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Volumn 41, Issue 3, 2015, Pages 367-382

The Pathogenesis of Systemic Sclerosis

Author keywords

Autoimmunity; Fibrosis; Pathogenesis; Scleroderma; Systemic sclerosis; Vasculopathy

Indexed keywords

AUTOANTIBODY; CHEMOKINE; CONNECTIVE TISSUE GROWTH FACTOR; CXCL4 CHEMOKINE; CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR A; ENDOTHELIN RECEPTOR B; HLA ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 4; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; INTERLEUKIN DERIVATIVE; VASOCONSTRICTOR AGENT;

EID: 84937974685     PISSN: 0889857X     EISSN: 15583163     Source Type: Journal    
DOI: 10.1016/j.rdc.2015.04.002     Document Type: Review
Times cited : (105)

References (103)
  • 1
    • 40349098515 scopus 로고    scopus 로고
    • Genetics and genomic studies in scleroderma (systemic sclerosis)
    • v
    • Agarwal S.K., Tan F.K., Arnett F.C. Genetics and genomic studies in scleroderma (systemic sclerosis). Rheum Dis Clin North Am 2008, 34:17-40. v.
    • (2008) Rheum Dis Clin North Am , vol.34 , pp. 17-40
    • Agarwal, S.K.1    Tan, F.K.2    Arnett, F.C.3
  • 2
    • 0038004795 scopus 로고    scopus 로고
    • Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies
    • Feghali-Bostwick C., Medsger T.A., Wright T.M. Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies. Arthritis Rheum 2003, 48:1956-1963.
    • (2003) Arthritis Rheum , vol.48 , pp. 1956-1963
    • Feghali-Bostwick, C.1    Medsger, T.A.2    Wright, T.M.3
  • 3
    • 0033744766 scopus 로고    scopus 로고
    • Genetic factors in the etiology of systemic sclerosis and Raynaud phenomenon
    • Tan F.K., Arnett F.C. Genetic factors in the etiology of systemic sclerosis and Raynaud phenomenon. Curr Opin Rheumatol 2000, 12:511-519.
    • (2000) Curr Opin Rheumatol , vol.12 , pp. 511-519
    • Tan, F.K.1    Arnett, F.C.2
  • 4
    • 0037785169 scopus 로고    scopus 로고
    • Systemic sclerosis: the susceptible host (genetics and environment)
    • Tan F.K. Systemic sclerosis: the susceptible host (genetics and environment). Rheum Dis Clin North Am 2003, 29:211-237.
    • (2003) Rheum Dis Clin North Am , vol.29 , pp. 211-237
    • Tan, F.K.1
  • 5
    • 0028854244 scopus 로고
    • HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies
    • Morel P.A., Chang H.J., Wilson J.W., et al. HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies. Hum Immunol 1995, 42:35-42.
    • (1995) Hum Immunol , vol.42 , pp. 35-42
    • Morel, P.A.1    Chang, H.J.2    Wilson, J.W.3
  • 6
    • 0026669338 scopus 로고
    • Association of amino acid sequences in the HLA-DQB1 first domain with antitopoisomerase I autoantibody response in scleroderma (progressive systemic sclerosis)
    • Reveille J.D., Durban E., MacLeod-St Clair M.J., et al. Association of amino acid sequences in the HLA-DQB1 first domain with antitopoisomerase I autoantibody response in scleroderma (progressive systemic sclerosis). J Clin Invest 1992, 90:973-980.
    • (1992) J Clin Invest , vol.90 , pp. 973-980
    • Reveille, J.D.1    Durban, E.2    MacLeod-St Clair, M.J.3
  • 7
    • 0035320790 scopus 로고    scopus 로고
    • Class II HLA associations with autoantibodies in scleroderma: a highly significant role for HLA-DP
    • Gilchrist F.C., Bunn C., Foley P.J., et al. Class II HLA associations with autoantibodies in scleroderma: a highly significant role for HLA-DP. Genes Immun 2001, 2:76-81.
    • (2001) Genes Immun , vol.2 , pp. 76-81
    • Gilchrist, F.C.1    Bunn, C.2    Foley, P.J.3
  • 8
    • 0036094293 scopus 로고    scopus 로고
    • High prevalence of polymorphisms of angiotensin-converting enzyme (I/D) and endothelial nitric oxide synthase (Glu298Asp) in patients with systemic sclerosis
    • Fatini C., Gensini F., Sticchi E., et al. High prevalence of polymorphisms of angiotensin-converting enzyme (I/D) and endothelial nitric oxide synthase (Glu298Asp) in patients with systemic sclerosis. Am J Med 2002, 112:540-544.
    • (2002) Am J Med , vol.112 , pp. 540-544
    • Fatini, C.1    Gensini, F.2    Sticchi, E.3
  • 9
    • 33749364967 scopus 로고    scopus 로고
    • Endothelin axis polymorphisms in patients with scleroderma
    • Fonseca C., Renzoni E., Sestini P., et al. Endothelin axis polymorphisms in patients with scleroderma. Arthritis Rheum 2006, 54:3034-3042.
    • (2006) Arthritis Rheum , vol.54 , pp. 3034-3042
    • Fonseca, C.1    Renzoni, E.2    Sestini, P.3
  • 10
    • 34548843398 scopus 로고    scopus 로고
    • A polymorphism in the CTGF promoter region associated with systemic sclerosis
    • Fonseca C., Lindahl G.E., Ponticos M., et al. A polymorphism in the CTGF promoter region associated with systemic sclerosis. N Engl J Med 2007, 357:1210-1220.
    • (2007) N Engl J Med , vol.357 , pp. 1210-1220
    • Fonseca, C.1    Lindahl, G.E.2    Ponticos, M.3
  • 11
    • 0031687121 scopus 로고    scopus 로고
    • Association of microsatellite markers near the fibrillin 1 gene on human chromosome 15q with scleroderma in a Native American population
    • Tan F.K., Stivers D.N., Foster M.W., et al. Association of microsatellite markers near the fibrillin 1 gene on human chromosome 15q with scleroderma in a Native American population. Arthritis Rheum 1998, 41:1729-1737.
    • (1998) Arthritis Rheum , vol.41 , pp. 1729-1737
    • Tan, F.K.1    Stivers, D.N.2    Foster, M.W.3
  • 12
    • 0036846150 scopus 로고    scopus 로고
    • Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma
    • Zhou X., Tan F.K., Reveille J.D., et al. Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma. Arthritis Rheum 2002, 46:2990-2999.
    • (2002) Arthritis Rheum , vol.46 , pp. 2990-2999
    • Zhou, X.1    Tan, F.K.2    Reveille, J.D.3
  • 13
    • 65549154046 scopus 로고    scopus 로고
    • The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype
    • Rueda B., Broen J., Simeon C., et al. The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype. Hum Mol Genet 2009, 18:2071-2077.
    • (2009) Hum Mol Genet , vol.18 , pp. 2071-2077
    • Rueda, B.1    Broen, J.2    Simeon, C.3
  • 14
    • 77950315193 scopus 로고    scopus 로고
    • BANK1 functional variants are associated with susceptibility to diffuse systemic sclerosis in Caucasians
    • Rueda B., Gourh P., Broen J., et al. BANK1 functional variants are associated with susceptibility to diffuse systemic sclerosis in Caucasians. Ann Rheum Dis 2010, 69:700-705.
    • (2010) Ann Rheum Dis , vol.69 , pp. 700-705
    • Rueda, B.1    Gourh, P.2    Broen, J.3
  • 15
    • 58249123282 scopus 로고    scopus 로고
    • Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis
    • Dieudé P., Guedj M., Wipff J., et al. Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis. Arthritis Rheum 2009, 60:225-233.
    • (2009) Arthritis Rheum , vol.60 , pp. 225-233
    • Dieudé, P.1    Guedj, M.2    Wipff, J.3
  • 16
    • 68049112537 scopus 로고    scopus 로고
    • STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis
    • Dieudé P., Guedj M., Wipff J., et al. STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis. Arthritis Rheum 2009, 60:2472-2479.
    • (2009) Arthritis Rheum , vol.60 , pp. 2472-2479
    • Dieudé, P.1    Guedj, M.2    Wipff, J.3
  • 17
    • 77951765348 scopus 로고    scopus 로고
    • Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
    • Radstake T.R., Gorlova O., Rueda B., et al. Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat. Genet. 2010, 42:426-429.
    • (2010) Nat. Genet. , vol.42 , pp. 426-429
    • Radstake, T.R.1    Gorlova, O.2    Rueda, B.3
  • 18
    • 79960934301 scopus 로고    scopus 로고
    • Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis
    • Allanore Y., Saad M., Dieudé P., et al. Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. PLoS Genet 2011, 7:e1002091.
    • (2011) PLoS Genet , vol.7 , pp. e1002091
    • Allanore, Y.1    Saad, M.2    Dieudé, P.3
  • 19
    • 40449133001 scopus 로고    scopus 로고
    • Polymorphisms in the CD3Z gene influence TCRzeta expression in systemic lupus erythematosus patients and healthy controls
    • Gorman C.L., Russell A.I., Zhang Z., et al. Polymorphisms in the CD3Z gene influence TCRzeta expression in systemic lupus erythematosus patients and healthy controls. J. Immunol 2008, 180:1060-1070.
    • (2008) J. Immunol , vol.180 , pp. 1060-1070
    • Gorman, C.L.1    Russell, A.I.2    Zhang, Z.3
  • 20
    • 79960943814 scopus 로고    scopus 로고
    • Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy
    • Gorlova O., Martin J.E., Rueda B., et al. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. PLoS Genet 2011, 7:e1002178.
    • (2011) PLoS Genet , vol.7 , pp. e1002178
    • Gorlova, O.1    Martin, J.E.2    Rueda, B.3
  • 21
    • 84942508220 scopus 로고    scopus 로고
    • Defining Genetic Risk for Scleroderma Renal Crisis: A Genome-Wide Analysis of Anti-Rna Polymerase Antibody-Positive Systemic Sclerosis
    • Guerra S.G., Fonseca C., Nihtyanova S.I., et al. Defining Genetic Risk for Scleroderma Renal Crisis: A Genome-Wide Analysis of Anti-Rna Polymerase Antibody-Positive Systemic Sclerosis. Br Soc Rheumatol 2015, 54(Suppl 1):i159.
    • (2015) Br Soc Rheumatol , vol.54 , pp. i159
    • Guerra, S.G.1    Fonseca, C.2    Nihtyanova, S.I.3
  • 22
    • 0018710455 scopus 로고
    • Vinyl chloride: a review
    • Binns C.H. Vinyl chloride: a review. J Soc Occup Med 1979, 29:134-141.
    • (1979) J Soc Occup Med , vol.29 , pp. 134-141
    • Binns, C.H.1
  • 23
    • 0020698835 scopus 로고
    • Genetic susceptibility to scleroderma-like syndrome induced by vinyl chloride
    • Black C.M., Welsh K.I., Walker A.E., et al. Genetic susceptibility to scleroderma-like syndrome induced by vinyl chloride. Lancet 1983, 1:53-55.
    • (1983) Lancet , vol.1 , pp. 53-55
    • Black, C.M.1    Welsh, K.I.2    Walker, A.E.3
  • 24
    • 0022870871 scopus 로고
    • Genetic susceptibility to scleroderma-like syndrome in symptomatic and asymptomatic workers exposed to vinyl chloride
    • Black C., Pereira S., McWhirter A., et al. Genetic susceptibility to scleroderma-like syndrome in symptomatic and asymptomatic workers exposed to vinyl chloride. J Rheumatol 1986, 13:1059-1062.
    • (1986) J Rheumatol , vol.13 , pp. 1059-1062
    • Black, C.1    Pereira, S.2    McWhirter, A.3
  • 26
    • 0019490889 scopus 로고
    • Toxic-allergic syndrome caused by ingestion of rapeseed oil denatured with aniline
    • Tabuenca J.M. Toxic-allergic syndrome caused by ingestion of rapeseed oil denatured with aniline. Lancet 1981, 2:567-568.
    • (1981) Lancet , vol.2 , pp. 567-568
    • Tabuenca, J.M.1
  • 27
    • 0025307579 scopus 로고
    • Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan
    • Silver R.M., Heyes M.P., Maize J.C., et al. Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan. N Engl J Med 1990, 322:874-881.
    • (1990) N Engl J Med , vol.322 , pp. 874-881
    • Silver, R.M.1    Heyes, M.P.2    Maize, J.C.3
  • 28
    • 0031780295 scopus 로고    scopus 로고
    • Is occupational organic solvent exposure a risk factor for scleroderma?
    • Nietert P.J., Sutherland S.E., Silver R.M., et al. Is occupational organic solvent exposure a risk factor for scleroderma?. Arthritis Rheum 1998, 41:1111-1118.
    • (1998) Arthritis Rheum , vol.41 , pp. 1111-1118
    • Nietert, P.J.1    Sutherland, S.E.2    Silver, R.M.3
  • 29
    • 84888012841 scopus 로고    scopus 로고
    • Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature
    • Marie I., Gehanno J.F., Bubenheim M., et al. Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature. Autoimmun Rev 2014, 13:151-156.
    • (2014) Autoimmun Rev , vol.13 , pp. 151-156
    • Marie, I.1    Gehanno, J.F.2    Bubenheim, M.3
  • 30
    • 33846213225 scopus 로고    scopus 로고
    • Occupational exposure to solvents and gender-related risk of systemic sclerosis: a metaanalysis of case-control studies
    • Kettaneh A., Al Moufti O., Tiev K.P., et al. Occupational exposure to solvents and gender-related risk of systemic sclerosis: a metaanalysis of case-control studies. J Rheumatol 2007, 34:97-103.
    • (2007) J Rheumatol , vol.34 , pp. 97-103
    • Kettaneh, A.1    Al Moufti, O.2    Tiev, K.P.3
  • 31
    • 0028152438 scopus 로고
    • Expression and shedding of intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 by normal and scleroderma fibroblasts. Effects of interferon-gamma, tumor necrosis factor alpha, and estrogen
    • Shi-Wen X., Panesar M., Vancheeswaran R., et al. Expression and shedding of intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 by normal and scleroderma fibroblasts. Effects of interferon-gamma, tumor necrosis factor alpha, and estrogen. Arthritis Rheum 1994, 37:1689-1697.
    • (1994) Arthritis Rheum , vol.37 , pp. 1689-1697
    • Shi-Wen, X.1    Panesar, M.2    Vancheeswaran, R.3
  • 32
    • 0024853634 scopus 로고
    • Determination of an epitope of the diffuse systemic sclerosis marker antigen DNA topoisomerase I: sequence similarity with retroviral p30gag protein suggests a possible cause for autoimmunity in systemic sclerosis
    • Maul G.G., Jimenez S.A., Riggs E., et al. Determination of an epitope of the diffuse systemic sclerosis marker antigen DNA topoisomerase I: sequence similarity with retroviral p30gag protein suggests a possible cause for autoimmunity in systemic sclerosis. Proc Natl Acad Sci U S A 1989, 86:8492-8496.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 8492-8496
    • Maul, G.G.1    Jimenez, S.A.2    Riggs, E.3
  • 33
    • 0033790892 scopus 로고    scopus 로고
    • Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells
    • Lunardi C., Bason C., Navone R., et al. Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells. Nat Med 2000, 6:1183-1186.
    • (2000) Nat Med , vol.6 , pp. 1183-1186
    • Lunardi, C.1    Bason, C.2    Navone, R.3
  • 34
    • 77956390135 scopus 로고    scopus 로고
    • Close temporal relationship between onset of cancer and scleroderma in patients with RNA polymerase I/III antibodies
    • Shah A.A., Rosen A., Hummers L., et al. Close temporal relationship between onset of cancer and scleroderma in patients with RNA polymerase I/III antibodies. Arthritis Rheum 2010, 62:2787-2795.
    • (2010) Arthritis Rheum , vol.62 , pp. 2787-2795
    • Shah, A.A.1    Rosen, A.2    Hummers, L.3
  • 35
    • 84897517521 scopus 로고    scopus 로고
    • Association of anti-RNA polymerase III autoantibodies and cancer in scleroderma.
    • Moinzadeh P., Fonseca C., Hellmich M., et al. Association of anti-RNA polymerase III autoantibodies and cancer in scleroderma. Arthritis Res Ther 2014, 16:R53.
    • (2014) Arthritis Res Ther , vol.16 , pp. R53
    • Moinzadeh, P.1    Fonseca, C.2    Hellmich, M.3
  • 36
    • 84892166613 scopus 로고    scopus 로고
    • Association of the autoimmune disease scleroderma with an immunologic response to cancer
    • Joseph C.G., Darrah E., Shah A.A., et al. Association of the autoimmune disease scleroderma with an immunologic response to cancer. Science 2014, 343:152-157.
    • (2014) Science , vol.343 , pp. 152-157
    • Joseph, C.G.1    Darrah, E.2    Shah, A.A.3
  • 37
    • 0343081333 scopus 로고    scopus 로고
    • Systemic sclerosis: current pathogenetic concepts and future prospects for targeted therapy
    • Systemic sclerosis: current pathogenetic concepts and future prospects for targeted therapy. Lancet 1996, 347:1453-1458.
    • (1996) Lancet , vol.347 , pp. 1453-1458
  • 38
    • 0026040431 scopus 로고
    • The endothelium: its role in scleroderma
    • Pearson J.D. The endothelium: its role in scleroderma. Ann Rheum Dis 1991, 50(Suppl 4):866-871.
    • (1991) Ann Rheum Dis , vol.50 , pp. 866-871
    • Pearson, J.D.1
  • 39
    • 0033624608 scopus 로고    scopus 로고
    • Increased alpha2-adrenergic constriction of isolated arterioles in diffuse scleroderma
    • Flavahan N.A., Flavahan S., Liu Q., et al. Increased alpha2-adrenergic constriction of isolated arterioles in diffuse scleroderma. Arthritis Rheum 2000, 43:1886-1890.
    • (2000) Arthritis Rheum , vol.43 , pp. 1886-1890
    • Flavahan, N.A.1    Flavahan, S.2    Liu, Q.3
  • 40
    • 0029116310 scopus 로고
    • Endothelins
    • Levin E.R. Endothelins. N Engl J Med 1995, 333:356-363.
    • (1995) N Engl J Med , vol.333 , pp. 356-363
    • Levin, E.R.1
  • 41
    • 0025836185 scopus 로고
    • Endothelin, an endothelial-dependent vasoconstrictor in scleroderma. Enhanced production and profibrotic action
    • Kahaleh M.B. Endothelin, an endothelial-dependent vasoconstrictor in scleroderma. Enhanced production and profibrotic action. Arthritis Rheum 1991, 34:978-983.
    • (1991) Arthritis Rheum , vol.34 , pp. 978-983
    • Kahaleh, M.B.1
  • 42
    • 0026439371 scopus 로고
    • Significance of plasma endothelin-1 levels in patients with systemic sclerosis
    • Yamane K., Miyauchi T., Suzuki N., et al. Significance of plasma endothelin-1 levels in patients with systemic sclerosis. J Rheumatol 1992, 19:1566-1571.
    • (1992) J Rheumatol , vol.19 , pp. 1566-1571
    • Yamane, K.1    Miyauchi, T.2    Suzuki, N.3
  • 43
    • 0028029736 scopus 로고
    • Circulating endothelin-1 levels in systemic sclerosis subsets-a marker of fibrosis or vascular dysfunction?
    • Vancheeswaran R., Magoulas T., Efrat G., et al. Circulating endothelin-1 levels in systemic sclerosis subsets-a marker of fibrosis or vascular dysfunction?. J Rheumatol 1994, 21:1838-1844.
    • (1994) J Rheumatol , vol.21 , pp. 1838-1844
    • Vancheeswaran, R.1    Magoulas, T.2    Efrat, G.3
  • 44
    • 0032860659 scopus 로고    scopus 로고
    • Immunohistological study endothelin-1 and endothelin-A and B receptors in two patients with scleroderma renal crisis
    • Kobayashi H., Nishimaki T., Kaise S., et al. Immunohistological study endothelin-1 and endothelin-A and B receptors in two patients with scleroderma renal crisis. Clin Rheumatol 1999, 18:425-427.
    • (1999) Clin Rheumatol , vol.18 , pp. 425-427
    • Kobayashi, H.1    Nishimaki, T.2    Kaise, S.3
  • 45
    • 84889049254 scopus 로고    scopus 로고
    • Targeting the endothelin axis in scleroderma renal crisis: rationale and feasibility
    • Penn H., Quillinan N., Khan K., et al. Targeting the endothelin axis in scleroderma renal crisis: rationale and feasibility. QJM 2013, 106(9):839-848.
    • (2013) QJM , vol.106 , Issue.9 , pp. 839-848
    • Penn, H.1    Quillinan, N.2    Khan, K.3
  • 46
    • 0028040486 scopus 로고
    • Localization of endothelin-1 and its binding sites in scleroderma skin
    • Vancheeswaran R., Azam A., Black C., et al. Localization of endothelin-1 and its binding sites in scleroderma skin. J Rheumatol 1994, 21:1268-1276.
    • (1994) J Rheumatol , vol.21 , pp. 1268-1276
    • Vancheeswaran, R.1    Azam, A.2    Black, C.3
  • 47
    • 0033910117 scopus 로고    scopus 로고
    • Exhaled nitric oxide in systemic sclerosis: relationships with lung involvement and pulmonary hypertension
    • Rolla G., Colagrande P., Scappaticci E., et al. Exhaled nitric oxide in systemic sclerosis: relationships with lung involvement and pulmonary hypertension. J Rheumatol 2000, 27:1693-1698.
    • (2000) J Rheumatol , vol.27 , pp. 1693-1698
    • Rolla, G.1    Colagrande, P.2    Scappaticci, E.3
  • 48
    • 0034049907 scopus 로고    scopus 로고
    • Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis: findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1
    • Andersen G.N., Caidahl K., Kazzam E., et al. Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis: findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1. Arthritis Rheum 2000, 43:1085-1093.
    • (2000) Arthritis Rheum , vol.43 , pp. 1085-1093
    • Andersen, G.N.1    Caidahl, K.2    Kazzam, E.3
  • 49
    • 31044434666 scopus 로고    scopus 로고
    • Variations of neuronal nitric oxide synthase in systemic sclerosis skin
    • Ibba-Manneschi L., Niissalo S., Milia A.F., et al. Variations of neuronal nitric oxide synthase in systemic sclerosis skin. Arthritis Rheum 2006, 54:202-213.
    • (2006) Arthritis Rheum , vol.54 , pp. 202-213
    • Ibba-Manneschi, L.1    Niissalo, S.2    Milia, A.F.3
  • 50
    • 0030031147 scopus 로고    scopus 로고
    • IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines
    • Carvalho D., Savage C.O., Black C.M., et al. IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines. J Clin Invest 1996, 97:111-119.
    • (1996) J Clin Invest , vol.97 , pp. 111-119
    • Carvalho, D.1    Savage, C.O.2    Black, C.M.3
  • 51
    • 0033758304 scopus 로고    scopus 로고
    • Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95
    • Sgonc R., Gruschwitz M.S., Boeck G., et al. Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95. Arthritis Rheum 2000, 43:2550-2562.
    • (2000) Arthritis Rheum , vol.43 , pp. 2550-2562
    • Sgonc, R.1    Gruschwitz, M.S.2    Boeck, G.3
  • 52
    • 33745877171 scopus 로고    scopus 로고
    • Induction of apoptosis and fibrillin 1 expression in human dermal endothelial cells by scleroderma sera containing anti-endothelial cell antibodies
    • Ahmed S.S., Tan F.K., Arnett F.C., et al. Induction of apoptosis and fibrillin 1 expression in human dermal endothelial cells by scleroderma sera containing anti-endothelial cell antibodies. Arthritis Rheum 2006, 54:2250-2262.
    • (2006) Arthritis Rheum , vol.54 , pp. 2250-2262
    • Ahmed, S.S.1    Tan, F.K.2    Arnett, F.C.3
  • 53
    • 0343384264 scopus 로고    scopus 로고
    • Detection of activated complement complex C5b-9 and complement receptor C5a in skin biopsies of patients with systemic sclerosis (scleroderma)
    • Sprott H., Müller-Ladner U., Distler O., et al. Detection of activated complement complex C5b-9 and complement receptor C5a in skin biopsies of patients with systemic sclerosis (scleroderma). J Rheumatol 2000, 27:402-404.
    • (2000) J Rheumatol , vol.27 , pp. 402-404
    • Sprott, H.1    Müller-Ladner, U.2    Distler, O.3
  • 54
    • 0038718531 scopus 로고    scopus 로고
    • Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species
    • Grote K., Flach I., Luchtefeld M., et al. Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species. Circ Res 2003, 92:e80-e86.
    • (2003) Circ Res , vol.92 , pp. e80-e86
    • Grote, K.1    Flach, I.2    Luchtefeld, M.3
  • 55
    • 42949146126 scopus 로고    scopus 로고
    • Specific oxidative stress parameters differently correlate with nailfold capillaroscopy changes and organ involvement in systemic sclerosis
    • Riccieri V., Spadaro A., Fuksa L., et al. Specific oxidative stress parameters differently correlate with nailfold capillaroscopy changes and organ involvement in systemic sclerosis. Clin Rheumatol 2008, 27:225-230.
    • (2008) Clin Rheumatol , vol.27 , pp. 225-230
    • Riccieri, V.1    Spadaro, A.2    Fuksa, L.3
  • 56
    • 4143072810 scopus 로고    scopus 로고
    • Defective vasculogenesis in systemic sclerosis
    • Kuwana M., Okazaki Y., Yasuoka H., et al. Defective vasculogenesis in systemic sclerosis. Lancet 2004, 364:603-610.
    • (2004) Lancet , vol.364 , pp. 603-610
    • Kuwana, M.1    Okazaki, Y.2    Yasuoka, H.3
  • 57
    • 35348891629 scopus 로고    scopus 로고
    • Antiangiogenic plasma activity in patients with systemic sclerosis
    • Mulligan-Kehoe M.J., Drinane M.C., Mollmark J., et al. Antiangiogenic plasma activity in patients with systemic sclerosis. Arthritis Rheum 2007, 56:3448-3458.
    • (2007) Arthritis Rheum , vol.56 , pp. 3448-3458
    • Mulligan-Kehoe, M.J.1    Drinane, M.C.2    Mollmark, J.3
  • 58
    • 0025182959 scopus 로고
    • Adhesion receptors of the immune system
    • Springer T.A. Adhesion receptors of the immune system. Nature 1990, 346:425-434.
    • (1990) Nature , vol.346 , pp. 425-434
    • Springer, T.A.1
  • 59
    • 0032703621 scopus 로고    scopus 로고
    • Abnormalities of adhesion molecules and chemokines in scleroderma
    • Sato S. Abnormalities of adhesion molecules and chemokines in scleroderma. Curr Opin Rheumatol 1999, 11:503-507.
    • (1999) Curr Opin Rheumatol , vol.11 , pp. 503-507
    • Sato, S.1
  • 60
    • 0026749372 scopus 로고
    • Expression of adhesion proteins involved in cell-cell and cell-matrix interactions in the skin of patients with progressive systemic sclerosis
    • Gruschwitz M., von den Driesch P., Kellner I., et al. Expression of adhesion proteins involved in cell-cell and cell-matrix interactions in the skin of patients with progressive systemic sclerosis. J Am Acad Dermatol 1992, 27:169-177.
    • (1992) J Am Acad Dermatol , vol.27 , pp. 169-177
    • Gruschwitz, M.1    von den Driesch, P.2    Kellner, I.3
  • 61
    • 0027157113 scopus 로고
    • Serum ELAM-1 is increased in vasculitis, scleroderma, and systemic lupus erythematosus
    • Carson C.W., Beall L.D., Hunder G.G., et al. Serum ELAM-1 is increased in vasculitis, scleroderma, and systemic lupus erythematosus. J Rheumatol 1993, 20:809-814.
    • (1993) J Rheumatol , vol.20 , pp. 809-814
    • Carson, C.W.1    Beall, L.D.2    Hunder, G.G.3
  • 62
    • 0027256663 scopus 로고
    • Circulating intercellular adhesion molecule-1 in patients with systemic sclerosis
    • Sfikakis P.P., Tesar J., Baraf H., et al. Circulating intercellular adhesion molecule-1 in patients with systemic sclerosis. Clin Immunol Immunopathol 1993, 68:88-92.
    • (1993) Clin Immunol Immunopathol , vol.68 , pp. 88-92
    • Sfikakis, P.P.1    Tesar, J.2    Baraf, H.3
  • 63
    • 0031876649 scopus 로고    scopus 로고
    • Different patterns of endothelial cell activation in renal and pulmonary vascular disease in scleroderma
    • Stratton R.J., Coghlan J.G., Pearson J.D., et al. Different patterns of endothelial cell activation in renal and pulmonary vascular disease in scleroderma. QJM 1998, 91:561-566.
    • (1998) QJM , vol.91 , pp. 561-566
    • Stratton, R.J.1    Coghlan, J.G.2    Pearson, J.D.3
  • 64
    • 0031025143 scopus 로고    scopus 로고
    • Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: implications for pathogenesis
    • Casciola-Rosen L., Wigley F., Rosen A. Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: implications for pathogenesis. J Exp Med 1997, 185:71-79.
    • (1997) J Exp Med , vol.185 , pp. 71-79
    • Casciola-Rosen, L.1    Wigley, F.2    Rosen, A.3
  • 65
    • 0036269002 scopus 로고    scopus 로고
    • Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis
    • Chizzolini C., Raschi E., Rezzonico R., et al. Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis. Arthritis Rheum 2002, 46:1602-1613.
    • (2002) Arthritis Rheum , vol.46 , pp. 1602-1613
    • Chizzolini, C.1    Raschi, E.2    Rezzonico, R.3
  • 66
    • 79951499538 scopus 로고    scopus 로고
    • Involvement of functional autoantibodies against vascular receptors in systemic sclerosis
    • Riemekasten G., Philippe A., Näther M., et al. Involvement of functional autoantibodies against vascular receptors in systemic sclerosis. Ann Rheum Dis 2011, 70:530-536.
    • (2011) Ann Rheum Dis , vol.70 , pp. 530-536
    • Riemekasten, G.1    Philippe, A.2    Näther, M.3
  • 67
    • 33745277147 scopus 로고    scopus 로고
    • Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis
    • Baroni S.S., Santillo M., Bevilacqua F., et al. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med 2006, 354:2667-2676.
    • (2006) N Engl J Med , vol.354 , pp. 2667-2676
    • Baroni, S.S.1    Santillo, M.2    Bevilacqua, F.3
  • 68
    • 1942468042 scopus 로고    scopus 로고
    • Increased transendothelial migration of scleroderma lymphocytes
    • Stummvoll G.H., Aringer M., Grisar J., et al. Increased transendothelial migration of scleroderma lymphocytes. Ann Rheum Dis 2004, 63:569-574.
    • (2004) Ann Rheum Dis , vol.63 , pp. 569-574
    • Stummvoll, G.H.1    Aringer, M.2    Grisar, J.3
  • 69
    • 0021154318 scopus 로고
    • Lymphocytes in the skin of patients with progressive systemic sclerosis. Quantification, subtyping, and clinical correlations
    • Roumm A.D., Whiteside T.L., Medsger T.A., et al. Lymphocytes in the skin of patients with progressive systemic sclerosis. Quantification, subtyping, and clinical correlations. Arthritis Rheum 1984, 27:645-653.
    • (1984) Arthritis Rheum , vol.27 , pp. 645-653
    • Roumm, A.D.1    Whiteside, T.L.2    Medsger, T.A.3
  • 70
    • 0033580449 scopus 로고    scopus 로고
    • Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group
    • Brent J., McMartin K., Phillips S., et al. Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. N Engl J Med 1999, 340:832-838.
    • (1999) N Engl J Med , vol.340 , pp. 832-838
    • Brent, J.1    McMartin, K.2    Phillips, S.3
  • 71
    • 42649134787 scopus 로고    scopus 로고
    • Clinical association of serum interleukin-17 levels in systemic sclerosis: is systemic sclerosis a Th17 disease?
    • Murata M., Fujimoto M., Matsushita T., et al. Clinical association of serum interleukin-17 levels in systemic sclerosis: is systemic sclerosis a Th17 disease?. J Dermatol Sci 2008, 50:240-242.
    • (2008) J Dermatol Sci , vol.50 , pp. 240-242
    • Murata, M.1    Fujimoto, M.2    Matsushita, T.3
  • 72
    • 67650114978 scopus 로고    scopus 로고
    • The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes
    • Radstake T.R., van Bon L., Broen J., et al. The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. PLoS One 2009, 4:e5903.
    • (2009) PLoS One , vol.4 , pp. e5903
    • Radstake, T.R.1    van Bon, L.2    Broen, J.3
  • 73
    • 77951238591 scopus 로고    scopus 로고
    • Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea
    • Antiga E., Quaglino P., Bellandi S., et al. Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea. Br J Dermatol 2010, 162:1056-1063.
    • (2010) Br J Dermatol , vol.162 , pp. 1056-1063
    • Antiga, E.1    Quaglino, P.2    Bellandi, S.3
  • 74
    • 79960903015 scopus 로고    scopus 로고
    • Novel insights on the role of the innate immune system in systemic sclerosis
    • York M.R. Novel insights on the role of the innate immune system in systemic sclerosis. Expert Rev Clin Immunol 2011, 7:481-489.
    • (2011) Expert Rev Clin Immunol , vol.7 , pp. 481-489
    • York, M.R.1
  • 75
    • 84871284466 scopus 로고    scopus 로고
    • Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma
    • Bhattacharyya S., Kelley K., Melichian D.S., et al. Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol 2013, 182:192-205.
    • (2013) Am J Pathol , vol.182 , pp. 192-205
    • Bhattacharyya, S.1    Kelley, K.2    Melichian, D.S.3
  • 76
    • 0025936460 scopus 로고
    • Expression and function of surface antigens on scleroderma fibroblasts
    • Abraham D., Lupoli S., McWhirter A., et al. Expression and function of surface antigens on scleroderma fibroblasts. Arthritis Rheum 1991, 34:1164-1172.
    • (1991) Arthritis Rheum , vol.34 , pp. 1164-1172
    • Abraham, D.1    Lupoli, S.2    McWhirter, A.3
  • 77
    • 0028009496 scopus 로고
    • Immunocytochemical localization and serologic detection of transforming growth factor beta 1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud's phenomenon
    • Higley H., Persichitte K., Chu S., et al. Immunocytochemical localization and serologic detection of transforming growth factor beta 1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud's phenomenon. Arthritis Rheum 1994, 37:278-288.
    • (1994) Arthritis Rheum , vol.37 , pp. 278-288
    • Higley, H.1    Persichitte, K.2    Chu, S.3
  • 78
    • 0028222602 scopus 로고
    • Immunohistochemical localization of transforming growth factor-beta 1 in the lungs of patients with systemic sclerosis, cryptogenic fibrosing alveolitis and other lung disorders
    • Corrin B., Butcher D., McAnulty B.J., et al. Immunohistochemical localization of transforming growth factor-beta 1 in the lungs of patients with systemic sclerosis, cryptogenic fibrosing alveolitis and other lung disorders. Histopathology 1994, 24:145-150.
    • (1994) Histopathology , vol.24 , pp. 145-150
    • Corrin, B.1    Butcher, D.2    McAnulty, B.J.3
  • 79
    • 28544437285 scopus 로고    scopus 로고
    • Circulating levels of active transforming growth factor beta1 are reduced in diffuse cutaneous systemic sclerosis and correlate inversely with the modified Rodnan skin score
    • Dziadzio M., Smith R.E., Abraham D.J., et al. Circulating levels of active transforming growth factor beta1 are reduced in diffuse cutaneous systemic sclerosis and correlate inversely with the modified Rodnan skin score. Rheumatology (Oxford) 2005, 44:1518-1524.
    • (2005) Rheumatology (Oxford) , vol.44 , pp. 1518-1524
    • Dziadzio, M.1    Smith, R.E.2    Abraham, D.J.3
  • 80
    • 0035079964 scopus 로고    scopus 로고
    • Up-regulated expression of transforming growth factor beta receptors in dermal fibroblasts in skin sections from patients with localized scleroderma
    • Kubo M., Ihn H., Yamane K., et al. Up-regulated expression of transforming growth factor beta receptors in dermal fibroblasts in skin sections from patients with localized scleroderma. Arthritis Rheum 2001, 44:731-734.
    • (2001) Arthritis Rheum , vol.44 , pp. 731-734
    • Kubo, M.1    Ihn, H.2    Yamane, K.3
  • 81
    • 0028607541 scopus 로고
    • Collagen type I is not under autocrine control by transforming growth factor-beta 1 in normal and scleroderma fibroblasts
    • McWhirter A., Colosetti P., Rubin K., et al. Collagen type I is not under autocrine control by transforming growth factor-beta 1 in normal and scleroderma fibroblasts. Lab. Invest 1994, 71:885-894.
    • (1994) Lab. Invest , vol.71 , pp. 885-894
    • McWhirter, A.1    Colosetti, P.2    Rubin, K.3
  • 82
    • 0026540461 scopus 로고
    • Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts
    • Yamakage A., Kikuchi K., Smith E.A., et al. Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts. J Exp Med 1992, 175:1227-1234.
    • (1992) J Exp Med , vol.175 , pp. 1227-1234
    • Yamakage, A.1    Kikuchi, K.2    Smith, E.A.3
  • 83
    • 0036545885 scopus 로고    scopus 로고
    • Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis
    • Leask A., Holmes A., Abraham D.J. Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis. Curr Rheumatol Rep 2002, 4:136-142.
    • (2002) Curr Rheumatol Rep , vol.4 , pp. 136-142
    • Leask, A.1    Holmes, A.2    Abraham, D.J.3
  • 84
    • 24944515520 scopus 로고    scopus 로고
    • N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma
    • Dziadzio M., Usinger W., Leask A., et al. N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma. QJM 2005, 98:485-492.
    • (2005) QJM , vol.98 , pp. 485-492
    • Dziadzio, M.1    Usinger, W.2    Leask, A.3
  • 85
    • 33744950568 scopus 로고    scopus 로고
    • CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts
    • Shi-wen X., Stanton L.A., Kennedy L., et al. CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem 2006, 281:10715-10726.
    • (2006) J Biol Chem , vol.281 , pp. 10715-10726
    • Shi-wen, X.1    Stanton, L.A.2    Kennedy, L.3
  • 86
    • 79959356378 scopus 로고    scopus 로고
    • Interleukin-6: a growth factor stimulating collagen synthesis in human tendon
    • Andersen M.B., Pingel J., Kjær M., et al. Interleukin-6: a growth factor stimulating collagen synthesis in human tendon. J Appl Physiol 2011, 110:1549-1554.
    • (2011) J Appl Physiol , vol.110 , pp. 1549-1554
    • Andersen, M.B.1    Pingel, J.2    Kjær, M.3
  • 87
    • 0034856397 scopus 로고    scopus 로고
    • Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis
    • Sato S., Hasegawa M., Takehara K. Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis. J Dermatol Sci 2001, 27:140-146.
    • (2001) J Dermatol Sci , vol.27 , pp. 140-146
    • Sato, S.1    Hasegawa, M.2    Takehara, K.3
  • 88
    • 0029941568 scopus 로고    scopus 로고
    • Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis
    • Salmon-Ehr V., Serpier H., Nawrocki B., et al. Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis. Arch Dermatol 1996, 132:802-806.
    • (1996) Arch Dermatol , vol.132 , pp. 802-806
    • Salmon-Ehr, V.1    Serpier, H.2    Nawrocki, B.3
  • 89
    • 0026601232 scopus 로고
    • Interleukin-1, interleukin-2, interleukin-4, interleukin-6, tumor necrosis factor α, and interferon-γ levels in sera from patients with scleroderma
    • Needleman B.W., Wigley F.M., Stair R.W. Interleukin-1, interleukin-2, interleukin-4, interleukin-6, tumor necrosis factor α, and interferon-γ levels in sera from patients with scleroderma. Arthritis Rheum 1992, 35:67-72.
    • (1992) Arthritis Rheum , vol.35 , pp. 67-72
    • Needleman, B.W.1    Wigley, F.M.2    Stair, R.W.3
  • 90
    • 31044456861 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells
    • Distler J.H., Jüngel A., Caretto D., et al. Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells. Arthritis Rheum 2006, 54:214-225.
    • (2006) Arthritis Rheum , vol.54 , pp. 214-225
    • Distler, J.H.1    Jüngel, A.2    Caretto, D.3
  • 91
    • 77955713805 scopus 로고    scopus 로고
    • Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis
    • Aden N., Nuttall A., Shiwen X., et al. Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis. J Invest Dermatol 2010, 130:2191-2200.
    • (2010) J Invest Dermatol , vol.130 , pp. 2191-2200
    • Aden, N.1    Nuttall, A.2    Shiwen, X.3
  • 92
    • 28444466925 scopus 로고    scopus 로고
    • CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production
    • Romagnani P., Maggi L., Mazzinghi B., et al. CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production. J Allergy Clin Immunol 2005, 116:1372-1379.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 1372-1379
    • Romagnani, P.1    Maggi, L.2    Mazzinghi, B.3
  • 93
    • 84893081873 scopus 로고    scopus 로고
    • Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis
    • van Bon L., Affandi A.J., Broen J., et al. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med 2014, 370:433-443.
    • (2014) N Engl J Med , vol.370 , pp. 433-443
    • van Bon, L.1    Affandi, A.J.2    Broen, J.3
  • 94
    • 29144443977 scopus 로고    scopus 로고
    • Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation
    • Carulli M.T., Ong V.H., Ponticos M., et al. Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation. Arthritis Rheum 2005, 52:3772-3782.
    • (2005) Arthritis Rheum , vol.52 , pp. 3772-3782
    • Carulli, M.T.1    Ong, V.H.2    Ponticos, M.3
  • 95
    • 0030883273 scopus 로고    scopus 로고
    • Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis
    • Shi-Wen X., Denton C.P., McWhirter A., et al. Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis. Arthritis Rheum 1997, 40:1237-1244.
    • (1997) Arthritis Rheum , vol.40 , pp. 1237-1244
    • Shi-Wen, X.1    Denton, C.P.2    McWhirter, A.3
  • 96
    • 0023876160 scopus 로고
    • Identification of fibroblasts responsible for increased collagen production in localized scleroderma by in situ hybridization
    • Kähäri V.M., Sandberg M., Kalimo H., et al. Identification of fibroblasts responsible for increased collagen production in localized scleroderma by in situ hybridization. J Invest Dermatol 1988, 90:664-670.
    • (1988) J Invest Dermatol , vol.90 , pp. 664-670
    • Kähäri, V.M.1    Sandberg, M.2    Kalimo, H.3
  • 97
    • 0023885251 scopus 로고
    • Localization of collagen mRNA in normal and scleroderma skin by in-situ hybridization
    • Scharffetter K., Lankat-Buttgereit B., Krieg T. Localization of collagen mRNA in normal and scleroderma skin by in-situ hybridization. Eur J Clin Invest 1988, 18:9-17.
    • (1988) Eur J Clin Invest , vol.18 , pp. 9-17
    • Scharffetter, K.1    Lankat-Buttgereit, B.2    Krieg, T.3
  • 98
    • 58149359860 scopus 로고    scopus 로고
    • Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing
    • Denton C.P., Khan K., Hoyles R.K., et al. Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing. J Invest Dermatol 2009, 129:194-204.
    • (2009) J Invest Dermatol , vol.129 , pp. 194-204
    • Denton, C.P.1    Khan, K.2    Hoyles, R.K.3
  • 99
    • 78751694228 scopus 로고    scopus 로고
    • An essential role for resident fibroblasts in experimental lung fibrosis is defined by lineage-specific deletion of high-affinity type II transforming growth factor β receptor
    • Hoyles R.K., Derrett-Smith E.C., Khan K., et al. An essential role for resident fibroblasts in experimental lung fibrosis is defined by lineage-specific deletion of high-affinity type II transforming growth factor β receptor. Am J Respir Crit Care Med 2011, 183:249-261.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 249-261
    • Hoyles, R.K.1    Derrett-Smith, E.C.2    Khan, K.3
  • 100
    • 0020066303 scopus 로고
    • Replication and phenotypic expression of control and scleroderma human fibroblasts: responses to growth factors
    • LeRoy E.C., Mercurio S., Sherer G.K. Replication and phenotypic expression of control and scleroderma human fibroblasts: responses to growth factors. Proc Natl Acad Sci U S A 1982, 79:1286-1290.
    • (1982) Proc Natl Acad Sci U S A , vol.79 , pp. 1286-1290
    • LeRoy, E.C.1    Mercurio, S.2    Sherer, G.K.3
  • 101
    • 33745918328 scopus 로고    scopus 로고
    • Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    • Wang Y., Fan P.-S., Kahaleh B. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum 2006, 54:2271-2279.
    • (2006) Arthritis Rheum , vol.54 , pp. 2271-2279
    • Wang, Y.1    Fan, P.-S.2    Kahaleh, B.3
  • 102
    • 0034881850 scopus 로고    scopus 로고
    • Abnormalities in fibrillin 1-containing microfibrils in dermal fibroblast cultures from patients with systemic sclerosis (scleroderma)
    • Wallis D.D., Tan F.K., Kielty C.M., et al. Abnormalities in fibrillin 1-containing microfibrils in dermal fibroblast cultures from patients with systemic sclerosis (scleroderma). Arthritis Rheum 2001, 44:1855-1864.
    • (2001) Arthritis Rheum , vol.44 , pp. 1855-1864
    • Wallis, D.D.1    Tan, F.K.2    Kielty, C.M.3
  • 103
    • 1542313925 scopus 로고    scopus 로고
    • Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen
    • Lemaire R., Farina G., Kissin E., et al. Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen. Arthritis Rheum 2004, 50:915-926.
    • (2004) Arthritis Rheum , vol.50 , pp. 915-926
    • Lemaire, R.1    Farina, G.2    Kissin, E.3


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