Ginsenoside Rg3 antagonizes adriamycin-induced cardiotoxicity by improving endothelial dysfunction from oxidative stress via upregulating the Nrf2-ARE pathway through the activation of akt

Phytomedicine

Volumn 22, Issue 10, 2015, Pages 875-884

  Wang, Xiaoying ^a   Chen, Lili ^a   Wang, Ting ^a   Jiang, Xiaoqing ^a   Zhang, Han ^a   Li, Pan ^a   Lv, Bin ^a   Gao, Xiumei ^a  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Adriamycin; Aortic ring; Cardiotoxicity; Ginsenoside Rg3; Nrf2; Oxidative stress

Indexed keywords

CALCIUM; DOXORUBICIN; GINSENOSIDE RG 3; PROTEIN KINASE B; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; ANTINEOPLASTIC ANTIBIOTIC; ANTIOXIDANT; CARDIOTONIC AGENT; GINSENOSIDE; NFE2L2 PROTEIN, RAT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CAPILLARY ENDOTHELIAL CELL; CARDIOTOXICITY; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; ECHOCARDIOGRAPHY; ENDOTHELIAL DYSFUNCTION; ETHNOPHARMACOLOGY; HEART CONTRACTION; HEART EJECTION FRACTION; HEART LEFT VENTRICLE OUTFLOW TRACT; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR ENDOTHELIUM; VASCULAR RING; ANIMAL; AORTA; CALCIUM SIGNALING; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENDOTHELIUM CELL; HEART LEFT VENTRICLE FUNCTION; METABOLISM; PANAX; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

PANAX GINSENG; RATTUS;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANT RESPONSE ELEMENTS; ANTIOXIDANTS; AORTA; APOPTOSIS; CALCIUM SIGNALING; CARDIOTONIC AGENTS; CARDIOTOXICITY; CELLS, CULTURED; DOXORUBICIN; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GINSENOSIDES; MALE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PANAX; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION; VENTRICULAR FUNCTION, LEFT;

EID: 84937889389     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2015.06.010     Document Type: Article

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