Zinc homeostasis in pediatric critical illness

Pediatric Critical Care Medicine

Volumn 10, Issue 1, 2009, Pages 29-34

  Cvijanovich, Natalie Z ^a   King, Janet C ^a   Flori, Heidi R ^a   Gildengorin, Ginny ^a   Wong, Hector R ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Critical illness; Inflammation; Metallothionein; Multiple organ failure; Pediatrics; Zinc

Indexed keywords

C REACTIVE PROTEIN; COPPER; CYTOKINE; INTERLEUKIN 6; METALLOTHIONEIN; METALLOTHIONEIN 1A; METALLOTHIONEIN 1B; METALLOTHIONEIN 1E; METALLOTHIONEIN 1F; METALLOTHIONEIN 1G; METALLOTHIONEIN 1H; METALLOTHIONEIN 1K; METALLOTHIONEIN 1X; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BLOOD SAMPLING; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; COPPER BLOOD LEVEL; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; FEMALE; HOMEOSTASIS; HOSPITAL ADMISSION; HUMAN; HYPOALBUMINEMIA; INFANT; INFLAMMATION; INTENSIVE CARE UNIT; MALE; MULTIPLE ORGAN FAILURE; PEDIATRIC HOSPITAL; PILOT STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; SCHOOL CHILD; TERTIARY HEALTH CARE; ZINC BLOOD LEVEL;

ALBUMINS; BLOOD CHEMICAL ANALYSIS; CHILD; CHILD, PRESCHOOL; COPPER; CRITICAL ILLNESS; FEMALE; HOMEOSTASIS; HUMANS; INFANT; INFLAMMATION MEDIATORS; INTENSIVE CARE UNITS, PEDIATRIC; INTERLEUKIN-6; LINEAR MODELS; MALE; METALLOTHIONEIN; MULTIPLE ORGAN FAILURE; PILOT PROJECTS; PROBABILITY; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SURVIVAL RATE; ZINC;

EID: 70349199272     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e31819371ce     Document Type: Article

References (23)

1. Brown KH, Peerson JM, Rivera J, et al: Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: A meta-analysis of randomized controlled trials. Am J Clin Nutr 2002; 75:1062-1071
2. Ho E, Courtemanche C, Ames BN: Zinc de-ficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. J Nutr 2003; 133:2543-2548
3. Frederickson CJ, Suh SW, Silva D, et al: Importance of zinc in the central nervous system: The zinc-containing neuron. J Nutr 2000; 130(5S Suppl):1471S-1483S
4. Fraker PJ, King LE: Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr 2004; 24:277-298
5. King JC, Shames DM, Woodhouse LR: Zinc homeostasis in humans. J Nutr 2000; 130(5S Suppl):1360S-1366S
6. King LE, Fraker PJ: Variations in the cell cycle status of lymphopoietic and myelopoietic cells created by zinc deficiency. J Infect Dis 2000; 182 (Suppl 1):S16-S22
7. Couzy F, Mansourian R, Labate A, et al: Effect of dietary phytic acid on zinc absorption in the healthy elderly, as assessed by serum concentration curve tests. Br J Nutr 1998; 80:177-182
8. Coyle P, Philcox JC, Carey LC, et al: Metal-lothionein: The multipurpose protein. Cell Mol Life Sci 2002; 59:627-647
9. Kanekiyo M, Itoh N, Kawasaki A, et al: Metallothionein modulates lipopolysaccharide-stimulated tumour necrosis factor expression in mouse peritoneal macrophages. Biochem J 15 2002; 361(Pt 2):363-369
10. Waelput W, Broekaert D, Vandekerckhove J, et al: A mediator role for metallothionein in tumor necrosis factor-induced lethal shock. J Exp Med 2001; 194:1617-1624
11. Maret W: Cellular zinc and redox states converge in the metallothionein/thionein pair. J Nutr 2003; 133(Suppl 1):1460S-1462S
12. Wong HR, Shanley TP, Sakthivel B, et al: Genome level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics 2007; 30:146-155
13. Pollack MM, Patel KM, Ruttimann UE: PRISM III: An updated pediatric risk of mortality score. Crit Care Med 1996; 24:743-752
14. Proulx F, Gauthier M, Nadeau D, et al: Timing and predictors of death in pediatric patients with multiple organ system failure. Crit Care Med 1994; 22:1025-1031
15. Hotz C, Peerson JM, Brown KH: Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: Reanalysis of the second National Health and Nutrition Examination Survey data (1976-1980). Am J Clin Nutr 2003; 78:756-764
16. Gaetke LM, McClain CJ, Talwalkar RT, et al: Effects of endotoxin on zinc metabolism in human volunteers. Am J Physiol 1997; 272(Pt 1):E952-E956
17. Duggan C, MacLeod WB, Krebs NF, et al: Plasma zinc concentrations are depressed during the acute phase response in children with falciparum malaria. J Nutr 2005; 135: 802-807
18. Boosalis MG, Solem LD, McCall JT, et al: Serum zinc response in thermal injury. J Am Coll Nutr 1988; 7:69-76
19. Uckan D, Cetin M, Dincer N, et al: Serum zinc and alkaline phosphatase values in pediatric bone marrow transplantation patients. Pediatr Hema-tol Oncol 2003; 20:265-271
20. Brooks WA, Santosham M, Naheed A, et al: Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: Randomised controlled trial. Lancet 2005; 366:999-1004
21. Brooks WA, Yunus M, Santoshan M, et al: Zinc for severe pneumonia in very young children: Double-blind placebo-controlled trial. Lancet 2004; 363:1683-1688
22. Liuzzi JP, Lichten LA, Rivera S, et al: In-terleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hy-pozincemia of the acute-phase response. Proc Natl Acad Sci USA 2005; 102: 6843-6848
23. Frederickson CJ, Maret W, Cuajungco MP: Zinc and excitotoxic brain injury: A new model. Neuroscientist 2004; 10:18-25