ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice

Alcoholism: Clinical and Experimental Research

Volumn 39, Issue 8, 2015, Pages 1465-1475

  Chaudhry, Kamaljit K ^a   Samak, Geetha ^a   Shukla, Pradeep K ^a   Mir, Hina ^a   Gangwar, Ruchika ^a   Manda, Bhargavi ^a   Isse, Toyohi ^b   Kawamoto, Toshihiro ^b   Salaspuro, Mikko ^c   Kaihovaara, Pertti ^c   Dietrich, Paula ^a   Dragatsis, Ioannis ^a   Nagy, Laura E ^d   Rao, Radha Krishna ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c UNIVERSITY OF HELSINKI   (Finland)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Acetaldehyde; Adherens Junction; Alcohol; Gut Permeability; Tight Junction

Indexed keywords

ACETALDEHYDE; ALANINE AMINOTRANSFERASE; ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ASPARTATE AMINOTRANSFERASE; INULIN; TIGHT JUNCTION PROTEIN; TRIACYLGLYCEROL; ALDEHYDE DEHYDROGENASE; ALDH2 PROTEIN, MOUSE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL JUNCTION; COLON MUCOSA; CONFOCAL MICROSCOPY; DESCENDING COLON; EVALUATION STUDY; FATTY LIVER; FEMALE; HISTOPATHOLOGY; ILEUM; IN VIVO STUDY; INTESTINE BARRIER DYSFUNCTION; INTESTINE EPITHELIUM CELL; INTESTINE FUNCTION DISORDER; INTESTINE MUCOSA PERMEABILITY; JEJUNUM; LIPID STORAGE; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; TIGHT JUNCTION; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DEFICIENCY; DRUG EFFECTS; GASTROINTESTINAL ABSORPTION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

MUS;

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; ANIMALS; ETHANOL; FATTY LIVER; FEMALE; GASTROINTESTINAL ABSORPTION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TIGHT JUNCTIONS;

EID: 84937690657     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12777     Document Type: Article

References (39)

1. Anderson C, Andersson T, Molander M (1991) Ethanol absorption across human skin measured by in vivo microdialysis technique. Acta Derm Venereol 71:389-393.
2. Anderson JM, van Itallie CM (2009) Physiology and function of the tight junction. Cold Spring Harb Perspect Biol 1:a002584.
3. Atkinson KJ, Rao RK (2001) Role of protein tyrosine phosphorylation in acetaldehyde-induced disruption of epithelial tight junctions. Am J Physiol Gastrointest Liver Physiol 280:G1280-G1288.
4. Basuroy S, Sheth P, Mansbach CM, Rao RK (2005) Acetaldehyde disrupts tight junctions and adherens junctions in human colonic mucosa: protection by EGF and L-glutamine. Am J Physiol Gastrointest Liver Physiol 289:G367-G375.
5. Bode JC, Bode C, Heidelbach R, Durr HK, Martini GA (1984) Jejunal microflora in patients with chronic alcohol abuse. Hepatogastroenterology 31:30-34.
6. Boffetta P, Hashibe M (2006) Alcohol and cancer. Lancet Oncol 7:149-156.
7. Duryee MJ, Klassen LW, Freeman TL, Willis MS, Tuma DJ, Thiele GM (2004) Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells. Alcohol Clin Exp Res 28:1931-1938.
8. Elamin E, Masclee A, Dekker J, Jonkers D (2014) Ethanol disrupts intestinal epithelial tight junction integrity through intracellular calcium-mediated Rho/ROCK activation. Am J Physiol Gastrointest Liver Physiol 306:G677-G685.
9. Eriksson CJ (2001) The role of acetaldehyde in the actions of alcohol (update 2000). Alcohol Clin Exp Res 25:15S-32S.
10. Ferrier L, Berard F, Debrauwer L, Chabo C, Langella P, Bueno L, Fioramonti J (2006) Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents. Am J Pathol 168:1148-1154.
11. Fisher SJ, Swaan PW, Eddington ND (2010) The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo. J Pharmacol Exp Ther 332:326-333.
12. Furuse M, Itoh M, Hirase T, Nagafuchi A, Yonemura S, Tsukita S (1994) Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol 127:1617-1626.
13. Gumbiner B, Stevenson B, Grimaldi A (1988) The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. J Cell Biol 107:1575-1587.
14. Isse T, Oyama T, Kitagawa K, Matsuno K, Matsumoto A, Yoshida A, Nakayama K, Kawamoto T (2002) Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics 12:621-626.
15. Jokelainen K, Matysiak-Budnik T, Makisalo H, Hockerstedt K, Salaspuro M (1996) High intracolonic acetaldehyde values produced by a bacteriocolonic pathway for ethanol oxidation in piglets. Gut 39:100-104.
16. Jokelainen K, Reinke LA, Nanji AA (2001) Nf-kappab activation is associated with free radical generation and endotoxemia and precedes pathological liver injury in experimental alcoholic liver disease. Cytokine 16:36-39.
17. Kirpich IA, Feng W, Wang Y, Liu Y, Barker DF, Barve SS, McClain CJ (2012) The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic toll-like receptor expression in a mouse model of alcoholic liver disease. Alcohol Clin Exp Res 36:835-846.
18. Kwon HJ, Won YS, Park O, Chang B, Duryee MJ, Thiele GE, Matsumoto A, Singh S, Abdelmegeed MA, Song BJ, Kawamoto T, Vasiliou V, Thiele GM, Gao B (2014) Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice. Hepatology 60:146-157.
19. Lilien J, Balsamo J, Arregui C, Xu G (2002) Turn-off, drop-out: functional state switching of cadherins. Dev Dyn 224:18-29.
20. Madara JL (1987) Intestinal absorptive cell tight junctions are linked to cytoskeleton. Am J Physiol 253:C171-C175.
21. Madara JL, Barenberg D, Carlson S (1986) Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity. J Cell Biol 102:2125-2136.
22. Mathurin P, Deng QG, Keshavarzian A, Choudhary S, Holmes EW, Tsukamoto H (2000) Exacerbation of alcoholic liver injury by enteral endotoxin in rats. Hepatology 32:1008-1017.
23. Morimoto K, Takeshita T (1996) Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes. Environ Health Perspect 104(Suppl 3):563-567.
24. Nanji AA, Su GL, Laposata M, French SW (2002) Pathogenesis of alcoholic liver disease-recent advances. Alcohol Clin Exp Res 26:731-736.
25. Rao R (2009) Endotoxemia and gut barrier dysfunction in alcoholic liver disease. Hepatology 50:638-644.
26. Rao RK (1998) Acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer. Alcohol Clin Exp Res 22:1724-1730.
27. Rao RK, Seth A, Sheth P (2004) Recent advances in alcoholic liver disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 286:G881-G884.
28. Rodgers LS, Fanning AS (2011) Regulation of epithelial permeability by the actin cytoskeleton. Cytoskeleton 68:653-660.
29. Ronis MJ, Korourian S, Blackburn ML, Badeaux J, Badger TM (2010) The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat. Alcohol 44:157-169.
30. Schafer C, Parlesak A, Schutt C, Bode JC, Bode C (2002) Concentrations of lipopolysaccharide-binding protein, bactericidal/permeability-increasing protein, soluble CD14 and plasma lipids in relation to endotoxaemia in patients with alcoholic liver disease. Alcohol Alcohol 37:81-86.
31. Seitz HK, Stickel F (2007) Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 7:599-612.
32. Seitz HK, Stickel F (2010) Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism. Genes Nutr 5:121-128.
33. Seth A, Basuroy S, Sheth P, Rao RK (2004) L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer. Am J Physiol Gastrointest Liver Physiol 287:G510-G517.
34. Sheth P, Seth A, Atkinson KJ, Gheyi T, Kale G, Giorgianni F, Desiderio DM, Li C, Naren A, Rao R (2007) Acetaldehyde dissociates the PTP1B-E-cadherin-beta-catenin complex in Caco-2 cell monolayers by a phosphorylation-dependent mechanism. Biochem J 402:291-300.
35. Sheth P, Seth A, Thangavel M, Basuroy S, Rao RK (2004) Epidermal growth factor prevents acetaldehyde-induced paracellular permeability in Caco-2 cell monolayer. Alcohol Clin Exp Res 28:797-804.
36. Suzuki T, Seth A, Rao R (2008) Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers. J Biol Chem 283:3574-3583.
37. Turner JR (2006) Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. Am J Pathol 169:1901-1909.
38. Wall TL, Peterson CM, Peterson KP, Johnson ML, Thomasson HR, Cole M, Ehlers CL (1997) Alcohol metabolism in Asian-American men with genetic polymorphisms of aldehyde dehydrogenase. Ann Intern Med 127:376-379.
39. Yokoyama T, Yokoyama A, Kato H, Tsujinaka T, Muto M, Omori T, Haneda T, Kumagai Y, Igaki H, Yokoyama M, Watanabe H, Yoshimizu H (2003) Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men. Cancer Epidemiol Biomarkers Prev 12:1227-1233.