Arterial structure and function in vascular ageing: Are you as old as your arteries?

Journal of Physiology

Volumn 594, Issue 8, 2016, Pages 2275-2284

  Thijssen, Dick H J ^a,b   Carter, Sophie E ^a   Green, Daniel J ^a,c  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ELASTIN; ENDOTHELIN 1; NITRIC OXIDE;

AGING; ARTERIAL STIFFNESS; ARTERY; ATHEROSCLEROSIS; BLOOD VESSEL FUNCTION; BLOOD VESSEL WALL; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL AGING; DISEASE PREDISPOSITION; HUMAN; INFLAMMATION; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; ANIMAL; GROWTH, DEVELOPMENT AND AGING; HEMODYNAMICS; METABOLISM; PATHOLOGY; PHYSIOLOGY;

AGING; ANIMALS; ARTERIES; ATHEROSCLEROSIS; HEMODYNAMICS; HUMANS;

EID: 84937919957     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/JP270597     Document Type: Review

References (100)

1. AlGhatrif M, Strait JB, Morrell CH, Canepa M, Wright J, Elango P, Scuteri A, Najjar SS, Ferrucci L & Lakatta EG (2013). Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging. Hypertension 62, 934-941.
2. Allan GM, Nouri F, Korownyk C, Kolber MR, Vandermeer B & McCormack J (2013). Agreement among cardiovascular disease risk calculators. Circulation 127, 1948-1956.
3. Asai K, Kudej RK, Takagi G, Kudej AB, Natividad F, Shen YT, Vatner DE & Vatner SF (2001). Paradoxically enhanced endothelin-B receptor-mediated vasoconstriction in conscious old monkeys. Circulation 103, 2382-2386.
4. Avolio AP, Deng FQ, Li WQ, Luo YF, Huang ZD, Xing LF & O'Rourke MF (1985). Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China. Circulation 71, 202-210.
5. Blacher J & Safar ME (2005). Large-artery stiffness, hypertension and cardiovascular risk in older patients. Nat Clin Prac Cardiovasc Med 2, 450-455.
6. Black MA, Cable NT, Thijssen DH & Green DJ (2009). Impact of age, sex, and exercise on brachial artery flow-mediated dilatation. Am J Physiol Heart Circ Physiol 297, H1109-H1116.
7. Black MA, Green DJ & Cable NT (2008). Exercise prevents age-related decline in nitric-oxide-mediated vasodilator function in cutaneous microvessels. J Physiol 586, 3511-3524.
8. Boutouyrie P, Bussy C, Hayoz D, Hengstler J, Dartois N, Laloux B, Brunner H & Laurent S (2000). Local pulse pressure and regression of arterial wall hypertrophy during long-term antihypertensive treatment. Circulation 101, 2601-2606.
9. Brownlee M (1995). Advanced protein glycosylation in diabetes and aging. Annu Rev Med 46, 223-234.
10. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK & Deanfield JE (1992). Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340, 1111-1115.
11. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J & Deanfield JE (1994). Aging is associated with endothelial dysfunction in healthy-men years before the age-related decline in women. J Am Coll Cardiol 24, 471-476.
12. Cencioni C, Spallotta F, Mai A, Martelli F, Farsetti A, Zeiher AM & Gaetano C (2015). Sirtuin function in aging heart and vessels. J Mol Cell Cardiol 83, 55-61.
13. Chauhan A, More RS, Mullins PA, Taylor G, Petch MC & Schofield PM (1996). Aging-associated endothelial dysfunction in humans is reversed by l-arginine. J Am Coll Cardiol 28, 1796-1804.
14. Chen L, Daum G, Fischer JW, Hawkins S, Bochaton-Piallat ML, Gabbiani G & Clowes AW (2000). Loss of expression of the beta subunit of soluble guanylyl cyclase prevents nitric oxide-mediated inhibition of DNA synthesis in smooth muscle cells of old rats. Cir Res 86, 520-525.
15. D'Agostino RB Sr, Vasan RS, Pencina MJ, Wolf PA, Cobain M, Massaro JM & Kannel WB (2008). General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 117, 743-753.
16. de Ruijter W, Westendorp RG, Assendelft WJ, den Elzen WP, de Craen AJ, le Cessie S & Gussekloo J (2009). Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study. BMJ 338, a3083.
17. Dinenno FA, Jones PP, Seals DR & Tanaka H (2000). Age-associated arterial wall thickening is related to elevations in sympathetic activity in healthy humans. Am J Physiol Heart Circ Physiol 278, H1205-H1210.
18. Donato AJ, Black AD, Jablonski KL, Gano LB & Seals DR (2008). Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell 7, 805-812.
19. Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE & Seals DR (2007). Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ Res 100, 1659-1666.
20. Donato AJ, Gano LB, Eskurza I, Silver AE, Gates PE, Jablonski K & Seals DR (2009). Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase. Am J Physiol Heart Circ Physiol 297, H425-H432.
21. Donato AJ, Lesniewski LA & Delp MD (2005). The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles. Cardiovasc Res 66, 393-401.
22. Donato AJ, Morgan RG, Walker AE & Lesniewski LA (2015). Cellular and molecular biology of aging endothelial cells. J Mol Cell Cardiol, doi: 10.1016/j.yjmcc.2015.01.021.
23. Eigenbrodt ML, Bursac Z, Rose KM, Couper DJ, Tracy RE, Evans GW, Brancati FL & Mehta JL (2006). Common carotid arterial interadventitial distance (diameter) as an indicator of the damaging effects of age and atherosclerosis, a cross-sectional study of the Atherosclerosis Risk in Community Cohort Limited Access Data (ARICLAD), 1987-89. Cardiovasc Ultrasound 4, 1.
24. Engelen L, Ferreira I, Stehouwer CD, Boutouyrie P, Laurent S & Reference Values for Arterial Measurements C (2013). Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors. Eur Heart J 34, 2368-2380.
25. Erusalimsky JD (2009). Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol (1985) 106, 326-332.
26. Eskurza I, Monahan KD, Robinson JA & Seals DR (2004). Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing. J Physiol 556, 315-324.
27. Eskurza I, Myerburgh LA, Kahn ZD & Seals DR (2005). Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. J Physiol 568, 1057-1065.
28. Folkow B ( 1978). The fourth Volhard lecture: cardiovascular structural adaptation; its role in the initiation and maintenance of primary hypertension. Clin Sci Mol Med Suppl 4, 3s-22 s.
29. Fritze O, Romero B, Schleicher M, Jacob MP, Oh DY, Starcher B, Schenke-Layland K, Bujan J & Stock UA (2012). Age-related changes in the elastic tissue of the human aorta. J Vasc Res 49, 77-86.
30. Gano LB, Donato AJ, Pierce GL, Pasha HM, Magerko KA, Roeca C & Seals DR (2011). Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise. Physiol Genomics 43, 895-902.
31. Gerhard M, Roddy MA, Creager SJ & Creager MA (1996). Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 27, 849-853.
32. Green DJ, Dawson EA, Groenewoud HMM, Jones H & Thijssen DHJ (2014). Is flow-mediated dilation nitric oxide mediated? A meta-analysis. Hypertension 63, 376-382.
33. Green DJ, Jones H, Thijssen D, Cable NT & Atkinson G (2011). Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter? Hypertension 57, 363-369.
34. Green DJ, Swart A, Exterkate A, Naylor LH, Black MA, Cable NT & Thijssen DH (2010). Impact of age, sex and exercise on brachial and popliteal artery remodelling in humans. Atherosclerosis 210, 525-530.
35. Higashi Y, Sasaki S, Nakagawa K, Kimura M, Noma K, Hara K, Jitsuiki D, Goto C, Oshima T, Chayama K & Yoshizumi M (2006). Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production. Atherosclerosis 186, 390-395.
36. Holowatz LA, Houghton BL, Wong BJ, Wilkins BW, Harding AW, Kenney WL & Minson CT (2003). Nitric oxide and attenuated reflex cutaneous vasodilation in aged skin. Am J Physiol Heart Circ Physiol 284, H1662-H1667.
37. Holowatz LA, Thompson CS & Kenney WL (2006). l-arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin. J Physiol 574, 573-581.
38. Homma S, Hirose N, Ishida H, Ishii T & Araki G (2001). Carotid plaque and intima-media thickness assessed by b-mode ultrasonography in subjects ranging from young adults to centenarians. Stroke 32, 830-835.
39. IJzerman RG, de Jongh RT, Beijk MAM, van Weissenbruch MM, Delemarre-van de Waal HA, Serne EH & Stehouwer CDA (2003). Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin. Eur J Clin Invest 33, 536-542.
40. Inaba Y, Chen JA & Bergmann SR (2010). Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis. Int J Cardiovasc Imaging 26, 631-640.
41. Jensen-Urstad K, Jensen-Urstad M & Johansson J (1999). Carotid artery diameter correlates with risk factors for cardiovascular disease in a population of 55-year-old subjects. Stroke 30, 1572-1576.
42. Johnson KM, Dowe DA & Brink JA (2009). Traditional clinical risk assessment tools do not accurately predict coronary atherosclerotic plaque burden: a CT angiography study. AJR Am J Roentgenol 192, 235-243.
43. Kannel WB, Dawber TR, Kagan A, Revotskie N & Stokes J3rd (1961). Factors of risk in the development of coronary heart disease - six year follow-up experience. The Framingham Study. Ann Int Med 55, 33-50.
44. Kloss S, Bouloumie A & Mulsch A (2000). Aging and chronic hypertension decrease expression of rat aortic soluble guanylyl cyclase. Hypertension 35, 43-47.
45. Kovacic JC, Moreno P, Hachinski V, Nabel EG & Fuster V (2011). Cellular senescence, vascular disease, and aging: Part 1 of a 2-part review. Circulation 123, 1650-1660.
46. Labropoulos N, Zarge J, Mansour MA, Kang SS & Baker WH (1998). Compensatory arterial enlargement is a common pathobiologic response in early atherosclerosis. Am J Surg 176, 140-143.
47. Lakatta EG & Levy D (2003). Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease. Circulation 107, 139-146.
48. Lorenz MW, Markus HS, Bots ML, Rosvall M & Sitzer M (2007). Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 115, 459-467.
49. Lorenz MW, Schaefer C, Steinmetz H & Sitzer M (2010). Is carotid intima media thickness useful for individual prediction of cardiovascular risk? Ten-year results from the Carotid Atherosclerosis Progression Study (CAPS). Eur Heart J 31, 2041-2048.
50. Lorenz MW, von Kegler S, Steinmetz H, Markus HS & Sitzer M (2006). Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke 37, 87-92.
51. Mahmood SS, Levy D, Vasan RS & Wang TJ (2014). The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective. Lancet 383, 999-1008.
52. Meyer ML, Tanaka H, Palta P, Cheng S, Gouskova N, Aguilar D & Heiss G (2015). Correlates of segmental pulse wave velocity in older adults: The Atherosclerosis Risk in Communities (ARIC) Study. Am J Hypertens, pii: hpv079, PMID: 26045531.
53. Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H & Komuro I (2002). Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 105, 1541-1544.
54. Montero D, Pierce GL, Stehouwer CD, Padilla J & Thijssen DH (2015). The impact of age on vascular smooth muscle function in humans. J Hypertens 33, 445-453; discussion 453.
55. Moreau KL, Donato AJ, Seals DR, DeSouza CA & Tanaka H (2003). Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women. Cardiovascular Research 57, 861-868.
56. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G et al. (2003). From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation 108, 1772-1778.
57. Najjar SS, Scuteri A & Lakatta EG (2005). Arterial aging: is it an immutable cardiovascular risk factor? Hypertension 46, 454-462.
58. O'Rourke MF & Hashimoto J (2007). Mechanical factors in arterial aging: a clinical perspective. J Am Coll Cardiol 50, 1-13.
59. Oudegeest-Sander MH, Olde Rikkert MG, Smits P, Thijssen DH, van Dijk AP, Levine BD & Hopman MT (2013). The effect of an advanced glycation end-product crosslink breaker and exercise training on vascular function in older individuals: a randomized factorial design trial. Exp Gerontol 48, 1509-1517.
60. Paneni F, Costantino S & Cosentino F (2015). Molecular pathways of arterial aging. Clin Sci (Lond) 128, 69-79.
61. Parker BA, Ridout SJ & Proctor DN (2006). Age and flow-mediated dilation: a comparison of dilatory responsiveness in the brachial and popliteal arteries. Am J Physiol Heart Circ Physiol 291, H3043-H3049.
62. Pierce GL & Larocca TJ (2008). Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults? J Physiol 586, 2673-2674.
63. Pierce GL, Lesniewski LA, Lawson BR, Beske SD & Seals DR (2009). Nuclear factor-κB activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation 119, 1284-1292.
64. Polak JF, Kronmal RA, Tell GS, O'Leary DH, Savage PJ, Gardin JM, Rutan GH & Borhani NO (1996). Compensatory increase in common carotid artery diameter. Relation to blood pressure and artery intima-media thickness in older adults. Cardiovascular Health Study. Stroke 27, 2012-2015.
65. Polak JF, Pencina MJ, Meisner A, Pencina KM, Brown LS, Wolf PA & D'Agostino RB Sr (2010). Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT. J Ultrasound Med 29, 1759-1768.
66. Ras RT, Streppel MT, Draijer R & Zock PL (2013). Flow-mediated dilation and cardiovascular risk prediction: A systematic review with meta-analysis. Int J Cardiol 168, 344-351.
67. Rippe C, Blimline M, Magerko KA, Lawson BR, LaRocca TJ, Donato AJ & Seals DR (2012). MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation. Exp Gerontol 47, 45-51.
68. Rodriguez-Manas L, El-Assar M, Vallejo S, Lopez-Doriga P, Solis J, Petidier R, Montes M, Nevado J, Castro M, Gomez-Guerrero C, Peiro C & Sanchez-Ferrer CF (2009). Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation. Aging Cell 8, 226-238.
69. Sandgren T, Sonesson B, Ahlgren AR & Lanne T (1998). Factors predicting the diameter of the popliteal artery in healthy humans. J Vasc Surg 28, 284-289.
70. Sandgren T, Sonesson B, Ahlgren R & Lanne T (1999). The diameter of the common femoral artery in healthy human: influence of sex, age, and body size. J Vasc Surg 29, 503-510.
71. Schachinger V, Britten MB & Zeiher AM (2000). Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101, 1899-1906.
72. Schmidt-Trucksass A, Grathwohl D, Schmid A, Boragk R, Upmeier C, Keul J & Huonker M (1999). Structural, functional, and hemodynamic changes of the common carotid artery with age in male subjects. Arterioscler Thromb Vasc Biol 19, 1091-1097.
73. Seals DR, Jablonski KL & Donato AJ (2011). Aging and vascular endothelial function in humans. Clin Sci (Lond) 120, 357-375.
74. Shechter M, Shechter A, Koren-Morag N, Feinberg MS & Hiersch L (2014). Usefulness of brachial artery flow-mediated dilation to predict long-term cardiovascular events in subjects without heart disease. Am J Cardiol 113, 162-167.
75. Silber HA, Ouyang P, Bluemke DA, Gupta SN, Foo TK & Lima JA (2005). Why is flow-mediated dilation dependent on arterial size? Assessment of the shear stimulus using phase-contrast magnetic resonance imaging. Am J Physiol Heart Circ Physiol 288, H822-H828.
76. Singh N, Prasad S, Singer DR & MacAllister RJ (2002). Ageing is associated with impairment of nitric oxide and prostanoid dilator pathways in the human forearm. Clin Sci 102, 595-600.
77. Siontis GC, Tzoulaki I, Siontis KC & Ioannidis JP (2012). Comparisons of established risk prediction models for cardiovascular disease: systematic review. BMJ 344, e3318.
78. Taddei S, Galetta F, Virdis A, Ghiadoni L, Salvetti G, Franzoni F, Giusti C & Salvetti A (2000). Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation 101, 2896-2901.
79. Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A & Salvetti A (2001). Age-related reduction of NO availability and oxidative stress in humans. Hypertension 38, 274-279.
80. Taddei S, Virdis A, Mattei P, Ghiadoni L, Fasolo CB, Sudano I & Salvetti A (1997). Hypertension causes premature aging of endothelial function in humans. Hypertension 29, 736-743.
81. Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA & Seals DR (2000). Aging, habitual exercise, and dynamic arterial compliance. Circulation 102, 1270-1275.
82. Tanaka H, Dinenno FA, Monahan KD, DeSouza CA & Seals DR (2001). Carotid artery wall hypertrophy with age is related to local systolic blood pressure in healthy men. Arterioscler Thromb Vasc Biol 21, 82-87.
83. Tew GA, Klonizakis M & Saxton JM (2010). Effects of ageing and fitness on skin-microvessel vasodilator function in humans. Eur J Appl Physiol 109, 173-181.
84. Thijssen DH, Dawson EA, Black MA, Hopman MT, Cable NT & Green DJ (2008). Heterogeneity in conduit artery function in humans: impact of arterial size. Am J Physiol Heart Circ Physiol 295, H1927-H1934.
85. Thijssen DH, de Groot P, Kooijman M, Smits P & Hopman MT (2006). Sympathetic nervous system contributes to the age-related impairment of flow-mediated dilation of the superficial femoral artery. Am J Physiol Heart Circ Physiol 291, H3122-H3129.
86. Thijssen DH, Rongen GA, van Dijk A, Smits P & Hopman MT (2007). Enhanced endothelin-1-mediated leg vascular tone in healthy older subjects. J Appl Physiol 103, 852-857.
87. Thijssen DH, Willems L, van den Munckhof I, Scholten R, Hopman MT, Dawson EA, Atkinson G, Cable NT & Green DJ (2011). Impact of wall thickness on conduit artery function in humans: is there a "Folkow" effect? Atherosclerosis 217, 415-419.
88. van den Munckhof I, Scholten R, Cable NT, Hopman MT, Green DJ & Thijssen DH (2012). Impact of age and sex on carotid and peripheral arterial wall thickness in humans. Acta Physiol (Oxf) 206, 220-228.
89. van der Heijden-Spek JJ, Staessen JA, Fagard RH, Hoeks AP, Boudier HA & vanBortel LM (2000). Effect of age on brachial artery wall properties differs from the aorta and is gender dependent: a population study. Hypertension 35, 637-642.
90. Van Guilder GP, Westby CM, Greiner JJ, Stauffer BL & DeSouza CA (2007). Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise. Hypertension 50, 403-409.
91. Vita JA, Treasure CB, Nabel EG, McLenachan JM, Fish RD, Yeung AC, Vekshtein VI, Selwyn AP & Ganz P (1990). Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 81, 491-497.
92. Vlachopoulos C, Aznaouridis K & Stefanadis C (2010). Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 55, 1318-1327.
93. Vuilleumier P, Decosterd D, Maillard M, Burnier M & Hayoz D (2002). Postischemic forearm skin reactive hyperemia is related to cardovascular risk factors in a healthy female population. J Hypertens 20, 1753-1757.
94. Wang TJ, Gona P, Larson MG, Tofler GH, Levy D, Newton-Cheh C, Jacques PF, Rifai N, Selhub J, Robins SJ, Benjamin EJ, D'Agostino RB & Vasan RS (2006). Multiple biomarkers for the prediction of first major cardiovascular events and death. New Eng J Med 355, 2631-2639.
95. Weidinger F, Frick M, Alber HF, Ulmer H, Schwarzacher SP & Pachinger O (2002). Association of wall thickness of the brachial artery measured with high-resolution ultrasound with risk factors and coronary artery disease. Am J Cardiol 89, 1025-1029.
96. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H & Kannel WB (1998). Prediction of coronary heart disease using risk factor categories. Circulation 97, 1837-1847.
97. Yeboah J, Crouse JR, Hsu FC, Burke GL & Herrington DM (2007). Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation 115, 2390-2397.
98. Yeboah J, Folsom AR, Burke GL, Johnson C, Polak JF, Post W, Lima JA, Crouse JR & Herrington DM (2009). Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation 120, 502-509.
99. Zeiher AM, Drexler H, Saurbier B & Just H (1993). Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest 92, 652-662.
100. Zieman SJ & Kass DA (2004). Advanced glycation endproduct crosslinking in the cardiovascular system: potential therapeutic target for cardiovascular disease. Drugs 64, 459-470.