Ionizing radiation sensitizes breast cancer cells to Bcl-2 inhibitor, ABT-737, through regulating Mcl-1

Radiation Research

Volumn 182, Issue 6, 2014, Pages 618-625

  Wu, Hao ^a   Schiff, Devora S ^a   Lin, Yong ^a   Neboori, Hanmanth J R ^a   Goyal, Sharad ^a   Feng, Zhaohui ^a   Haffty, Bruce G ^a  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; PROTEIN BAK; PROTEIN BCL 2; PROTEIN MCL 1; SMALL INTERFERING RNA; ABT-737; BIPHENYL DERIVATIVE; MCL1 PROTEIN, HUMAN; MYELOID LEUKEMIA FACTOR 1; NITROPHENOL; PIPERAZINE DERIVATIVE; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CELL PROLIFERATION; CLONOGENIC ASSAY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; IONIZING RADIATION; MCF 7 CELL LINE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; RADIOSENSITIVITY; SENSITIZATION; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; CELL SURVIVAL; DEFICIENCY; DRUG EFFECTS; DRUG SCREENING; GENE SILENCING; GENETICS; METABOLISM; PATHOLOGY; RADIATION RESPONSE; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BIPHENYL COMPOUNDS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NITROPHENOLS; PIPERAZINES; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; SULFONAMIDES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84918586816     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR13856.1     Document Type: Article

References (35)

1. Fisher B, Jeong JH, Anderson S, Bryant J, Fisher ER, Wolmark N. Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. N Engl J Med 2002; 347:567-75
2. Haffty BG, Carter D, Flynn SD, Fischer DB, Brash DE, Simons J, et al. Local recurrence versus new primary: clinical analysis of 82 breast relapses and potential applications for genetic fingerprinting. Int J Radiat Oncol Biol Phys 1993; 27:575-83
3. Fisher B, Anderson S, Fisher ER, Redmond C, Wickerham DL, Wolmark N, et al. Significance of ipsilateral breast tumour recurrence after lumpectomy. Lancet 1991; 338:327-31
4. Zhou L, Yuan R, Serggio L. Molecular mechanisms of irradiationinduced apoptosis. Front Biosci 2003; 8:d9-19
5. Balcer-Kubiczek EK. Apoptosis in radiation therapy: a doubleedged sword. Exp Oncol 2012; 34:277-85
6. Adams JM, Cory S. Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Curr Opin Immunol 2007; 19:488-96
7. Oakes SR, Vaillant F, Lim E, Lee L, Breslin K, Feleppa F, et al. Sensitization of BCL-2-expressings breast tumors to chemotherapy by the BH3 mimetic ABT-737. Proc Natl Acad Sci U S A 2012; 109:2766-71
8. Mirkovic N, Voehringer DW, Story MD, McConkey DJ, McDonnell TJ, Meyn RE. Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols. Oncogene 1997; 15:1461-70
9. Kyprianou N, King ED, Bradbury D, Rhee JG. bcl-2 overexpression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells. Int J Cancer 1997; 70:341-8
10. Labi V, Grespi F, Baumgartner F, Villunger A. Targeting the Bcl- 2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?. Cell Death Differ 2008; 15:977-87
11. Kang MH, Reynolds CP. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res 2009; 15:1126-32
12. Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005; 435:677-81
13. Tse C, Shoemaker AR, Adickes J, Anderson MG, Chen J, Jin S, et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res 2008; 68:3421-8
14. Miyashita T, Reed JC. bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res 1992; 52:5407-11
15. Miyashita T, Reed JC. Bcl-2 oncoprotein blocks chemotherapyinduced apoptosis in a human leukemia cell line. Blood 1993; 81:151-7
16. Wang ZB, Zhang Y, Liu YQ, Guo Y, Xu H, Dong B, et al. Bcl-xL overexpression restricts gamma-radiation-induced apoptosis. Cell Biol Int 2006; 30:15-20
17. Song L, Coppola D, Livingston S, Cress D, Haura EB. Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells. Cancer Biol Ther 2005; 4:267-76
18. Yang Q, Moran MS, Haffty BG. Bcl-2 expression predicts local relapse for early-stage breast cancer receiving conserving surgery and radiotherapy. Breast Cancer Res Treat 2009; 115:343-8
19. Decker P, Isenberg D, Muller S. Inhibition of caspase-3-mediated poly(ADP-ribose) polymerase (PARP) apoptotic cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis. J Biol Chem 2000; 275:9043-6
20. Koh DW, Dawson TM, Dawson VL. Mediation of cell death by poly(ADP-ribose) polymerase-1. Pharmacol Res 2005; 52:5-14
21. Pietenpol JA, Papadopoulos N, Markowitz S, Willson JK, Kinzler KW, Vogelstein B. Paradoxical inhibition of solid tumor cell growth by bcl2. Cancer Res 1994; 54:3714-7
22. Chonghaile TN, Letai A. Mimicking the BH3 domain to kill cancer cells. Oncogene 2008; 27:S149-57
23. Cragg MS, Harris C, Strasser A, Scott CL. Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat Rev Cancer 2009; 9:321-6
24. Lieber J, Kirchner B, Eicher C, Warmann SW, Seitz G, Fuchs J, et al. Inhibition of Bcl-2 and Bcl-X enhances chemotherapy sensitivity in hepatoblastoma cells. Pediatr Blood Cancer 2010; 55:1089-95
25. Gandhi L, Camidge DR, Ribeiro de Oliveira M, Bonomi P, Gandara D, Khaira D, et al. Phase I study of Navitoclax (ABT- 263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. J Clin Oncol 2011; 29:909-16
26. Kozopas KM, Yang T, Buchan HL, Zhou P, Craig RW. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci U S A 1993; 90:3516-20
27. Derenne S, Monia B, Dean NM, Taylor JK, Rapp MJ, Harousseau JL. Antisense Strategy Shows That Mcl-1 Rather Than Bcl-2 or Bclx(L) Is An Essential Survival Protein of Human Myeloma Cells. Blood 2002; 100:194-9
28. Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, et al. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl- 2, until displaced by BH3-only proteins. Genes Dev 2005; 19:1294-305
29. Shimazu T, Degenhardt K, Nur-E-Kamal A, Zhang J, Yoshida T, Zhang Y, et al. NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition. Genes Dev 2007; 21:929-41
30. Cuconati A, Mukherjee C, Perez D, White E. DNA damage response and MCL-1 destruction initiate apoptosis in adenovirusinfected cells. Genes Dev 2003; 17:2922-32
31. Krajewski S, Bodrug S, Krajewska M, Shabaik A, Gascoyne R, Berean K, et al. Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am J Pathol 1995; 146:1309-19
32. Yecies D, Carlson NE, Deng J, Letai A. Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1. Blood 2010; 115:3304-13
33. Bray K, Chen HY, Karp CM, May M, Ganesan S, Karantza- Wadsworth V, et al. Bcl-2 modulation to activate apoptosis in prostate cancer. Mol Cancer Res 2009; 7:1487-96
34. Keuling AM, Felton KE, Parker AA, Akbari M, Andrew SE, Tron VA. RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway. PLoS One 2009; 4:e6651
35. Nijhawan D, Fang M, Traer E, Zhong Q, Gao W, Du F, et al. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 2003; 17(12): 1475-86