Functional Assessment of Disease-Associated Regulatory Variants In Vivo Using a Versatile Dual Colour Transgenesis Strategy in Zebrafish

PLoS Genetics

Volumn 11, Issue 6, 2015, Pages

  Bhatia, Shipra ^a   Gordon, Christopher T ^b   Foster, Robert G ^a   Melin, Lucie ^b   Abadie, Véronique ^c   Baujat, Geneviève ^b   Vazquez, Marie Paule ^b   Amiel, Jeanne ^b   Lyonnet, Stanislas ^b   van Heyningen, Veronica ^a,d   Kleinjan, Dirk A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON REGULATORY FACTOR 6; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX9; EYE PROTEIN; GREEN FLUORESCENT PROTEIN; HOMEODOMAIN PROTEIN; INTERFERON REGULATORY FACTOR; IRF6 PROTEIN, ZEBRAFISH; PAIRED BOX TRANSCRIPTION FACTOR; PAX6 PROTEIN, HUMAN; PROTEIN BINDING; REPRESSOR PROTEIN; SHHA PROTEIN, ZEBRAFISH; ZEBRAFISH PROTEIN;

ALLELE; ARTICLE; BRAIN DEVELOPMENT; CIS ISOMER; CIS-REGULATORY ELEMENT; COMPARATIVE STUDY; CONTROLLED STUDY; DUAL COLOR REPORTER TRANSGENESIS; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE TARGETING; GENETIC VARIABILITY; GENOME; HUMAN; IN VIVO STUDY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PIERRE ROBIN SYNDROME; POINT MUTATION; PROTEIN BINDING; REGULATORY SEQUENCE; SEQUENCE ANALYSIS; TRANSGENICS; VALIDATION STUDY; ZEBRA FISH; ANIMAL; GENETICS; METABOLISM; TRANSGENE;

DANIO RERIO;

ANIMALS; EYE PROTEINS; GREEN FLUORESCENT PROTEINS; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; INTERFERON REGULATORY FACTORS; PAIRED BOX TRANSCRIPTION FACTORS; PAX6 TRANSCRIPTION FACTOR; PIERRE ROBIN SYNDROME; PROTEIN BINDING; REGULATORY ELEMENTS, TRANSCRIPTIONAL; REPRESSOR PROTEINS; TRANSGENES; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84937795136     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005193     Document Type: Article

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