메뉴 건너뛰기




Volumn 32, Issue 2, 2015, Pages

Rac1 expression in epithelial ovarian cancer: effect on cell EMT and clinical outcome

Author keywords

Cell migration; EMT; Ovarian cancer; Prognosis; Rac1

Indexed keywords

CA 125 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE P38; P21 ACTIVATED KINASE 1; RAC1 PROTEIN; UVOMORULIN; VIMENTIN; RAC1 PROTEIN, HUMAN;

EID: 84938058544     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-014-0329-5     Document Type: Article
Times cited : (53)

References (35)
  • 1
    • 77955635233 scopus 로고    scopus 로고
    • Cancer statistics, 2010
    • Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;50(5):277–300. doi:10.3322/caac.20073.
    • (2010) CA Cancer J Clin , vol.50 , Issue.5 , pp. 277-300
    • Jemal, A.1    Siegel, R.2    Xu, J.3    Ward, E.4
  • 3
    • 71249149587 scopus 로고    scopus 로고
    • Autoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer
    • COI: 1:CAS:528:DC%2BD1MXhsFGrsbvM
    • Tang L, Yang J, Ng SK, Rodriguez N, Choi PW, Vitonis A, et al. Autoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer. Eur J Cancer. 2010;46(1):170–9. doi:10.1016/j.ejca.2009.10.003.
    • (2010) Eur J Cancer , vol.46 , Issue.1 , pp. 170-179
    • Tang, L.1    Yang, J.2    Ng, S.K.3    Rodriguez, N.4    Choi, P.W.5    Vitonis, A.6
  • 4
    • 84858747280 scopus 로고    scopus 로고
    • Screening for ovarian cancer in the general population
    • Gentry-Maharaj A, Menon U. Screening for ovarian cancer in the general population. Best Pract Res Clin Obstet Gynaecol. 2012;26(2):243–56. doi:10.1016/j.bpobgyn.2011.11.006.
    • (2012) Best Pract Res Clin Obstet Gynaecol , vol.26 , Issue.2 , pp. 243-256
    • Gentry-Maharaj, A.1    Menon, U.2
  • 5
    • 84872920575 scopus 로고    scopus 로고
    • Ovarian cancer: making its own rules-again
    • Kohn EC, Hurteau J. Ovarian cancer: making its own rules-again. Cancer. 2013;119(3):474–6. doi:10.1002/cncr.27833.
    • (2013) Cancer , vol.119 , Issue.3 , pp. 474-476
    • Kohn, E.C.1    Hurteau, J.2
  • 6
    • 84885573480 scopus 로고    scopus 로고
    • TAZ mediates lysophosphatidic acid-induced migration and proliferation of epithelial ovarian cancer cells
    • COI: 1:CAS:528:DC%2BC3sXhsF2rur3E
    • Jeong GO, Shin SH, Seo EJ, Kwon YW, Heo SC, Kim KH, et al. TAZ mediates lysophosphatidic acid-induced migration and proliferation of epithelial ovarian cancer cells. Cell Physiol Biochem. 2013;32(2):253–63. doi:10.1159/000354434.
    • (2013) Cell Physiol Biochem , vol.32 , Issue.2 , pp. 253-263
    • Jeong, G.O.1    Shin, S.H.2    Seo, E.J.3    Kwon, Y.W.4    Heo, S.C.5    Kim, K.H.6
  • 7
    • 84881125188 scopus 로고    scopus 로고
    • Expression proteomics predicts loss of RXR-γ during progression of epithelial ovarian cancer
    • COI: 1:CAS:528:DC%2BC3sXhtlWgt7vO
    • Kalra RS, Bapat SA. Expression proteomics predicts loss of RXR-γ during progression of epithelial ovarian cancer. PLoS One. 2013;8(8):e70398. doi:10.1371/journal.pone.0070398.
    • (2013) PLoS One , vol.8 , Issue.8 , pp. 70398
    • Kalra, R.S.1    Bapat, S.A.2
  • 8
    • 84880704914 scopus 로고    scopus 로고
    • Thrombin promotes epithelial ovarian cancer cell invasion by inducing epithelial–mesenchymal transition
    • COI: 1:CAS:528:DC%2BC2cXmt1Slsb0%3D
    • Zhong YC, Zhang T, Di W, Li WP. Thrombin promotes epithelial ovarian cancer cell invasion by inducing epithelial–mesenchymal transition. J Gynecol Oncol. 2013;24(3):265–72. doi:10.3802/jgo.2013.24.3.265.
    • (2013) J Gynecol Oncol , vol.24 , Issue.3 , pp. 265-272
    • Zhong, Y.C.1    Zhang, T.2    Di, W.3    Li, W.P.4
  • 9
    • 84872267912 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition from a natural gestational orchestration to a bizarre cancer disturbance
    • COI: 1:CAS:528:DC%2BC3sXls1GnsQ%3D%3D
    • Shirkoohi R. Epithelial mesenchymal transition from a natural gestational orchestration to a bizarre cancer disturbance. Cancer Sci. 2013;104(1):28–35. doi:10.1111/cas.12074.
    • (2013) Cancer Sci , vol.104 , Issue.1 , pp. 28-35
    • Shirkoohi, R.1
  • 10
    • 84859113973 scopus 로고    scopus 로고
    • E-cadherin’s dark side: possible role in tumor progression
    • COI: 1:CAS:528:DC%2BC38Xns1Cgsr4%3D
    • Rodriguez FJ, Lewis-Tuffin LJ, Anastasiadis PZ. E-cadherin’s dark side: possible role in tumor progression. Biochim Biophys Acta. 2012;1826(1):23–31. doi:10.1016/j.bbcan.2012.03.002.
    • (2012) Biochim Biophys Acta , vol.1826 , Issue.1 , pp. 23-31
    • Rodriguez, F.J.1    Lewis-Tuffin, L.J.2    Anastasiadis, P.Z.3
  • 11
    • 77950814616 scopus 로고    scopus 로고
    • The epithelial–mesenchymal transition and the estrogen-signaling in ovarian cancer
    • COI: 1:CAS:528:DC%2BC3cXkvV2jsbc%3D
    • Gallo D, Ferlini C, Scambia G. The epithelial–mesenchymal transition and the estrogen-signaling in ovarian cancer. Curr Drug Targets. 2010;11(4):474–81.
    • (2010) Curr Drug Targets , vol.11 , Issue.4 , pp. 474-481
    • Gallo, D.1    Ferlini, C.2    Scambia, G.3
  • 13
    • 77954617035 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces invasion and migration of ovarian cancer cells by decreasing the expression of E-cadherin, beta-catenin, and caveolin-1
    • COI: 1:CAS:528:DC%2BC3cXhtVSltbzM
    • Hu J, Shao S, Song Y, Zhao J, Dong Y, Gong L, Yang P. Hepatocyte growth factor induces invasion and migration of ovarian cancer cells by decreasing the expression of E-cadherin, beta-catenin, and caveolin-1. Anat Rec (Hoboken). 2010;293:1134–9. doi:10.1016/j.canlet.2009.09.017.
    • (2010) Anat Rec (Hoboken) , vol.293 , pp. 1134-1139
    • Hu, J.1    Shao, S.2    Song, Y.3    Zhao, J.4    Dong, Y.5    Gong, L.6    Yang, P.7
  • 14
    • 84864058435 scopus 로고    scopus 로고
    • The relevance and role of vascular endothelial growth factor C, matrix metalloproteinase-2 and E-cadherin in epithelial ovarian cancer
    • COI: 1:CAS:528:DC%2BC38Xit1ejurg%3D
    • Huang KJ, Sui LH. The relevance and role of vascular endothelial growth factor C, matrix metalloproteinase-2 and E-cadherin in epithelial ovarian cancer. Med Oncol. 2012;29(1):318–23. doi:10.1007/s12032-010-9817-4.
    • (2012) Med Oncol , vol.29 , Issue.1 , pp. 318-323
    • Huang, K.J.1    Sui, L.H.2
  • 15
    • 79959559880 scopus 로고    scopus 로고
    • Role of Rho GTPases and their regulators in cancer progression
    • Rathinam R, Berrier A, Alahari SK. Role of Rho GTPases and their regulators in cancer progression. Front Biosci (Landmark Ed). 2011;1(16):2561–71.
    • (2011) Front Biosci (Landmark Ed) , vol.1 , Issue.16 , pp. 2561-2571
    • Rathinam, R.1    Berrier, A.2    Alahari, S.K.3
  • 16
    • 35248852444 scopus 로고    scopus 로고
    • Rac1 activity regulates proliferation of aggressive metastatic melanoma
    • COI: 1:CAS:528:DC%2BD2sXhtF2ms7bE
    • Bauer NN, Chen YW, Samant RS, Shevde LA, Fodstad O. Rac1 activity regulates proliferation of aggressive metastatic melanoma. Exp Cell Res. 2007;313(18):3832–9.
    • (2007) Exp Cell Res , vol.313 , Issue.18 , pp. 3832-3839
    • Bauer, N.N.1    Chen, Y.W.2    Samant, R.S.3    Shevde, L.A.4    Fodstad, O.5
  • 17
    • 77952956960 scopus 로고    scopus 로고
    • Rac1 modulates TGF-beta1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes
    • Santibáñez JF, Kocić J, Fabra A, Cano A, Quintanilla M. Rac1 modulates TGF-beta1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes. FEBS Lett. 2010;584(11):2305–10. doi:10.1016/j.febslet.2010.03.042.
    • (2010) FEBS Lett , vol.584 , Issue.11 , pp. 2305-2310
    • Santibáñez, J.F.1    Kocić, J.2    Fabra, A.3    Cano, A.4    Quintanilla, M.5
  • 18
    • 84872336385 scopus 로고    scopus 로고
    • Rac1/PAK1 signaling promotes epithelial–mesenchymal transition of podocytes in vitro via triggering β-catenin transcriptional activity under high glucose conditions
    • COI: 1:CAS:528:DC%2BC3sXosFKrsQ%3D%3D
    • Lv Z, Hu M, Zhen J, Lin J, Wang Q, Wang R. Rac1/PAK1 signaling promotes epithelial–mesenchymal transition of podocytes in vitro via triggering β-catenin transcriptional activity under high glucose conditions. Int J Biochem Cell Biol. 2013;45(2):255–64. doi:10.1016/j.biocel.2012.11.003.
    • (2013) Int J Biochem Cell Biol , vol.45 , Issue.2 , pp. 255-264
    • Lv, Z.1    Hu, M.2    Zhen, J.3    Lin, J.4    Wang, Q.5    Wang, R.6
  • 19
    • 84871345975 scopus 로고    scopus 로고
    • Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells
    • Hage B, Meinel K, Baum I, Giehl K, Menke A. Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells. Cell Commun Signal. 2009;7:23. doi:10.1186/1478-811X-7-23.
    • (2009) Cell Commun Signal , vol.7 , pp. 23
    • Hage, B.1    Meinel, K.2    Baum, I.3    Giehl, K.4    Menke, A.5
  • 20
    • 84865679743 scopus 로고    scopus 로고
    • High level of WAVE1 expression is associated with tumor aggressiveness and unfavorable prognosis of epithelial ovarian cancer
    • COI: 1:CAS:528:DC%2BC38XpvFGgsbw%3D
    • Zhang J, Tang L, Shen L, Zhou S, Duan Z, Xiao L, et al. High level of WAVE1 expression is associated with tumor aggressiveness and unfavorable prognosis of epithelial ovarian cancer. Gynecol Oncol. 2012;127(1):223–30. doi:10.1016/j.ygyno.2012.06.008.
    • (2012) Gynecol Oncol , vol.127 , Issue.1 , pp. 223-230
    • Zhang, J.1    Tang, L.2    Shen, L.3    Zhou, S.4    Duan, Z.5    Xiao, L.6
  • 21
    • 84885325980 scopus 로고    scopus 로고
    • Overexpression of c-Abl predicts unfavorable outcome in epithelial ovarian cancer
    • COI: 1:CAS:528:DC%2BC3sXhtFCjt7bF
    • Zhou S, Tang L, Wang H, Dai J, Zhang J, Shen L, et al. Overexpression of c-Abl predicts unfavorable outcome in epithelial ovarian cancer. Gynecol Oncol. 2013;131(1):69–76. doi:10.1016/j.ygyno.2013.06.031.
    • (2013) Gynecol Oncol , vol.131 , Issue.1 , pp. 69-76
    • Zhou, S.1    Tang, L.2    Wang, H.3    Dai, J.4    Zhang, J.5    Shen, L.6
  • 22
    • 77952602705 scopus 로고    scopus 로고
    • Rac1 regulates neuronal polarization through the WAVE complex
    • COI: 1:CAS:528:DC%2BC3cXovVWnu7g%3D
    • Tahirovic S, Hellal F, Neukirchen D, Hindges R, Garvalov BK, Flynn KC, et al. Rac1 regulates neuronal polarization through the WAVE complex. J Neurosci. 2010;30(20):6930–43. doi:10.1523/JNEUROSCI.5395-09.2010.
    • (2010) J Neurosci , vol.30 , Issue.20 , pp. 6930-6943
    • Tahirovic, S.1    Hellal, F.2    Neukirchen, D.3    Hindges, R.4    Garvalov, B.K.5    Flynn, K.C.6
  • 23
    • 79955480132 scopus 로고    scopus 로고
    • Novel role of Rac1/WAVE signaling mechanism in regulation of the epithelial Na+ channel
    • COI: 1:CAS:528:DC%2BC3MXkvFart7Y%3D
    • Karpushev AV, Levchenko V, Ilatovskaya DV, Pavlov TS, Staruschenko A. Novel role of Rac1/WAVE signaling mechanism in regulation of the epithelial Na+ channel. Hypertension. 2011;57(5):996–1002.
    • (2011) Hypertension , vol.57 , Issue.5 , pp. 996-1002
    • Karpushev, A.V.1    Levchenko, V.2    Ilatovskaya, D.V.3    Pavlov, T.S.4    Staruschenko, A.5
  • 24
    • 0037102301 scopus 로고    scopus 로고
    • Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
    • COI: 1:CAS:528:DC%2BD38XmtV2gu78%3D
    • Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature. 2002;418(6899):790–3. doi:10.1161/HYPERTENSIONAHA.110.157784.
    • (2002) Nature , vol.418 , Issue.6899 , pp. 790-793
    • Eden, S.1    Rohatgi, R.2    Podtelejnikov, A.V.3    Mann, M.4    Kirschner, M.W.5
  • 25
    • 33846847697 scopus 로고    scopus 로고
    • Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell–cell adhesion
    • COI: 1:CAS:528:DC%2BD2sXht1GmsL0%3D
    • Yamazaki D, Oikawa T, Takenawa T. Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell–cell adhesion. J Cell Sci. 2007;120(Pt 1):86–100.
    • (2007) J Cell Sci , vol.120 , pp. 86-100
    • Yamazaki, D.1    Oikawa, T.2    Takenawa, T.3
  • 26
    • 67749127390 scopus 로고    scopus 로고
    • Rapid signaling of estrogen to WAVE1 and moesin controls neuronal spine formation via the actin cytoskeleton
    • COI: 1:CAS:528:DC%2BD1MXpsFOntbY%3D
    • Sanchez AM, Flamini MI, Fu XD, Mannella P, Giretti MS, Goglia L, et al. Rapid signaling of estrogen to WAVE1 and moesin controls neuronal spine formation via the actin cytoskeleton. Mol Endocrinol. 2009;23(8):1193–202. doi:10.1210/me.2008-0408.
    • (2009) Mol Endocrinol , vol.23 , Issue.8 , pp. 1193-1202
    • Sanchez, A.M.1    Flamini, M.I.2    Fu, X.D.3    Mannella, P.4    Giretti, M.S.5    Goglia, L.6
  • 27
    • 67349117959 scopus 로고    scopus 로고
    • Tyrosine kinase B receptor and BDNF expression in ovarian cancers-effect on cell migration, angiogenesis and clinical outcome
    • COI: 1:CAS:528:DC%2BD1MXnsFajs7o%3D
    • Au CW, Siu MK, Liao X, Wong ES, Ngan HY, Tam KF, et al. Tyrosine kinase B receptor and BDNF expression in ovarian cancers-effect on cell migration, angiogenesis and clinical outcome. Cancer Lett. 2009;281(2):151–61. doi:10.1016/j.canlet.2009.02.025.
    • (2009) Cancer Lett , vol.281 , Issue.2 , pp. 151-161
    • Au, C.W.1    Siu, M.K.2    Liao, X.3    Wong, E.S.4    Ngan, H.Y.5    Tam, K.F.6
  • 28
    • 84856692785 scopus 로고    scopus 로고
    • Targeted inhibition of telomerase activity combined with chemotherapy demonstrates synergy in eliminating ovarian cancer spheroid-forming cells
    • COI: 1:CAS:528:DC%2BC38Xit1OqtLw%3D
    • Meng Erhong, Taylor Brandon, Ray Anasuya, Shevde LA, Rocconi RP. Targeted inhibition of telomerase activity combined with chemotherapy demonstrates synergy in eliminating ovarian cancer spheroid-forming cells. Gynecol Oncol. 2012;124(3):598–605. doi:10.1016/j.ygyno.2011.11.018.
    • (2012) Gynecol Oncol , vol.124 , Issue.3 , pp. 598-605
    • Meng, E.1    Taylor, B.2    Ray, A.3    Shevde, L.A.4    Rocconi, R.P.5
  • 29
    • 33845243747 scopus 로고    scopus 로고
    • Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton
    • COI: 1:CAS:528:DC%2BD28Xht1Kgs77J
    • Kalfa TA, Pushkaran S, Mohandas N, Hartwig JH, Fowler VM, Johnson JF, et al. Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood. 2006;108(12):3637–45.
    • (2006) Blood , vol.108 , Issue.12 , pp. 3637-3645
    • Kalfa, T.A.1    Pushkaran, S.2    Mohandas, N.3    Hartwig, J.H.4    Fowler, V.M.5    Johnson, J.F.6
  • 30
    • 84862777514 scopus 로고    scopus 로고
    • RAC1 activation mediates Twist1-induced cancer cell migration
    • COI: 1:CAS:528:DC%2BC38Xjs1Wgu7o%3D
    • Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, et al. RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol. 2012;14(4):366–74. doi:10.1038/ncb2455.
    • (2012) Nat Cell Biol. , vol.14 , Issue.4 , pp. 366-374
    • Yang, W.H.1    Lan, H.Y.2    Huang, C.H.3    Tai, S.K.4    Tzeng, C.H.5    Kao, S.Y.6
  • 31
    • 0034659739 scopus 로고    scopus 로고
    • Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b
    • COI: 1:CAS:528:DC%2BD3cXksF2nsLw%3D
    • Schnelzer A, Prechtel D, Knaus U, Dehne K, Gerhard M, Graeff H, et al. Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene. 2000;19(26):3013–20.
    • (2000) Oncogene , vol.19 , Issue.26 , pp. 3013-3020
    • Schnelzer, A.1    Prechtel, D.2    Knaus, U.3    Dehne, K.4    Gerhard, M.5    Graeff, H.6
  • 32
    • 0035504739 scopus 로고    scopus 로고
    • Gene expression profiles of pancreatic cancer and stromal desmoplasia
    • COI: 1:CAS:528:DC%2BD3MXovVOntbk%3D
    • Crnogorac-Jurcevic T, Efthimiou E, Capelli P, Blaveri E, Baron A, Terris B, et al. Gene expression profiles of pancreatic cancer and stromal desmoplasia. Oncogene. 2001;20(50):7437–46.
    • (2001) Oncogene , vol.20 , Issue.50 , pp. 7437-7446
    • Crnogorac-Jurcevic, T.1    Efthimiou, E.2    Capelli, P.3    Blaveri, E.4    Baron, A.5    Terris, B.6
  • 33
    • 77949876005 scopus 로고    scopus 로고
    • Epithelial–mesenchymal transition in ovarian cancer
    • COI: 1:CAS:528:DC%2BC3cXjvFKhtbY%3D
    • Vergara D, Merlot B, Lucot JP, Collinet P, Vinatier D, Fournier I, et al. Epithelial–mesenchymal transition in ovarian cancer. Cancer Lett. 2010;291(1):59–66. doi:10.1016/j.canlet.2009.09.017.
    • (2010) Cancer Lett , vol.291 , Issue.1 , pp. 59-66
    • Vergara, D.1    Merlot, B.2    Lucot, J.P.3    Collinet, P.4    Vinatier, D.5    Fournier, I.6
  • 34
    • 70349786405 scopus 로고    scopus 로고
    • PAKing up to the endothelium
    • Galan Moya EM, Le Guelte A, Gavard J. PAKing up to the endothelium. Cell Signal. 2009;21(12):1727–37. doi:10.1016/j.cellsig.2009.08.006.
    • (2009) Cell Signal , vol.21 , Issue.12 , pp. 1727-1737
    • Galan Moya, E.M.1    Le Guelte, A.2    Gavard, J.3
  • 35
    • 0036674213 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration
    • COI: 1:CAS:528:DC%2BD38XmsFarsr4%3D
    • Bakin AV, Rinehart C, Tomlinson AK. p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci. 2002;115(pt15):3193–206.
    • (2002) J Cell Sci , vol.115 , pp. 3193-3206
    • Bakin, A.V.1    Rinehart, C.2    Tomlinson, A.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.