Thalamic lesions in multiple sclerosis by 7T MRI: Clinical implications and relationship to cortical pathology

Multiple Sclerosis

Volumn 21, Issue 9, 2015, Pages 1139-1150

  Harrison, Daniel M ^a   Oh, Jiwon ^a   Roy, Snehashis ^b   Wood, Emily T ^a,c   Whetstone, Anna ^a   Seigo, Michaela A ^a   Jones, Craig K ^a,d   Pham, Dzung ^b   Van Zijl, Peter ^a,d   Reich, Daniel S ^a,c   Calabresi, Peter A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d KENNEDY KRIEGER INSTITUTE   (United States)

Author keywords

MRI; multiple sclerosis

Indexed keywords

ADULT; ARTICLE; BRAIN DAMAGE; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE COURSE; EXPANDED DISABILITY STATUS SCALE; FEMALE; GRAY MATTER; HUMAN; IMAGE ANALYSIS; MALE; MULTIPLE SCLEROSIS; NEUROIMAGING; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; REPRODUCIBILITY; SIGNAL NOISE RATIO; THALAMUS; WHITE MATTER LESION; BRAIN CORTEX; COMPUTER ASSISTED DIAGNOSIS; MIDDLE AGED; PATHOLOGY; PROCEDURES; WHITE MATTER; BRAIN INJURY; OUTCOME ASSESSMENT; OVOID LESION; PACED AUDITORY SERIAL ADDITION TEST; PERIVENTRICULAR LESION; SCORING SYSTEM; THALAMUS NUCLEUS;

ADULT; CEREBRAL CORTEX; FEMALE; GRAY MATTER; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; THALAMUS; WHITE MATTER;

EID: 84937691980     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458514558134     Document Type: Article

References (35)

1. Geurts JJ, Barkhof F,. Grey matter pathology in multiple sclerosis. Lancet Neurol 2008; 7: 841-851.
2. Kidd D, Barkhof F, McConnell R,. Cortical lesions in multiple sclerosis. Brain 1999; 122 (Pt 1): 17-26.
3. Peterson JW, Bö L, Mörk S,. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 2001; 50: 389-400.
4. Gilmore CP, Geurts JJ, Evangelou N,. Spinal cord grey matter lesions in multiple sclerosis detected by post-mortem high field MR imaging. Mult Scler 2009; 15: 180-188.
5. Geurts JJ, Bö L, Roosendaal SD,. Extensive hippocampal demyelination in multiple sclerosis. J Neuropathol Exp Neurol 2007; 66: 819-827.
6. Vercellino M, Masera S, Lorenzatti M,. Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter. J Neuropathol Exp Neurol 2009; 68: 489-502.
7. Kutzelnigg A, Lucchinetti CF, Stadelmann C,. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 2005; 128: 2705-2712.
8. Benedict RH, Zivadinov R, Carone DA,. Regional lobar atrophy predicts memory impairment in multiple sclerosis. AJNR Am J Neuroradiol 2005; 26: 1824-1831.
9. Fisher E, Rudick RA, Cutter G,. Relationship between brain atrophy and disability: An 8-year follow-up study of multiple sclerosis patients. Mult Scler 2000; 6: 373-377.
10. Geurts JJ, Pouwels PJ, Uitdehaag BM,. Intracortical lesions in multiple sclerosis: Improved detection with 3D double inversion-recovery MR imaging. Radiology 2005; 236: 254-260.
11. Nelson F, Poonawalla AH, Hou P,. Improved identification of intracortical lesions in multiple sclerosis with phase-sensitive inversion recovery in combination with fast double inversion recovery MR imaging. AJNR Am J Neuroradiol 2007; 28: 1645-1649.
12. Kilsdonk ID, de Graaf WL, Soriano AL,. Multicontrast MR imaging at 7T in multiple sclerosis: Highest lesion detection in cortical gray matter with 3D-FLAIR. AJNR Am J Neuroradiol 2013; 34: 791-796.
13. Geurts JJ, Reuling IE, Vrenken H,. MR spectroscopic evidence for thalamic and hippocampal, but not cortical, damage in multiple sclerosis. Magn Reson Med 2006; 55: 478-483.
14. Houtchens MK, Benedict RH, Killiany R,. Thalamic atrophy and cognition in multiple sclerosis. Neurology 2007; 69: 1213-1223.
15. Ge Y, Jensen JH, Lu H,. Quantitative assessment of iron accumulation in the deep gray matter of multiple sclerosis by magnetic field correlation imaging. AJNR Am J Neuroradiol 2007; 28: 1639-1644.
16. Hammond KE, Metcalf M, Carvajal L,. Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron. Ann Neurol 2008; 64: 707-713.
17. Shiee N, Bazin PL, Ozturk A.,. A topology-preserving approach to the segmentation of brain images with multiple sclerosis lesions. Neuroimage 2010; 49: 1524-1535.
18. Fischer JS, Rudick RA, Cutter GR,. The Multiple Sclerosis Functional Composite Measure (MSFC): An integrated approach to MS clinical outcome assessment. National MS Society Clinical Outcomes Assessment Task Force. Mult Scler 1999; 5: 244-250.
19. Rudick R, Antel J, Confavreux C,. Recommendations from the National Multiple Sclerosis Society Clinical Outcomes Assessment Task Force. Ann Neurol 1997; 42: 379-382.
20. Villar LM, Sadaba MC, Roldan E,. Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS. J Clin Invest 2005; 115: 187-194.
21. Asgari N, Khorooshi R, Lillevang ST,. Complement-dependent pathogenicity of brain-specific antibodies in cerebrospinal fluid. J Neuroimmunol 2013; 254: 76-82.
22. Magliozzi R, Howell OW, Reeves C,. A gradient of neuronal loss and meningeal inflammation in multiple sclerosis. Ann Neurol 2010; 68: 477-493.
23. Bö L, Geurts JJ, van der Valk P,. Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis. Arch Neurol 2007; 64: 76-80.
24. van Horssen J, Brink BP, de Vries HE,. The blood-brain barrier in cortical multiple sclerosis lesions. J Neuropathol Exp Neurol 2007; 66: 321-328.
25. Chitnis T, Imitola J, Wang Y,. Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegeneration. Am J Pathol 2007; 170: 1695-1712.
26. Liu Y, Teige I, Birnir B,. Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE. Nat Med 2006; 12: 518-525.
27. Bø L, Vedeler CA, Nyland H,. Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration. Mult Scler 2003; 9: 323-331.
28. Mainero C, Benner T, Radding A,. In vivo imaging of cortical pathology in multiple sclerosis using ultra-high field MRI. Neurology 2009; 73: 941-948.
29. Tallantyre EC, Brookes MJ, Dixon JE,. Demonstrating the perivascular distribution of MS lesions in vivo with 7-Tesla MRI. Neurology 2008; 70: 2076-2078.
30. Calabrese M, Filippi M, Rovaris M,. Morphology and evolution of cortical lesions in multiple sclerosis. A longitudinal MRI study. Neuroimage 2008; 42: 1324-1328.
31. Calabrese M, Filippi M, Rovaris M,. Evidence for relative cortical sparing in benign multiple sclerosis: A longitudinal magnetic resonance imaging study. Mult Scler 2009; 15: 36-41.
32. Neema M, Arora A, Healy BC,. Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis. J Neuroimaging 2009; 19: 3-8.
33. Bakshi R, Benedict RH, Bermel RA,. T2 hypointensity in the deep gray matter of patients with multiple sclerosis: A quantitative magnetic resonance imaging study. Arch Neurol 2002; 59: 62-68.
34. Cifelli A, Arridge M, Jezzard P,. Thalamic neurodegeneration in multiple sclerosis. Ann Neurol 2002; 52: 650-653.
35. Vaughan JT, Garwood M, Collins CM,. 7T vs. 4T: RF power, homogeneity, and signal-to-noise comparison in head images. Magn Reson Med 2001; 46: 24-30.