Effects of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside on learning and memory abilities of rats with chronic cerebral ischemia

Chinese Journal of Pharmacology and Toxicology

Volumn 22, Issue 2, 2008, Pages 108-115

  Liu, Li ^a,b   Li, Lin ^a   Zhao, Ling ^a   Zhang, Li ^a   Li, Ya Li ^a   Ye, Cui Fei ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b NATIONAL INSTITUTE FOR THE CONTROL OF PHARMACEUTICAL AND BIOLOGICAL PRODUCTS   (China)

Author keywords

2,3,5,4 tetrahydroxystilbene 2 O D glucoside; Acetylcholinesterase; Cerebral ischemia; Learning; Memory; Microtubule associated proteins; Phosphoprotein phosphatase; Polygonum multiflorum Thunb

Indexed keywords

2,3,5,4' TETRAHYDROXYSTILBENE 2 O BETA DEXTRO GLUCOSIDE; ACETYLCHOLINESTERASE; GLUCOSIDE; MICROTUBULE ASSOCIATED PROTEIN 2; PHOSPHOPROTEIN PHOSPHATASE 2A; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CAROTID ARTERY LIGATION; CHRONIC DISEASE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LEARNING; MALE; MAZE TEST; MEMORY; NEUROPSYCHOLOGICAL TEST; NONHUMAN; PASSIVE AVOIDANCE; PROTEIN EXPRESSION; RAT;

POLYGONUM MULTIFLORUM; RATTUS;

EID: 43049133248     PISSN: 10003002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Nihashi T, Inao S, Kajita Y, Kawai T, Sugimoto T, Niwa M, et al. Expression and distribution of beta amyloid precursor protein and beta amyloid peptide in reactive astrocytes after transient middle cerebral artery occlusion [J]. Acta Neurochir (Wien), 2001, 143(3):287-295.
2. Shi J, Yang SH, Stubley L, Day AL, Simpkins JW. Hypoperfusion induces overexpression of beta-amyloid precursor protein mRNA in a focal ischemic rodent model [J]. Brain Res, 2000, 853(1):1-4.
3. Lin B, Schmidt-Kastner R, Busto R, Ginsberg MD. Progressive parenchymal deposition of beta-amyloid precursor protein in rat brain following global cerebral ischemia [J]. Acta Neuropathol, 1999, 97(4):359-368.
4. Schetinger MR, Bonan CD, Frassetto SS, Wyse AT, Schierholt RC, Webber A, et al. Pre-conditioning to global cerebral ischemia changes hippocampal acetylcholinesterase in the rat [J]. Biochem Mol Biol Int, 1999, 47(3):473-478.
5. Goedert M, Cohen ES, Jakes R, Cohen P. p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [J]. FEBS Lett, 1992, 312(1):95-99.
6. Nakayama A, Ogawa A, Fukuta Y, Kudo K. Relation between lymphatic vessel diameter and clinicopathologic parameters in squamous cell carcinomas of the oral region [J]. Cancer, 1999, 86(2):200-206.
7. Rundén E, Seglen PO, Haug FM, Ottersen OP, Wieloch T, Shamloo M, et al. Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism [J]. J Neurosci, 1998, 18(18):7296-7305.
8. Horiguchi T, Shima H, Suga S, Ogino M, Shimizu K, Toya S, et al. Transient forebrain ischemia induces expression of serine/threonine protein phosphatase 1 mRNA in the vulnerable regions of gerbil brain [J]. Neurosci Lett, 2002, 325(2):115-118.
9. Raley-Susman KM, Murata J. Time course of protein changes following in vitro ischemia in the rat hippocampal slice [J]. Brain Res, 1995, 694(1-2):94-102.
10. Zhang L, Li L, Li YL. Mechanism of the protection of stilbene glycoside which is the effective component of tuber fleeceflower root on nerve cells [J]. Chin J Clin Rehabil, 2004, 8(1):118-120.
11. Zhao L, Li YL, Zhang L, Jin HT, Li L. Effects of tetrahydroxystilbene- glucoside on rat model of β-amyloid increase induced by hypercholesterol [J]. Chin Pharmcol Bull, 2005, 21(1):49-52.
12. Xie WJ, Li L, Wei HF, Chu J, Ye CF, Zhang L, et al. Effect of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside on hippocampal genes expression in mimetic-dementia mice induced by D-galactose [J]. Chin J Pharmacol Toxicol, 2005, 19(1):24-28.
13. Chu J, Ye CF, Li L. Effects of stilbene-glycoside on learning and memory and inflammatory reaction of brain in dementia mice [J]. Tradit Chin Drug Res Clin Phar macol, 2004, 15(4):235-237.
14. Lu YR, Deng QH, Che QF, Liu B, Shao AX. Quantitative determination of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D glucoside in polygonum multiflorum and its preparation [J]. J Beijing Univ Tradit Chin Med, 1998, 21(6):31-33.
15. Wang ZH, Yin XJ, Lin CQ. Effect of dihydroergotamine mesilate on rehabilitation of cerebral infarction patient [J]. Chin J Integrat Med Cardio/Cerebrovasc Dis, 2004, 2(9):519-520.
16. Liu XD, Wan Q, Wei D, Wang XM. Cognitive and non-cognitive functions in patients with vascular dementia and the interventional efficacy of dihydroergotamine mesilate plus nimodipine [J]. Chin J Clin Rehabil, 2005, 9(20):48-49.
17. Zhao L, Liu L, Li YL, Zhang L, Zhang L, Li L. Effects of chronic brain hypoperfusion on cerebral free radical metabolism and learning-memory function [J]. Chin J Behav Med Sci, 2005, 14(11):961-963.
18. Gong CX, Singh TJ, Grundke-Iqbal I, Iqbal K. Phosphoprotein phosphatase activities in Alzheimer disease brain [J]. J Neurochem, 1993, 61(3):921-927.
19. Eriksson JE, Brautigan DL, Vallee R, Olmsted J, Fujiki H, Goldman RD. Cytoskeletal integrity in interphase cells requires protein phosphatase activity [J]. Proc Natl Acad Sci USA, 1992, 89(22):11093-11097.
20. Matesic DF, Lin RC. Microtubule-associated protein 2 as an early indicator of ischemia-induced neurodegeneration in the gerbil forebrain [J]. J Neurochem, 1994, 63(3):1012-1020.