Bidirectional gene organization: a common architectural feature of the human genome. Cell 2002, 109:807-809.
4. Trinklein N.D., Aldred S.F., Hartman S.J., Schroeder D.I., Otillar R.P., Myers R.M. An abundance of bidirectional promoters in the human genome. Genome Res. 2004, 14:62-66.
5. Wei W., Pelechano V., Järvelin A.I., Steinmetz L.M. Functional consequences of bidirectional promoters. Trends Genet. 2011, 27:267-276.
6. Wakano C., Byun J.S., Di L.J., Gardner K. The dual lives of bidirectional promoters. Biochim. Biophys. Acta 2012, 1819:688-693.
7. Orekhova A.S., Rubtsov P.M. Bidirectional promoters in the transcription of mammalian genomes. Biochemistry (Mosc) 2013, 78:335-341.
8. Li Y.Y., Yu H., Guo Z.M., Guo T.Q., Tu K., Li Y.X. Systematic analysis of head-to-head gene organization: evolutionary conservation and potential biological relevance. PLoS Comput. Biol. 2006, 2:e74.
9. Yang M.Q., Koehly L.M., Elnitski L.L. Comprehensive annotation of bidirectional promoters identifies co-regulation among breast and ovarian cancer genes. PLoS Comput. Biol. 2007, 3:e72.
10. Xu C.F., Chambers J.A., Solomon E. Complex regulation of the BRCA1 gene. J. Biol. Chem. 1997, 272:20994-20997.
11. Suen T.C., Tang M.S., Goss P.E. Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. Biochim. Biophys. Acta 2005, 1728:126-134.
12. Zanotto E., Shah Z.H., Jacobs H.T. The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y. Nucleic Acids Res. 2007, 35:664-677.
13. Zanotto E., Lehtonen V., Jacobs H.T. Modulation of Mrps12/Sarsm promoter activity in response to mitochondrial stress. Biochim. Biophys. Acta 2008, 1783:2352-2362.
14. Zanotto E., Häkkinen A., Teku G., Shen B., Ribeiro A.S., Jacobs H.T. NF-Y influences directionality of transcription from the bidirectional Mrps12/Sarsm promoter in both mouse and human cells. Biochim. Biophys. Acta 2009, 1789:432-442.
15. Chen P.Y., Chang W.S., Chou R.H., Lai Y.K., Lin S.C., Chi C.Y., Wu C.W. Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner. BMC Mol. Biol. 2007, 9(8):2.
16. Chen P.Y., Chang W.S., Lai Y.K., Wu C.W. c-Myc regulates the coordinated transcription of brain disease-related PDCD10-SERPINI1 bidirectional gene pair. Mol. Cell. Neurosci. 2009, 42:23-32.
17. Voth H., Oberthuer A., Simon T., Kahlert Y., Berthold F., Fischer M. Co-regulated expression of HAND2 and DEIN by a bidirectional promoter with asymmetrical activity in neuroblastoma. BMC Mol. Biol. 2009, 10:28.
18. Sturgill T.W., Stoddard P.B., Cohn S.M., Mayo M.W. The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors. Mol. Cancer 2010, 9:104. 10.1186/1476-4598-9-104.
19. Guarguaglini G., Battistoni A., Pittoggi C., Di Matteo G., Di Fiore B., Lavia P. Expression of the murine RanBP1 and Htf9-c genes is regulated from a shared bidirectional promoter during cell cycle progression. Biochem. J. 1997, 325:277-286.
20. Ji Y., Xie M., Lan H., Zhang Y., Long Y., Weng H., Li D., Cai W., Zhu H., Niu Y., Yang Z., Zhang C., Song F., Bu Y. PRR11 is a novel gene implicated in cell cycle progression and lung cancer. Int. J. Biochem. Cell Biol. 2013, 45:645-656.
21. Zhang C., Zhang Y., Li Y., Zhu H., Wang Y., Cai W., Zhu J., Ozaki T., Bu Y. PRR11 regulates late-S to G2/M phase progression and induces premature chromatin condensation (PCC). Biochem. Biophys. Res. Commun. 2015, (accepted for publication, in press). 10.1016/j.bbrc.2015.01.139.
22. Hanisch A., Silljé H.H., Nigg E.A. Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. EMBO J. 2006, 25:5504-5515.
23. Rice L., Waters C.E., Eccles J., Garside H., Sommer P., Kay P., Blackhall F.H., Zeef L., Telfer B., Stratford I., Clarke R., Singh D., Stevens A., White A., Ray D.W. Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor. J. Endocrinol. 2008, 198:499-509.
24. Jeyaprakash A.A., Santamaria A., Jayachandran U., Chan Y.W., Benda C., Nigg E.A., Conti E. Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface. Mol. Cell 2012, 46:274-286.
25. Imbriano C., Gnesutta N., Mantovani R. The NF-Y/p53 liaison: well beyond repression. Biochim. Biophys. Acta 2012, 1825:131-139.
26. Dolfini D., Gatta R., Mantovani R. NF-Y and the transcriptional activation of CCAAT promoters. Crit. Rev. Biochem. Mol. Biol. 2012, 47:29-49.
27. Dolfini D., Mantovani R. Targeting the Y/CCAAT box in cancer: YB-1 (YBX1) or NF-Y?. Cell Death Differ. 2013, 20:676-685.
28. Benatti P., Dolfini D., Viganò A., Ravo M., Weisz A., Imbriano C. Specific inhibition of NF-Y subunits triggers different cell proliferation defects. Nucleic Acids Res. 2011, 39:5356-5368.
29. Nardini M., Gnesutta N., Donati G., Gatta R., Forni C., Fossati A., Vonrhein C., Moras D., Romier C., Bolognesi M., Mantovani R. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. Cell 2013, 152:132-143.
30. Malumbres M., Carnero A. Cell cycle deregulation: a common motif in cancer. Prog. Cell Cycle Res. 2003, 5:5-18.
31. Malumbres M., Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer 2009, 9:153-166.
32. Shi W., Gerster K., Alajez N.M., Tsang J., Waldron L., Pintilie M., Hui A.B., Sykes J., P'ng C., Miller N., McCready D., Fyles A., Liu F.F. MicroRNA-301 mediates proliferation and invasion in human breast cancer. Cancer Res. 2011, 71:2926-2937.
33. Lu Z., Li Y., Takwi A., Li B., Zhang J., Conklin D.J., Young K.H., Martin R., Li Y. MiR-301a as an NF-κB activator in pancreatic cancer cells. EMBO J. 2011, 30:57-67.
34. Mycko M.P., Cichalewska M., Machlanska A., Cwiklinska H., Mariasiewicz M., Selmaj K.W. MicroRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:E1248-E1257.
35. Chen Z., Chen L.Y., Dai H.Y., Wang P., Gao S., Wang K. MiR-301a promotes pancreatic cancer cell proliferation by directly inhibiting Bim expression. J. Cell. Biochem. 2012, 113:3229-3235.
36. Liu L., Nie J., Chen L., Dong G., Du X., Wu X., Tang Y., Han W. The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression. PLoS One 2013, 8:e55532.
37. Bu Y., Suenaga Y., Ono S., Koda T., Song F., Nakagawara A., Ozaki T. Sp1-mediated transcriptional regulation of NFBD1/MDC1 plays a critical role in DNA damage response pathway. Genes Cells 2008, 13:53-66.
38. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001, 25:402-408.
39. Takeuchi T., Tomida S., Yatabe Y., Kosaka T., Osada H., Yanagisawa K., et al. Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors. J. Clin. Oncol. 2006, 24:1679-1688.
40. Liu Z., Niu Y., Li C., Yang Y., Gao C. Integrating multiple microarray datasets on oral squamous cell carcinoma to reveal dysregulated networks. Head Neck 2012, 34:1789-1797.