Efficacy and Safety of Intravenous Ferric Carboxymaltose in Geriatric Inpatients at a German Tertiary University Teaching Hospital: A Retrospective Observational Cohort Study of Clinical Practice

Anemia

Volumn 2015, Issue , 2015, Pages

  Bach, Matthias ^a   Geisel, Tabea ^b,c   Martin, Julia ^b,c   Schulze, Bettina ^a   Schaefer, Roland ^d   Virgin, Garth ^e   Stein, Juergen ^b,c,d  

^a St Elisabethen Krankenhaus   (Germany)

^b Crohn Colitis Center Rhein Main   (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^e Vifor (International) Inc   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84937702114     PISSN: 20901267     EISSN: 20901275     Source Type: Journal    
DOI: 10.1155/2015/647930     Document Type: Article

References (49)

1. J. M. Guralnik, R. S. Eisenstaedt, L. Ferrucci, H. G. Klein, and R. C. Woodman, "Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia, " Blood, vol. 104, no. 8, pp. 2263-2268, 2004.
2. M. Tettamanti, U. Lucca, F. Gandini et al., "Prevalence, incidence and types of mild anemia in the elderly: the 'Health and Anemia'population-based study, " Haematologica, vol. 95, no. 11, pp. 1849-1856, 2010.
3. T. Geisel, J. Martin, B. Schulze et al., "An etiologic profile of anemia in 405 geriatric patients, " Anemia, vol. 2014, Article ID 932486, 7 pages, 2014.
4. I. Petrosyan, G. Blaison, E. Andrès, and L. Federici, "Anaemia in the elderly: an aetiologic profile of a prospective cohort of 95 hospitalised patients, " European Journal of InternalMedicine, vol. 23, no. 6, pp. 524-528, 2012.
5. L. Ferrucci, R.D. Semba, J.M. Guralnik et al., "Proinflammatory state, hepcidin, and anemia in older persons, " Blood, vol. 115, no. 18, pp. 3810-3816, 2010.
6. L. Balducci, "An overlooked problem: anemia in the elderly patient with cancer, " The Journal of Supportive Oncology, vol. 5, no. 3, pp. 115-116, 2007.
7. E. A. Price, R. Mehra, T. H. Holmes, and S. L. Schrier, "Anemia in older persons: etiology and evaluation, " Blood Cells, Molecules, & Diseases, vol. 46, no. 2, pp. 159-165, 2011.
8. A. R. Nissenson, L. T. Goodnough, and R. W. Dubois, "Anemia: not just an innocent bystander?" Archives of Internal Medicine, vol. 163, no. 12, pp. 1400-1404, 2003.
9. S. D. Denny, M. N. Kuchibhatla, and H. J. Cohen, "Impact of anemia on mortality, cognition, and function in communitydwelling elderly, " The American Journal ofMedicine, vol. 119, no. 4, pp. 327-334, 2006.
10. B.W. J. H. Penninx, M. Pahor, R. C.Woodman, and J.M. Guralnik, "Anemia in old age is associated with increased mortality and hospitalization, " Journals of Gerontology. Series A Biological Sciences and Medical Sciences, vol. 61, no. 5, pp. 474-479, 2006.
11. M. Andro, P. Le Squere, S. Estivin, and A. Gentric, "Anaemia and cognitive performances in the elderly: a systematic review, " European Journal of Neurology, vol. 20, no. 9, pp. 1234-1240, 2013.
12. M. Thein, W. B. Ershler, A. S. Artz et al., "Diminished quality of life and physical function in community-dwelling elderly with anemia, " Medicine, vol. 88, no. 2, pp. 107-114, 2009.
13. B. W. J. H. Penninx, M. Pahor, M. Cesari et al., "Anemia is associated with disability and decreased physical performance and muscle strength in the elderly, " Journal of the American Geriatrics Society, vol. 52, no. 5, pp. 719-724, 2004.
14. B. W. J. H. Penninx, J. M. Guralnik, G. Onder, L. Ferrucci, R. B. Wallace, and M. Pahor, "Anemia and decline in physical performance among older persons, " The American Journal of Medicine, vol. 115, no. 2, pp. 104-110, 2003.
15. E. Riva, M. Tettamanti, P. Mosconi et al., "Association of mild anemia with hospitalization and mortality in the elderly: the Health and Anemia population-based study, " Haematologica, vol. 94, no. 1, pp. 22-28, 2009.
16. N. A. Zakai, R. Katz, C. Hirsch et al., "A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study, " Archives of Internal Medicine, vol. 165, no. 19, pp. 2214-2220, 2005.
17. U. Lucca, M. Tettamanti, P. Mosconi et al., "Association of mild anemia with cognitive, functional, mood and quality of life outcomes in the elderly: the 'Health and Anemia' study, " PLoS ONE, vol. 3, no. 4, Article ID e1920, 2008.
18. R. Woodman, L. Ferrucci, and J. Guralnik, "Anemia in older adults, " Current Opinion in Hematology, vol. 12, no. 2, pp. 123-128, 2005.
19. P. Beris, M. Muñoz, J. A. García-Erce, D. Thomas, A. Maniatis, and P. van der Linden, "Perioperative anaemia management: consensus statement on the role of intravenous iron, " British Journal of Anaesthesia, vol. 100, no. 5, pp. 599-604, 2008.
20. L. T. Goodnough and S. L. Schrier, "Evaluation and management of anemia in the elderly, " The American Journal of Hematology, vol. 89, no. 1, pp. 88-96, 2014.
21. S. F. Clark, "Iron deficiency anemia, " Nutrition in Clinical Practice, vol. 23, no. 2, pp. 128-141, 2008.
22. J. Stein, F. Hartmann, and A. U. Dignass, "Diagnosis and management of iron deficiency anemia in patients with IBD, " Nature Reviews Gastroenterology & Hepatology, vol. 7, no. 11, pp. 599-610, 2010.
23. M. H. Bross, K. Soch, and T. Smith-Knuppel, "Anemia in older persons, "TheAmerican Family Physician, vol. 82, no. 5, pp. 480-487, 2010.
24. S. B. Silverstein and G. M. Rodgers, "Parenteral iron therapy options, " American Journal of Hematology, vol. 76, no. 1, pp. 74-78, 2004.
25. A. Shander, L. T. Goodnough, M. Javidroozi et al., "Iron deficiency anemia-bridging the knowledge and practice gap, " Transfusion Medicine Reviews, vol. 28, no. 3, pp. 156-166, 2014.
26. M. Auerbach, L. T. Goodnough, and A. Shander, "Iron: the new advances in therapy, " Best Practice & Research: Clinical Anaesthesiology, vol. 27, no. 1, pp. 131-140, 2013.
27. M. Auerbach and H. Ballard, "Clinical use of intravenous iron: administration, efficacy, and safety, " Hematology/the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, vol. 2010, pp. 338-347, 2010.
28. N. R. Dossabhoy, S. Turley, R. Gascoyne, M. Tapolyai, and K. Sulaiman, "Safety of total dose iron dextran infusion in geriatric patients with chronic kidney disease and iron deficiency anemia, " Renal Failure, vol. 36, no. 7, pp. 1033-1037, 2014.
29. R. A. Moore, H. Gaskell, P. Rose, and J. Allan, "Meta-analysis of efficacy and safety of intravenous ferric carboxymaltose (Ferinject) from clinical trial reports and published trial data, " BMC Blood Disorders, vol. 11, article 4, 2011.
30. G. Röhrig, T. Steinmetz, J. Stein et al., "Efficacy and tolerability of ferric carboxymaltose in geriatric patients with anemia. Data from three non-interventional studies, " MMW Fortschritte der Medizin, vol. 156, pp. 48-53, 2014.
31. World Health Organization, "Nutritional anemia: report of a WHO Scientific Group, " Technical Report Series 405, 1968.
32. S. van Santen, E. C. van Dongen-Lases, F. de Vegt et al., "Hepcidin and hemoglobin content parameters in the diagnosis of iron deficiency in rheumatoid arthritis patients with anemia, " Arthritis and Rheumatism, vol. 63, no. 12, pp. 3672-3680, 2011.
33. A. M. Ganzoni, "Intravenous iron-dextran: therapeutic and experimental possibilities, " Schweizerische Medizinische Wochenschrift, vol. 100, no. 7, pp. 301-303, 1970.
34. R. Evstatiev, P.Marteau, T. Iqbal et al., "FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease, " Gastroenterology, vol. 141, no. 3, pp. 846.e2-853.e2, 2011.
35. W. Reinisch, M. Staun, R. K. Tandon et al., "A randomized, open-label, non-inferiority study of intravenous iron isomaltoside 1, 000 (Monofer) compared with oral iron for treatment of anemia in IBD (PROCEED), " The American Journal of Gastroenterology, vol. 108, no. 12, pp. 1877-1888, 2013.
36. E. A. Jankowska, S. vonHaehling, S.D. Anker, I. C.MacDougall, and P. Ponikowski, "Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives, " European Heart Journal, vol. 34, no. 11, pp. 816-826, 2013.
37. M. Kapoor, M. D. Schleinitz, A. Gemignani, and W.-C. Wu, "Outcomes of patients with chronic heart failure and iron deficiency treated with intravenous iron: a meta-analysis, " Cardiovascular & Hematological Disorders-Drug Targets, vol. 13, no. 1, pp. 35-44, 2013.
38. D. W. Coyne, T. Kapoian, W. Suki et al., "Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) study, " Journal of the American Society of Nephrology, vol. 18, no. 3, pp. 975-984, 2007.
39. G. Wong, K. Howard, E. Hodson, M. Irving, and J. C. Craig, "An economic evaluation of intravenous versus oral iron supplementation in people on haemodialysis, " Nephrology Dialysis Transplantation, vol. 28, no. 2, pp. 413-420, 2013.
40. H. T. Steinmetz, "The role of intravenous iron in the treatment of anemia in cancer patients, "Therapeutic Advances inHematology, vol. 3, no. 3, pp. 177-191, 2012.
41. M. Auerbach and H. Ballard, "Intravenous iron in oncology, " Journal of the National Comprehensive Cancer Network, vol. 6, no. 6, pp. 585-592, 2008.
42. O. Schröder, O. Mickisch, U. Seidler et al., "Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease - a randomized, controlled, open-label, multicenter study, " The American Journal of Gastroenterology, vol. 100, no. 11, pp. 2503-2509, 2005.
43. J. A. García-Erce, J. Cuenca, F. Martínez, R. Cardona, L. Pérez-Serrano, and M.Muñoz, "Perioperative intravenous iron preserves iron stores and may hasten the recovery from postoperative anaemia after knee replacement surgery, " Transfusion Medicine, vol. 16, no. 5, pp. 335-341, 2006.
44. J. Cuenca, J. A. García-Erce, and M. Muñoz, "Efficacy of intravenous iron sucrose administration for correcting preoperative anemia in patients scheduled for major orthopedic surgery, " Anesthesiology, vol. 109, no. 1, pp. 151-152, 2008.
45. M. Muñoz, S. Gómez-Ramírez, E. Martín-Montañez, J. Pavía, J. Cuenca, and J. A. García-Erce, "Perioperative intravenous iron: an upfront therapy for treating anaemia and reducing transfusion requirements, " Nutrición Hospitalaria, vol. 27, no. 6, pp. 1817-1836, 2012.
46. M. Auerbach, J. A. Pappadakis, H. Bahrain, S. A. Auerbach, H. Ballard, and N. V. Dahl, "Safety and efficacy of rapidly administered (one hour) one gramof lowmolecularweight iron dextran (INFeD) for the treatment of iron deficient anemia, "The American Journal of Hematology, vol. 86, no. 10, pp. 860-862, 2011.
47. M. Auerbach, W. Strauss, S. Auerbach, S. Rineer, and H. Bahrain, "Safety and efficacy of total dose infusion of 1, 020 mg of ferumoxytol administered over 15 min, " American Journal of Hematology, vol. 88, no. 11, pp. 944-947, 2013.
48. C.-L. Chuang, R.-S. Liu, Y.-H. Wei, T.-P. Huang, and D.-C. Tarng, "Early prediction of response to intravenous iron supplementation by reticulocyte haemoglobin content and highfluorescence reticulocyte count in haemodialysis patients, " Nephrology Dialysis Transplantation, vol. 18, no. 2, pp. 370-377, 2003.
49. N. Tessitore, G. P. Solero, G. Lippi et al., "The role of iron status markers in predicting response to intravenous iron in haemodialysis patients on maintenance erythropoietin, " NephrologyDialysis Transplantation, vol. 16, no. 7, pp. 1416-1423, 2001.