Half-life of DISC1 protein and its pathological significance under hypoxia stress

Neuroscience Research

Volumn 97, Issue , 2015, Pages 1-6

  Barodia, Sandeep Kumar ^a   Park, Sang Ki ^a,b   Ishizuka, Koko ^a   Sawa, Akira ^a   Kamiya, Atsushi ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Disrupted in schizophrenia 1 (DISC1); Hypoxia; Oxygen glucose deprivation; Protein half life; Ubiquitin proteasome system

Indexed keywords

DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV B2; PROTEASOME; UBIQUITIN; UNCLASSIFIED DRUG; DISC1 PROTEIN, RAT; NERVE PROTEIN;

ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; HALF LIFE TIME; IN VITRO STUDY; NEUROPATHOLOGY; PC12 CELL LINE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN SYNTHESIS; ANIMAL; METABOLISM; RAT;

ANIMALS; CELL HYPOXIA; HALF-LIFE; IN VITRO TECHNIQUES; NERVE TISSUE PROTEINS; PC12 CELLS; PROTEOLYSIS; RATS;

EID: 84937635587     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2015.02.008     Document Type: Article

References (34)

1. Agrawal M., Kumar V., Singh A.K., Kashyap M.P., Khanna V.K., Siddiqui M.A., Pant A.B. Trans-resveratrol protects ischemic PC12 Cells by inhibiting the hypoxia associated transcription factors and increasing the levels of antioxidant defense enzymes. ACS Chem. Neurosci. 2013, 4:285-294.
2. Bibel M., Richter J., Lacroix E., Barde Y.A. Generation of a defined and uniform population of CNS progenitors and neurons from mouse embryonic stem cells. Nat. Protoc. 2007, 2:1034-1043.
3. Brandon N.J., Sawa A. Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat. Rev. Neurosci. 2011, 12:707-722.
4. Buee L., Bussiere T., Buee-Scherrer V., Delacourte A., Hof P.R. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res. Brain Res. Rev. 2000, 33:95-130.
5. Ciechanover A. Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat. Rev. Mol. Cell Biol. 2005, 6:79-87.
6. Davies P., Koppel J. Mechanism-based treatments for Alzheimer's disease. Dialogues Clin. Neurosci. 2009, 11:159-169.
7. Fernandez-Checa J.C., Kaplowitz N., Garcia-Ruiz C., Colell A., Miranda M., Mari M., Ardite E., Morales A. GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am. J. Physiol. 1997, 273:G7-G17.
8. Fonseca R., Vabulas R.M., Hartl F.U., Bonhoeffer T., Nagerl U.V. A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP. Neuron 2006, 52:239-245.
9. Gianazza E., Crawford J., Miller I. Detecting oxidative post-translational modifications in proteins. Amino Acids 2007, 33:51-56.
10. Hara M.R., Agrawal N., Kim S.F., Cascio M.B., Fujimuro M., Ozeki Y., Takahashi M., Cheah J.H., Tankou S.K., Hester L.D., Ferris C.D., Hayward S.D., Snyder S.H., Sawa A. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat. Cell Biol. 2005, 7:665-674.
11. Hershko A. The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle. Cell Death Differ. 2005, 12:1191-1197.
12. Hikida T., Gamo N.J., Sawa A. DISC1 as a therapeutic target for mental illnesses. Expert Opin. Ther. Targets 2012, 16:1151-1160.
13. Hu X., Rea H.C., Wiktorowicz J.E., Perez-Polo J.R. Proteomic analysis of hypoxia/ischemia-induced alteration of cortical development and dopamine neurotransmission in neonatal rat. J. Proteome Res. 2006, 5:2396-2404.
14. Ishizuka K., Kamiya A., Oh E.C., Kanki H., Seshadri S., Robinson J.F., Murdoch H., Dunlop A.J., Kubo K., Furukori K., Huang B., Zeledon M., Hayashi-Takagi A., Okano H., Nakajima K., Houslay M.D., Katsanis N., Sawa A. DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature 2011, 473:92-96.
15. Kamiya A., Kubo K., Tomoda T., Takaki M., Youn R., Ozeki Y., Sawamura N., Park U., Kudo C., Okawa M., Ross C.A., Hatten M.E., Nakajima K., Sawa A. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat. Cell Biol. 2005, 7:1167-1178.
16. Kamiya A., Sedlak T.W., Pletnikov M.V. DISC1 pathway in brain development: exploring therapeutic targets for major psychiatric disorders. Front. Psychiatry 2012, 3:25.
17. Kamiya A., Tomoda T., Chang J., Takaki M., Zhan C., Morita M., Cascio M.B., Elashvili S., Koizumi H., Takanezawa Y., Dickerson F., Yolken R., Arai H., Sawa A. DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. Hum. Mol. Genet. 2006, 15:3313-3323.
18. Kubo K., Tomita K., Uto A., Kuroda K., Seshadri S., Cohen J., Kaibuchi K., Kamiya A., Nakajima K. Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi. Biochem. Biophys. Res. Commun. 2010, 400:631-637.
19. Kvajo M., McKellar H., Arguello P.A., Drew L.J., Moore H., MacDermott A.B., Karayiorgou M., Gogos J.A. A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:7076-7081.
20. Lee C.S., Han E.S., Park E.S., Bang H. Inhibition of MG132-induced mitochondrial dysfunction and cell death in PC12 cells by 3-morpholinosydnonimine. Brain Res. 2005, 1036:18-26.
21. Mao L.M., Wang W., Chu X.P., Zhang G.C., Liu X.Y., Yang Y.J., Haines M., Papasian C.J., Fibuch E.E., Buch S., Chen J.G., Wang J.Q. Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine. Nat. Neurosci. 2009, 12:602-610.
22. Millar J.K., Christie S., Semple C.A., Porteous D.J. Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia. Genomics 2000, 67:69-77.
23. Millen J., MacLean M.R., Houslay M.D. Hypoxia-induced remodelling of PDE4 isoform expression and cAMP handling in human pulmonary artery smooth muscle cells. Eur. J. Cell Biol. 2006, 85:679-691.
24. Nakata K., Lipska B.K., Hyde T.M., Ye T., Newburn E.N., Morita Y., Vakkalanka R., Barenboim M., Sei Y., Weinberger D.R., Kleinman J.E. DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:15873-15878.
25. Narayan S., Nakajima K., Sawa A. DISC1: a key lead in studying cortical development and associated brain disorders. Neuroscientist 2013, 19:451-464.
26. Niwa M., Kamiya A., Murai R., Kubo K., Gruber A.J., Tomita K., Lu L., Tomisato S., Jaaro-Peled H., Seshadri S., Hiyama H., Huang B., Kohda K., Noda Y., O'Donnell P., Nakajima K., Sawa A., Nabeshima T. Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron 2010, 65:480-489.
27. Ohira K., Furuta T., Hioki H., Nakamura K.C., Kuramoto E., Tanaka Y., Funatsu N., Shimizu K., Oishi T., Hayashi M., Miyakawa T., Kaneko T., Nakamura S. Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells. Nat. Neurosci. 2010, 13:173-179.
28. Patrick G.N., Bingol B., Weld H.A., Schuman E.M. Ubiquitin-mediated proteasome activity is required for agonist-induced endocytosis of GluRs. Curr. Biol. 2003, 13:2073-2081.
29. Patrick G.N., Zhou P., Kwon Y.T., Howley P.M., Tsai L.H. p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. J. Biol. Chem. 1998, 273:24057-24064.
30. Price J.C., Guan S., Burlingame A., Prusiner S.B., Ghaemmaghami S. Analysis of proteome dynamics in the mouse brain. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:14508-14513.
31. Schmidt-Kastner R., van Os J., Steinbusch W.M., Schmitz C. Gene regulation by hypoxia and the neurodevelopmental origin of schizophrenia. Schizophr. Res. 2006, 84:253-271.
32. Tanaka K., Suzuki T., Chiba T. The ligation systems for ubiquitin and ubiquitin-like proteins. Mol. Cells 1998, 8:503-512.
33. Taya S., Shinoda T., Tsuboi D., Asaki J., Nagai K., Hikita T., Kuroda S., Kuroda K., Shimizu M., Hirotsune S., Iwamatsu A., Kaibuchi K. DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J. Neurosci. 2007, 27:15-26.
34. Toyama B.H., Hetzer M.W. Protein homeostasis: live long, won't prosper. Nat. Rev. Mol. Cell Biol. 2013, 14:55-61.