The aberrant fusion proteins PML-RARα and PLZF-RARα contribute to the overexpression of cyclin a1 in acute promyelocytic leukemia

Blood

Volumn 96, Issue 12, 2000, Pages 3894-3899

  Muller, C ^a   Yang, R ^a   Park, D J ^a   Serve, H ^a   Berdel, W E ^a   Koeffler, H P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN A1; HYBRID PROTEIN; RETINOIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW CULTURE; CANCER CELL CULTURE; CELL PROLIFERATION; GENE CONTROL; GENE FUSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL;

EID: 0034548845     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.12.3894.h8003894_3894_3899     Document Type: Article

References (29)

1. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines
2. A distinct cyclin A is expressed in germ cells in the mouse
3. Regulation of meiosis during mammalian spermatogenesis: The A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage
4. Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation
5. Ionizing radiation induces apoptosis and elevates cyclin A1-cdk2 activity before but not after the midblastula transition in Xenopus
6. Cyclin A1 is required for meiosis in the male mouse
7. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene
8. Cyclin A1 expression in leukemia and normal hematopoietic cells
9. Cyclin A1 is predominantly expressed in hematological malignancies with myeloid differentiation
10. An altered nuclear migration into the daughter bud is induced by the cyclin A1-mediated Cdc28 kinase through an aberrant spindle movement in Saccharomyces cerevisae
11. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins
12. Gene rearrangements in the molecular pathogenesis of acute promyelocytic leukemia
13. Acute leukemia with promyelocytic features in PML/RARa transgenic mice
14. A PML-RARalpha transgene initiates murine acute promyelocytic leukemia
15. Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences
16. The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells
17. Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor a (RARa) and PLZF-RARa fusion proteins on retinoic acid signalling
18. Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines while tissue-specific expression of cyclin A1 is methylation independent
19. c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression
20. NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)
21. Establishment and characterization of a novel acute promyelocytic leukemia cell line (UF-1) with retinoic acid-resistant features
22. Two distinctly regulated events, priming and triggering, during retinoid induced maturation and resistanee of NB4 promyelocytic leukemia cell line
23. RAR-independent RXR signaling induces t(15;17) leukemia cell maturation
24. Cloning of the cyclin A1 genomic structure and characterization of the promoter region; GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene
25. A decade of molecular biology of retinoic acid receptors
26. Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity
27. B-myb antisense oligonucleotides inhibit proliferation of human hematopoietic cell lines
28. Activation of human B-Myb by cyclins