-
1
-
-
33749027737
-
Can pharmacogenetics help rescue drugs withdrawn from the market?
-
Shah, R. R. (2006). Can pharmacogenetics help rescue drugs withdrawn from the market? Pharmacogenomics,6, 889–908.
-
(2006)
Pharmacogenomics
, vol.6
, pp. 889-908
-
-
Shah, R.R.1
-
2
-
-
69749089278
-
-
McGuinness, R. P., Proctor, J. M., Gallant, D. L., van Staden, C. J., Ly, J. T., Tang, F. L., et al. (2009). Enhanced selectivity screening of GPCR ligands using a label-free cell based assay technology. ,12(8), 812–823
-
McGuinness, R. P., Proctor, J. M., Gallant, D. L., van Staden, C. J., Ly, J. T., Tang, F. L., et al. (2009). Enhanced selectivity screening of GPCR ligands using a label-free cell based assay technology. Combinational Chemistry and High Throughput Screening,12(8), 812–823.
-
Combinational Chemistry and High Throughput Screening
-
-
-
3
-
-
58849132807
-
The future of drug safety testing: Expanding the view and narrowing the focus
-
Stevens, J. L., & Baker, T. K. (2009). The future of drug safety testing: Expanding the view and narrowing the focus. Drug Discovery Today,3–4, 162–167.
-
(2009)
Drug Discovery Today
, vol.3-4
, pp. 162-167
-
-
Stevens, J.L.1
Baker, T.K.2
-
4
-
-
8844262805
-
Cellular dielectric spectroscopy: A powerful new approach to label-free cellular analysis
-
Ciambrone, G. J., Liu, V. F., Lin, D. C., McGuinness, R. P., Leung, G. K., & Pitchford, S. (2004). Cellular dielectric spectroscopy: A powerful new approach to label-free cellular analysis. Journal of Biomolecular Screening,6, 467–480.
-
(2004)
Journal of Biomolecular Screening
, vol.6
, pp. 467-480
-
-
Ciambrone, G.J.1
Liu, V.F.2
Lin, D.C.3
McGuinness, R.P.4
Leung, G.K.5
Pitchford, S.6
-
6
-
-
77956486698
-
Label-free whole-cell assays: Expanding the scope of GPCR screening
-
Scott, C. W., & Peters, M. F. (2010). Label-free whole-cell assays: Expanding the scope of GPCR screening. Drug Discovery Today,17–18, 704–716.
-
(2010)
Drug Discovery Today
, vol.17-18
, pp. 704-716
-
-
Scott, C.W.1
Peters, M.F.2
-
7
-
-
82855168014
-
Functional cardiotoxicity profiling and screening using the xCELLigence RTCA Cardio System
-
Xi, B., Wang, T., Li, N., Ouyang, W., Zhang, W., Wu, J., et al. (2011). Functional cardiotoxicity profiling and screening using the xCELLigence RTCA Cardio System. Journal of the Association for Laboratory Automation,6, 415–421.
-
(2011)
Journal of the Association for Laboratory Automation
, vol.6
, pp. 415-421
-
-
Xi, B.1
Wang, T.2
Li, N.3
Ouyang, W.4
Zhang, W.5
Wu, J.6
Xu, X.7
Wang, X.8
Abassi, Y.A.9
-
8
-
-
84863116827
-
Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment
-
Abassi, Y. A., Xi, B., Li, N., Ouyang, W., Seiler, A., Watzele, M., et al. (2012). Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment. British Journal of Pharmacology,5, 1424–1441.
-
(2012)
British Journal of Pharmacology
, vol.5
, pp. 1424-1441
-
-
Abassi, Y.A.1
Xi, B.2
Li, N.3
Ouyang, W.4
Seiler, A.5
Watzele, M.6
Kettenhofen, R.7
Bohlen, H.8
Ehlich, A.9
Kolossov, E.10
Wang, X.11
Xu, X.12
-
9
-
-
80052487012
-
Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes
-
Guo, L., Abrams, R. M., Babiarz, J. E., Cohen, J. D., Kameoka, S., Sanders, M. J., et al. (2011). Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. Toxicological Sciences,1, 281–289.
-
(2011)
Toxicological Sciences
, vol.1
, pp. 281-289
-
-
Guo, L.1
Abrams, R.M.2
Babiarz, J.E.3
Cohen, J.D.4
Kameoka, S.5
Sanders, M.J.6
Chiao, E.7
Kolaja, K.L.8
-
10
-
-
77956064817
-
Cell adhesion: Integrating cytoskeletal dynamics and cellular tension
-
Parsons, J. T., Horwitz, A. R., & Schwartz, M. A. (2010). Cell adhesion: Integrating cytoskeletal dynamics and cellular tension. Nature Reviews Molecular Cell Biology,9, 633–643.
-
(2010)
Nature Reviews Molecular Cell Biology
, vol.9
, pp. 633-643
-
-
Parsons, J.T.1
Horwitz, A.R.2
Schwartz, M.A.3
-
11
-
-
0032901396
-
Positive force- and [Ca2+]i-frequency relationships in rat ventricular trabeculae at physiological frequencies
-
Layland, J., & Kentish, J. C. (1999). Positive force- and [Ca2+]i-frequency relationships in rat ventricular trabeculae at physiological frequencies. American Journal of Physiology,1(Pt 2), H9–H18.
-
(1999)
American Journal of Physiology
, vol.1
, pp. 9-18
-
-
Layland, J.1
Kentish, J.C.2
-
12
-
-
67650022307
-
Absence of transverse tubules contributes to non-uniform Ca(2+) wavefronts in mouse and human embryonic stem cell-derived cardiomyocytes
-
Lieu, D. K., Liu, J., Siu, C. W., McNerney, G. P., Tse, H. F., Abu-Khalil, A., et al. (2009). Absence of transverse tubules contributes to non-uniform Ca(2+) wavefronts in mouse and human embryonic stem cell-derived cardiomyocytes. Stem Cells and Development,10, 1493–1500.
-
(2009)
Stem Cells and Development
, vol.10
, pp. 1493-1500
-
-
Lieu, D.K.1
Liu, J.2
Siu, C.W.3
McNerney, G.P.4
Tse, H.F.5
Abu-Khalil, A.6
Huser, T.7
Li, R.A.8
-
13
-
-
0024418364
-
Ultrastructural morphometric analysis of cultured neonatal and adult rat ventricular cardiac muscle cells
-
Delcarpio, J. B., Claycomb, W. C., & Moses, R. L. (1989). Ultrastructural morphometric analysis of cultured neonatal and adult rat ventricular cardiac muscle cells. American Journal of Anatomy,4, 335–345.
-
(1989)
American Journal of Anatomy
, vol.4
, pp. 335-345
-
-
Delcarpio, J.B.1
Claycomb, W.C.2
Moses, R.L.3
-
14
-
-
78751687308
-
Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells
-
Germanguz, I., Sedan, O., Zeevi-Levin, N., Shtrichman, R., Barak, E., Ziskind, A., et al. (2011). Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells. Journal of Cellular and Molecular Medicine,1, 38–51.
-
(2011)
Journal of Cellular and Molecular Medicine
, vol.1
, pp. 38-51
-
-
Germanguz, I.1
Sedan, O.2
Zeevi-Levin, N.3
Shtrichman, R.4
Barak, E.5
Ziskind, A.6
Eliyahu, S.7
Meiry, G.8
Amit, M.9
Itskovitz-Eldor, J.10
Binah, O.11
-
15
-
-
36649012968
-
Regulation of systolic [Ca2+]i and cellular Ca2+ flux balance in rat ventricular myocytes by SR Ca2+ L-type Ca2+ current and diastolic [Ca2+]i
-
Dibb, K. M., Eisner, D. A., & Trafford, A. W. (2007). Regulation of systolic [Ca2+]i and cellular Ca2+ flux balance in rat ventricular myocytes by SR Ca2+ L-type Ca2+ current and diastolic [Ca2+]i. The Journal of Physiology,2, 579–592.
-
(2007)
The Journal of Physiology
, vol.2
, pp. 579-592
-
-
Dibb, K.M.1
Eisner, D.A.2
Trafford, A.W.3
-
16
-
-
61549114668
-
Model of excitation-contraction coupling of rat neonatal ventricular myocytes
-
Korhonen, T., Hanninen, S. L., & Tavi, P. (2009). Model of excitation-contraction coupling of rat neonatal ventricular myocytes. Biophysical Journal,3, 1189–1209.
-
(2009)
Biophysical Journal
, vol.3
, pp. 1189-1209
-
-
Korhonen, T.1
Hanninen, S.L.2
Tavi, P.3
-
17
-
-
84870875516
-
Evaluation of cellular impedance measures of cardiomyocyte cultures for drug screening applications
-
Peters, M. F., Scott, C. W., Ochalski, R., & Dragan, Y. P. (2012). Evaluation of cellular impedance measures of cardiomyocyte cultures for drug screening applications. Assay and Drug Development Technologies,6, 525–532.
-
(2012)
Assay and Drug Development Technologies
, vol.6
, pp. 525-532
-
-
Peters, M.F.1
Scott, C.W.2
Ochalski, R.3
Dragan, Y.P.4
-
18
-
-
79952122944
-
Cell death assays for drug discovery
-
Kepp, O., Galluzzi, L., Lipinski, M., Yuan, J., & Kroemer, G. (2011). Cell death assays for drug discovery. Nature Reviews Drug Discovery,3, 221–237.
-
(2011)
Nature Reviews Drug Discovery
, vol.3
, pp. 221-237
-
-
Kepp, O.1
Galluzzi, L.2
Lipinski, M.3
Yuan, J.4
Kroemer, G.5
-
19
-
-
84886552532
-
Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity
-
Lamore, S. D., Kamendi, H. W., Scott, C. W., Dragan, Y. P., & Peters, M. F. (2013). Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity. Toxicological Sciences,2, 402–413.
-
(2013)
Toxicological Sciences
, vol.2
, pp. 402-413
-
-
Lamore, S.D.1
Kamendi, H.W.2
Scott, C.W.3
Dragan, Y.P.4
Peters, M.F.5
-
20
-
-
84871600132
-
Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells
-
Sirenko, O., Crittenden, C., Callamaras, N., Hesley, J., Chen, Y. W., Funes, C., et al. (2013). Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells. Journal of Biomolecular Screening,1, 39–53.
-
(2013)
Journal of Biomolecular Screening
, vol.1
, pp. 39-53
-
-
Sirenko, O.1
Crittenden, C.2
Callamaras, N.3
Hesley, J.4
Chen, Y.W.5
Funes, C.6
Rusyn, I.7
Anson, B.8
Cromwell, E.F.9
-
21
-
-
41849095624
-
Balancing drug risk and benefit: Toward refining the process of FDA decisions affecting patient care
-
Schiller, L. R., & Johnson, D. A. (2008). Balancing drug risk and benefit: Toward refining the process of FDA decisions affecting patient care. American Journal of Gastroenterology,4, 815–819.
-
(2008)
American Journal of Gastroenterology
, vol.4
, pp. 815-819
-
-
Schiller, L.R.1
Johnson, D.A.2
-
22
-
-
0344492207
-
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development
-
Redfern, W. S., Carlsson, L., Davis, A. S., Lynch, W. G., MacKenzie, I., Palethorpe, S., et al. (2003). Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development. Cardiovascular Research,1, 32–45.
-
(2003)
Cardiovascular Research
, vol.1
, pp. 32-45
-
-
Redfern, W.S.1
Carlsson, L.2
Davis, A.S.3
Lynch, W.G.4
MacKenzie, I.5
Palethorpe, S.6
Siegl, P.K.7
Strang, I.8
Sullivan, A.T.9
Wallis, R.10
Camm, A.J.11
Hammond, T.G.12
-
23
-
-
48149084580
-
Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines
-
Lu, H. R., Vlaminckx, E., Hermans, A. N., Rohrbacher, J., Van Ammel, K., Towart, R., et al. (2008). Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines. British Journal of Pharmacology,7, 1427–1438.
-
(2008)
British Journal of Pharmacology
, vol.7
, pp. 1427-1438
-
-
Lu, H.R.1
Vlaminckx, E.2
Hermans, A.N.3
Rohrbacher, J.4
Van Ammel, K.5
Towart, R.6
Pugsley, M.7
Gallacher, D.J.8
-
24
-
-
84890320017
-
Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model
-
Guo, L., Coyle, L., Abrams, R. M., Kemper, R., Chiao, E. T., & Kolaja, K. L. (2013). Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicological Sciences,2, 581–594.
-
(2013)
Toxicological Sciences
, vol.2
, pp. 581-594
-
-
Guo, L.1
Coyle, L.2
Abrams, R.M.3
Kemper, R.4
Chiao, E.T.5
Kolaja, K.L.6
-
25
-
-
79151474418
-
An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation
-
Gintant, G. (2011). An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation. Pharmacology & Therapeutics,2, 109–119.
-
(2011)
Pharmacology & Therapeutics
, vol.2
, pp. 109-119
-
-
Gintant, G.1
-
26
-
-
84896692500
-
Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the cardiac safety research consortium
-
Sager, P. T., Gintant, G., Turner, J. R., Pettit, S., & Stockbridge, N. (2014). Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the cardiac safety research consortium. American Heart Journal,3, 292–300.
-
(2014)
American Heart Journal
, vol.3
, pp. 292-300
-
-
Sager, P.T.1
Gintant, G.2
Turner, J.R.3
Pettit, S.4
Stockbridge, N.5
-
27
-
-
83055173972
-
Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes
-
Jonsson, M. K., Wang, Q. D., & Becker, B. (2011). Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes. Assay and Drug Development Technologies,6, 589–599.
-
(2011)
Assay and Drug Development Technologies
, vol.6
, pp. 589-599
-
-
Jonsson, M.K.1
Wang, Q.D.2
Becker, B.3
-
28
-
-
84861391189
-
In vitro model for assessing arrhythmogenic properties of drugs based on high-resolution impedance measurements
-
Nguemo, F., Saric, T., Pfannkuche, K., Watzele, M., Reppel, M., & Hescheler, J. (2012). In vitro model for assessing arrhythmogenic properties of drugs based on high-resolution impedance measurements. Cellular Physiology and Biochemistry,5–6, 819–832.
-
(2012)
Cellular Physiology and Biochemistry
, vol.5-6
, pp. 819-832
-
-
Nguemo, F.1
Saric, T.2
Pfannkuche, K.3
Watzele, M.4
Reppel, M.5
Hescheler, J.6
-
29
-
-
84883339589
-
Regulatory watch: Speedy validation sought for new cardiotoxicity testing strategy
-
Chi, K. R. (2013). Regulatory watch: Speedy validation sought for new cardiotoxicity testing strategy. Nature Reviews Drug Discovery,9, 655.
-
(2013)
Nature Reviews Drug Discovery
, vol.9
, pp. 655
-
-
Chi, K.R.1
-
30
-
-
79952095377
-
Cardiotoxicity associated with targeting kinase pathways in cancer
-
Mellor, H. R., Bell, A. R., Valentin, J. P., & Roberts, R. R. (2011). Cardiotoxicity associated with targeting kinase pathways in cancer. Toxicological Sciences,1, 14–32.
-
(2011)
Toxicological Sciences
, vol.1
, pp. 14-32
-
-
Mellor, H.R.1
Bell, A.R.2
Valentin, J.P.3
Roberts, R.R.4
-
31
-
-
84859105875
-
Validation of an in vitro contractility assay using canine ventricular myocytes
-
Harmer, A. R., Abi-Gerges, N., Morton, M. J., Pullen, G. F., Valentin, J. P., & Pollard, C. E. (2012). Validation of an in vitro contractility assay using canine ventricular myocytes. Toxicology and Applied Pharmacology,2, 162–172.
-
(2012)
Toxicology and Applied Pharmacology
, vol.2
, pp. 162-172
-
-
Harmer, A.R.1
Abi-Gerges, N.2
Morton, M.J.3
Pullen, G.F.4
Valentin, J.P.5
Pollard, C.E.6
-
32
-
-
79551610758
-
Cardiotoxicity of kinase inhibitors: The prediction and translation of preclinical models to clinical outcomes
-
Force, T., & Kolaja, K. L. (2011). Cardiotoxicity of kinase inhibitors: The prediction and translation of preclinical models to clinical outcomes. Nature Reviews Drug Discovery,2, 111–126.
-
(2011)
Nature Reviews Drug Discovery
, vol.2
, pp. 111-126
-
-
Force, T.1
Kolaja, K.L.2
-
33
-
-
84884134230
-
Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes
-
Doherty, K. R., Wappel, R. L., Talbert, D. R., Trusk, P. B., Moran, D. M., Kramer, J. W., et al. (2013). Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicology and Applied Pharmacology,1, 245–255.
-
(2013)
Toxicology and Applied Pharmacology
, vol.1
, pp. 245-255
-
-
Doherty, K.R.1
Wappel, R.L.2
Talbert, D.R.3
Trusk, P.B.4
Moran, D.M.5
Kramer, J.W.6
Brown, A.M.7
Shell, S.A.8
Bacus, S.9
-
34
-
-
81255142147
-
Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations
-
Cohen, J. D., Babiarz, J. E., Abrams, R. M., Guo, L., Kameoka, S., Chiao, E., et al. (2011). Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations. Toxicology and Applied Pharmacology,1, 74–83.
-
(2011)
Toxicology and Applied Pharmacology
, vol.1
, pp. 74-83
-
-
Cohen, J.D.1
Babiarz, J.E.2
Abrams, R.M.3
Guo, L.4
Kameoka, S.5
Chiao, E.6
Taunton, J.7
Kolaja, K.L.8
-
35
-
-
84939926918
-
-
Lim, J., Taoka, B. M., Lee, S., Northrup, A., Altman, M., Sloman, D., et al. (2011). Pyrazolo[1,5-A]. World Patent WO 2011/087999 A1, 21 July 2011
-
Lim, J., Taoka, B. M., Lee, S., Northrup, A., Altman, M., Sloman, D., et al. (2011). Pyrazolo[1,5-A]pyrimidines as MARK inhibitors. World Patent WO 2011/087999 A1, 21 July 2011.
-
pyrimidines as MARK inhibitors
-
-
-
36
-
-
80755125565
-
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
-
Anastassiadis, T., Deacon, S. W., Devarajan, K., Ma, H., & Peterson, J. R. (2011). Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nature Biotechnology,11, 1039–1045.
-
(2011)
Nature Biotechnology
, vol.11
, pp. 1039-1045
-
-
Anastassiadis, T.1
Deacon, S.W.2
Devarajan, K.3
Ma, H.4
Peterson, J.R.5
-
37
-
-
80755125575
-
Comprehensive analysis of kinase inhibitor selectivity
-
Davis, M. I., Hunt, J. P., Herrgard, S., Ciceri, P., Wodicka, L. M., Pallares, G., et al. (2011). Comprehensive analysis of kinase inhibitor selectivity. Nature Biotechnology,11, 1046–1051.
-
(2011)
Nature Biotechnology
, vol.11
, pp. 1046-1051
-
-
Davis, M.I.1
Hunt, J.P.2
Herrgard, S.3
Ciceri, P.4
Wodicka, L.M.5
Pallares, G.6
Hocker, M.7
Treiber, D.K.8
Zarrinkar, P.P.9
-
38
-
-
84887878750
-
Phenotypic screening with human iPS cell-derived cardiomyocytes: HTS-compatible assays for interrogating cardiac hypertrophy
-
Carlson, C., Koonce, C., Aoyama, N., Einhorn, S., Fiene, S., Thompson, A., et al. (2013). Phenotypic screening with human iPS cell-derived cardiomyocytes: HTS-compatible assays for interrogating cardiac hypertrophy. Journal of Biomolecular Screening,10, 1203–1211.
-
(2013)
Journal of Biomolecular Screening
, vol.10
, pp. 1203-1211
-
-
Carlson, C.1
Koonce, C.2
Aoyama, N.3
Einhorn, S.4
Fiene, S.5
Thompson, A.6
Swanson, B.7
Anson, B.8
Kattman, S.9
-
39
-
-
0030053811
-
Surface:volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: Species-dependence and developmental effects
-
Satoh, H., Delbridge, L. M., Blatter, L. A., & Bers, D. M. (1996). Surface:volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: Species-dependence and developmental effects. Biophysical Journal,3, 1494–1504.
-
(1996)
Biophysical Journal
, vol.3
, pp. 1494-1504
-
-
Satoh, H.1
Delbridge, L.M.2
Blatter, L.A.3
Bers, D.M.4
-
40
-
-
84861340604
-
Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture
-
Feinberg, A. W., Alford, P. W., Jin, H., Ripplinger, C. M., Werdich, A. A., Sheehy, S. P., et al. (2012). Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture. Biomaterials,23, 5732–5741.
-
(2012)
Biomaterials
, vol.23
, pp. 5732-5741
-
-
Feinberg, A.W.1
Alford, P.W.2
Jin, H.3
Ripplinger, C.M.4
Werdich, A.A.5
Sheehy, S.P.6
Grosberg, A.7
Parker, K.K.8
-
41
-
-
84868093154
-
Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility
-
Blazeski, A., Zhu, R., Hunter, D. W., Weinberg, S. H., Zambidis, E. T., & Tung, L. (2012). Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility. Progress in Biophysics and Molecular Biology,2–3, 166–177.
-
(2012)
Progress in Biophysics and Molecular Biology
, vol.2-3
, pp. 166-177
-
-
Blazeski, A.1
Zhu, R.2
Hunter, D.W.3
Weinberg, S.H.4
Zambidis, E.T.5
Tung, L.6
-
43
-
-
79958021542
-
How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?
-
Laverty, H., Benson, C., Cartwright, E., Cross, M., Garland, C., Hammond, T., et al. (2011). How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? British Journal of Pharmacology,4, 675–693.
-
(2011)
British Journal of Pharmacology
, vol.4
, pp. 675-693
-
-
Laverty, H.1
Benson, C.2
Cartwright, E.3
Cross, M.4
Garland, C.5
Hammond, T.6
Holloway, C.7
McMahon, N.8
Milligan, J.9
Park, B.10
Pirmohamed, M.11
Pollard, C.12
Radford, J.13
Roome, N.14
Sager, P.15
Singh, S.16
Suter, T.17
Suter, W.18
Trafford, A.19
Volders, P.20
Wallis, R.21
Weaver, R.22
York, M.23
Valentin, J.24
more..
-
44
-
-
84876526111
-
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity
-
Liang, P., Lan, F., Lee, A. S., Gong, T., Sanchez-Freire, V., Wang, Y., et al. (2013). Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation,16, 1677–1691.
-
(2013)
Circulation
, vol.16
, pp. 1677-1691
-
-
Liang, P.1
Lan, F.2
Lee, A.S.3
Gong, T.4
Sanchez-Freire, V.5
Wang, Y.6
Diecke, S.7
Sallam, K.8
Knowles, J.W.9
Wang, P.J.10
Nguyen, P.K.11
Bers, D.M.12
Robbins, R.C.13
Wu, J.C.14
-
45
-
-
84880678710
-
Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays
-
Harris, K., Aylott, M., Cui, Y., Louttit, J. B., McMahon, N. C., & Sridhar, A. (2013). Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays. Toxicological Sciences,2, 412–426.
-
(2013)
Toxicological Sciences
, vol.2
, pp. 412-426
-
-
Harris, K.1
Aylott, M.2
Cui, Y.3
Louttit, J.B.4
McMahon, N.C.5
Sridhar, A.6
-
46
-
-
84883791986
-
Screening drug-induced arrhythmia events using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays
-
Navarrete, E. G., Liang, P., Lan, F., Sanchez-Freire, V., Simmons, C., Gong, T., et al. (2013). Screening drug-induced arrhythmia events using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation,11(Suppl 1), S3–S13.
-
(2013)
Circulation
, vol.11
, pp. 3-13
-
-
Navarrete, E.G.1
Liang, P.2
Lan, F.3
Sanchez-Freire, V.4
Simmons, C.5
Gong, T.6
Sharma, A.7
Burridge, P.W.8
Patlolla, B.9
Lee, A.S.10
Wu, H.11
Beygui, R.E.12
Wu, S.M.13
Robbins, R.C.14
Bers, D.M.15
Wu, J.C.16
-
47
-
-
84888861133
-
Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity
-
Sirenko, O., Cromwell, E. F., Crittenden, C., Wignall, J. A., Wright, F. A., & Rusyn, I. (2013). Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity. Toxicology and Applied Pharmacology,3, 500–507.
-
(2013)
Toxicology and Applied Pharmacology
, vol.3
, pp. 500-507
-
-
Sirenko, O.1
Cromwell, E.F.2
Crittenden, C.3
Wignall, J.A.4
Wright, F.A.5
Rusyn, I.6
-
48
-
-
84870715347
-
High throughput measurement of Ca(2)(+) dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry
-
Cerignoli, F., Charlot, D., Whittaker, R., Ingermanson, R., Gehalot, P., Savchenko, A., et al. (2012). High throughput measurement of Ca(2)(+) dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry. Journal of Pharmacological and Toxicological Methods,3, 246–256.
-
(2012)
Journal of Pharmacological and Toxicological Methods
, vol.3
, pp. 246-256
-
-
Cerignoli, F.1
Charlot, D.2
Whittaker, R.3
Ingermanson, R.4
Gehalot, P.5
Savchenko, A.6
Gallacher, D.J.7
Towart, R.8
Price, J.H.9
McDonough, P.M.10
Mercola, M.11
-
49
-
-
77549085427
-
Biohybrid thin films for measuring contractility in engineered cardiovascular muscle
-
Alford, P. W., Feinberg, A. W., Sheehy, S. P., & Parker, K. K. (2010). Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. Biomaterials,13, 3613–3621.
-
(2010)
Biomaterials
, vol.13
, pp. 3613-3621
-
-
Alford, P.W.1
Feinberg, A.W.2
Sheehy, S.P.3
Parker, K.K.4
-
50
-
-
84875237101
-
Phenotypic profiling of structural cardiotoxins in vitro reveals dependency on multiple mechanisms of toxicity
-
Pointon, A., Abi-Gerges, N., Cross, M. J., & Sidaway, J. E. (2013). Phenotypic profiling of structural cardiotoxins in vitro reveals dependency on multiple mechanisms of toxicity. Toxicological Sciences,2, 317–326.
-
(2013)
Toxicological Sciences
, vol.2
, pp. 317-326
-
-
Pointon, A.1
Abi-Gerges, N.2
Cross, M.J.3
Sidaway, J.E.4
-
51
-
-
0037049977
-
Cardiac excitation-contraction coupling
-
Bers, D. M. (2002). Cardiac excitation-contraction coupling. Nature,6868, 198–205.
-
(2002)
Nature
, vol.6868
, pp. 198-205
-
-
Bers, D.M.1
-
52
-
-
84875506766
-
Human induced pluripotent stem cells and their use in drug discovery for toxicity testing
-
Scott, C. W., Peters, M. F., & Dragan, Y. P. (2013). Human induced pluripotent stem cells and their use in drug discovery for toxicity testing. Toxicology Letters,1, 49–58.
-
(2013)
Toxicology Letters
, vol.1
, pp. 49-58
-
-
Scott, C.W.1
Peters, M.F.2
Dragan, Y.P.3
|