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Volumn 10, Issue , 2010, Pages

GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; DOXORUBICIN; GU 40C4; GU 81; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 2; ANTINEOPLASTIC AGENT; GU 81 COMPOUND; PEPTIDE; PEPTOID; VASCULOTROPIN A;

EID: 77955082181     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-397     Document Type: Article
Times cited : (28)

References (35)
  • 1
    • 0037482404 scopus 로고    scopus 로고
    • American Cancer Society: Cancer Facts and Figures 2009
    • American Cancer Society: Cancer Facts and Figures 2009. Atlanta, GA: American Cancer Society 2009,
    • (2009) Atlanta, GA: American Cancer Society
  • 2
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • 10.1056/NEJM197111182852108, 4938153
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285(21):1182-1186. 10.1056/NEJM197111182852108, 4938153.
    • (1971) N Engl J Med , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.1
  • 3
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 2002, 29(6 Suppl 16):15-18.
    • (2002) Semin Oncol , vol.29 , Issue.6 SUPPL 16 , pp. 15-18
    • Folkman, J.1
  • 4
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: an organizing principle for drug discovery?
    • 10.1038/nrd2115, 17396134
    • Folkman J. Angiogenesis: an organizing principle for drug discovery?. Nat Rev Drug Discov 2007, 6(4):273-286. 10.1038/nrd2115, 17396134.
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.4 , pp. 273-286
    • Folkman, J.1
  • 5
    • 28144462911 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in tumor angiogenesis and malignancies
    • 10.1177/1534735405282557, 16282508
    • Pradeep CR, Sunila ES, Kuttan G. Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in tumor angiogenesis and malignancies. Integr Cancer Ther 2005, 4(4):315-321. 10.1177/1534735405282557, 16282508.
    • (2005) Integr Cancer Ther , vol.4 , Issue.4 , pp. 315-321
    • Pradeep, C.R.1    Sunila, E.S.2    Kuttan, G.3
  • 8
    • 52949138886 scopus 로고    scopus 로고
    • Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinib
    • 10.1093/annonc/mdn389, 18550575
    • Lacouture ME, Reilly LM, Gerami P, Guitart J. Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinib. Ann Oncol 2008, 19(11):1955-1961. 10.1093/annonc/mdn389, 18550575.
    • (2008) Ann Oncol , vol.19 , Issue.11 , pp. 1955-1961
    • Lacouture, M.E.1    Reilly, L.M.2    Gerami, P.3    Guitart, J.4
  • 9
    • 67651146533 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts
    • 10.1158/1535-7163.MCT-09-0280, 19567820
    • Roland CL, Dineen SP, Lynn KD, Sullivan LA, Dellinger MT, Sadegh L, Sullivan JP, Shames DS, Brekken RA. Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts. Mol Cancer Ther 2009, 8(7):1761-1771. 10.1158/1535-7163.MCT-09-0280, 19567820.
    • (2009) Mol Cancer Ther , vol.8 , Issue.7 , pp. 1761-1771
    • Roland, C.L.1    Dineen, S.P.2    Lynn, K.D.3    Sullivan, L.A.4    Dellinger, M.T.5    Sadegh, L.6    Sullivan, J.P.7    Shames, D.S.8    Brekken, R.A.9
  • 10
    • 70449580340 scopus 로고    scopus 로고
    • Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer
    • 10.1371/journal.pone.0007669, 2766251, 19888452
    • Roland CL, Lynn KD, Toombs JE, Dineen SP, Udugamasooriya DG, Brekken RA. Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer. PLoS One 2009, 4(11):e7669. 10.1371/journal.pone.0007669, 2766251, 19888452.
    • (2009) PLoS One , vol.4 , Issue.11
    • Roland, C.L.1    Lynn, K.D.2    Toombs, J.E.3    Dineen, S.P.4    Udugamasooriya, D.G.5    Brekken, R.A.6
  • 11
    • 55749088393 scopus 로고    scopus 로고
    • Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
    • 10.1158/1535-7163.MCT-08-0013, 18852116
    • Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM, Lynch M. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 2008, 7(10):3129-3140. 10.1158/1535-7163.MCT-08-0013, 18852116.
    • (2008) Mol Cancer Ther , vol.7 , Issue.10 , pp. 3129-3140
    • Wilhelm, S.M.1    Adnane, L.2    Newell, P.3    Villanueva, A.4    Llovet, J.M.5    Lynch, M.6
  • 12
    • 42649106504 scopus 로고    scopus 로고
    • A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity
    • 10.1021/ja711193x, 18386897
    • Udugamasooriya DG, Dineen SP, Brekken RA, Kodadek T. A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity. J Am Chem Soc 2008, 130(17):5744-5752. 10.1021/ja711193x, 18386897.
    • (2008) J Am Chem Soc , vol.130 , Issue.17 , pp. 5744-5752
    • Udugamasooriya, D.G.1    Dineen, S.P.2    Brekken, R.A.3    Kodadek, T.4
  • 14
    • 0142244181 scopus 로고    scopus 로고
    • Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
    • 1892434, 14578209
    • Lin EY, Jones JG, Li P, Zhu L, Whitney KD, Muller WJ, Pollard JW. Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 2003, 163(5):2113-2126. 1892434, 14578209.
    • (2003) Am J Pathol , vol.163 , Issue.5 , pp. 2113-2126
    • Lin, E.Y.1    Jones, J.G.2    Li, P.3    Zhu, L.4    Whitney, K.D.5    Muller, W.J.6    Pollard, J.W.7
  • 15
    • 55249083520 scopus 로고    scopus 로고
    • The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues
    • 10.1016/j.bmcl.2008.07.023, 2593102, 18653335
    • Udugamasooriya DG, Dunham G, Ritchie C, Brekken RA, Kodadek T. The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues. Bioorg Med Chem Lett 2008, 18(22):5892-5894. 10.1016/j.bmcl.2008.07.023, 2593102, 18653335.
    • (2008) Bioorg Med Chem Lett , vol.18 , Issue.22 , pp. 5892-5894
    • Udugamasooriya, D.G.1    Dunham, G.2    Ritchie, C.3    Brekken, R.A.4    Kodadek, T.5
  • 16
    • 0032544690 scopus 로고    scopus 로고
    • Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes
    • 10.1074/jbc.273.38.24665, 9733764
    • Souza SC, de Vargas LM, Yamamoto MT, Lien P, Franciosa MD, Moss LG, Greenberg AS. Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes. J Biol Chem 1998, 273(38):24665-24669. 10.1074/jbc.273.38.24665, 9733764.
    • (1998) J Biol Chem , vol.273 , Issue.38 , pp. 24665-24669
    • Souza, S.C.1    de Vargas, L.M.2    Yamamoto, M.T.3    Lien, P.4    Franciosa, M.D.5    Moss, L.G.6    Greenberg, A.S.7
  • 17
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • 10.1074/jbc.270.45.26746, 7592907
    • Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995, 270(45):26746-26749. 10.1074/jbc.270.45.26746, 7592907.
    • (1995) J Biol Chem , vol.270 , Issue.45 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 18
    • 0025772167 scopus 로고
    • Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets
    • Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, Londos C. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J Biol Chem 1991, 266(17):11341-11346.
    • (1991) J Biol Chem , vol.266 , Issue.17 , pp. 11341-11346
    • Greenberg, A.S.1    Egan, J.J.2    Wek, S.A.3    Garty, N.B.4    Blanchette-Mackie, E.J.5    Londos, C.6
  • 19
    • 0037356826 scopus 로고    scopus 로고
    • The role of the novel adipocyte-derived hormone adiponectin in human disease
    • 10.1530/eje.0.1480293, 12611609
    • Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol 2003, 148(3):293-300. 10.1530/eje.0.1480293, 12611609.
    • (2003) Eur J Endocrinol , vol.148 , Issue.3 , pp. 293-300
    • Diez, J.J.1    Iglesias, P.2
  • 20
    • 0036432925 scopus 로고    scopus 로고
    • Adiponectin: a link between excess adiposity and associated comorbidities?
    • 10.1007/s00109-002-0378-7, 12436346
    • Ukkola O, Santaniemi M. Adiponectin: a link between excess adiposity and associated comorbidities?. J Mol Med 2002, 80(11):696-702. 10.1007/s00109-002-0378-7, 12436346.
    • (2002) J Mol Med , vol.80 , Issue.11 , pp. 696-702
    • Ukkola, O.1    Santaniemi, M.2
  • 23
    • 47949097072 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice
    • 10.1158/0008-5472.CAN-07-6705, 18519694
    • Dineen SP, Lynn KD, Holloway SE, Miller AF, Sullivan JP, Shames DS, Beck AW, Barnett CC, Fleming JB, Brekken RA. Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice. Cancer Res 2008, 68(11):4340-4346. 10.1158/0008-5472.CAN-07-6705, 18519694.
    • (2008) Cancer Res , vol.68 , Issue.11 , pp. 4340-4346
    • Dineen, S.P.1    Lynn, K.D.2    Holloway, S.E.3    Miller, A.F.4    Sullivan, J.P.5    Shames, D.S.6    Beck, A.W.7    Barnett, C.C.8    Fleming, J.B.9    Brekken, R.A.10
  • 24
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • 10.1084/jem.193.6.727, 2193412, 11257139
    • Lin EY, Nguyen AV, Russell RG, Pollard JW. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 2001, 193(6):727-740. 10.1084/jem.193.6.727, 2193412, 11257139.
    • (2001) J Exp Med , vol.193 , Issue.6 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 25
    • 27944490875 scopus 로고    scopus 로고
    • VEGF as a therapeutic target in cancer
    • 10.1159/000088479, 16301831
    • Ferrara N. VEGF as a therapeutic target in cancer. Oncology 2005, 69(Suppl 3):11-16. 10.1159/000088479, 16301831.
    • (2005) Oncology , vol.69 , Issue.SUPPL 3 , pp. 11-16
    • Ferrara, N.1
  • 26
    • 0242468884 scopus 로고    scopus 로고
    • A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer
    • 10.1053/j.seminoncol.2003.08.013, 14613032
    • Cobleigh MA, Langmuir VK, Sledge GW, Miller KD, Haney L, Novotny WF, Reimann JD, Vassel A. A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer. Semin Oncol 2003, 30(5 Suppl 16):117-124. 10.1053/j.seminoncol.2003.08.013, 14613032.
    • (2003) Semin Oncol , vol.30 , Issue.5 SUPPL 16 , pp. 117-124
    • Cobleigh, M.A.1    Langmuir, V.K.2    Sledge, G.W.3    Miller, K.D.4    Haney, L.5    Novotny, W.F.6    Reimann, J.D.7    Vassel, A.8
  • 27
    • 33644863498 scopus 로고    scopus 로고
    • Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF
    • 10.1074/jbc.M508199200, 16278208
    • Liang WC, Wu X, Peale FV, Lee CV, Meng YG, Gutierrez J, Fu L, Malik AK, Gerber HP, Ferrara N, et al. Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. J Biol Chem 2006, 281(2):951-961. 10.1074/jbc.M508199200, 16278208.
    • (2006) J Biol Chem , vol.281 , Issue.2 , pp. 951-961
    • Liang, W.C.1    Wu, X.2    Peale, F.V.3    Lee, C.V.4    Meng, Y.G.5    Gutierrez, J.6    Fu, L.7    Malik, A.K.8    Gerber, H.P.9    Ferrara, N.10
  • 28
    • 0034665166 scopus 로고    scopus 로고
    • Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice
    • Brekken RA, Overholser JP, Stastny VA, Waltenberger J, Minna JD, Thorpe PE. Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice. Cancer Res 2000, 60(18):5117-5124.
    • (2000) Cancer Res , vol.60 , Issue.18 , pp. 5117-5124
    • Brekken, R.A.1    Overholser, J.P.2    Stastny, V.A.3    Waltenberger, J.4    Minna, J.D.5    Thorpe, P.E.6
  • 29
    • 38749097333 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an autocrine survival factor for breast tumour cells under hypoxia
    • Barr MP, Bouchier-Hayes DJ, Harmey JJ. Vascular endothelial growth factor is an autocrine survival factor for breast tumour cells under hypoxia. Int J Oncol 2008, 32(1):41-48.
    • (2008) Int J Oncol , vol.32 , Issue.1 , pp. 41-48
    • Barr, M.P.1    Bouchier-Hayes, D.J.2    Harmey, J.J.3
  • 30
    • 0005339099 scopus 로고    scopus 로고
    • Tumor-associated macrophages in breast cancer
    • 10.1023/A:1020304003704, 12463738
    • Leek RD, Harris AL. Tumor-associated macrophages in breast cancer. J Mammary Gland Biol Neoplasia 2002, 7(2):177-189. 10.1023/A:1020304003704, 12463738.
    • (2002) J Mammary Gland Biol Neoplasia , vol.7 , Issue.2 , pp. 177-189
    • Leek, R.D.1    Harris, A.L.2
  • 31
    • 0029816609 scopus 로고    scopus 로고
    • Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma
    • Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J, Harris AL. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res 1996, 56(20):4625-4629.
    • (1996) Cancer Res , vol.56 , Issue.20 , pp. 4625-4629
    • Leek, R.D.1    Lewis, C.E.2    Whitehouse, R.3    Greenall, M.4    Clarke, J.5    Harris, A.L.6
  • 32
    • 33751579930 scopus 로고    scopus 로고
    • Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma
    • 10.1002/ijc.22217, 17019708
    • Salnikov AV, Heldin NE, Stuhr LB, Wiig H, Gerber H, Reed RK, Rubin K. Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma. Int J Cancer 2006, 119(12):2795-2802. 10.1002/ijc.22217, 17019708.
    • (2006) Int J Cancer , vol.119 , Issue.12 , pp. 2795-2802
    • Salnikov, A.V.1    Heldin, N.E.2    Stuhr, L.B.3    Wiig, H.4    Gerber, H.5    Reed, R.K.6    Rubin, K.7
  • 35
    • 33846970929 scopus 로고    scopus 로고
    • Quantitative evaluation of the relative cell permeability of peptoids and peptides
    • 10.1021/ja0668623, 2530819, 17283989
    • Kwon YU, Kodadek T. Quantitative evaluation of the relative cell permeability of peptoids and peptides. J Am Chem Soc 2007, 129(6):1508-1509. 10.1021/ja0668623, 2530819, 17283989.
    • (2007) J Am Chem Soc , vol.129 , Issue.6 , pp. 1508-1509
    • Kwon, Y.U.1    Kodadek, T.2


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