Complement-dependent pathogenicity of brain-specific antibodies in cerebrospinal fluid

Journal of Neuroimmunology

Volumn 254, Issue 1-2, 2013, Pages 76-82

  Asgari, Nasrin ^a   Khorooshi, Reza ^a   Lillevang, Søren T ^b   Owens, Trevor ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Cerebrospinal fluid; Immunoglobulin; Mouse; Neuromyelitis optica

Indexed keywords

AQUAPORIN 4; AUTOANTIBODY; BRAIN SPECIFIC ANTIBODY; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; CASE REPORT; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID LEVEL; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; EPENDYMA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN DEPOSITION; INJECTION SITE; MOUSE; MYELOOPTIC NEUROPATHY; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN PURIFICATION;

ANIMALS; AQUAPORIN 4; BRAIN; COMPLEMENT SYSTEM PROTEINS; DEMYELINATING DISEASES; EPENDYMA; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN G; INJECTIONS, SPINAL; MICE; MICE, INBRED C57BL; NEUROMYELITIS OPTICA; TRANSFECTION;

EID: 84871681992     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2012.09.010     Document Type: Article

References (33)

1. Amiry-Moghaddam M., Ottersen O.P. The molecular basis of water transport in the brain. Nat. Rev. Neurosci. 2003, 4:991-1001.
2. Asgari N., Lillevang S.T., Skejoe H.P., Falah M., Stenager E., Kyvik K.O. A population-based study of neuromyelitis optica in Caucasians. Neurology 2011, 76:1589-1595.
3. Asgari N., Owens T., Frokiaer J., Stenager E., Lillevang S.T., Kyvik K.O. Neuromyelitis optica (NMO) - an autoimmune disease of the central nervous system (CNS). Acta Neurol. Scand. 2011, 123:369-384.
4. Asgari N., Nielsen C., Stenager E., Kyvik K., Lillevang S. HLA, PTPN22 and PD-1 associations as markers of autoimmunity in neuromyelitis optica. Mult. Scler. 2012, 18:23-30.
5. Barnum S.R. Complement biosynthesis in the central nervous system. Crit. Rev. Oral Biol. Med. 1995, 6:132-146.
6. Bennett J.L., Lam C., Kalluri S.R., Saikali P., Bautista K., DuPree C., Glogowska M., Case D., Antel J.P., Owens G.P., Gilden D., Nessler S., Stadelmann C., Hemmer B. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann. Neurol. 2009, 66:617-629.
7. Bernal F., Graus F., Pifarre A., Saiz A., Benyahia B., Ribalta T. Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis. Acta Neuropathol. 2002, 103:509-515.
8. Bradl M., Misu T., Takahashi T., Watanabe M., Mader S., Reindl M., Adzemovic M., Bauer J., Berger T., Fujihara K., Itoyama Y., Lassmann H. Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo. Ann. Neurol. 2009, 66:630-643.
9. Dalmau J., Rosenfeld M.R. Paraneoplastic syndromes of the CNS. Lancet Neurol. 2008, 7:327-340.
10. Dalmau J., Gleichman A.J., Hughes E.G., Rossi J.E., Peng X., Lai M., Dessain S.K., Rosenfeld M.R., Balice-Gordon R., Lynch D.R. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008, 7:1091-1098.
11. Furlan R., Pluchino S., Marconi P.C., Martino G. Cytokine gene delivery into the central nervous system using intrathecally injected nonreplicative viral vectors. Methods Mol. Biol. 2003, 215:279-289.
12. Goren O., Adorjan I., Kalman M. Heterogeneous occurrence of aquaporin-4 in the ependyma and in the circumventricular organs in rat and chicken. Anat. Embryol. (Berl) 2006, 211:155-172.
13. Hinson S.R., Romero M.F., Popescu B.F., Lucchinetti C.F., Fryer J.P., Wolburg H., Fallier-Becker P., Noell S., Lennon V.A. Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:1245-1250.
14. Iglesias A., Bauer J., Litzenburger T., Schubart A., Linington C. T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia 2001, 36:220-234.
15. Jarius S., Franciotta D., Paul F., Ruprecht K., Bergamaschi R., Rommer P.S., Reuss R., Probst C., Kristoferitsch W., Wandinger K.P., Wildemann B. Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance. J. Neuroinflammation 2010, 7:52.
16. Kabat E.A., Moore D.H., Landow H. An electrophoretic study of the protein components in cerebrospinal fluid and their relationship to the serum proteins. J. Clin. Invest. 1942, 21:571-577.
17. Khorooshi R., Owens T. Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system. J. Immunol. 2010, 185:1258-1264.
18. Kinoshita M., Nakatsuji Y., Kimura T., Moriya M., Takata K., Okuno T., Kumanogoh A., Kajiyama K., Yoshikawa H., Sakoda S. Neuromyelitis optica: passive transfer to rats by human immunoglobulin. Biochem. Biophys. Res. Commun. 2009, 386:623-627.
19. Lennon V.A., Wingerchuk D.M., Kryzer T.J., Pittock S.J., Lucchinetti C.F., Fujihara K., Nakashima I., Weinshenker B.G. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 2004, 364:2106-2112.
20. Linington C., Lassmann H. Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titre to the myelin/oligodendrocyte glycoprotein (MOG). J. Neuroimmunol. 1987, 17:61-69.
21. Lucchinetti C.F., Mandler R.N., McGavern D., Bruck W., Gleich G., Ransohoff R.M., Trebst C., Weinshenker B., Wingerchuk D., Parisi J.E., Lassmann H. A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica. Brain 2002, 125:1450-1461.
22. Millward J.M., Caruso M., Campbell I.L., Gauldie J., Owens T. IFN-gamma-induced chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system. J. Immunol. 2007, 178:8175-8182.
23. Nielsen S., Frokiaer J., Marples D., Kwon T.H., Agre P., Knepper M.A. Aquaporins in the kidney: from molecules to medicine. Physiol. Rev. 2002, 82:205-244.
24. Oshio K., Binder D.K., Yang B., Schecter S., Verkman A.S., Manley G.T. Expression of aquaporin water channels in mouse spinal cord. Neuroscience 2004, 127:685-693.
25. Ratelade J., Bennett J.L., Verkman A.S. Intravenous neuromyelitis optica autoantibody in mice targets aquaporin-4 in peripheral organs and area postrema. PLoS One 2011, 6:e27412.
26. Roemer S.F., Parisi J.E., Lennon V.A., Benarroch E.E., Lassmann H., Bruck W., Mandler R.N., Weinshenker B.G., Pittock S.J., Wingerchuk D.M., Lucchinetti C.F. Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis. Brain 2007, 130:1194-1205.
27. Saadoun S., Waters P., Bell B.A., Vincent A., Verkman A.S., Papadopoulos M.C. Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain 2010, 133:349-361.
28. Saadoun S., Waters P., Macdonald C., Bridges L.R., Bell B.A., Vincent A., Verkman A.S., Papadopoulos M.C. T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. J. Neuroimmunol. 2011, 235:27-32.
29. Schluesener H.J., Sobel R.A., Linington C., Weiner H.L. A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J. Immunol. 1987, 139:4016-4021.
30. Takahashi T., Fujihara K., Nakashima I., Misu T., Miyazawa I., Nakamura M., Watanabe S., Shiga Y., Kanaoka C., Fujimori J., Sato S., Itoyama Y. Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. Brain 2007, 130:1235-1243.
31. Tran E.H., Prince E.N., Owens T. IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines. J. Immunol. 2000, 164:2759-2768.
32. Weinshenker B.G., Wingerchuk D.M., Pittock S.J., Lucchinetti C.F., Lennon V.A. NMO-IgG: a specific biomarker for neuromyelitis optica. Dis. Markers 2006, 22:197-206.
33. Wingerchuk D.M., Lennon V.A., Lucchinetti C.F., Pittock S.J., Weinshenker B.G. The spectrum of neuromyelitis optica. Lancet Neurol. 2007, 6:805-815.