Demethylation of IGFBP5 by Histone Demethylase KDM6B Promotes Mesenchymal Stem Cell-Mediated Periodontal Tissue Regeneration by Enhancing Osteogenic Differentiation and Anti-Inflammation Potentials

Stem Cells

Volumn 33, Issue 8, 2015, Pages 2523-2536

  Liu, Dayong ^a,b   Wang, Yuejun ^a,b   Jia, Zhi ^b   Wang, Liping ^a   Wang, Jinsong ^a   Yang, Dongmei ^a   Song, Jianqiu ^b   Wang, Songlin ^a   Fan, Zhipeng ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Histone demethylase; Inflammation; Insulin like growth factor binding protein 5; Lysine (K) specific demethylase 6B; Mesenchymal stem cells; Osteogenic differentiation

Indexed keywords

HISTONE DEMETHYLASE; HISTONE DEMETHYLASE LYSINE (K) SPECIFIC DEMETHYLASE 6B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 5; UNCLASSIFIED DRUG; HISTONE; KDM6B PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; GENE REPRESSION; HISTONE DEMETHYLATION; HISTONE METHYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LOSS OF FUNCTION MUTATION; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PERIODONTITIS; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TISSUE REGENERATION; TOOTH; UPREGULATION; ANIMAL; DISEASE MODEL; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; METHYLATION; MINIPIG; PERIODONTIUM; PHYSIOLOGY; PIG; REGENERATION;

SUIDAE;

ANIMALS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; HISTONES; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; METHYLATION; OSTEOGENESIS; PERIODONTITIS; PERIODONTIUM; REGENERATION; SWINE; SWINE, MINIATURE;

EID: 84937639646     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2018     Document Type: Article

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