TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7

FEBS Letters

Volumn 589, Issue 12, 2015, Pages 1322-1330

  Wang, Yanming ^a   Yan, Shanshan ^a   Yang, Bo ^a   Wang, Yan ^b   Zhou, Haiyan ^c   Lian, Qiaoshi ^c   Sun, Bing ^c  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b INSTITUTE PASTEUR OF SHANGHAI   (China)

^c INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Feedback regulation; IRF7; K48 linked ubiquitination; Proteasome dependent degradation; TLR7 9; TRIM35

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 7; IRF7 PROTEIN, MOUSE; LIGAND; MEMBRANE PROTEIN; PROTEASOME; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; TLR7 PROTEIN, MOUSE; TLR9 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRIM35 PROTEIN, MOUSE;

AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL LINE; CHEMISTRY; DENDRITIC CELL; DOWN REGULATION; GENETICS; GERMFREE ANIMAL; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; MUTATION; PROTEIN STABILITY; RNA INTERFERENCE; UBIQUITINATION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELL LINE; CELLS, CULTURED; DENDRITIC CELLS; DOWN-REGULATION; HUMANS; INTERFERON REGULATORY FACTOR-7; INTERFERON TYPE I; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; RECOMBINANT PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SPECIFIC PATHOGEN-FREE ORGANISMS; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 9; UBIQUITINATION;

EID: 84937758011     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2015.04.019     Document Type: Article

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