-
1
-
-
84855829764
-
Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina with a combination of linezolid, moxifloxacin, and thioridazine
-
Abbate E., Vescovo M., Natiello M., Cufre M., Garcia A., Gonzalez Montaner P., Ambroggi M., Ritacco V., van Soolingen D. Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina with a combination of linezolid, moxifloxacin, and thioridazine. J. Antimicrob. Chemother. 2012, 67:473-477.
-
(2012)
J. Antimicrob. Chemother.
, vol.67
, pp. 473-477
-
-
Abbate, E.1
Vescovo, M.2
Natiello, M.3
Cufre, M.4
Garcia, A.5
Gonzalez Montaner, P.6
Ambroggi, M.7
Ritacco, V.8
van Soolingen, D.9
-
2
-
-
84865434996
-
Amino acid-derived 1,2-benisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets
-
Alex D., Fay-Andrieu F., May J., Thampi L., Dou D., Mooney A., Groutas W., Calderone R. Amino acid-derived 1,2-benisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets. Antimicrob. Agents Chemother. 2012, 56:4630-4639.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 4630-4639
-
-
Alex, D.1
Fay-Andrieu, F.2
May, J.3
Thampi, L.4
Dou, D.5
Mooney, A.6
Groutas, W.7
Calderone, R.8
-
3
-
-
70349616273
-
Screen for specific modulators of autophagy reveals novel therapeutic inhibitors of TORC1 signaling
-
Balgi A.D., Fonesca B.D., Donahue E., Tsang T.C.F., Lajoie P., Proud C.G., Nabi I.R., Roberge M. Screen for specific modulators of autophagy reveals novel therapeutic inhibitors of TORC1 signaling. PLoS ONE 2009, 4:e7124.
-
(2009)
PLoS ONE
, vol.4
, pp. e7124
-
-
Balgi, A.D.1
Fonesca, B.D.2
Donahue, E.3
Tsang, T.C.F.4
Lajoie, P.5
Proud, C.G.6
Nabi, I.R.7
Roberge, M.8
-
4
-
-
70149095995
-
Independent association of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of combined cohort of 262 patients
-
Bicanic T., Muzoora C., Brouwer A.E., Meintjes G., Longley N., Taseera K., Rebe K., Loyse A., Jarivis J., Bekker L.G., Wood R., Limmathurostakul D., Chierakul W., Stepniewska K., White N.J., Jaffar S., Harrison T.S. Independent association of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of combined cohort of 262 patients. Clin. Infect. Dis. 2009, 49:702-709.
-
(2009)
Clin. Infect. Dis.
, vol.49
, pp. 702-709
-
-
Bicanic, T.1
Muzoora, C.2
Brouwer, A.E.3
Meintjes, G.4
Longley, N.5
Taseera, K.6
Rebe, K.7
Loyse, A.8
Jarivis, J.9
Bekker, L.G.10
Wood, R.11
Limmathurostakul, D.12
Chierakul, W.13
Stepniewska, K.14
White, N.J.15
Jaffar, S.16
Harrison, T.S.17
-
5
-
-
84872254791
-
Drug repurposing in chemical genomics: can we learn from the past to improve the future?
-
Bisson W. Drug repurposing in chemical genomics: can we learn from the past to improve the future?. Curr. Top. Med. Chem. 2012, 12:1867-1868.
-
(2012)
Curr. Top. Med. Chem.
, vol.12
, pp. 1867-1868
-
-
Bisson, W.1
-
6
-
-
84866953429
-
Antifungal drug discovery: something old and something new
-
Butts A., Krysan D.J. Antifungal drug discovery: something old and something new. PLoS Pathog. 2012, 8:e1002870.
-
(2012)
PLoS Pathog.
, vol.8
, pp. e1002870
-
-
Butts, A.1
Krysan, D.J.2
-
7
-
-
84873109558
-
A re-purposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis
-
Butts A., DiDone L., Koselny K., Baxter B.K., Chabrier-Rosello Y., Wellington M., Krysan D.J. A re-purposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis. Eukaryot. Cell 2013, 12:278-287.
-
(2013)
Eukaryot. Cell
, vol.12
, pp. 278-287
-
-
Butts, A.1
DiDone, L.2
Koselny, K.3
Baxter, B.K.4
Chabrier-Rosello, Y.5
Wellington, M.6
Krysan, D.J.7
-
8
-
-
84903369179
-
Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF-hand proteins and synergize with fluconazole in vivo
-
Butts A., Koselny K., Chabrier-Roselló Y., Semighini C.P., Brown J.C.S., Wang X., Annadurai S., DiDon L., Tabroff J., Childers W.E., Abou-Gharbia M., Wellington M., Cardenas M.E., Madhani H.D., Heitman J., Krysan D.J. Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF-hand proteins and synergize with fluconazole in vivo. mBio 2014, 5:e00765.
-
(2014)
mBio
, vol.5
, pp. e00765
-
-
Butts, A.1
Koselny, K.2
Chabrier-Roselló, Y.3
Semighini, C.P.4
Brown, J.C.S.5
Wang, X.6
Annadurai, S.7
DiDon, L.8
Tabroff, J.9
Childers, W.E.10
Abou-Gharbia, M.11
Wellington, M.12
Cardenas, M.E.13
Madhani, H.D.14
Heitman, J.15
Krysan, D.J.16
-
10
-
-
33746381549
-
A clinical drug library screen identifies astemizole as an antimalarial agent
-
Chong C.R., Chen X., Shi L., Liu J.O., Sullivan D.J. A clinical drug library screen identifies astemizole as an antimalarial agent. Nat. Chem. Biol. 2006, 2:415-416.
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 415-416
-
-
Chong, C.R.1
Chen, X.2
Shi, L.3
Liu, J.O.4
Sullivan, D.J.5
-
11
-
-
84875765407
-
Combination therapy for cryptococcal meningitis
-
Day J.N., Chau T.T., Wolbers M., et al. Combination therapy for cryptococcal meningitis. N. Engl. J. Med. 2013, 368:1291-1302.
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 1291-1302
-
-
Day, J.N.1
Chau, T.T.2
Wolbers, M.3
-
12
-
-
77956678680
-
A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis
-
DiDone L., Scrimale T., Baxter B.K., Krysan D.J. A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis. Nat. Protoc. 2010, 5:1107-1114.
-
(2010)
Nat. Protoc.
, vol.5
, pp. 1107-1114
-
-
DiDone, L.1
Scrimale, T.2
Baxter, B.K.3
Krysan, D.J.4
-
13
-
-
80052955028
-
Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives
-
Dou D., Alex D., Du B., Tiew K.C., Aravapalli S., Mandadapu S.R., Calderone R., Groutas W.C. Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives. Bioorg. Med. Chem. 2011, 19:5782-5787.
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 5782-5787
-
-
Dou, D.1
Alex, D.2
Du, B.3
Tiew, K.C.4
Aravapalli, S.5
Mandadapu, S.R.6
Calderone, R.7
Groutas, W.C.8
-
14
-
-
27544434211
-
Lineage-specific gene loss following mitochondrial endosymbiosis and its potential for function prediction in eukaryotes
-
Gabaldon T., Huynen M.A. Lineage-specific gene loss following mitochondrial endosymbiosis and its potential for function prediction in eukaryotes. Bioinformatics 2005, 21:S144-150.
-
(2005)
Bioinformatics
, vol.21
, pp. S144-150
-
-
Gabaldon, T.1
Huynen, M.A.2
-
15
-
-
77951237516
-
Mechanism of synergistic effect of amiodarone and fluconazole in C. albicans
-
Gamarra S., Rocha E.M., Zhang Y.Q., Parks S., Rao R., Perlin D. Mechanism of synergistic effect of amiodarone and fluconazole in C. albicans. Antimicrob. Agents Chemother. 2010, 54:153-1761.
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 153-1761
-
-
Gamarra, S.1
Rocha, E.M.2
Zhang, Y.Q.3
Parks, S.4
Rao, R.5
Perlin, D.6
-
16
-
-
80052856780
-
Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis and fusariosis
-
Hata K., Horii T., Miyazaki M., Watanabe N.A., Okubo M., Sonoda J., Nakamoto K., Tanaka K., Shirotori S., Murai N., Inoue S., Matsukura M., Abe S., Yoshimatsu K., Asada M. Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis and fusariosis. Antimicrob. Agents Chemother. 2011, 55:4543-4551.
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 4543-4551
-
-
Hata, K.1
Horii, T.2
Miyazaki, M.3
Watanabe, N.A.4
Okubo, M.5
Sonoda, J.6
Nakamoto, K.7
Tanaka, K.8
Shirotori, S.9
Murai, N.10
Inoue, S.11
Matsukura, M.12
Abe, S.13
Yoshimatsu, K.14
Asada, M.15
-
17
-
-
0025811453
-
Distribution of tamoxifen and metabolites into brain tissue and brain metastases in breast cancer patients
-
Lein E.A., Wester K., Lonning P.E., Solheim E., Ueland P.M. Distribution of tamoxifen and metabolites into brain tissue and brain metastases in breast cancer patients. Br. J. Cancer 1991, 63:641-645.
-
(1991)
Br. J. Cancer
, vol.63
, pp. 641-645
-
-
Lein, E.A.1
Wester, K.2
Lonning, P.E.3
Solheim, E.4
Ueland, P.M.5
-
18
-
-
42049087374
-
In vitro and in vivo antifungal activities of T-2307, a novel arylamidine
-
Mitsuyama J., Nomura N., Hashiomoto K., Yamada E., Nishikawa H., Kaeriyama M., Kimura A., Todo Y., Narita H. In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. Antimicrob. Agents Chemother. 2008, 52:1318-1324.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 1318-1324
-
-
Mitsuyama, J.1
Nomura, N.2
Hashiomoto, K.3
Yamada, E.4
Nishikawa, H.5
Kaeriyama, M.6
Kimura, A.7
Todo, Y.8
Narita, H.9
-
19
-
-
0037416986
-
Clinical concentrations of thioridazine kill intracellular multi-drug resistant Mycobacterium tuberculosis
-
Ordway D., Viveiros L., Bettencourt R., Aleida J., Martins M., Kristiansen J.E., Molnar J., Amaral L. Clinical concentrations of thioridazine kill intracellular multi-drug resistant Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 2003, 47:917-922.
-
(2003)
Antimicrob. Agents Chemother.
, vol.47
, pp. 917-922
-
-
Ordway, D.1
Viveiros, L.2
Bettencourt, R.3
Aleida, J.4
Martins, M.5
Kristiansen, J.E.6
Molnar, J.7
Amaral, L.8
-
20
-
-
62349130224
-
Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS
-
Park B.J., Wannemuehler K.A., Marston B.J., Govender N., Pappas P.G., Chiller T.M. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 2009, 23:525-530.
-
(2009)
AIDS
, vol.23
, pp. 525-530
-
-
Park, B.J.1
Wannemuehler, K.A.2
Marston, B.J.3
Govender, N.4
Pappas, P.G.5
Chiller, T.M.6
-
21
-
-
84875767957
-
Efficiently killing a sugar-coated yeast
-
Perfect J.R. Efficiently killing a sugar-coated yeast. N. Engl. J. Med. 2013, 368:1354-1356.
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 1354-1356
-
-
Perfect, J.R.1
-
22
-
-
75749092958
-
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America
-
Perfect J.R., Dismukes W.E., Dromer F., Goldman D.L., Graybill J.R., Hamill R.J., Harrison T.S., Larsen R.A., Lortholary O., Nguyen M.H., Pappas P.G., Powderly W.G., Singh N., Sobel J.D., Sorrell T.C. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America. Clin. Infect. Dis. 2010, 50:291-322.
-
(2010)
Clin. Infect. Dis.
, vol.50
, pp. 291-322
-
-
Perfect, J.R.1
Dismukes, W.E.2
Dromer, F.3
Goldman, D.L.4
Graybill, J.R.5
Hamill, R.J.6
Harrison, T.S.7
Larsen, R.A.8
Lortholary, O.9
Nguyen, M.H.10
Pappas, P.G.11
Powderly, W.G.12
Singh, N.13
Sobel, J.D.14
Sorrell, T.C.15
-
23
-
-
84881369581
-
Synthesis and antifungal activities of miltefosine analogs
-
Ravu R.R., Chen Y.L., Jacob M.R., Pan X., Agarwal A.K., Khan S.I., Heitman J., Clark A.M., Li X.C. Synthesis and antifungal activities of miltefosine analogs. Bioorg. Med. Chem. Lett. 2013, 23:4828-4831.
-
(2013)
Bioorg. Med. Chem. Lett.
, vol.23
, pp. 4828-4831
-
-
Ravu, R.R.1
Chen, Y.L.2
Jacob, M.R.3
Pan, X.4
Agarwal, A.K.5
Khan, S.I.6
Heitman, J.7
Clark, A.M.8
Li, X.C.9
-
24
-
-
0026064491
-
Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient
-
Robinson S.P., Langan-Fahey S.M., Johnson D.A., Jordan V.C. Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient. Drug Metab. Dispos. 1991, 19:36-43.
-
(1991)
Drug Metab. Dispos.
, vol.19
, pp. 36-43
-
-
Robinson, S.P.1
Langan-Fahey, S.M.2
Johnson, D.A.3
Jordan, V.C.4
-
25
-
-
84922217054
-
Antifungal drug development: challenges, unmet clinical needs, and new approaches
-
Roemer T., Krysan D.J. Antifungal drug development: challenges, unmet clinical needs, and new approaches. Cold Spring Harb. Perspect. Med. 2014, 1:4.
-
(2014)
Cold Spring Harb. Perspect. Med.
, vol.1
, pp. 4
-
-
Roemer, T.1
Krysan, D.J.2
-
26
-
-
84880954681
-
Cryptococcosis due to Cryptococcus gattii
-
Rolston K.V. Cryptococcosis due to Cryptococcus gattii. Clin. Infect. Dis. 2013, 57:552-554.
-
(2013)
Clin. Infect. Dis.
, vol.57
, pp. 552-554
-
-
Rolston, K.V.1
-
27
-
-
84868007836
-
T-2307 causes collapse of mitochondrial membrane potential in yeast
-
Shibata T., Takahashi T., Yamada E., Kimura A., Nishikawa H., Hayakawa H., Nomura N., Mitsuyama J. T-2307 causes collapse of mitochondrial membrane potential in yeast. Antimicrob. Agents Chemother. 2012, 56:5892-5897.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 5892-5897
-
-
Shibata, T.1
Takahashi, T.2
Yamada, E.3
Kimura, A.4
Nishikawa, H.5
Hayakawa, H.6
Nomura, N.7
Mitsuyama, J.8
-
28
-
-
70249093302
-
Treatment of cryptococcal meningitis in resource-limited settings
-
Sloan D.J., Dedicoat M.J., Lalloo D.G. Treatment of cryptococcal meningitis in resource-limited settings. Curr. Opin. Infect. Dis. 2009, 22:455-463.
-
(2009)
Curr. Opin. Infect. Dis.
, vol.22
, pp. 455-463
-
-
Sloan, D.J.1
Dedicoat, M.J.2
Lalloo, D.G.3
-
29
-
-
79959580788
-
Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole
-
Spitzer M., Griffiths E., Blakely K.M., Wildenhain J., Tyers M., Wright G.D. Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole. Mol. Syst. Biol. 2011, 7:499.
-
(2011)
Mol. Syst. Biol.
, vol.7
, pp. 499
-
-
Spitzer, M.1
Griffiths, E.2
Blakely, K.M.3
Wildenhain, J.4
Tyers, M.5
Wright, G.D.6
-
30
-
-
34249069582
-
Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections
-
Steinbach W.J., Reedy J.L., Cramer R.A., Perfect J.R., Heitman J. Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nat. Rev. Microbiol. 2007, 5:418-430.
-
(2007)
Nat. Rev. Microbiol.
, vol.5
, pp. 418-430
-
-
Steinbach, W.J.1
Reedy, J.L.2
Cramer, R.A.3
Perfect, J.R.4
Heitman, J.5
-
31
-
-
84902117554
-
Overcoming drug development bottlenecks with repurposing
-
Strittmatter S.M. Overcoming drug development bottlenecks with repurposing. Nat. Med. 2014, 20:590-591.
-
(2014)
Nat. Med.
, vol.20
, pp. 590-591
-
-
Strittmatter, S.M.1
-
32
-
-
0038662549
-
Medicinal genetics approach towards identifying the molecular target of a novel inhibitor of fungal cell wall assembly
-
Tsukahara K., Hata K., Nakamoto K., Sagane K., Watanabe N.A., Kuromitsu J., Kai J., Tsuchiya M., Ohba F., Jigami Y., Yoshimatsu K., Nagasu T. Medicinal genetics approach towards identifying the molecular target of a novel inhibitor of fungal cell wall assembly. Mol. Microbiol. 2003, 48:1029-1042.
-
(2003)
Mol. Microbiol.
, vol.48
, pp. 1029-1042
-
-
Tsukahara, K.1
Hata, K.2
Nakamoto, K.3
Sagane, K.4
Watanabe, N.A.5
Kuromitsu, J.6
Kai, J.7
Tsuchiya, M.8
Ohba, F.9
Jigami, Y.10
Yoshimatsu, K.11
Nagasu, T.12
-
33
-
-
76649137973
-
Astemizole and an analogue promote fungicidal activity of fluconazole against Cryptococcus neoformans var. grubii and Cryptococcus gattii
-
Vu K., Gelli A. Astemizole and an analogue promote fungicidal activity of fluconazole against Cryptococcus neoformans var. grubii and Cryptococcus gattii. Med. Mycol. 2010, 48:255-262.
-
(2010)
Med. Mycol.
, vol.48
, pp. 255-262
-
-
Vu, K.1
Gelli, A.2
-
34
-
-
1542268206
-
Selective optimization of side activities: another way for drug discovery
-
Wermuth C.G. Selective optimization of side activities: another way for drug discovery. J. Med. Chem. 2004, 47:1303-1314.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 1303-1314
-
-
Wermuth, C.G.1
-
35
-
-
31944444671
-
Hexadecylphophocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis
-
Widmer F., Wright L.C., Obando D., Handke R., Ganendren R., Ellis D.H., Sorrell T.C. Hexadecylphophocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis. Antimicrob. Agents Chemother. 2006, 50:414-421.
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, pp. 414-421
-
-
Widmer, F.1
Wright, L.C.2
Obando, D.3
Handke, R.4
Ganendren, R.5
Ellis, D.H.6
Sorrell, T.C.7
-
36
-
-
84872860214
-
Limited activity of miltefosine in murine models of cryptococcal meningoencephalitis and disseminated cryptococcosis
-
Wiederhold N.P., Najvar L.K., Bocanegra R., Kirkpatrick W.R., Sorrell T.C., Patterson T.F. Limited activity of miltefosine in murine models of cryptococcal meningoencephalitis and disseminated cryptococcosis. Antimicrob. Agents Chemoether. 2013, 57:745-750.
-
(2013)
Antimicrob. Agents Chemoether.
, vol.57
, pp. 745-750
-
-
Wiederhold, N.P.1
Najvar, L.K.2
Bocanegra, R.3
Kirkpatrick, W.R.4
Sorrell, T.C.5
Patterson, T.F.6
-
37
-
-
84872936823
-
Evaluation of the anticryptococcal activity of antibiotic polymixin B in vitro and in vivo
-
Zhai B., Lin X. Evaluation of the anticryptococcal activity of antibiotic polymixin B in vitro and in vivo. Int. J. Antimicrob. Agents 2013, 41:250-254.
-
(2013)
Int. J. Antimicrob. Agents
, vol.41
, pp. 250-254
-
-
Zhai, B.1
Lin, X.2
-
38
-
-
77953689696
-
Polymixin B, in combination with fluconazole, exerts a potent fungicidal effect
-
Zhai B., Zhou H., Yang L., Zhang J., Giam G.-Z., Xiang X., Lin X. Polymixin B, in combination with fluconazole, exerts a potent fungicidal effect. J. Antimicrob. Chemother. 2010, 65:931-938.
-
(2010)
J. Antimicrob. Chemother.
, vol.65
, pp. 931-938
-
-
Zhai, B.1
Zhou, H.2
Yang, L.3
Zhang, J.4
Giam, G.-Z.5
Xiang, X.6
Lin, X.7
-
39
-
-
84862509101
-
The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal infections
-
Zhai B., Wu C., Wang L., Sachs M.S., Lin X. The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal infections. Antimicrob. Agents Chemother. 2012, 56:3758-3766.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 3758-3766
-
-
Zhai, B.1
Wu, C.2
Wang, L.3
Sachs, M.S.4
Lin, X.5
|