A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies

Journal of Pharmaceutical and Biomedical Analysis

Volumn 66, Issue , 2012, Pages 371-375

  Lin, Hongxia ^a   Gounder, Murugesan K ^a   Bertino, Joseph R ^a   Kong, Ah Ng Tony ^a,b   DiPaola, Robert S ^a   Stein, Mark N ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

HPLC UV; Pharmacokinetics; R ( ) gossypol

Indexed keywords

CARBOPLATIN; GOSSYPOL; GOSSYPOL ACETIC ACID; ISOSORBIDE; PACLITAXEL;

ADVANCED CANCER; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MAXIMUM PLASMA CONCENTRATION; MULTIPLE CYCLE TREATMENT; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SOLID TUMOR; VALIDATION STUDY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GOSSYPOL; HUMANS; LIMIT OF DETECTION; NEOPLASMS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 84861222655     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.03.029     Document Type: Article

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