Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27KIP1/p15INK4b signaling

Cellular and Molecular Life Sciences

Volumn 72, Issue 15, 2015, Pages 2949-2960

  Liu, Shuang ^a   Wang, Xinyue ^a   Zhao, Qian ^b   Liu, Shu ^a   Zhang, Huishan ^a   Shi, Junchao ^a,c   Li, Na ^a,c   Lei, Xiaohua ^a   Zhao, Huashan ^a,c   Deng, Zhili ^a,c   Cao, Yujing ^a   Ning, Lina ^a   Xia, Guoliang ^b   Duan, Enkui ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b CHINA AGRICULTURAL UNIVERSITY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Adult stem cells; Akt; Cellular senescence; p15INK4b; p27KIP1; Skin derived precursors

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 1C; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; CYCLIN DEPENDENT KINASE INHIBITOR 2C; CYCLIN DEPENDENT KINASE INHIBITOR 2D; CYCLINE; HISTONE H2AX; KI 67 ANTIGEN; MESSENGER RNA; PROTEIN KINASE B; RETINOBLASTOMA PROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR FKHRL1; CYCLIN DEPENDENT KINASE; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN;

ARTICLE; CELL AGING; CELL EXPANSION; CELL PROLIFERATION; CELL RENEWAL; CELL STRUCTURE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; GAIN OF FUNCTION MUTATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN SKIN DERIVED PRECURSOR; IN VITRO STUDY; INTRACELLULAR SIGNALING; LOSS OF FUNCTION MUTATION; MICROARRAY ANALYSIS; MOLECULAR DYNAMICS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SKIN CELL; STEM CELL; UPREGULATION; AGING; ANTAGONISTS AND INHIBITORS; CELL CULTURE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKIN;

AGING; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SKIN; STEM CELLS;

EID: 84937731227     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-1877-3     Document Type: Article

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