Physicochemical analysis and repeated-dose 90-days oral toxicity study of nanocalcium carbonate in Sprague-Dawley rats

Nanotoxicology

Volumn 9, Issue 5, 2015, Pages 603-612

  Sung, Jae Hyuck ^a,b   Park, Soo Jin ^c   Jeong, Min Sook ^c   Song, Kyung Seuk ^b   Ahn, Kyu Sup ^b   Ryu, Hyun Ryol ^b   Lee, Han ^c   Song, Mi Ryoung ^c   Cho, Myung Haing ^a,d,e   Kim, Jun Sung ^c  

^a Seoul National University   (South Korea)

^b Korea Institute of Construction Materials   (South Korea)

^c RandD Center   (South Korea)

^d Seoul National University   (South Korea)

^e Seoul National University   (South Korea)

Author keywords

90 day oral toxicity testing; Nanocalcium carbonate; Physicochemical characteristics

Indexed keywords

CALCIUM CARBONATE; MICROCALCIUM CARBONATE; NANOCALCIUM CARBONATE; NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BODY WEIGHT; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRON SPIN RESONANCE; FEMALE; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; HISTOPATHOLOGY; HYDRODYNAMICS; IONIZATION; MALE; MOUTH DISEASE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; NONHUMAN; ORAL TOXICITY; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SPIN TRAPPING; SURFACE AREA; TOXICITY TESTING; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG RELEASE; ORAL DRUG ADMINISTRATION; SOLUBILITY; SPRAGUE DAWLEY RAT; SURFACE PROPERTY;

RATTUS;

ADMINISTRATION, ORAL; ANIMALS; CALCIUM CARBONATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG LIBERATION; FEMALE; HYDROGEN-ION CONCENTRATION; MALE; NANOPARTICLES; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PARTICLE SIZE; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SURFACE PROPERTIES; TOXICITY TESTS, SUBCHRONIC;

EID: 84937917108     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2014.958587     Document Type: Article

References (24)

1. Aguilar F, Dusemund B, Galtier P, Gilbert J, Gott DM, Grilli S, et al. 2011. Scientific opinion on re-evaluation of calcium carbonate (E 170) as a food additive. EFSA J 9:2318-91.
2. Brunauer S Emmett PH, Teller E. 1938. Adsorption of gases in multimolecular layers. J Am Chem Soc 60:309-19.
3. Dickerson RN, Morgan LM, Croce MA, Minard G, Brown RO. 2007. Dose-dependent characteristics of intravenous calcium therapy for hypocalcemic critically ill trauma patients receiving specialized nutritional support. Nutrition 23:9-15.
4. Hu Q, Ji H, Liu Y, Zjang M, Xu X, Tang R. 2010. Preparing nano-calcium phosphate particles via a biologically friendly pathway. Biomed Mater 5:041001 (8p).
5. Huang S, Chen JC, Hsu CW, Chang WH. 2009. Effects of nano calcium carbonate and nano calcium citrate on toxicity in ICR mice and on bone mineral density in an ovariectomized mice model. Nanotechnology 20:375102-8.
6. Jeong MS, Cho HS, Park SJ, Song KS, Ahn KS, Cho MH, Kim JS. 2013. Physico-chemical characterization-based safety evaluation of nanocalcium. Food Chem Toxicol 60:308-17.
7. John NH. 2004. Minerals: vitamin and mineral safety. 2nd ed. Washington, DC: Council for Responsible Nutrition (CRN).
8. Joseph T, Morrison M. 2006. Nanotechnology in agriculture and food: A nanoforum report. Available at: www. nanoforum. org.
9. McCarthy JT, Kumar R. 1999. Divalent cation metabolism: calcium. disorders of water, electrolytes and acid base/acute renal failure. In: Schrier RW, Bonventre JV, Bert TW, eds. Atlas of diseases of the kidney. Hoboken: Wiley, John & Sons, Inc. Vol. 1, 5. 1-5. 14.
10. Ministry of Food and Drug Safety (MFDS) Notification No. 2013-121. Toxicity Test Standards of Medicine and Medical Supplies (5th revision, Apr 2013). Cheongju, Korea: Ministry of Food and Drug Safety. Ministry of Food and Drug Safety (MFDS) Notification No. 2013-40.
11. Principles of Good Laboratory Practice (5th revision, Apr 2013). Cheongju, Korea: Ministry of Food and Drug Safety.
12. Mozafari MR, Johnson C, Hatziantoniou S, Demetzos C. 2008. Nano liposomes and their applications in food nanotechnology. J Liposome Res 18:309-27.
13. Munday GR, Guise TA. 1999. Hormonal control of calcium homeostasis. Clin Chem 45:81347-52.
14. OECD Guideline for the Testing of Chemicals (1998). Available at: http:// www. oecd-ilibrary. org/environment/oecd-guidelines-for-the-testing-ofchemicals- chem-guide-pkg-en.
15. Park HS, Ahn J, Kwak HS. 2008. Effect of nano-calcium-enriched milk on calcium metabolism in ovariectomized rats. J Med Food 11: 454-9.
16. Park HS, Jeon BJ, Ahn J, Kwak HS. 2007. Effects of nanocalcium supplemented milk on bone calcium metabolism in ovariectomized Rats. Asian-Aust J Anim Sci 20:1266-71.
17. Park SJ, Park YC, Lee SW, Jeong MS, Yu KN, Jung H, et al. 2011. Comparing the toxic mechanism of synthesized zinc oxide nanomaterials by physicochemical characterization and reactive oxygen species properties. Toxicol Lett 207:197-203.
18. Prakash A, Sen S, Dixit R. 2013. The emerging usage and applications of nanotechnology in food processing industries. Int J Pharm Sci Rev Res 22:107-11.
19. Richardson ML, Gangolli S. 1993. C23 Calcium carbonate. The dictionary of substances and their effects. Cambridge, UK: Royal Society of Chemistry 2:43-44.
20. Shaltiel G, Bar-David E, Meiron OE, Waltman E, Shechter A, Aflalo ED, et al. 2013. Bone loss prevention in ovariectomized rats using stable amorphous calcium carbonate. Health 5:18-29.
21. Sokolova V, Kozlova D, Knuschke T, Buer J, Westendorf AM, Epple M. 2013. Mechanism of the uptake of cationic and anionic calcium phosphate nanoparticles by cells. Acta Biomaterialia 9: 7527-35.
22. Streppel B, Hirscher M. 2011. BET specific surface area and pore structure of MOFs determined by hydrogen adsorption at 20 K. Phys Chem Chem Phys 13:3220-22.
23. Utsumi H, Hakoda M, Shimbara S, Nagaoka H, Chung-s Y, Hamada A. 1994. Active oxygen species generated during chlorination and ozonation. Water Sci Technol 30:91-9.
24. Yanagawa N, Lee DBN. (1992). Renal handling of calcium and phosphorus. In: Coe FL, Favus MJ, eds. Disorders of bone and mineral metabolism. New York: Raven Press, 3-40.