A limited role for the cell cycle regulator cyclin A1 in murine leukemogenesis

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Bäumer, Nicole ^a   Bäumer, Sebastian ^a   Haak, Miriam ^a,b   Koschmieder, Steffen ^c   Schönig, Kai ^d   Berdel, Wolfgang E ^a   Müller Tidow, Carsten ^a,e  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b MILTENYI BIOTEC GMBH   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A1; ONCOPROTEIN; PROMYELOCYTIC LEUKEMIA-RETINOIC ACID RECEPTOR ALPHA FUSION ONCOPROTEIN;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER STEM CELL; CANCER SURVIVAL; CELL CYCLE REGULATION; CONTROLLED STUDY; CROSS BREEDING; DRUG TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; KNOCKOUT MOUSE; LEUKEMOGENESIS; LOSS OF FUNCTION MUTATION; MOUSE; MOUSE MODEL; MOUSE STRAIN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE; UPREGULATION; ACUTE MYELOID LEUKEMIA; ANIMAL; GENE EXPRESSION REGULATION; GENE TARGETING; GENETICS; PATHOLOGY;

MURINAE; MUS; MUS MUSCULUS;

ANIMALS; CYCLIN A1; GENE EXPRESSION REGULATION, LEUKEMIC; GENE KNOCK-IN TECHNIQUES; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; ONCOGENE PROTEINS, FUSION; UP-REGULATION;

EID: 84937865328     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0129147     Document Type: Article

References (31)

1. Bruyere C, Meijer L. Targeting cyclin-dependent kinases in anti-neoplastic therapy. Curr Opin Cell Biol. 2013; 25: 772-9. doi: S0955-0674(13)00146-4 [pii] doi: 10.1016/j.ceb.2013.08.004 PMID: 24011867
2. Müller-Tidow C, Ji P, Diederichs S, Potratz J, Bäumer N, Kohler G, et al. The cyclin A1-CDK2 complex regulates DNA double-strand break repair. Mol Cell Biol. 2004; 24: 8917-28. doi: 10.1128/MCB.24.20. 8917-8928.2004 24/20/8917 [pii]. PMID: 15456866
3. van der Meer T, Chan WY, Palazon LS, Nieduszynski C, Murphy M, Sobczak-Thepot J, et al. Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice. Reproduction. 2004; 127: 503-511. doi: 10.1530/rep.1.00131 PMID: 15047941
4. Liu D, Matzuk MM, Sung WK, Guo Q, Wang P, Wolgemuth DJ. Cyclin A1 is required for meiosis in the male mouse. Nat Genet. 1998; 20: 377-80. PMID: 9843212
5. Yang R, Nakamaki T, Lübbert M, Said J, Sakashita A, Freyaldenhoven BS, et al. Cyclin A1 expression in leukemia and normal hematopoietic cells. Blood. 1999; 93: 2067-74. PMID: 10068680
6. Ekberg J, Holm C, Jalili S, Richter J, Anagnostaki L, Landberg G, et al. Expression of cyclin A1 and cell cycle proteins in hematopoietic cells and acute myeloid leukemia and links to patient outcome. Eur J Haematol. 2005; 75: 106-115. doi: EJH473 [pii]. PMID: 16004607
7. Müller C, Yang R, Park DJ, Serve H, Berdel WE, Koeffler HP. The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia. Blood. 2000; 96: 3894-9. PMID: 11090075
8. Munari E, Chaux A, Maldonado L, Comperat E, Varinot J, Bivalacqua TJ, et al. Cyclin A1 expression predicts progression in pT1 urothelial carcinoma of bladder: A tissue microarray study of 149 patients treated by transurethral resection. Histopathology. 2015; 66: 262-269. doi: 10.1111/his.12499 PMID: 25039670
9. Liu Y, Huang Y, Zhu GZ. Cyclin A1 is a transcriptional target of PITX2 and overexpressed in papillary thyroid carcinoma. Mol Cell Biochem. 2013; 384: 221-227. doi: 10.1007/s11010-013-1801-9 PMID: 24002705
10. Syed Khaja AS, Dizeyi N, Kopparapu PK, Anagnostaki L, Harkonen P, Persson JL. Cyclin A1 modulates the expression of vascular endothelial growth factor and promotes hormone-dependent growth and angiogenesis of breast cancer. PLoS One. 2013; 8: e72210. doi: 10.1371/journal.pone.0072210 PMID: 23991063
11. Wegiel B, Bjartell A, Tuomela J, Dizeyi N, Tinzl M, Helczynski L, et al. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. J Natl Cancer Inst. 2008; 100: 1022-1036. doi: 10.1093/jnci/djn214 PMID: 18612129
12. Holm C, Ora I, Brunhoff C, Anagnostaki L, Landberg G, Persson JL. Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia. Leuk Res. 2006; 30: 254-261. doi: S0145-2126(05)00283-3 [pii]. PMID: 16182364
13. Iida H, Towatari M, Tanimoto M, Morishita Y, Kodera Y, Saito H. Overexpression of cyclin E in acute myelogenous leukemia. Blood. 1997; 90: 3707-3713. PMID: 9345056
14. Liao C, Wang XY, Wei HQ, Li SQ, Merghoub T, Pandolfi PP, et al. Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1. Proc Natl Acad Sci U S A. 2001; 98: 6853-8. PMID: 11381140
15. Westervelt P, Lane AA, Pollock JL, Oldfather K, Holt MS, Zimonjic DB, et al. High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression. Blood. 2003; 102: 1857-1865. doi: 10.1182/blood-2002-12-3779 PMID: 12750176
16. Diederichs S, Bäumer N, Schultz N, Hamra FK, Schrader MG, Sandstede ML, et al. Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development. Int J Cancer. 2005; 116: 207-217. doi: 10.1002/ijc.21034 PMID: 15800920
17. Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, et al. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. J Biol Chem. 2004; 279: 33727-41. doi: 10.1074/ jbc.M401708200 M401708200 [pii]. PMID: 15159402
18. Hebestreit K, Grottrup S, Emden D, Veerkamp J, Ruckert C, Klein HU, et al. Leukemia gene atlas-a public platform for integrative exploration of genome-wide molecular data. PLoS One. 2012; 7: e39148. doi: 10.1371/journal.pone.0039148 PMID: 22720055
19. Haferlach T, Kohlmann A, Wieczorek L, Basso G, Kronnie GT, Bene MC, et al. Clinical utility of microarray- based gene expression profiling in the diagnosis and subclassification of leukemia: Report from the international microarray innovations in leukemia study group. J Clin Oncol. 2010; 28: 2529-2537. doi: 10.1200/JCO.2009.23.4732 PMID: 20406941
20. Yu J, Müller H, Hehn S, Koschmieder S, Schönig K, Berdel WE, et al. Construction and application of an inducible system for homogenous expression levels in bulk cell lines. PLoS One. 2009; 4: e6445. doi: 10.1371/journal.pone.0006445 PMID: 19649290
21. Schönig K, Kentner D, Gossen M, Baldinger T, Miao J, Welzel K, et al. Development of a BAC vector for integration-independent and tight regulation of transgenes in rodents via the tet system. Transgenic Res. 2011; 20: 709-720. doi: 10.1007/s11248-010-9427-0 PMID: 20640885
22. Schönig K, Schwenk F, Rajewsky K, Bujard H. Stringent doxycycline dependent control of CRE recombinase in vivo. Nucleic Acids Res. 2002; 30: e134. PMID: 12466566
23. Koschmieder S, Gottgens B, Zhang P, Iwasaki-Arai J, Akashi K, Kutok JL, et al. Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCRABL leukemogenesis. Blood. 2005; 105: 324-334. doi: 10.1182/blood-2003-12-4369 PMID: 15331442
24. Schemionek M, Elling C, Steidl U, Bäumer N, Hamilton A, Spieker T, et al. BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells. Blood. 2010; 115: 3185-95. doi: blood- 2009-04-215376 [pii] doi: 10.1182/blood-2009-04-215376 PMID: 20053753
25. Bäumer N, Krause A, Köhler G, Lettermann S, Evers G, Hascher A, et al. Proteinase-activated receptor 1 (PAR1) regulates leukemic stem cell functions. PLoS One. 2014; 9: e94993. doi: 10.1371/journal. pone.0094993 PMID: 24740120
26. Vukman KV, Metz M, Maurer M, O'Neill SM. Isolation and culture of peritoneal cell-derived mast cells. Bio Protocol. 2014; 4: e1052.
27. Bäumer N, Tickenbrock L, Tschanter P, Lohmeyer L, Diederichs S, Bäumer S, et al. Inhibitor of cyclindependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. J Biol Chem. 2011; 286: 28210-22. doi: M110.203471 [pii] doi: 10.1074/jbc.M110. 203471 PMID: 21540187
28. Kelly LM, Kutok JL, Williams IR, Boulton CL, Amaral SM, Curley DP, et al. PML/RARalpha and FLT3- ITD induce an APL-like disease in a mouse model. Proc Natl Acad Sci U S A. 2002; 99: 8283-8288. doi: 10.1073/pnas.122233699 PMID: 12060771
29. Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, et al. Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell. 2009; 138: 352-65. doi: S0092- 8674(09)00527-3 [pii] doi: 10.1016/j.cell.2009.04.062 PMID: 19592082
30. Gopinathan L, Tan SL, Padmakumar VC, Coppola V, Tessarollo L, Kaldis P. Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis. Cancer Res. 2014; 74: 3870-3879. doi: 10.1158/0008- 5472.CAN-13-3440 PMID: 24802190
31. Ochsenreither S, Majeti R, Schmitt T, Stirewalt D, Keilholz U, Loeb KR, et al. Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen. Blood. 2012; 119: 5492-5501. doi: 10.1182/blood-2011-07-365890 PMID: 22529286