C-terminal modification of osteopontin inhibits interaction with the α Vβ 3-integrin

Journal of Biological Chemistry

Volumn 287, Issue 6, 2012, Pages 3788-3797

  Christensen, Brian ^a   Kläning, Eva ^a   Nielsen, Mette S ^a   Andersen, Mikkel H ^a   Sørensen, Esben S ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ARG GLY ASPS; C TERMINUS; C-TERMINAL REGIONS; CELL ATTACHMENTS; DEPHOSPHORYLATIONS; INTEGRIN BINDING; INTEGRIN RECEPTORS; INTEGRINS; ISOFORMS; MAMMALIAN SPECIES; OSTEOPONTIN; PHOSPHORYLATED PROTEINS;

ADHESION; CELL ADHESION; MAMMALS;

PHOSPHORYLATION;

OSTEOPONTIN; PLASMIN; THROMBIN; VITRONECTIN RECEPTOR;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

CELL LINE; HUMANS; INTEGRIN ALPHAVBETA3; OSTEOPONTIN; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY;

MAMMALIA;

EID: 84856699976     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.277996     Document Type: Article

References (35)

1. Anborgh, P. H., Mutrie, J. C., Tuck, A. B., and Chambers, A. F. (2011) Pre- and post-translational regulation of osteopontin in cancer. J. Cell Commun. Signal. 5, 111-122
2. Frenzel, D. F., and Weiss, J. M. (2011) Osteopontin and allergic disease: pathophysiology and implications for diagnostics and therapy. Expert Rev. Clin. Immunol. 7, 93-109
3. Lund, S. A., Giachelli, C. M., and Scatena, M. (2009) The role of osteopontin in inflammatory processes. J. Cell Commun. Signal 3, 311-322
4. Senger, D. R., Perruzzi, C. A., Gracey, C. F., Papadopoulos, A., and Tenen, D. G. (1988) Secreted phosphoproteins associated with neoplastic transformation: close homology with plasma proteins cleaved during blood coagulation. Cancer Res. 48, 5770-5774
5. Sodek, J., Ganss, B., and McKee, M. D. (2000) Osteopontin. Crit. Rev. Oral Biol. Med. 11, 279-303
6. Christensen, B., Petersen, T. E., and Sørensen, E. S. (2008) Post-translational modification and proteolytic processing of urinary osteopontin. Biochem. J. 411, 53-61 (Pubitemid 351482346)
7. Schack, L., Lange, A., Kelsen, J., Agnholt, J., Christensen, B., Petersen, T. E., and Sørensen, E. S. (2009) Considerable variation in the concentration of osteopontin in human milk, bovine milk, and infant formulas. J. Dairy Sci. 92, 5378-5385
8. Fisher, L. W., Torchia, D. A., Fohr, B., Young, M. F., and Fedarko, N. S. (2001) Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin. Biochem. Biophys. Res. Commun. 280, 460-465 (Pubitemid 32912812)
9. Gericke, A., Qin, C., Spevak, L., Fujimoto, Y., Butler, W. T., Sørensen, E. S., and Boskey, A. L. (2005) Importance of phosphorylation for osteopontin regulation of biomineralization. Calcif. Tissue Int. 77, 45-54 (Pubitemid 41504172)
10. Yamaguchi, Y., Hanashima, S., Yagi, H., Takahashi, Y., Sasakawa, H., Kurimoto, E., Iguchi, T., Kon, S., Uede, T., and Kato, K. (2010) NMR characterization of intramolecular interaction of osteopontin, an intrinsically disordered protein with cryptic integrin-binding motifs. Biochem. Biophys. Res. Commun. 393, 487-491
11. Platzer, G., Schedlbauer, A., Chemelli, A., Ozdowy, P., Coudevylle, N., Auer, R., Kontaxis, G., Hartl, M., Miles, A. J., Wallace, B. A., Glatter, O., Bister, K., and Konrat, R. (2011) The metastasis-associated extracellular matrix protein osteopontin forms transient structure in ligand interaction sites. Biochemistry 50, 6113-6124
12. 1 to osteopontin. Matrix Biol. 24, 418-427
13. Kazanecki, C. C., Uzwiak, D. J., and Denhardt, D. T. (2007) Control of osteopontin signaling and function by post-translational phosphorylation and protein folding. J. Cell. Biochem. 102, 912-924 (Pubitemid 350036931)
14. 1 integrin binding sites within a 38-amino acid domain in the N-terminal thrombin fragment of human osteopontin. J. Biol. Chem. 276, 13483-13489
15. 1 binds to a novel recognition sequence (SV-VYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. J. Biol. Chem. 274, 36328-36334
16. 2 integrin. J. Immunol. 182, 6943-6950
17. Qin, C., Baba, O., and Butler, W. T. (2004) Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis. Crit. Rev. Oral Biol. Med. 15, 126-136
18. Agnihotri, R., Crawford, H. C., Haro, H., Matrisian, L. M., Havrda, M. C., and Liaw, L. (2001) Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin). J. Biol. Chem. 276, 28261-28267
19. Christensen, B., Schack, L., Kläning, E., and Sørensen, E. S. (2010) Osteopontin is cleaved at multiple sites close to its integrin-binding motifs in milk and is a novel substrate for plasmin and cathepsin D. J. Biol. Chem. 285, 7929-7937
20. Senger, D. R., Perruzzi, C. A., Papadopoulos-Sergiou, A., and Van de Water, L. (1994) Adhesive properties of osteopontin: regulation by a naturally occurring thrombin cleavage in close proximity to the GRGDS cell-binding domain. Mol. Biol. Cell 5, 565-574 (Pubitemid 24183445)
21. Sørensen, E. S., Højrup, P., and Petersen, T. E. (1995) Posttranslational modifications of bovine osteopontin: identification of 28 phosphorylation and 3 O-glycosylation sites. Protein Sci. 4, 2040-2049
22. Christensen, B., Nielsen, M. S., Haselmann, K. F., Petersen, T. E., and Sørensen, E. S. (2005) Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and 5 O-glycosylation sites and their biological implications. Biochem. J. 390, 285-292 (Pubitemid 41192254)
23. Keykhosravani, M., Doherty-Kirby, A., Zhang, C., Brewer, D., Goldberg, H. A., Hunter, G. K., and Lajoie, G. (2005) Comprehensive identification of post-translational modifications of rat bone osteopontin by mass spectrometry. Biochemistry 44, 6990-7003 (Pubitemid 40632417)
24. Christensen, B., Kazanecki, C. C., Petersen, T. E., Rittling, S. R., Denhardt, D. T., and Sørensen, E. S. (2007) Cell type-specific post-translational modifications of mouse osteopontin are associated with different adhesive properties. J. Biol. Chem. 282, 19463-19472 (Pubitemid 47100061)
25. Ek-Rylander, B., and Andersson, G. (2010) Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase. Exp. Cell Res. 316, 443-451
26. 3 potentiate bone resorption. J. Biol. Chem. 268, 9901-9907
27. Kazanecki, C. C., Kowalski, A. J., Ding, T., Rittling, S. R., and Denhardt, D. T. (2007) Characterization of anti-osteopontin monoclonal antibodies: binding sensitivity to post-translational modifications. J. Cell. Biochem. 102, 925-935 (Pubitemid 350036932)
28. 3. Blood 86, 2606-2615
29. Pear, W. S., Nolan, G. P., Scott, M. L., and Baltimore, D. (1993) Production of high titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. U.S.A. 90, 8392-8396 (Pubitemid 23277674)
30. Miura, Y., Kato, K., Takegawa, Y., Kurogochi, M., Furukawa, J., Shinohara, Y., Nagahori, N., Amano, M., Hinou, H., and Nishimura, S. (2010) Glycoblotting-assisted O-glycomics: ammonium carbamate allows for highly efficient O-glycan release from glycoproteins. Anal. Chem. 82, 10021-10029
31. Ek-Rylander, B., Flores, M., Wendel, M., Heinegård, D., and Andersson, G. (1994) Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase: modulation of osteoclast adhesion in vitro. J. Biol. Chem. 269, 14853-14856
32. Katayama, Y., House, C. M., Udagawa, N., Kazama, J. J., McFarland, R. J., Martin, T. J., and Findlay, D. M. (1998) Casein kinase 2 phosphorylation of recombinant rat osteopontin enhances adhesion of osteoclasts but not osteoblasts. J. Cell. Physiol. 176, 179-187 (Pubitemid 28277207)
33. Lee, J. L., Wang, M. J., Sudhir, P. R., Chen, G. D., Chi, C. W., and Chen, J. Y. (2007) Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cells. Cancer Res. 67, 2089-2097
34. Weber, G. F., Zawaideh, S., Hikita, S., Kumar, V. A., Cantor, H., and Ashkar, S. (2002) Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation. J. Leukocyte Biol. 72, 752-761 (Pubitemid 36277847)
35. 9 integrin-mediated cell binding and migration. Matrix Biol. 28, 11-19