c-Myc regulates the coordinated transcription of brain disease-related PDCD10-SERPINI1 bidirectional gene pair

Molecular and Cellular Neuroscience

Volumn 42, Issue 1, 2009, Pages 23-32

  Chen, Ping Yen ^a,b   Chang, Wun Shaing W ^a   Lai, Yiu Kay ^b,c   Wu, Cheng Wen ^a,d,e  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c DA YEH UNIVERSITY   (Taiwan)

^d INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^e Institute of Traditional Medicine   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; BRAIN PROTEIN; CYCLIC NUCLEOTIDE; CYSTEINE; DNA; GLYCINE; NEUROSERPIN; PROTEIN PDCD10; PROTEINASE INHIBITOR; THREONINE; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ARTICLE; BRAIN CANCER; BRAIN DISEASE; BRAIN MALFORMATION; CENTRAL NERVOUS SYSTEM DISEASE; CHROMOSOME 3Q; DNA FLANKING REGION; DOWN REGULATION; GENE MUTATION; GENETIC CODE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN METHYLATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

APOPTOSIS REGULATORY PROTEINS; AZACITIDINE; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DNA METHYLATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INHIBITORS; GLIOBLASTOMA; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEUROBLASTOMA; NEUROPEPTIDES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; SERPINS; TRANSCRIPTIONAL ACTIVATION;

EID: 67651122900     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2009.05.001     Document Type: Article

References (64)

1. Adachi N., and Lieber M.R. Bidirectional gene organization: a common architectural feature of the human genome. Cell 109 (2002) 807-809
2. Agirre X., Roman-Gomez J., Vazquez I., Jimenez-Velasco A., Garate L., Montiel-Duarte C., Artieda P., Cordeu L., Lahortiga I., Calasanz M.J., Heiniger A., Torres A., Minna J.D., and Prosper F. Abnormal methylation of the common PARK2 and PACRG promoter is associated with down-regulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia. Int. J. Cancer 118 (2006) 1945-1953
3. Bastian P.J., Yegnasubramanian S., Palapattu G.S., Rogers C.G., Lin X., De Marzo A.M., and Nelson W.G. Molecular biomarker in prostate cancer: the role of CpG island hypermethylation. Eur. Urol. 46 (2004) 698-708
4. Baudino T.A., McKay C., Pendeville-Samain H., Nilsson J.A., Maclean K.H., White E.L., Davis A.C., Ihle J.N., and Cleveland J.L. c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev. 16 (2002) 2530-2543
5. Bergametti F., Denier C., Labauge P., Arnoult M., Boetto S., Clanet M., Coubes P., Echenne B., Ibrahim R., Irthum B., Jacquet G., Lonjon M., Moreau J.J., Neau J.P., Parker F., Tremoulet M., and Tournier-Lasserve E. Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations. Am. J. Hum. Genet. 76 (2005) 42-51
6. Blackwood E.M., Kretzner L., and Eisenman R.N. Myc and Max function as a nucleoprotein complex. Curr. Opin. Genet. Dev. 2 (1992) 227-235
7. Boutanaev A.M., Kalmykova A.I., Shevelyov Y.Y., and Nurminsky D.I. Large clusters of co-expressed genes in the Drosophila genome. Nature 420 (2002) 666-669
8. Burbelo P.D., Martin G.R., and Yamada Y. Alpha 1(IV) and alpha 2(IV) collagen genes are regulated by a bidirectional promoter and a shared enhancer. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 9679-9682
9. Byrd P.J., Cooper P.R., Stankovic T., Kullar H.S., Watts G.D., Robinson P.J., and Taylor M.R. A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies. Hum. Mol. Genet. 5 (1996) 1785-1791
10. Cartharius K., Frech K., Grote K., Klocke B., Haltmeier M., Klingenhoff A., Frisch M., Bayerlein M., and Werner T. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 21 (2005) 2933-2942
11. Chang W.S.W., Chang N.T., Lin S.C., Wu C.W., and Wu F.Y. Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26. Genes Chromo. Cancer 29 (2000) 240-255
12. Chen P.Y., Chang W.S.W., Chou R.H., Lai Y.K., Lin S.C., Chi C.Y., and Wu C.W. Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner. BMC Mol. Biol. 8 (2007) 2
13. Cinelli P., Madani R., Tsuzuki N., Vallet P., Arras M., Zhao C.N., Osterwalder T., Rulicke T., and Sonderegger P. Neuroserpin, a neuroprotective factor in focal ischemic stroke. Mol. Cell. Neurosci. 18 (2001) 443-457
14. Conzen S.D., Gottlob K., Kandel E.S., Khanduri P., Wagner A.J., O'Leary M., and Hay N. Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis. Mol. Cell. Biol. 20 (2000) 6008-6018
15. Davis R.L., Shrimpton A.E., Holohan P.D., Bradshaw C., Feiglin D., Collins G.H., Sonderegger P., Kinter J., Becker L.M., Lacbawan F., Krasnewich D., Muenke M., Lawrence D.A., Yerby M.S., Shaw C.M., Gooptu B., Elliott P.R., Finch J.T., Carrell R.W., and Lomas D.A. Familial dementia caused by polymerization of mutant neuroserpin. Nature 401 (1999) 376-379
16. Davis R.L., Shrimpton A.E., Carrell R.W., Lomas D.A., Gerhard L., Baumann B., Lawrence D.A., Yepes M., Kim T.S., Ghetti B., Piccardo P., Takao M., Lacbawan F., Muenke M., Sifers R.N., Bradshaw C.B., Kent P.F., Collins G.H., Larocca D., and Holohan P.D. Association between conformational mutations in neuroserpin and onset and severity of dementia. Lancet 359 (2002) 2242-2247
17. Galaktionov K., Chen X., and Beach D. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382 (1996) 511-517
18. Grandori C., Mac J., Siebelt F., Ayer D.E., and Eisenman R.N. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. EMBO J. 15 (1996) 4344-4357
19. Greene W.K., Sontani Y., Sharp M.A., Dunn D.S., Kees U.R., and Bellgard M.I. A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene. Gene 391 (2007) 223-232
20. Guclu B., Ozturk A.K., Pricola K.L., Bilguvar K., Shin D., O'Roak B.J., and Gunel M. Mutations in apoptosis-related gene, PDCD10, cause cerebral cavernous malformation 3. Neurosurgery 57 (2005) 1008-1013
21. Hansen J.J., Bross P., Westergaard M., Nielsen M.N., Eiberg H., Børglum A.D., Mogensen J., Kristiansen K., Bolund L., and Gregersen N. Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter. Hum. Genet. 112 (2003) 71-77
22. Hirose S., Payne S.H., and Loomis W.F. cis-Acting site controlling bidirectional transcription at the growth-differentiation transition in Dictyostelium discoideum. Eukaryot. Cell. 5 (2006) 1104-1110
23. Kamath R.S., Fraser A.G., Dong Y., Poulin G., Durbin R., Gotta M., Kanapin A., Le Bot N., Moreno S., Sohrmann M., Welchman D.P., Zipperlen P., and Ahringer J. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421 (2003) 231-237
24. Koyanagi K.O., Hagiwara M., Itoh T., Gojobori T., and Imanishi T. Comparative genomics of bidirectional gene pairs and its implications for the evolution of a transcriptional regulation system. Gene 353 (2005) 169-176
25. Lee S.T., Choi K.W., Yeo H.T., Kim J.W., Ki C.S., and Cho Y.D. Identification of an Arg35X mutation in the PDCD10 gene in a patient with cerebral and multiple spinal cavernous malformations. J. Neurol. Sci. 267 (2008) 177-181
26. Lercher M.J., Blumenthal T., and Hurst L.D. Coexpression of neighboring genes in Caenorhabditis elegans is mostly due to operons and duplicate genes. Genome Res. 13 (2003) 238-243
27. Li Y.Y., Yu H., Guo Z.M., Guo T.Q., Tu K., and Li Y.X. Systematic analysis of head-to-head gene organization: evolutionary conservation and potential biological relevance. PLoS Comput. Biol. 2 (2006) e74
28. Linton J.P., Yen J.Y., Selby E., Chen Z., Chinsky J.M., Liu K., Kellems R.E., and Crouse G.F. Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene. Mol. Cell. Biol. 9 (1989) 3058-3072
29. Liquori C.L., Berg M.J., Squitieri F., Ottenbacher M., Sorlie M., Leedom T.P., Cannella M., Maglione V., Ptacek L., Johnson E.W., and Marchuk D.A. Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus. Hum. Mut. 27 118 (2006)
30. Luscher B., and Larsson L.G. The basic region/helix-loop-helix/leucine zipper domain of Myc proto-oncoproteins: function and regulation. Oncogene 18 (1999) 2955-2966
31. Ma X., Zhao H., Shan J., Long F., Chen Y., Chen Y., Zhang Y., Han X., and Ma D. PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway. Mol. Biol. Cell 18 (2007) 1965-1978
32. Miltenberger R.J., Sukow K.A., and Farnham P.J. An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants. Mol. Cell. Biol. 15 (1995) 2527-2535
33. Miranda E., MacLeod I., Davies M.J., Pérez J., Römisch K., Crowther D.C., and Lomas D.A. The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB. Hum. Mol. Genet. 17 (2008) 1527-1539
34. Osterwalder T., Contartese J., Stoeckli E.T., Kuhn T.B., and Sonderegger P. Neuroserpin, an axonally secreted serine protease inhibitor. EMBO J. 15 (1996) 2944-2953
35. Pöschl E., Pollner R., and Kuhn K. The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure. EMBO J. 7 (1988) 2687-2695
36. Purmann A., Toedling J., Schueler M., Carninci P., Lehrach H., Hayashizaki Y., Huber W., and Sperling S. Genomic organization of transcriptomes in mammals: coregulation and cofunctionality. Genomics 89 (2007) 580-587
37. Reisman D., Elkind N.B., Roy B., Beamon J., and Rotter V. c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif. Cell. Growth Differ. 4 (1993) 57-65
38. Remaley A.T., Bark S., Walts A.D., Freeman L., Shulenin S., Annilo T., Elgin E., Rhodes H.E., Joyce C., Dean M., Santamarina-Fojo S., and Brewer Jr. H.B. Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster. Biochem. Biophys. Res. Commun. 295 (2002) 276-282
39. Revencu N., and Vikkula M. Cerebral cavernous malformation: new molecular and clinical insights. J. Med. Genet. 43 (2006) 716-721
40. Rice P., Longden I., and Bleasby A. EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet. 16 (2000) 276-277
41. Schlossmacher M.G., Frosch M.P., Gai W.P., Medina M., Sharma N., Forno L., Ochiishi T., Shimura H., Sharon R., Hattori N., Langston J.W., Mizuno Y., Hyman B.T., Selkoe D.J., and Kosik K.S. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am. J. Pathol. 160 (2002) 1655-1667
42. Sémon M., and Duret L. Evolutionary origin and maintenance of coexpressed gene clusters in mammals. Mol. Biol. Evol. 23 (2006) 1715-1723
43. Singer G.A., Lloyd A.T., Huminiecki L.B., and Wolfe K.H. Clusters of co-expressed genes in mammalian genomes are conserved by natural selection. Mol. Biol. Evol. 22 (2005) 767-775 (Erratum in Mol. Biol. Evol. 2005 22, 1160)
44. Shim H., Dolde C., Lewis B.C., Wu C.S., Dang G., Jungmann R.A., Dalla-Favera R., and Dang C.V. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 6658-6663
45. Shu J., Jelinek J., Chang H., Shen L., Qin T., Chung W., Oki Y., and Issa J.P. Silencing of bidirectional promoters by DNA methylation in tumorigenesis. Cancer Res. 66 (2006) 5077-5084
46. Skrabanek L., and Wolfe K.H. Eukaryote genome duplication - where's the evidence?. Curr. Opin. Gene. Dev. 8 (1998) 694-700
47. Stahl S., Gaetzner S., Voss K., Brackertz B., Schleider E., Sürücü O., Kunze E., Netzer C., Korenke C., Finckh U., Habek M., Poljakovic Z., Elbracht M., Rudnik-Schöneborn S., Bertalanffy H., Sure U., and Felbor U. Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex. Hum. Mutat. 29 (2008) 709-717
48. Steiner P., Philipp A., Lukas J., Godden-Kent D., Pagano M., Mittnacht S., Bartek J., and Eilers M. Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J. 14 (1995) 4814-4826
49. Takai D., and Jones P.A. Origins of bidirectional promoters: computational analyses of intergenic distance in the human genome. Mol. Biol. Evol. 21 (2004) 463-467
50. Tanriover G., Boylan A.J., Diluna M.L., Pricola K.L., Louvi A., and Gunel M. PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit. Neurosurgery 62 (2008) 930-938
51. Trinklein N.D., Aldred S.F., Hartman S.J., Schroeder D.I., Otillar R.P., and Myers R.M. An abundance of bidirectional promoters in the human genome. Genome Res. 14 (2004) 62-66
52. Verlaan D.J., Roussel J., Laurent S.B., Elger C.E., Siegel A.M., and Rouleau G.A. CCM3 mutations are uncommon in cerebral cavernous malformations. Neurology 65 (2005) 1982-1983
53. Voss K., Stahl S., Schleider E., Ullrich S., Nickel J., Mueller T.D., and Felbor U. CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. Neurogenetics 8 (2007) 249-256
54. Wang Y.G., Liu H.T., Zhang Y.M., and Ma D.L. cDNA cloning and expression of an apoptosis-related gene, human TFAR15 gene. Sci. China 42 (1999) 323-329
55. West A., Farrer M., Petrucelli L., Cookson M., Lockhart P., and Hardy J. Identification and characterization of the human parkin gene promoter. J. Neurochem. 78 (2001) 1146-1152
56. West A.B., Lockhart P.J., O'Farell C., and Farrer M.J. Identification of a novel gene linked to parkin via a bi-directional promoter. J. Mol. Biol. 326 (2003) 11-19
57. West A.B., Kapatos G., O'Farrell C., Gonzalez-de-Chavez F., Chiu K., Farrer M.J., and Maidment N.T. N-myc regulates parkin expression. J Biol. Chem. 279 (2004) 28896-28902
58. Williams E.J., and Bowles D.J. Coexpression of neighboring genes in the genome of Arabidopsis thaliana. Genome Res. 14 (2004) 1060-1067
59. Wu K.J., Mattioli M., Morse H.C., and Dalla-Favera R. c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cbeta) gene. Oncogene 21 (2002) 7872-7882
60. Xiao Q., Claassen G., Shi J., Adachi S., Sedivy J., and Hann S.R. Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis. Genes Dev. 12 (1998) 3803-3808
61. Yepes M., Sandkvist M., Wong M.K., Coleman T.A., Smith E., Cohan S.L., and Lawrence D.A. Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis. Blood 96 (2000) 569-576
62. Ying J., Li H., Cui Y., Wong A.H., Langford C., and Tao Q. Epigenetic disruption of two proapoptotic genes MAPK10/JNK3 and PTPN13/FAP-1 in multiple lymphomas and carcinomas through hypermethylation of a common bidirectional promoter. Leukemia 20 (2006) 1173-1175
63. Zhan S., Horrocks J., and Lukens L.N. Islands of co-expressed neighbouring genes in Arabidopsis thaliana suggest higher-order chromosome domains. Plant J. 45 (2006) 347-357
64. Zornig M., and Evan G.I. Cell cycle: on target with Myc. Curr. Biol. 6 (1996) 1553-1556