Metabolite profiling of Clostridium difficile ribotypes using small molecular weight volatile organic compounds

Metabolomics

Volumn 11, Issue 2, 2015, Pages 251-260

  Kuppusami, S ^a   Clokie, M R J ^a   Panayi, T ^a   Ellis, A M ^a   Monks, P S ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Clostridium difficile; Ribotype; Volatile organic compounds

Indexed keywords

CRESOL; DIMETHYL SULFIDE; DIMETHYLAMINE; ETHYLENE SULFIDE; METHANOL; METHYL THIOACETATE; UNCLASSIFIED DRUG; VOLATILE ORGANIC COMPOUND;

ARTICLE; BACTERIAL VIRULENCE; BACTERIUM CULTURE; CLUSTER ANALYSIS; CONTROLLED STUDY; MASS SPECTROMETRY; METABOLITE; METABOLOMICS; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; PRINCIPAL COMPONENT ANALYSIS; PROTON TRANSFER REACTION; RIBOTYPING; SENSITIVITY AND SPECIFICITY; TIME OF FLIGHT MASS SPECTROMETRY;

EID: 84937772996     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-014-0692-4     Document Type: Article

References (42)

1. Barber, S., et al. (2012). Increased sensitivity in proton transfer reaction mass spectrometry by incorporation of a radio frequency ion funnel. Analytical Chemistry,84, 5387–5391. doi:10.1021/ac300894t.
2. Bartlett, J. G. (1990). Clostridium-difficile - Clinical considerations. Reviews of Infectious Diseases,12, S243–S251.
3. Bauer, M. P., et al. (2011). Clostridium difficile infection in Europe: a hospital-based survey. Lancet,377, 63–73. doi:10.1016/s0140-6736(10)61266-4.
4. Berg, J. D., Mills, R. G., & Coleman, D. J. (1985). Improved Gas-Liquid-Chromatography Method for the indentification of clostridium-difficile. Journal of Clinical Pathology,38, 108–110. doi:10.1136/jcp.38.1.108.
5. Blake, R. S., Monks, P. S., & Ellis, A. M. (2009). Proton-Transfer Reaction Mass Spectrometry. Chemical Reviews,109, 861–896. doi:10.1021/Cr800364q.
6. Blake, R. S., Whyte, C., Hughes, C. O., Ellis, A. M., & Monks, P. S. (2004). Demonstration of proton-transfer reaction time-of-flight mass spectrometry for real-time analysis of trace volatile organic compounds. Analytical Chemistry,76, 3841–3845. doi:10.1021/Ac0498260.
7. Bruins, M., et al. (2009). Device-independent, real-time identification of bacterial pathogens with a metal oxide-based olfactory sensor. European Journal of Clinical Microbiology and Infectious Diseases,28, 775–780. doi:10.1007/s10096-009-0700-1.
8. Bunge, M., et al. (2008). On-line monitoring of microbial volatile metabolites by proton transfer reaction-mass spectrometry. Applied and Environmental Microbiology,74, 2179–2186. doi:10.1128/aem.02069-07.
9. Burns, D. A., & Minton, N. P. (2011). Sporulation studies in Clostridium difficile. Journal of Microbiological Methods,87, 133–138. doi:10.1016/j.mimet.2011.07.017.
10. Cheknis, A. K., et al. (2009). Distribution of Clostridium difficile strains from a North American, European and Australian trial of treatment for C. difficile infections: 2005-2007. Anaerobe,15, 230–233. doi:10.1016/j.anaerobe.2009.09.001.
11. Clements, A. C. A., Magalhaes, R. J. S., Tatem, A. J., Paterson, D. L., & Riley, T. V. (2010). Clostridium difficile PCR ribotype 027: assessing the risks of further worldwide spread. The Lancet Infectious Diseases,10, 395–404.
12. Dawson, L. F., et al. (2011). The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains. BMC Microbiology,11, 86. doi:10.1186/1471-2180-11-86.
13. Elsden, S. R., Hilton, M. G., & Waller, J. M. (1976). End products of metabolism of aromatic amino-acids by clostridia. Archives of Microbiology,107, 283–288. doi:10.1007/bf00425340.
14. Freeman, J., et al. (2010). The changing epidemiology of Clostridium difficile infections. Clinical Microbiology Reviews,23, 529–549. doi:10.1128/cmr.00082-09.
15. Garner, C. E., et al. (2007). Volatile organic compounds from faeces and their potential for diagnosis of gastrointestinal disease. The Faseb Journal,21, 1675–1688. doi:10.1096/fj.06-6927com.
16. Grein, J. D., Ochner, M., Hoang, H., Jin, A., Morgan, M. A., & Murthy, A. R. (2014). Comparison of testing approaches for Clostridium difficile infection at a large community hospital. Clinical Microbiology and Infection,20, 65–69. doi:10.1111/1469-0691.12198.
17. Hargreaves, K. R., Colvin, H. V., Patel, K. V., Clokie, J. J. P., & Clokie, M. R. J. (2013). Genetically diverse Clostridium difficile strains harboring abundant prophages in an estuarine environment. Applied and Environmental Microbiology,79, 6236–6243. doi:10.1128/aem.01849-13.
18. Indra, A., et al. (2008). Characterization of Clostridium difficile isolates using capillary gel electrophoresis-based PCR ribotyping. Journal of Medical Microbiology,57, 1377–1382. doi:10.1099/jmm.0.47714-0.
19. Kai, M., Haustein, M., Molina, F., Petri, A., Scholz, B., & Piechulla, B. (2009). Bacterial volatiles and their action potential. Applied Microbiology and Biotechnology,81, 1001–1012. doi:10.1007/s00253-008-1760-3.
20. Knoop, F. C., Owens, M., & Crocker, I. C. (1993). Clostridium difficile:Clinical disease and diagnosis. Clinical Microbiology Reviews,6, 251–265.
21. Labbe, A. C., et al. (2008). Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strain. Antimicrobial Agents and Chemotherapy,52, 3180–3187. doi:10.1128/aac.00146-08.
22. Nale, J. Y., Shan, J. Y., Hickenbotham, P. T., Fawley, W. N., Wilcox, M. H., & Clokie, M. R. J. (2012). Diverse temperate bacteriophage carriage in Clostridium difficile 027 Strains. PLoS One,7, e37263. doi:10.1371/journal.pone.0037263.
23. Nunez-Montiel, O. L., Thompson, F. S., & Dowell, V. R. (1983). Norleucine-Tyrosine broth for rapid indetification of Clostridium difficile by gas-liquid-chromatography. Journal of Clinical Microbiology,17, 382–385.
24. Perl, T., et al. (2011). Detection of characteristic metabolites of Aspergillus fumigatus and Candida species using ion mobility spectrometry - metabolic profiling by volatile organic compounds. Mycoses,54, E828–E837. doi:10.1111/j.1439-0507.2011.02037.x.
25. Phillips, K. D., & Rogers, P. A. (1981). Rapid detection and presumptive indetification of Clostridium difficile by p-cresol production of a selective medium. Journal of Clinical Pathology,34, 642–644. doi:10.1136/jcp.34.6.642.
26. Pons, J. L., Rimbault, A., Darbord, J. C., & Leluan, G. (1985). Gas-Chromatographic mass-spectrometric analysis of volatile amines produced by several strains of Clostridium. Journal of Chromatography,337, 213–221. doi:10.1016/0378-4347(85)80034-7.
27. Probert, C. S. J. (2011). Role of faecal gas analysis for the diagnosis of IBD. Biochemical Society Transactions,39, 1079–1080. doi:10.1042/bst0391079.
28. Probert, C. S. J., Jones, P. R. H., & Ratcliffe, N. M. (2004). A novel method for rapidly diagnosing the causes of diarrhoea. Gut,53, 58–61. doi:10.1136/gut.53.1.58.
29. Rimbault, A., Niel, P., Darbord, J. C., & Leluan, G. (1986). Headspace gas-chromatographic mass-spectrometric analysis of light-hydrocarbons and voaltile organosulfur compounds in reduced-pressure cultures of Clostridium. Journal of Chromatography,375, 11–25. doi:10.1016/s0378-4347(00)83687-7.
30. Scotter, J. M., Allardyce, R. A., Langford, V., Hill, A., & Murdoch, D. R. (2006). The rapid evaluation of bacterial growth in blood cultures by selected ion flow tube-mass spectrometry (SIFT-MS) and comparison with the BacT/ALERT automated blood culture system. Journal of Microbiological Methods,65, 628–631. doi:10.1016/j.mimet.2005.09.016.
31. Settle, C., & Kerr, K. G. (2011). Diarrhoea after broad spectrum antimicrobials. BMJ,342, d3798–d3798. doi:10.1136/bmj.d3798.
32. Stabler, R. A., et al. (2012). Macro and micro diversity of Clostridium difficile isolates from diverse sources and geographical locations. PLoS One,7, e31559. doi:10.1371/journal.pone.0031559.
33. Stotzky, G., & Schenck, S. (1976). Volatile organic compounds and microorganisms. Critical Reviews In Microbiology,4, 333–382. doi:10.3109/10408417609102303.
34. Tait, E., Perry, J. D., Stanforth, S. P., & Dean, J. R. (2014). Use of volatile compounds as a diagnostic tool for the detection of pathogenic bacteria. TrAc Trends in Analytical Chemistry,53, 117–125. doi:10.1016/j.trac.2013.08.011.
35. Thorn, R. M. S., Reynolds, D. M., & Greenman, J. (2011). Multivariate analysis of bacterial volatile compound profiles for discrimination between selected species and strains in vitro. Journal of Microbiological Methods,84, 258–264. doi:10.1016/j.mimet.2010.12.001.
36. Varmuza, K., & Filzmoser, P. (2009). Introduction to multivariate statistical analysis in chemometrics. Boca Raton: CRC Press.
37. Warny, M., et al. (2005). Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. The Lancet,366, 1079–1084.
38. White, I. R., et al. (2013). Real-time multi-marker measurement of organic compounds in human breath: towards fingerprinting breath. Journal of Breath Research,7, 017112. doi:10.1088/1752-7155/7/1/017112.
39. Wiegand, P. N., Nathwani, D., Wilcox, M. H., Stephens, J., Shelbaya, A., & Haider, S. (2012). Clinical and economic burden of Clostridium difficile infection in Europe: a systematic review of healthcare-facility-acquired infection. Journal of Hospital Infection,81, 1–14. doi:10.1016/j.jhin.2012.02.004.
40. Wilcox, M. H., et al. (2012). Changing epidemiology of Clostridium difficile infection following the introduction of a national ribotyping-based surveillance scheme in England. Clinical Infectious Diseases,55, 1056–1063. doi:10.1093/cid/cis614.
41. Wyche, K. P., Blake, R. S., Willis, K. A., Monks, P. S., & Ellis, A. M. (2005). Differentiation of isobaric compounds using chemical ionization reaction mass spectrometry. Rapid Communications in Mass Spectrometry,19, 3356–3362. doi:10.1002/Rcm.2202.
42. Wyche, K. P., et al. (2007). Technical note: Performance of chemical ionization reaction time-of-flight mass spectrometry (CIR-TOF-MS) for the measurement of atmospherically significant oxygenated volatile organic compounds. Atmospheric Chemistry and Physics,7, 609–620.