메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype

Author keywords

[No Author keywords available]

Indexed keywords

FH535; FRZB PROTEIN; GLYCOPROTEIN; SULFONAMIDE;

EID: 84937880263     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep12465     Document Type: Article
Times cited : (288)

References (56)
  • 1
    • 77956641496 scopus 로고    scopus 로고
    • A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer
    • Pang, R. et al. A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer. Cell Stem Cell 6, 603-15 (2010).
    • (2010) Cell Stem Cell , vol.6 , pp. 603-615
    • Pang, R.1
  • 2
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann, P.C. et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1, 313-23 (2007).
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1
  • 3
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani, S.A. et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-15 (2008).
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1
  • 5
    • 78149262994 scopus 로고    scopus 로고
    • Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models
    • Liu, H. et al. Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci USA 107, 18115-20 (2010).
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 18115-18120
    • Liu, H.1
  • 6
    • 77953702668 scopus 로고    scopus 로고
    • Acute myeloid leukemia and the Wnt pathway
    • Eaves, C.J. , Humphries, R.K. Acute myeloid leukemia and the Wnt pathway. N Engl J Med 362, 2326-7 (2010).
    • (2010) N Engl J Med , vol.362 , pp. 2326-2327
    • Eaves, C.J.1    Humphries, R.K.2
  • 7
    • 43049144313 scopus 로고    scopus 로고
    • Wnt signaling and stem cell control
    • Nusse, R. Wnt signaling and stem cell control. Cell Res 18, 523-7 (2008).
    • (2008) Cell Res , vol.18 , pp. 523-527
    • Nusse, R.1
  • 8
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya, T. , Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 843-50 (2005).
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 9
    • 84891364732 scopus 로고    scopus 로고
    • Cancer stemness in Wnt-driven mammary tumorigenesis
    • Monteiro, J. et al. Cancer stemness in Wnt-driven mammary tumorigenesis. Carcinogenesis 35, 2-13 (2014).
    • (2014) Carcinogenesis , vol.35 , pp. 2-13
    • Monteiro, J.1
  • 10
    • 70349932747 scopus 로고    scopus 로고
    • Towards an integrated view of Wnt signaling in development
    • van Amerongen, R. , Nusse, R. Towards an integrated view of Wnt signaling in development. Development 136, 3205-14 (2009).
    • (2009) Development , vol.136 , pp. 3205-3214
    • Van Amerongen, R.1    Nusse, R.2
  • 11
    • 0345059767 scopus 로고    scopus 로고
    • Applying the principles of stem-cell biology to cancer
    • Pardal, R., Clarke, M.F. , Morrison, S.J. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 3, 895-902 (2003).
    • (2003) Nat Rev Cancer , vol.3 , pp. 895-902
    • Pardal, R.1    Clarke, M.F.2    Morrison, S.J.3
  • 12
    • 0026894053 scopus 로고
    • Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
    • Miyoshi, Y. et al. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1, 229-33 (1992).
    • (1992) Hum Mol Genet , vol.1 , pp. 229-233
    • Miyoshi, Y.1
  • 13
    • 0026630266 scopus 로고
    • APC mutations occur early during colorectal tumorigenesis
    • Powell, S.M. et al. APC mutations occur early during colorectal tumorigenesis. Nature 359, 235-7 (1992).
    • (1992) Nature , vol.359 , pp. 235-237
    • Powell, S.M.1
  • 14
    • 0035138178 scopus 로고    scopus 로고
    • Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling
    • van de Wetering, M. et al. Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling. Cancer Res 61, 278-84 (2001).
    • (2001) Cancer Res , vol.61 , pp. 278-284
    • Van De Wetering, M.1
  • 15
    • 0033545570 scopus 로고    scopus 로고
    • Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes
    • Ugolini, F. et al. Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes. Oncogene 18, 1903-10 (1999).
    • (1999) Oncogene , vol.18 , pp. 1903-1910
    • Ugolini, F.1
  • 16
    • 33745026527 scopus 로고    scopus 로고
    • Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis
    • Veeck, J. et al. Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis. Oncogene 25, 3479-88 (2006).
    • (2006) Oncogene , vol.25 , pp. 3479-3488
    • Veeck, J.1
  • 17
    • 13644251086 scopus 로고    scopus 로고
    • Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors
    • Klopocki, E. et al. Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors. Int J Oncol 25, 641-9 (2004).
    • (2004) Int J Oncol , vol.25 , pp. 641-649
    • Klopocki, E.1
  • 18
    • 82755176633 scopus 로고    scopus 로고
    • Regulation of breast cancer-induced bone lesions by beta-catenin protein signaling
    • Chen, Y., Shi, H.Y., Stock, S.R., Stern, P.H. , Zhang, M. Regulation of breast cancer-induced bone lesions by beta-catenin protein signaling. J Biol Chem 286, 42575-84 (2011).
    • (2011) J Biol Chem , vol.286 , pp. 42575-42584
    • Chen, Y.1    Shi, H.Y.2    Stock, S.R.3    Stern, P.H.4    Zhang, M.5
  • 19
    • 84887089961 scopus 로고    scopus 로고
    • Wnt signaling in triple negative breast cancer is associated with metastasis
    • Dey, N. et al. Wnt signaling in triple negative breast cancer is associated with metastasis. BMC Cancer 13, 537 (2013).
    • (2013) BMC Cancer , vol.13 , pp. 537
    • Dey, N.1
  • 20
    • 79955496473 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium
    • Pacheco-Pinedo, E.C. et al. Wnt/beta-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. J Clin Invest 121, 1935-45 (2011).
    • (2011) J Clin Invest , vol.121 , pp. 1935-1945
    • Pacheco-Pinedo, E.C.1
  • 21
  • 22
    • 84957591389 scopus 로고    scopus 로고
    • Roles of Wntbeta-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment
    • Mao, J. et al. Roles of Wnt/beta-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment. Cell Death Dis 5, e1039 (2014).
    • (2014) Cell Death Dis , vol.5 , pp. e1039
    • Mao, J.1
  • 23
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: Components, mechanisms, and diseases
    • MacDonald, B.T., Tamai, K. , He, X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17, 9-26 (2009).
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 24
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
    • Aslakson, C.J. , Miller, F.R. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res 52, 1399-405 (1992).
    • (1992) Cancer Res , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 25
    • 41549133557 scopus 로고    scopus 로고
    • Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction
    • Gan, X.Q. et al. Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction. J Cell Biol 180, 1087-100 (2008).
    • (2008) J Cell Biol , vol.180 , pp. 1087-1100
    • Gan, X.Q.1
  • 26
    • 60549111070 scopus 로고    scopus 로고
    • Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
    • Charafe-Jauffret, E. et al. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res 69, 1302-13 (2009).
    • (2009) Cancer Res , vol.69 , pp. 1302-1313
    • Charafe-Jauffret, E.1
  • 27
    • 80054879984 scopus 로고    scopus 로고
    • Breast cancer stem cell markers CD44, CD24 and ALDH1: Expression distribution within intrinsic molecular subtype
    • Ricardo, S. et al. Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype. J Clin Pathol 64, 937-46 (2011).
    • (2011) J Clin Pathol , vol.64 , pp. 937-946
    • Ricardo, S.1
  • 28
    • 57349087670 scopus 로고    scopus 로고
    • Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice
    • Grange, C., Lanzardo, S., Cavallo, F., Camussi, G. , Bussolati, B. Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice. Neoplasia 10, 1433-43 (2008).
    • (2008) Neoplasia , vol.10 , pp. 1433-1443
    • Grange, C.1    Lanzardo, S.2    Cavallo, F.3    Camussi, G.4    Bussolati, B.5
  • 29
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh, S.K. et al. Identification of human brain tumour initiating cells. Nature 432, 396-401 (2004).
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1
  • 30
    • 33846095137 scopus 로고    scopus 로고
    • Identification and expansion of human colon-cancer-initiating cells
    • Ricci-Vitiani, L. et al. Identification and expansion of human colon-cancer-initiating cells. Nature 445, 111-5 (2007).
    • (2007) Nature , vol.445 , pp. 111-115
    • Ricci-Vitiani, L.1
  • 31
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • Wellner, U. et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 11, 1487-95 (2009).
    • (2009) Nat Cell Biol , vol.11 , pp. 1487-1495
    • Wellner, U.1
  • 32
    • 84876086500 scopus 로고    scopus 로고
    • High aldehyde dehydrogenase activity enhances stem cell features in breast cancer cells by activating hypoxiainducible factor-2alpha
    • Kim, R.J. et al. High aldehyde dehydrogenase activity enhances stem cell features in breast cancer cells by activating hypoxiainducible factor-2alpha. Cancer Lett 333, 18-31 (2013).
    • (2013) Cancer Lett , vol.333 , pp. 18-31
    • Kim, R.J.1
  • 33
    • 33751346643 scopus 로고    scopus 로고
    • CD44+/CD24 breast cancer cells exhibit enhanced invasive properties: An early step necessary for metastasis
    • Sheridan, C. et al. CD44+/CD24? breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res 8, R59 (2006).
    • (2006) Breast Cancer Res , vol.8 , pp. R59
    • Sheridan, C.1
  • 34
    • 84874658093 scopus 로고    scopus 로고
    • Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types
    • de Beca, F.F. et al. Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types. J Clin Pathol 66, 187-91 (2013).
    • (2013) J Clin Pathol , vol.66 , pp. 187-191
    • De Beca, F.F.1
  • 35
    • 0033545845 scopus 로고    scopus 로고
    • The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
    • Shtutman, M. et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci USA 96, 5522-7 (1999).
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5522-5527
    • Shtutman, M.1
  • 36
    • 84863263755 scopus 로고    scopus 로고
    • The Wnt/beta-catenin pathway regulates self-renewal of cancer stem-like cells in human gastric cancer
    • Cai, C. , Zhu, X. The Wnt/beta-catenin pathway regulates self-renewal of cancer stem-like cells in human gastric cancer. Mol Med Rep 5, 1191-6 (2012).
    • (2012) Mol Med Rep , vol.5 , pp. 1191-1196
    • Cai, C.1    Zhu, X.2
  • 37
    • 0035907390 scopus 로고    scopus 로고
    • Akt participation in the Wnt signaling pathway through Dishevelled
    • Fukumoto, S. et al. Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem 276, 17479-83 (2001).
    • (2001) J Biol Chem , vol.276 , pp. 17479-17483
    • Fukumoto, S.1
  • 38
    • 73449139396 scopus 로고    scopus 로고
    • The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1beta
    • Kaler, P., Godasi, B.N., Augenlicht, L. , Klampfer, L. The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1beta. Cancer Microenviron 2, 69-80 (2009).
    • (2009) Cancer Microenviron , vol.2 , pp. 69-80
    • Kaler, P.1    Godasi, B.N.2    Augenlicht, L.3    Klampfer, L.4
  • 39
    • 34247468876 scopus 로고    scopus 로고
    • Regulation of the actin cytoskeleton in cancer cell migration and invasion
    • Yamaguchi, H. , Condeelis, J. Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta 1773, 642-52 (2007).
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 642-652
    • Yamaguchi, H.1    Condeelis, J.2
  • 40
    • 0028837170 scopus 로고
    • Activation of the small GTP-binding proteins rho and rac by growth factor receptors
    • Nobes, C.D., Hawkins, P., Stephens, L. , Hall, A. Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J Cell Sci 108 (Pt 1) 225-33 (1995).
    • (1995) J Cell Sci , vol.108 , pp. 225-233
    • Nobes, C.D.1    Hawkins, P.2    Stephens, L.3    Hall, A.4
  • 41
    • 0020606340 scopus 로고
    • Breast carcinoma: Pattern of metastasis at autopsy
    • Lee, Y.T. Breast carcinoma: pattern of metastasis at autopsy. J Surg Oncol 23, 175-80 (1983).
    • (1983) J Surg Oncol , vol.23 , pp. 175-180
    • Lee, Y.T.1
  • 43
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D. , Weinberg, R.A. Hallmarks of cancer: the next generation. Cell 144, 646-74 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 44
    • 63649147784 scopus 로고    scopus 로고
    • Dysregulation of Hedgehog Wnt and Notch signalling pathways in breast cancer
    • Zardawi, S.J., O'Toole, S.A., Sutherland, R.L. , Musgrove, E.A. Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer. Histol Histopathol 24, 385-98 (2009).
    • (2009) Histol Histopathol , vol.24 , pp. 385-398
    • Zardawi, S.J.1    O'Toole, S.A.2    Sutherland, R.L.3    Musgrove, E.A.4
  • 45
    • 74549167752 scopus 로고    scopus 로고
    • Cytoplasmic localization of beta-catenin is a marker of poor outcome in breast cancer patients
    • Lopez-Knowles, E. et al. Cytoplasmic localization of beta-catenin is a marker of poor outcome in breast cancer patients. Cancer Epidemiol Biomarkers Prev 19, 301-9 (2010).
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 301-309
    • Lopez-Knowles, E.1
  • 46
    • 84891278007 scopus 로고    scopus 로고
    • ALDH1-positive cancer stem cells predict engraftment of primary breast tumors and are governed by a common stem cell program
    • Charafe-Jauffret, E. et al. ALDH1-positive cancer stem cells predict engraftment of primary breast tumors and are governed by a common stem cell program. Cancer Res 73, 7290-300 (2013).
    • (2013) Cancer Res , vol.73 , pp. 7290-7300
    • Charafe-Jauffret, E.1
  • 47
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier, C. et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1, 555-67 (2007).
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1
  • 48
    • 79958271033 scopus 로고    scopus 로고
    • Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines
    • Cao, L. et al. Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines. BMC Gastroenterol 11, 71 (2011).
    • (2011) BMC Gastroenterol , vol.11 , pp. 71
    • Cao, L.1
  • 49
    • 55749106963 scopus 로고    scopus 로고
    • Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells
    • Grimshaw, M.J. et al. Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells. Breast Cancer Res 10, R52 (2008).
    • (2008) Breast Cancer Res , vol.10 , pp. R52
    • Grimshaw, M.J.1
  • 50
    • 69449102415 scopus 로고    scopus 로고
    • Lymphatic metastasis of breast cancer cells is associated with differential gene expression profiles that predict cancer stem cell-like properties and the ability to survive, establish and grow in a foreign environment
    • Pandit, T.S. et al. Lymphatic metastasis of breast cancer cells is associated with differential gene expression profiles that predict cancer stem cell-like properties and the ability to survive, establish and grow in a foreign environment. Int J Oncol 35, 297-308 (2009).
    • (2009) Int J Oncol , vol.35 , pp. 297-308
    • Pandit, T.S.1
  • 51
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
    • Fillmore, C.M. , Kuperwasser, C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 10, R25 (2008).
    • (2008) Breast Cancer Res , vol.10 , pp. R25
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 52
    • 0038488950 scopus 로고    scopus 로고
    • A multigenic program mediating breast cancer metastasis to bone
    • Kang, Y. et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3, 537-49 (2003).
    • (2003) Cancer Cell , vol.3 , pp. 537-549
    • Kang, Y.1
  • 53
    • 23144461051 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to lung
    • Minn, A.J. et al. Genes that mediate breast cancer metastasis to lung. Nature 436, 518-24 (2005).
    • (2005) Nature , vol.436 , pp. 518-524
    • Minn, A.J.1
  • 54
    • 37649001973 scopus 로고    scopus 로고
    • ID genes mediate tumor reinitiation during breast cancer lung metastasis
    • Gupta, G.P. et al. ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc Natl Acad Sci USA 104, 19506-11 (2007).
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19506-19511
    • Gupta, G.P.1
  • 55
    • 45549088943 scopus 로고    scopus 로고
    • Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17
    • Nam, J.S. et al. Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17. Cancer Res 68, 3915-23 (2008).
    • (2008) Cancer Res , vol.68 , pp. 3915-3923
    • Nam, J.S.1
  • 56
    • 33746884603 scopus 로고    scopus 로고
    • Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells
    • Nam, J.S. et al. Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells. Cancer Res 66, 7176-84 (2006).
    • (2006) Cancer Res , vol.66 , pp. 7176-7184
    • Nam, J.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.