Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation

British Journal of Anaesthesia

Volumn 114, Issue 6, 2015, Pages 990-999

  Mertens, K ^a   Lowes, D A ^a   Webster, N R ^a   Talib, J ^c   Hall, L ^c   Davies, M J ^c,d   Beattie, J H ^b   Galley, H F ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

^c University of Sydney   (Australia)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Critical illness; Mitochondria, oxidative damage; Selenium; Sepsis; Zinc

Indexed keywords

GLUTATHIONE PEROXIDASE 3; INTERLEUKIN 6; SELENIUM; TRACE ELEMENT; ZINC; ZINC TRANSPORTER; ANTIOXIDANT; GLUTATHIONE PEROXIDASE;

ARTICLE; CLINICAL ARTICLE; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SELENIUM BLOOD LEVEL; SEPSIS; UMBILICAL VEIN ENDOTHELIAL CELL; ZINC BLOOD LEVEL; ADOLESCENT; ADULT; AGED; BLOOD; CELL CULTURE; DEFICIENCY; DRUG EFFECTS; ENDOTHELIUM CELL; FEMALE; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIOXIDANTS; CELLS, CULTURED; CRITICAL ILLNESS; ENDOTHELIAL CELLS; FEMALE; GLUTATHIONE PEROXIDASE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-6; MALE; MIDDLE AGED; MITOCHONDRIA; OXIDATIVE STRESS; SELENIUM; SEPSIS; YOUNG ADULT; ZINC;

EID: 84937965462     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aev073     Document Type: Article

References (41)

1. Crouser ED. Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome. Mitochondrion 2004; 4: 729-41
2. Rink L, Gabriel P. Zinc and the immune system. Proc Nutr Soc 2000; 59: 541-52
3. Hambidge M. Human zinc deficiency. J Nutr 2000; 130: 1344S-9S
4. Coyle P, Philcox JC, Carey LC, Rofe AM. Metallothionein: the multipurpose protein. Cell Mol Life Sci 2002; 59: 627-47
5. Holben DH, Smith AM. The diverse role of selenium within selenoproteins: a review. J Am Diet Assoc 1999; 99: 836-43
6. KhoCW, Park SG, Lee DH, et al. Activity staining of glutathione peroxidase after two-dimensional gel electrophoresis. Mol Cells 2004; 18: 369-73
7. Kumar A, Ray P, Kanwar M, Sharma M, Varma S. A comparative analysis of antibody repertoire against Staphylococcus aureus antigens in patients with deep-seated versus superficial staphylococcal infections. Int J Med Sci 2005; 2: 129-36
8. Yang TT, Sinai P, Kain SR. An acid phosphatase assay for quantifying the growth of adherent and nonadherent cells. Anal Biochem 1996; 241: 103-8
9. Lowes DA, Galley HF. Mitochondrial protection by the thioredoxin-2 and glutathione systems in an in vitro endothelial model of sepsis. Biochem J 2011; 436: 123-32
10. Galley HF, Lowes DA, Allen L, Cameron G, Aucott LS, Webster NR. Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis. J Pineal Res 2014; 56: 427-38
11. Lowes DA, Almawash AM, Webster NR, Reid VL, Galley HF. Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis. Br J Anaesth 2011; 107: 193-201
12. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20: 864-74
13. Goode HF, Kelleher J, Walker BE. Zinc concentrations in pure populations of peripheral blood neutrophils, lymphocytes and monocytes. Ann Clin Biochem 1989; 26: 89-95
14. Hill AL, Lowes DA, Webster NR, Sheth CC, Gow NAR, Galley HF. Regulation of pentraxin-3 by antioxidants. Br J Anaesth 2009; 103: 833-9
15. Gustafsson A, Ljunggren L, Bodelsson M, Berkestedt I. The prognostic value of suUPAR compared to other inflammatory markers in patients with severe sepsis. Biomark Insights 2012; 7: 39-44
16. Morgan PE, Pattison DI, Talib J, et al. High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase. Free Radic Biol Med 2011; 51: 1815-22
17. Hawkins CL, Morgan PE, Davies MJ. Quantification of protein modification by oxidants. Free Radic Biol Med 2009; 46: 965-88
18. Lei XG, Evenson JK, Thompson KM, Sunde RA. Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium. J Nutr 1995; 125: 1438-46
19. Strachan S. Trace elements. Curr Anaesth Crit Care 2010; 21: 44-8
20. Prasad AS, Bao B, Beck FWJ, Sarkar FH. Zinc-suppressed inflammatory cytokines by induction of A20-mediated inhibition of nuclear factor-κB. Nutrition 2011; 27: 816-23
21. Ho E, Courtemanche C, Ames BN. Zinc deficiency induces oxidative DNA damage and increases P53 expression in human lung fibroblasts. J Nutr 2003; 133: 2543-8
22. Liu M, Bao S, Gálvez-Peralta M, et al. ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB. Cell Rep 2013; 3: 386-400
23. Garrabou G, Morén C, López S, et al. The effects of sepsis on mitochondria. J Infect Dis 2012; 205: 392-400
24. Davies MJ. The oxidative environment and protein damage. Biochim Biophys Acta 2005; 1703: 93-109
25. Davies MJ. Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention. J Clin Biochem Nutr 2011; 48: 8-19
26. Skaff O, Pattison DI, Morgan PE, et al. Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage. Biochem J 2012; 441: 305-16
27. Cook NL, Pattison DI, Davies MJ. Myeloperoxidase-derived oxidants rapidly oxidize and disrupt zinc-cysteine/histidine clusters in proteins. Free Radic Biol Med 2012; 53: 2072-80
28. Nedoboy PE, Morgan PE, Mocatta TJ, Richards AM, Winterbourn CC, Davies MJ. High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction. Free Radic Res 2014; 48: 1256-66
29. van der Veen BS, deWinther MP, Heeringa P. Myeloperoxidase: molecularmechanisms of action and their relevance to human health and disease. Antioxid Redox Signal 2009; 11: 2899-937
30. Cander B, Dundar ZD, Gul M, Girisgin S. Prognostic value of serum zinc levels in critically ill patients. J Crit Care 2011; 26: 42-6
31. Duncan A, Dean P, Simm M, O'Reilly DS, Kinsella J. Zinc supplementation in intensive care: results of a UK survey. J Crit Care 2012; 27: 102.e1-6
32. Taylor CM, Goode HF, Aggett PJ, Bremner I, Walker BE, Kelleher J. Symptomatic zinc deficiency in experimental zinc deprivation. J Clin Pathol 1992; 45: 83-4
33. Cvijanovich NZ, King JC, Flori HR, Gildengorin G, Wong HR. Zinc homeostasis in pediatric critical illness. Pediatr Crit Care Med 2009; 10: 29-34
34. Liuzzi JP, Lichten LA, Rivera S, et al. Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci USA 2005; 102: 6843-8
35. King JC. Does zinc absorption reflect zinc status? Int J Vitam Nutr Res 2010; 80: 300-6
36. Sakr Y, Maia VPL, Santos C, et al. Adjuvant selenium supplementation in the form of sodium selenite in postoperative critically ill patients with severe sepsis. Crit Care 2014; 18: R68
37. Huang TS, Shyu YC, Chen HY, et al. Effect of parenteral selenium supplementation in critically ill patients: a systematic review and meta-analysis. PLoS ONE 2013; 8: e54431
38. Maehira F, Luyo GA, Miyagi I, et al. Alterations of serum selenium concentrations in the acute phase of pathological conditions. Clin Chim Acta 2002; 316: 137-46
39. Defi IR, Yamazaki C, Kameo S, et al. Acute phase response of selenium status and glutathione peroxidase activity in blood plasma before and after total knee arthroplasty surgery. Biol Trace Elem Res 2011; 144: 388-95
40. Besecker BY, Exline MC, Hollyfield J, et al. A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission. Am J Clin Nutr 2011; 93: 1356-64
41. Visser J, Labadarios D, Blaauw R. Micronutrient supplementation for critically ill adults: a systematic review and metaanalysis. Nutrition 2011; 27: 745-58