Liver damage associated with polygonum multiflorum Thunb.: A systematic review of case reports and case series

Evidence-based Complementary and Alternative Medicine

Volumn 2015, Issue , 2015, Pages

  Lei, Xiang ^a   Chen, Jing ^a   Ren, Jingtian ^b   Li, Yan ^a   Zhai, Jingbo ^a   Mu, Wei ^a   Zhang, Li ^a   Zheng, Wenke ^a   Tian, Guihua ^c   Shang, Hongcai ^a,d  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Center for Drug Reevaluation State Food and Drug Administration   (China)

^c BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d Dongzhimen Hospital of Beijing University of Chinese Medicine   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHINESE DRUG; FALLOPIA MULTIFLORA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ABDOMINAL TENDERNESS; ABNORMAL URINE COMPOSITION; ANOREXIA; ASCITES; CASE REPORT; CASE STUDY; CONSTIPATION; DIARRHEA; DIZZINESS; DRUG DOSAGE FORM; FALLOPIA MULTIFLORA; FAMILY HISTORY; FATIGUE; HAIR DISCOLORATION; HAIR LOSS; HEPATITIS; HEPATOMEGALY; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INSOMNIA; ISCHEMIC HEART DISEASE; JAUNDICE; LIVER INJURY; LIVER TOXICITY; LIVER TRANSPLANTATION; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PRURITUS; RASH; RECURRENT DISEASE; REFERENCE DATABASE; REVIEW; SPLENOMEGALY; SYSTEMATIC REVIEW; TREATMENT DURATION; VITILIGO;

EID: 84937991955     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2015/459749     Document Type: Review

References (99)

1. Q. T. Chen, L. H. Zhuo,W. Xu, Z. H. Huang, and X. H. Qiu, "Content changes of 5 components in Polygohum muhiflorum during processing," Chinese Journal of Experimental Traditional Medical Formulae, vol. 18, no. 5, pp. 66-71, 2012.
2. National Pharmacopoeia Committee, Chinese Pharmacopoeia, China Medical Science Press, Beijing, China, 2010.
3. X. Han, C. A.Wu,W.Wang, S. Liu, andL.Y.Wang, "Mechanism research of stilbene glucoside from Polygonum multiflovum thunb on hyperlipemia," Chinese Archives of Traditional Chinese Medicine, vol. 26, no. 8, pp. 1687-1689, 2008.
4. X. Gao, Y.-J. Hu, and L.-C. Fu, "Blood lipid-regulation of stilbene glycoside from Polygonum multiflorum," Zhongguo Zhongyao Zazhi, vol. 32, no. 4, pp. 323-326, 2007.
5. H. H. Cui, Y. Tian, and S. Y. Long, "The effective mechanism of 2, 3, 5, 4-tetrahy-droxystilbene-2-O-D-glucoside in antiatherosclerosis," Progress in Modern Biomedicine, vol. 9, no. 20, pp. 3968-3982, 2009.
6. W. J. Jin, Experimental Study on Concentrated Processed Fleece-Flower Root Decoction in the Treatment of Liver Fibrosis, Dalian Medical University, Dalian, China, 2004.
7. Y. Y. Yang, H. S. Wang, and S. B. Yang, "The clinical effect of treated nonalcoholic fatty liver disease," Chinese Journal of Modern Drug Application, vol. 7, no. 5, pp. 66-71, 2012.
8. X. Y. Wei, J. K. Zhang, Y. H. Luo, S. B. Chen, and J. L. Sun, "Antagonistic effect of Astragalus mongholicus and Polygonum multiflorum on thymocytes apoptosis induced by cyclophosphamide," Journal of China Pharmaceutical University, vol. 31, no. 1, pp. 35-38, 2000.
9. C. L. Ge and Y. Liu, "Polysaccharide from Polygonum multiflorum Thunb potentiates the immunological function in immunosuppressed mice," Chinese Journal of New Drugs, vol. 16, no. 24, pp. 2040-2042, 2007.
10. H. N. Kim, Y. R. Kim, J. Y. Jang et al., "Neuroprotective effects of Polygonum multiflorum extract against glutamateinduced oxidative toxicity in HT22 hippocampal cells," Journal of Ethnopharmacology, vol. 150, no. 1, pp. 108-115, 2013.
11. L. Liu, L. Li, L. Zhao, L. Zhang, Y.-L. Li, and C.-F. Ye, "Effects of 2,3,5,4-tetrahydroxystilbene-2-O-D-glucoside on learning and memory abilities of rats with chronic cerebral ischemia," Chinese Journal of Pharmacology and Toxicology, vol. 22, no. 2, pp. 108-115, 2008.
12. J. Yu, J. Xie, X.-J. Mao et al., "Comparison of laxative and antioxidant activities of raw, processed and fermented Polygoni multiflori Radix," Chinese Journal of Natural Medicines, vol. 10, no. 1, pp. 63-67, 2012.
13. X. X. Zhou, Study ofHighPurityTetrahydroxystilbeneGlucoside's Anti-Aging Effect and the Possible Mechanism, Fourth Military Medical University, Xi'an, China, 2013.
14. L. Zhang, X. Yang, and Y. Deng, "Evaluation and consideration on safety information abroad of Polygonum multiflorum and its preparations," Zhongguo Zhongyao Zazhi, vol. 34, no. 18, pp. 2414-2418, 2009.
15. G. Q. Shen, L. Jiang, and C. Y. Gong, "Polygonum multifloruminduced hepatic lesion: retrospective analysis and clinical monitoring," Evaluation and Analysis of Drug-Use in Hospitals of China, vol. 10, no. 11, pp. 1040-1042, 2010.
16. L.Lao,G.R.Hamilton, J. Fu, andB.M. Berman, "Is acupuncture safe? A systematic review of case reports," AlternativeTherapies in Health and Medicine, vol. 9, no. 1, pp. 72-83, 2003.
17. H. P. Liu, X. R. Wu, and J. Yuan, "Hepatic damage and agranulocytosis due to Polygonum multiflorum," Adverse Drug Reactions Journal, vol. 15, no. 5, pp. 298-300, 2013.
18. Y. J. Miao and Y. L. Yun, "Two cases of drug-induced hepatitis caused by Polygonum multiflorum," Chinese Journal of Drug Application and Monitoring, vol. 10, no. 1, pp. 61-62, 2013.
19. G. X. Zhao, "One case of hepatitis caused by Jin-Wu-Pian," Inner Mongol Journal of Traditional Chinese Medicine, vol. 32, no. 10, pp. 180-181, 2013.
20. S. Tan, "Pharmaceutical care one case of drug-induced hepatitis caused by Polygonum multiflorum," in Proceedings of the 9th Clinical Pharmacist Forum, 2013.
21. Y. Liu Z, Z. B. Hu, and X. F. Wang, "Processed Polygonum multiflorum induced one case liver damage and literature review," Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases, vol. 23, no. 3, pp. 176-177, 2013.
22. Y. Gao, L. Jia, and K. J. Yu, "Polygonimultiflori Radix praeparata and Tribuli fructus induced acute liver failure," Adverse Drug Reactions Journal, vol. 15, no. 5, pp. 294-295, 2013.
23. A. Banarova, T. Koller, and J. Payer, "Toxic hepatitis induced by Polygonum multiflorum," Vnitrni lekarstvi, vol. 58, no. 12, pp. 958-962, 2012.
24. L. S. Gao, "One case of drug-induced hepatitis caused by Polygonummultiflorum," HealthMust Read, vol. 11, no. 10, p. 576, 2012.
25. X. H. Kui and X. Q. Chen, "One case of drug-induced hepatitis caused by Polygonummultiflorumcombination a variety of cold medicine," Chinese Medicine, vol. 7, no. 2, p. 241, 2012.
26. Y. L. Shao and Q. Li, "Two cases of drug-induced hepatitis caused by Polygonum multiflorum," Journal of Qilu Nursing, vol. 18, no. 22, p. 111, 2012.
27. Y. C. Hu, H. Z. Li, and R. L. Chen, "One case of drug-induced hepatitis caused by Polygonummultiflorum," Herald of Medicine, vol. 31, no. 4, p. 542, 2012.
28. L. X. Zhen and C. Z. Zeng, "One case of drug-induced hepatitis caused by Polygonum multiflorum," Chinese Joumal of Ethnomedieine and Ethnopharmacy, no. 21, p. 50, 2012.
29. Z. X. Li and Z. Zhang, "Two cases of icteric viral hepatitis caused by unprocessed Polygonum multiflorum," Chinese Journal of Aesthetic Medicine, vol. 21, no. 12, p. 775, 2012.
30. S.P.Chen, F.M. Tan, andY.Y.Yang, "One case of acute hepatitis caused by Polygonummultiflorum," Chinese Hepatology, vol. 17, no. 1, p. 68, 2012.
31. S. M. Liu, Y. P. Tang, and Y. X. Gong, "One case of acute hepatitis caused by Yishen wufa," Chinese Journal of Integrated Traditional andWesternMedicine on Digestion, vol. 20, no. 4, p. 182, 2012.
32. S. M. Sun, "Two cases of liver damage caused by Polygonum multiflorum," Guide of China Medicine, vol. 9, no. 26, pp. 136-137, 2011.
33. M. X. Cao,M. Liu, R. R.Wu, F. Q. Liu, and X. Zhou, "One case of liver damage caused by processed Polygonum multiflorum," Chinese Journal of Pharmacovigilance, vol. 8, no. 8, p. 510, 2011.
34. Y. Liu,W.Y.Chen, Y. Q. Zhao, andH. Xiang, "One case of druginduced hepatitis caused by Shengfa Yangxue Capsule," Journal of Military Surgeon in Southwest China, vol. 13, no. 6, p. 1011, 2011.
35. Y. Q. Yan, "One case of liver damage caused by long-term low-dose administration of Polygonum multiflorum," Medical Journal of Beijing Military Region, vol. 23, no. 5, p. 41, 2011.
36. Z. Q. Wu and H. Y. Niu, "One case of severe liver damage caused by Polygonummultiflorum,"WorldHealthDigestMedical Periodieal, vol. 8, no. 12, pp. 414-415, 2011.
37. W. Z. Liu, Y. M. Teng, and L. Lei, "One case of acute liver injury caused by Shou-Wu-Wan," Journal of Shantou University Medical College, vol. 23, no. 3, p. 172, 2010.
38. M. X. Chen, X. Y. Chen, and W. Tang, "Two cases of druginduced hepatitis caused by Polygonum multiflorum," Sichuan Medical Journal, vol. 31, no. 9, pp. 1390-1391, 2010.
39. D. W. Yun, X. R. Guo, and X. F. Gao, "One case of liver injury caused by Shou-Wu-Wan," Chinese Journal of Coal Industry Medicine, vol. 13, no. 7, p. 1084, 2010.
40. M. Furukawa, S. Kasajima, Y. Nakamura et al., "Toxic hepatitis induced by Show-Wu-Pian, a Chinese herbal preparation," Internal Medicine, vol. 49, no. 15, pp. 1537-1540, 2010.
41. X. Y. Yan, Q. C.Meng, and Z. S. Yan, "One case of liver damage caused by Polygonum multiflorum," Chinese Journal of Difficult and Complicated Cases, vol. 8, no. 7, p. 399, 2009.
42. R.He, "One case of liver damage caused by Polygonum multiflorum after postpartum," Medical Journal of West China, vol. 21, no. 5, p. 774, 2009.
43. X. Y. Chen, "Plasmapheresis combined with hemofiltration treatment one case drug-induced hepatitis caused by Polygonum multiflorum," Journal of Emergency in Traditional Chinese Medicine, vol. 18, no. 5, pp. 824-826, 2009.
44. H. C. Cho, H. J.Min, C. Y. Ha et al., "Reactivation of Pulmonary tuberculosis in a patient with Polygonum multiflorum Thunb-Induced hepatitis," Gut and Liver, vol. 3, no. 1, pp. 52-56, 2009.
45. F. F. Wang, C. H. Jin, and M. Guan, "Three cases of hepatitis caused by Polygonummultiflorum," West ChinaMedical Journal, vol. 23, no. 3, p. 631, 2008.
46. B. S. Zhu, "One case of drug-induced hepatitis caused by Polygonum multiflorum," Journal of Huaihai Medicine, vol. 26, no. 4, p. 320, 2008.
47. J. Yang and Z. G. Li, "Two cases of drug-induced hepatitis caused by Polygonum multiflorum," ShanxiMedical Journal, vol. 37, no. 11, p. 973, 2008.
48. A. R. Laird, N. Ramchandani, E. M. Degoma, B. Avula, I. A. Khan, and N. Gesundheit, "Acute hepatitis associated with the use of an herbal supplement (Polygonum multiflorum) mimicking iron-overload syndrome," Journal of Clinical Gastroenterology, vol. 42, no. 7, pp. 861-862, 2008.
49. J. L. Yang and Y. J. Dong, "Two cases of liver damage caused by Shou-Wu-Pian," Journal of the Fourth Military Medical University, vol. 28, no. 2, p. 162, 2007.
50. P. Fu and Y. Yu, "One case of hepatitis caused by Polygonum multiflorum," China's Naturopathy, vol. 15, no. 3, p. 41, 2007.
51. X. D. Zhao, "One case of acute liver injury caused by Shou-Wu-Wan," Zhongguo Zhongyao Zazhi, vol. 32, no. 5, p. 444, 2007.
52. Z. Li, "Two cases of liver damage caused by Polygonum multiflorum," Chinese Journal ofMisdiagnostics, vol. 6, no. 10, p. 2033, 2006.
53. A. Ćardenas, J. C. Restrepo, F. Sierra, and G. Correa, "Acute hepatitis due to Shen-Min: a herbal product derived from Polygonum multiflorum," Journal of Clinical Gastroenterology, vol. 40, no. 7, pp. 629-632, 2006.
54. J. L. Han, "Hepatitis attributed to Radix Polygoni multiflori," Adverse Drug Reactions Journal, vol. 8, no. 5, p. 390, 2006.
55. D. Q. Yang, "Polygonum cause severe liver damage," Adverse Drug Reactions Journal, no. 6, p. 449, 2005.
56. B. Panis, D. R. Wong, P. M. Hooymans, P. A. G. M. De Smet, and P. P. R. Rosias, "Recurrent toxic hepatitis in a Caucasian girl related to the use of Shou-Wu-Pian, a Chinese herbal preparation," Journal of Pediatric Gastroenterology and Nutrition, vol. 41, no. 2, pp. 256-258, 2005.
57. C. Chen, C. J. Zhao, and X. Z. Yu, "One case of liver damage caused by Polygonummultiflorum," AnhuiMedical and Pharmaceutical Journal, vol. 9, no. 3, p. 204, 2005.
58. M. Y. Huo and S. H. Ling, "Hepatitis due to the concomitant administration of Shou-Wu-Pian and Yangxue Shengfa capsules," Adverse Drug Reactions Journal, no. 5, pp. 335-336, 2004.
59. G. Mazzanti, L. Battinelli, C. Daniele et al., "New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum multiflorum," Annals of Internal Medicine, vol. 140, no. 7, p. 30, 2004.
60. Z. Y. Shao, "Two cases of liver damage caused by Polygonum multiflorum," Zhejiang Journal of Integrated Traditional Chinese andWestern Medicine, vol. 13, no. 11, pp. 716-718, 2003.
61. M. Leng, "One case of acute severe liver injury caused by conventional dose Polygonum multiflorum," Journal of Henan Medical College for Staff andWorkers, vol. 14, no. 3, p. 277, 2002.
62. S. Q. Dai and Y. M. Li, "One case of liver damage caused by Polygonum multiflorum," Ningxia Medical Journal, vol. 24, no. 8, p. 501, 2002.
63. W.D. Yuan, "One case of acute liver injury caused by Polygonum multiflorum," Chinese Remedies and Clinics, vol. 2, no. 6, p. 416, 2002.
64. J. Sun, "One case of severe liver damage caused byChinese drugs for invigoration," Chinese Journal of Integrated Traditional and Western Medicine on Digestion, vol. 10, no. 5, p. 292, 2002.
65. J. Y. Yang, "One case of liver damage caused by Polygonum multiflorum," Turpan Science and Technology, no. 4, pp. 50-51, 2002.
66. G. J.-H. Park, S. P. Mann, and M. C. Ngu, "Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum," Journal of Gastroenterology andHepatology, vol. 16, no. 1, pp. 115-117, 2001.
67. J. Q. Sheng, "Familial acute liver injury caused by Polygonum multiflorum," Chinese Journal of Hepatology, vol. 6, no. 1, p. 59, 1998.
68. Z. H. Li, D. M. Gai, and X. R. Zhuang, "Hepatitis attributed to Polygonum multiflorum," Shandong Journal of Traditional Chinese Medicine, vol. 17, no. 7, pp. 23-24, 1998.
69. D. M. Fan and Z. L. Zhou, "One case of liver damage caused by Polygonum multiflorum," Journal of Norman BethuneUniversity of Medical Science, vol. 24, no. 3, p. 292, 1998.
70. F. X. Li, "One case of liver injury caused by Shou-Wu-Wan," Journal of New ChineseMedicine, vol. 29, no. 12, pp. 42-43, 1997.
71. Q. H. Ye, "One case of acute toxic liver disease caused by Polygonum multiflorum," Chinese Journal of Integrated Traditional andWestern Medicine, vol. 16, no. 12, p. 732, 1996.
72. W. F. Zhang, "One case of liver injury caused by Huo-Li-Su," Journal of Practical Traditional Chinese Medicine, vol. 13, no. 2, p. 41, 1997.
73. J. H. Niu, "One case of severe liver damage caused by Shou-Wu-Pian," New Drugs and Clinical Remedies, vol. 15, no. 6, p. 63, 1996.
74. M. H. He and X. J. Zhen, "Two cases of acute liver damage caused by Polygonum multiflorum," Shanxi Journal of Traditional Chinese Medicine, vol. 17, no. 5, p. 230, 1996.
75. P. P.-H. But, B. Tomlinson, and K.-L. Lee, "Hepatitis related to the Chinese medicine Shou-Wu-Pian manufactured from Polygonummultiflorum,"Veterinary andHuman Toxicology, vol. 38, no. 4, pp. 280-282, 1996.
76. H. Dong, D. Slain, J. Cheng, W. Ma, and W. Liang, "Eighteen cases of liver injury following ingestion of Polygonum multiflorum," Complementary Therapies in Medicine, vol. 22, no. 1, pp. 70-74, 2014.
77. X. Lian, T. T. Ke, and A. R. Hu, "Clinical analysis of 52 cases of drug-induced liver injury caused by Polygonum multiflorum and its preparations," Chinese Archives of Traditional Chinese Medicine, vol. 31, no. 5, pp. 1133-1134, 2013.
78. S. G. Zhang,W. Yi, R. J. Hao, J. F. Peng, and G. Zhao, "Analysis of 13 cases of liver damage caused by Polygonum multiflorum and its preparations," People's Military Surgeon, vol. 56, no. 6, pp. 699-700, 2013.
79. Y. Zhang, S. Chen, and L. Lu, "Clinical analysis of 36 cases of drug-induced liver injury by Polygonum multiflorum Thunb," Hainan Medical Journal, vol. 24, no. 2, pp. 235-237, 2013.
80. E. Ding, "Clinical analysis on the treatment of drug-induced liver injury by Polygonum multiflorum Thunb with magnesium isoglycyrrhizinate," InnerMongol Journal of Traditional Chinese Medicine, vol. 31, no. 11, pp. 15-16, 2012.
81. X. Q. Guo, "Clinical characteristics analysis of liver damage caused by Polygonum multiflorum," Chinese Community Doctors, vol. 14, no. 4, p. 416, 2012.
82. X. J. Xie, K. F. Ma, and Y. Liu, "Analysis of liver injury induced by Polygoni multiflori Radix," Drug Evaluation, vol. 9, no. 32, pp. 36-38, 2012.
83. L. Y. Song, "Correlation analysis of drug-induced liver injury caused by Polygonum multiflorum Thunb," Medical Journal of West China, vol. 23, no. 7, pp. 1300-1301, 2011.
84. Y.Wang, "Clinical research of drug-induced liver injury caused by Polygonum multiflorum,"Medical Innovation of China, vol. 8, no. 30, pp. 104-105, 2011.
85. K. A. Jung, H. J. Min, S. S. Yoo et al., "Drug-induced liver injury: twenty five cases of acute hepatitis following ingestion of Polygonum multiflorum thunb," Gut and Liver, vol. 5, no. 4, pp. 493-499, 2011.
86. S. X. Chen, P. Fan,W. X. He, J. Jiang, and Z. Y. Xiong, "Clinical Analysis of drug-induced liver injury caused by Polygonummultiflorum," Chinese Journal of Digestion and Medical Imageology, vol. 2, no. 5, pp. 266-268, 2012.
87. F. Liu and Z. Li, "Analysis of 7 cases of drug-induced liver injury by Polygonum multiflorum," InnerMongol Journal of Traditional Chinese Medicine, vol. 29, no. 6, p. 58, 2010.
88. G. Q. Liu, "Clinical analysis of 9 cases of drug-induced liver injury by Polygonum multiflorum Thunb," Contemporary Medicine, vol. 15, no. 30, p. 149, 2009.
89. J.Xu, M. R. Wang,C. L.He, Y. H. Sui, and F.Qiao, "Liver injury by peroral Polygonum multiflorum: an analysis of 40 cases," Military Medical Journal of Southeast China, vol. 11, no. 3, pp. 209-210, 2009.
90. X. X. Yang, N. Jiang, and J. M. Lin, "Clinical analysis of 13 patients with liver diease induced Polygonum multiflorum Thunb," Sichuan Medical Journal, vol. 29, no. 12, pp. 1619-1620, 2008.
91. X. H. Zhou and X. Qiu, "Clinical analysis of 11 cases of druginduced liver injury by Polygonum multiflorum Thunb," Journal of North Sichuan Medical College, vol. 20, no. 1, pp. 107-108, 2005.
92. X. Zhang, X. C. Ding, Y. Yang, P. Zhang, and F. F.Wu, "Clinical analysis of 6 patients with liver diease induced Polygonum multiflorum Thunb," Journal of NingxiaMedical College, vol. 22, no. 2, pp. 115-116, 2000.
93. W. Huang, Y. N. Zhang, and R. Sun, "Experimental study on the "Dose-Time-Toxicity" relationship of acute hepatotoxicity induced by different components from Polygonum multiflorum in mice," Chinese Journal of Pharmacovigilance, vol. 8, no. 4, pp. 193-197, 2011.
94. J. Yu, J. Xie, R.-H. Zhao, S.-Q. Cai, and Z. Chen, "Advances in studies on liver adverse reaction of Polygonum multiflorum," Chinese Traditional and Herbal Drugs, vol. 41, no. 7, pp. 1206-1210, 2010.
95. T. Noda, T. Yamada, T. Ohkubo et al., "Hot-water-extracts of Polygonum multiflorum do not induce any toxicity but elicit limited beneficial effects on the liver in mice," Journal of Health Science, vol. 55, no. 5, pp. 720-725, 2009.
96. Y. D. Liu, X. X. Huang, L. S. Wu, D. M. Sun, and D. Y. Lu, "Experimental study of liver toxicity of Polygonum multiflorum Thunb," Asia-Pacific Traditional Medicine, vol. 3, no. 4, pp. 71-72, 2007.
97. S. K. Zhou and L. D. Wu, "Analysis and preventivemeasures of adverse reaction of Chinese herbal medicine," Chinese Journal of Ethnomedicine and Ethnopharmacy, no. 12, pp. 43-44, 2013.
98. C. J. Guo, "Analysis of the causes of adverse reaction of traditional Chinese medicine decoction and recommendations," Information on Traditional Chinese Medicine, vol. 20, no. 3, pp. 168-170, 2013.
99. X. H. Sun, H. S. Ji, J. X. Han, and L. P. Wang, "Focus on the ADR charicteristics of traditional Chinese herbalmedicine and its preventmeasures fromthe liver damage by Poligonimultiflori radix," Guide of China Medicine, vol. 18, no. 34, pp. 21-22, 2010.