메뉴 건너뛰기




Volumn 78, Issue 4, 2015, Pages 259-269

The Anxiolytic and Antidepressant-like Effects of Testosterone and Estrogen in Gonadectomized Male Rats

Author keywords

Anxiety; Aromatase; Depression; Estradiol; Hippocampus; Testosterone

Indexed keywords

ANDROGEN RECEPTOR; COMPLEMENTARY DNA; DRUG METABOLITE; ESTRADIOL; ESTROGEN; FADROZOLE; MITOGEN ACTIVATED PROTEIN KINASE; PLACEBO; TESTOSTERONE; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; AROMATASE INHIBITOR;

EID: 84937638955     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2014.12.024     Document Type: Article
Times cited : (94)

References (49)
  • 1
    • 84887607561 scopus 로고    scopus 로고
    • The effect of testosterone levels on mood in men: A review
    • J.M. Johnson, L.B. Nachtigall, and T.A. Stern The effect of testosterone levels on mood in men: A review Psychosomatics 54 2013 509 514
    • (2013) Psychosomatics , vol.54 , pp. 509-514
    • Johnson, J.M.1    Nachtigall, L.B.2    Stern, T.A.3
  • 2
    • 16644396636 scopus 로고    scopus 로고
    • Low testosterone is associated with decreased function and increased mortality risk: A preliminary study of men in a geriatric rehabilitation unit
    • M.M. Shores, V.M. Moceri, D.A. Gruenewald, K.I. Brodkin, A.M. Matsumoto, and D.R. Kivlahan Low testosterone is associated with decreased function and increased mortality risk: A preliminary study of men in a geriatric rehabilitation unit J Am Geriatr Soc 52 2004 2077 2081
    • (2004) J Am Geriatr Soc , vol.52 , pp. 2077-2081
    • Shores, M.M.1    Moceri, V.M.2    Gruenewald, D.A.3    Brodkin, K.I.4    Matsumoto, A.M.5    Kivlahan, D.R.6
  • 5
    • 0037223737 scopus 로고    scopus 로고
    • Testosterone gel supplementation for men with refractory depression: A randomized, placebo-controlled trial
    • H.G. Pope Jr, G.H. Cohane, G. Kanayama, A.J. Siegel, and J.I. Hudson Testosterone gel supplementation for men with refractory depression: A randomized, placebo-controlled trial Am J Psychiatry 160 2003 105 111
    • (2003) Am J Psychiatry , vol.160 , pp. 105-111
    • Pope, H.G.1    Cohane, G.H.2    Kanayama, G.3    Siegel, A.J.4    Hudson, J.I.5
  • 6
    • 77952213725 scopus 로고    scopus 로고
    • Parallel-group placebo-controlled trial of testosterone gel in men with major depressive disorder displaying an incomplete response to standard antidepressant treatment
    • H.G. Pope Jr, R. Amiaz, B.P. Brennan, G. Orr, M. Weiser, J.F. Kelly, and et al. Parallel-group placebo-controlled trial of testosterone gel in men with major depressive disorder displaying an incomplete response to standard antidepressant treatment J Clin Psychopharmacol 30 2010 126 134
    • (2010) J Clin Psychopharmacol , vol.30 , pp. 126-134
    • Pope, H.G.1    Amiaz, R.2    Brennan, B.P.3    Orr, G.4    Weiser, M.5    Kelly, J.F.6
  • 7
    • 0031748956 scopus 로고    scopus 로고
    • Testosterone replacement therapy for hypogonadal men with SSRI-refractory depression
    • S.N. Seidman, and J.G. Rabkin Testosterone replacement therapy for hypogonadal men with SSRI-refractory depression J Affect Disord 48 1998 157 161
    • (1998) J Affect Disord , vol.48 , pp. 157-161
    • Seidman, S.N.1    Rabkin, J.G.2
  • 9
    • 64549093289 scopus 로고    scopus 로고
    • Depression-like behavior of aged male and female mice is ameliorated with administration of testosterone or its metabolites
    • C.A. Frye, and A.A. Walf Depression-like behavior of aged male and female mice is ameliorated with administration of testosterone or its metabolites Physiol Behav 97 2009 266 269
    • (2009) Physiol Behav , vol.97 , pp. 266-269
    • Frye, C.A.1    Walf, A.A.2
  • 10
    • 84858224466 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase 2 signaling in the hippocampal dentate gyrus mediates the antidepressant effects of testosterone
    • N. Carrier, and M. Kabbaj Extracellular signal-regulated kinase 2 signaling in the hippocampal dentate gyrus mediates the antidepressant effects of testosterone Biol Psychiatry 71 2012 642 651
    • (2012) Biol Psychiatry , vol.71 , pp. 642-651
    • Carrier, N.1    Kabbaj, M.2
  • 11
    • 84860525469 scopus 로고    scopus 로고
    • Testosterone and imipramine have antidepressant effects in socially isolated male but not female rats
    • N. Carrier, and M. Kabbaj Testosterone and imipramine have antidepressant effects in socially isolated male but not female rats Horm Behav 61 2012 678 685
    • (2012) Horm Behav , vol.61 , pp. 678-685
    • Carrier, N.1    Kabbaj, M.2
  • 12
    • 0032868687 scopus 로고    scopus 로고
    • Androgen actions on central serotonin neurotransmission: Relevance for mood, mental state and memory
    • G. Fink, B. Sumner, R. Rosie, H. Wilson, and J. McQueen Androgen actions on central serotonin neurotransmission: Relevance for mood, mental state and memory Behav Brain Res 105 1999 53 68
    • (1999) Behav Brain Res , vol.105 , pp. 53-68
    • Fink, G.1    Sumner, B.2    Rosie, R.3    Wilson, H.4    McQueen, J.5
  • 13
    • 84892883817 scopus 로고    scopus 로고
    • Sex differences in anxiety and depression: Role of testosterone
    • J. McHenry, N. Carrier, E. Hull, and M. Kabbaj Sex differences in anxiety and depression: Role of testosterone Front Neuroendocrinol 35 2013 42 57
    • (2013) Front Neuroendocrinol , vol.35 , pp. 42-57
    • McHenry, J.1    Carrier, N.2    Hull, E.3    Kabbaj, M.4
  • 14
    • 9144237423 scopus 로고    scopus 로고
    • Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons
    • Y. Hojo, T.A. Hattori, T. Enami, A. Furukawa, K. Suzuki, H.T. Ishii, and et al. Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons Proc Natl Acad Sci U S A 101 2004 865 870
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 865-870
    • Hojo, Y.1    Hattori, T.A.2    Enami, T.3    Furukawa, A.4    Suzuki, K.5    Ishii, H.T.6
  • 15
    • 67649649620 scopus 로고    scopus 로고
    • Brain aromatization: Classic roles and new perspectives
    • C.E. Roselli, M. Liu, and P.D. Hurn Brain aromatization: Classic roles and new perspectives Semin Reprod Med 27 2009 207 217
    • (2009) Semin Reprod Med , vol.27 , pp. 207-217
    • Roselli, C.E.1    Liu, M.2    Hurn, P.D.3
  • 17
    • 9244231261 scopus 로고    scopus 로고
    • Ultrastructural evidence that androgen receptors are located at extranuclear sites in the rat hippocampal formation
    • N.E. Tabori, L.S. Stewart, V. Znamensky, R.D. Romeo, S.E. Alves, B.S. McEwen, and T.A. Milner Ultrastructural evidence that androgen receptors are located at extranuclear sites in the rat hippocampal formation Neuroscience 130 2005 151 163
    • (2005) Neuroscience , vol.130 , pp. 151-163
    • Tabori, N.E.1    Stewart, L.S.2    Znamensky, V.3    Romeo, R.D.4    Alves, S.E.5    McEwen, B.S.6    Milner, T.A.7
  • 18
    • 0034675994 scopus 로고    scopus 로고
    • Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation
    • A. Migliaccio, G. Castoria, M. Di Domenico, A. de Falco, A. Bilancio, M. Lombardi, and et al. Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation EMBO J 19 2000 5406 5417
    • (2000) EMBO J , vol.19 , pp. 5406-5417
    • Migliaccio, A.1    Castoria, G.2    Di Domenico, M.3    De Falco, A.4    Bilancio, A.5    Lombardi, M.6
  • 19
    • 33745745579 scopus 로고    scopus 로고
    • Why sex matters for neuroscience
    • L. Cahill Why sex matters for neuroscience Nat Rev Neurosci 7 2006 477 484
    • (2006) Nat Rev Neurosci , vol.7 , pp. 477-484
    • Cahill, L.1
  • 20
    • 34748813696 scopus 로고    scopus 로고
    • Evolving knowledge of sex differences in brain structure, function, and chemistry
    • K.P. Cosgrove, C.M. Mazure, and J.K. Staley Evolving knowledge of sex differences in brain structure, function, and chemistry Biol Psychiatry 62 2007 847 855
    • (2007) Biol Psychiatry , vol.62 , pp. 847-855
    • Cosgrove, K.P.1    Mazure, C.M.2    Staley, J.K.3
  • 21
    • 13844291281 scopus 로고    scopus 로고
    • Wired on hormones: Endocrine regulation of hypothalamic development
    • R.B. Simerly Wired on hormones: Endocrine regulation of hypothalamic development Curr Opin Neurobiol 15 2005 81 85
    • (2005) Curr Opin Neurobiol , vol.15 , pp. 81-85
    • Simerly, R.B.1
  • 22
    • 0028240263 scopus 로고
    • Effects of testosterone and aromatase inhibition on estrogen receptor-like immunoreactivity in male rat brain
    • A.N. Clancy, and R.P. Michael Effects of testosterone and aromatase inhibition on estrogen receptor-like immunoreactivity in male rat brain Neuroendocrinology 59 1994 552 560
    • (1994) Neuroendocrinology , vol.59 , pp. 552-560
    • Clancy, A.N.1    Michael, R.P.2
  • 23
    • 33747624704 scopus 로고    scopus 로고
    • Effects of estrogen in the male rat medial amygdala: Infusion of an aromatase inhibitor lowers mating and bovine serum albumin-conjugated estradiol implants do not promote mating
    • G.G. Huddleston, J.C. Paisley, and A.N. Clancy Effects of estrogen in the male rat medial amygdala: Infusion of an aromatase inhibitor lowers mating and bovine serum albumin-conjugated estradiol implants do not promote mating Neuroendocrinology 83 2006 106 116
    • (2006) Neuroendocrinology , vol.83 , pp. 106-116
    • Huddleston, G.G.1    Paisley, J.C.2    Clancy, A.N.3
  • 24
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • D.W. Huang da, B.T. Sherman, and R.A. Lempicki Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources Nat Protoc 4 2009 44 57
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang da, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 25
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • D.W. Huang da, B.T. Sherman, and R.A. Lempicki Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists Nucleic Acids Res 37 2009 1 13
    • (2009) Nucleic Acids Res , vol.37 , pp. 1-13
    • Huang da, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 26
    • 79952697546 scopus 로고    scopus 로고
    • Individual differences in the effect of social defeat on anhedonia and histone acetylation in the rat hippocampus
    • F. Hollis, F. Duclot, A. Gunjan, and M. Kabbaj Individual differences in the effect of social defeat on anhedonia and histone acetylation in the rat hippocampus Horm Behav 59 2011 331 337
    • (2011) Horm Behav , vol.59 , pp. 331-337
    • Hollis, F.1    Duclot, F.2    Gunjan, A.3    Kabbaj, M.4
  • 28
    • 0022409340 scopus 로고
    • Organizational and activational effects of sex steroids on brain and behavior: A reanalysis
    • A.P. Arnold, and S.M. Breedlove Organizational and activational effects of sex steroids on brain and behavior: A reanalysis Horm Behav 19 1985 469 498
    • (1985) Horm Behav , vol.19 , pp. 469-498
    • Arnold, A.P.1    Breedlove, S.M.2
  • 29
    • 77952386471 scopus 로고    scopus 로고
    • Estrogen actions in the brain and the basis for differential action in men and women: A case for sex-specific medicines
    • G.E. Gillies, and S. McArthur Estrogen actions in the brain and the basis for differential action in men and women: A case for sex-specific medicines Pharmacol Rev 62 2010 155 198
    • (2010) Pharmacol Rev , vol.62 , pp. 155-198
    • Gillies, G.E.1    McArthur, S.2
  • 30
    • 23744481466 scopus 로고    scopus 로고
    • When is a sex difference not a sex difference?
    • M.M. McCarthy, and A.T. Konkle When is a sex difference not a sex difference? Front Neuroendocrinol 26 2005 85 102
    • (2005) Front Neuroendocrinol , vol.26 , pp. 85-102
    • McCarthy, M.M.1    Konkle, A.T.2
  • 31
    • 0043240266 scopus 로고    scopus 로고
    • The role of the extracellular signal-regulated kinase signaling pathway in mood modulation
    • H. Einat, P. Yuan, T.D. Gould, J. Li, J. Du, L. Zhang, and et al. The role of the extracellular signal-regulated kinase signaling pathway in mood modulation J Neurosci 23 2003 7311 7316
    • (2003) J Neurosci , vol.23 , pp. 7311-7316
    • Einat, H.1    Yuan, P.2    Gould, T.D.3    Li, J.4    Du, J.5    Zhang, L.6
  • 32
    • 0034671366 scopus 로고    scopus 로고
    • Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
    • J.E. Malberg, A.J. Eisch, E.J. Nestler, and R.S. Duman Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus J Neurosci 20 2000 9104 9110
    • (2000) J Neurosci , vol.20 , pp. 9104-9110
    • Malberg, J.E.1    Eisch, A.J.2    Nestler, E.J.3    Duman, R.S.4
  • 33
    • 0035034203 scopus 로고    scopus 로고
    • The cellular neurobiology of depression
    • H.K. Manji, W.C. Drevets, and D.S. Charney The cellular neurobiology of depression Nat Med 7 2001 541 547
    • (2001) Nat Med , vol.7 , pp. 541-547
    • Manji, H.K.1    Drevets, W.C.2    Charney, D.S.3
  • 34
    • 47149097819 scopus 로고    scopus 로고
    • Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress
    • X. Qi, W. Lin, J. Li, H. Li, W. Wang, D. Wang, and M. Sun Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress Neurobiol Dis 31 2008 278 285
    • (2008) Neurobiol Dis , vol.31 , pp. 278-285
    • Qi, X.1    Lin, W.2    Li, J.3    Li, H.4    Wang, W.5    Wang, D.6    Sun, M.7
  • 35
    • 75349108511 scopus 로고    scopus 로고
    • 17-Beta-estradiol increases neuronal excitability through MAP kinase-induced calpain activation
    • S. Zadran, Q. Qin, X. Bi, H. Zadran, Y. Kim, M.R. Foy, and et al. 17-Beta-estradiol increases neuronal excitability through MAP kinase-induced calpain activation Proc Natl Acad Sci U S A 106 2009 21936 21941
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 21936-21941
    • Zadran, S.1    Qin, Q.2    Bi, X.3    Zadran, H.4    Kim, Y.5    Foy, M.R.6
  • 36
    • 84863782433 scopus 로고    scopus 로고
    • Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines
    • P. Penzes, and M.E. Cahill Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines Cytoskeleton (Hoboken) 69 2012 426 441
    • (2012) Cytoskeleton (Hoboken) , vol.69 , pp. 426-441
    • Penzes, P.1    Cahill, M.E.2
  • 37
    • 0345465716 scopus 로고    scopus 로고
    • Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress
    • A.M. Magarinos, A. Deslandes, and B.S. McEwen Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress Eur J Pharmacol 371 1999 113 122
    • (1999) Eur J Pharmacol , vol.371 , pp. 113-122
    • Magarinos, A.M.1    Deslandes, A.2    McEwen, B.S.3
  • 38
    • 34548395111 scopus 로고    scopus 로고
    • The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior
    • H.D. Schmidt, and R.S. Duman The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior Behav Pharmacol 18 2007 391 418
    • (2007) Behav Pharmacol , vol.18 , pp. 391-418
    • Schmidt, H.D.1    Duman, R.S.2
  • 39
    • 0026781307 scopus 로고
    • Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons
    • Y. Watanabe, E. Gould, and B.S. McEwen Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons Brain Res 588 1992 341 345
    • (1992) Brain Res , vol.588 , pp. 341-345
    • Watanabe, Y.1    Gould, E.2    McEwen, B.S.3
  • 40
    • 16844385523 scopus 로고    scopus 로고
    • Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects
    • A. Neumeister, S. Wood, O. Bonne, A.C. Nugent, D.A. Luckenbaugh, T. Young, and et al. Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects Biol Psychiatry 57 2005 935 937
    • (2005) Biol Psychiatry , vol.57 , pp. 935-937
    • Neumeister, A.1    Wood, S.2    Bonne, O.3    Nugent, A.C.4    Luckenbaugh, D.A.5    Young, T.6
  • 41
    • 0041880262 scopus 로고    scopus 로고
    • Untreated depression and hippocampal volume loss
    • Y.I. Sheline, M.H. Gado, and H.C. Kraemer Untreated depression and hippocampal volume loss Am J Psychiatry 160 2003 1516 1518
    • (2003) Am J Psychiatry , vol.160 , pp. 1516-1518
    • Sheline, Y.I.1    Gado, M.H.2    Kraemer, H.C.3
  • 43
    • 0031039888 scopus 로고    scopus 로고
    • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    • G.G. Kuiper, B. Carlsson, K. Grandien, E. Enmark, J. Häggblad, S. Nilsson, and J.A. Gustafsson Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta Endocrinology 138 1997 863 870
    • (1997) Endocrinology , vol.138 , pp. 863-870
    • Kuiper, G.G.1    Carlsson, B.2    Grandien, K.3    Enmark, E.4    Häggblad, J.5    Nilsson, S.6    Gustafsson, J.A.7
  • 44
    • 84860342981 scopus 로고    scopus 로고
    • A role for the androgen metabolite, 5alpha androstane 3beta, 17beta diol (3β-Diol) in the regulation of the hypothalamo-pituitary-adrenal axis
    • R.J. Handa, D. Sharma, and R. Uht A role for the androgen metabolite, 5alpha androstane 3beta, 17beta diol (3β-Diol) in the regulation of the hypothalamo-pituitary-adrenal axis Front Endocrinol 2 2011 65
    • (2011) Front Endocrinol , vol.2 , pp. 65
    • Handa, R.J.1    Sharma, D.2    Uht, R.3
  • 45
    • 13844276633 scopus 로고    scopus 로고
    • Testosterone's anti-anxiety and analgesic effects may be due in part to actions of its 5α-reduced metabolites in the hippocampus
    • K.L. Edinger, and C.A. Frye Testosterone's anti-anxiety and analgesic effects may be due in part to actions of its 5α-reduced metabolites in the hippocampus Psychoneuroendocrinology 30 2005 418 430
    • (2005) Psychoneuroendocrinology , vol.30 , pp. 418-430
    • Edinger, K.L.1    Frye, C.A.2
  • 46
    • 54149103046 scopus 로고    scopus 로고
    • Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice
    • C.A. Frye, C.J. Koonce, K.L. Edinger, D.M. Osborne, and A.A. Walf Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice Horm Behav 54 2008 726 734
    • (2008) Horm Behav , vol.54 , pp. 726-734
    • Frye, C.A.1    Koonce, C.J.2    Edinger, K.L.3    Osborne, D.M.4    Walf, A.A.5
  • 47
    • 84896446478 scopus 로고    scopus 로고
    • Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats
    • A.E. Kudwa, R.F. McGivern, and R.J. Handa Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats Physiol Behav 129 2014 287 296
    • (2014) Physiol Behav , vol.129 , pp. 287-296
    • Kudwa, A.E.1    McGivern, R.F.2    Handa, R.J.3
  • 48
    • 67349197283 scopus 로고    scopus 로고
    • Chronic administration of androgens with actions at estrogen receptor beta have anti-anxiety and cognitive-enhancing effects in male rats
    • D.M. Osborne, K.L. Edinger, and C.A. Frye Chronic administration of androgens with actions at estrogen receptor beta have anti-anxiety and cognitive-enhancing effects in male rats Age (Dordr) 31 2009 191 198
    • (2009) Age (Dordr) , vol.31 , pp. 191-198
    • Osborne, D.M.1    Edinger, K.L.2    Frye, C.A.3
  • 49
    • 33745883573 scopus 로고    scopus 로고
    • Intrahippocampal administration of an androgen receptor antagonist, flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats
    • K.L. Edinger, and C.A. Frye Intrahippocampal administration of an androgen receptor antagonist, flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats Horm Behav 50 2006 216 222
    • (2006) Horm Behav , vol.50 , pp. 216-222
    • Edinger, K.L.1    Frye, C.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.