Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression

Molecular Psychiatry

Volumn 20, Issue 8, 2015, Pages 995-1001

  Milekic, M H ^a   Xin, Y ^a   O'Donnell, A ^b   Kumar, K K ^a   Bradley Moore, M ^a   Malaspina, D ^c   Moore, H ^a   Brunner, D ^a,d   Ge, Y ^e   Edwards, J ^f   Paul, S ^g   Haghighi, F G ^e   Gingrich, J A ^a  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Columbia University ^*  (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PSYCHOGENICS INC   (United States)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; SPERM DNA; UNCLASSIFIED DRUG;

ABNORMAL BEHAVIOR; AGING; ARTICLE; AUTISM; CONTROLLED STUDY; CPG ISLAND; DEVELOPMENTAL GENE; DNA METHYLATION; MALE; MOUSE; MUTATION RATE; NONHUMAN; PATERNAL AGE; PREPULSE INHIBITION; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; SCHIZOPHRENIA; SPERM; SPERMATOGENESIS; STARTLE REFLEX; TRANSCRIPTION REGULATION; 129 MOUSE; AGE; ANIMAL; BRAIN; FATHER; GENE EXPRESSION; GENETICS; METABOLISM; MOTOR ACTIVITY; SPERMATOZOON;

AGE FACTORS; AGING; ANIMALS; BRAIN; DNA METHYLATION; FATHERS; GENE EXPRESSION; MALE; MICE, 129 STRAIN; MOTOR ACTIVITY; REFLEX, STARTLE; SPERMATOZOA;

EID: 84937814732     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2014.84     Document Type: Article

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