First determination of azole resistance in Aspergillus fumigatus strains carrying the TR34/L98H mutations in Turkey

Journal of Infection and Chemotherapy

Volumn 21, Issue 8, 2015, Pages 581-586

  Özmerdiven, Gülşah Ece ^a   Ak, Seçil ^a   Ener, Beyza ^a   Ağca, Harun ^a   Cilo, Burcu Dalyan ^a   Tunca, Berrin ^a   Akalin, Halis ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

Aspergillus fumigatus; Azole resistance; TR34 L98H mutation

Indexed keywords

AMPHOTERICIN B; ITRACONAZOLE; POSACONAZOLE; VORICONAZOLE; ANTIFUNGAL AGENT; CYTOCHROME P-450 CYP51A, ASPERGILLUS; CYTOCHROME P450; FUNGAL PROTEIN; TRIAZOLE DERIVATIVE;

ADULT; AGED; ANTIFUNGAL RESISTANCE; ARTICLE; ASPERGILLOMA; ASPERGILLUS FUMIGATUS; CLINICAL ARTICLE; CYP51A GENE; FEMALE; FUNGAL GENE; FUNGAL STRAIN; FUNGUS ISOLATION; FUNGUS MUTATION; HUMAN; IN VITRO STUDY; LUNG ASPERGILLOSIS; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PROMOTER REGION; SEQUENCE ANALYSIS; TR34L98H GENE; TURKEY (REPUBLIC); ASPERGILLOSIS; DNA MUTATIONAL ANALYSIS; DRUG EFFECTS; GENETICS; MICROBIAL SENSITIVITY TEST; MIDDLE AGED; MUTATION; TURKEY; YOUNG ADULT;

ADULT; AGED; AMPHOTERICIN B; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CYTOCHROME P-450 ENZYME SYSTEM; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, FUNGAL; FEMALE; FUNGAL PROTEINS; HUMANS; ITRACONAZOLE; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MUTATION; PROMOTER REGIONS, GENETIC; TRIAZOLES; TURKEY; VORICONAZOLE; YOUNG ADULT;

EID: 84937633798     PISSN: 1341321X     EISSN: 14377780     Source Type: Journal    
DOI: 10.1016/j.jiac.2015.04.012     Document Type: Article

References (41)

1. Walsh T.J., Anaissie E.J., Denning D.W., Herbrecht R., Kontoyiannis D.P., Marr K.A., et al. Treatment of aspergillosis: clinical practice guidelines of the infectious diseases society of America. Clin Infect Dis 2008, 46:327-360.
2. Dagenais T.R., Keller N.P. Pathogenesis of Aspergillus fumigatus in invasive aspergillosis. Clin Microbiol Rev 2009, 22:447-465.
3. Segal B.H., Walsh T.J. Current approaches to diagnosis and treatment of invasive aspergillosis. Am J Respir Crit Care Med 2006, 173:707-717.
4. Herbrecht R., Denning D.W., Patterson T.F., Bennett J.E., Greene R.E., Oestman J.W., et al. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. NEngl J Med 2002, 347:408-415.
5. Cornely O.A., Maertens J., Winston D.J., Perfect J., Ullmann A.J., Walsh T.J., et al. Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia. NEngl J Med 2007, 356:348-359.
6. Ullmann A.J., Lipton J.H., Vesole D.H., Chandrasaker P., Langston A., Tarantalo S.R., et al. Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease. NEngl J Med 2007, 356:335-347.
7. Odds F.C., Brown A.J., Gow N.A. Antifungal agents: mechanisms of action. Trends Microbiol 2003, 11:272-279.
8. Bossche H.V., Koymans L., Moereels H. P450 inhibitors of use in medical treatment: focus on mechanisms of action. Pharmacol Ther 1995, 67:79-100.
9. Waterman M.R., Lepesheva G.I. Sterol 14 alpha-demethylase, an abundant and essential mixed function oxidase. Biochem Biophys Res Commun 2005, 338:418-422.
10. Denning D.W., Perlin D.S. Azole resistance in Aspergillus: a growing public health menace. Future Microbiol 2011, 6:1229-1232.
11. Mellado E., Garcia-Effron G., Alcazar-Fuoli L., Melchers W.J., Verweij P.E., Cuenca-Estrella M., et al. Anew Aspergillus fumigatus resistance mechanism conferring invitro cross-resistance to azole antifungals involves a combination of cyp51A alterations. Antimicrob Agents Chemother 2007, 51:1897-1904.
12. Bueid A., Howard S.J., Moore C.B., Richardson M.D., Harrison E., Bowyer P., et al. Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009. JAntimicrob Chemother 2010, 65:2116-2118.
13. Verweij P.E., Mellado E., Melchers W.J.G. Multiple-triazole-resistant aspergillosis. NEngl J Med 2007, 356:1481-1483.
14. Snelders E., Veld H.R.A., Rijs A.J., Kema G.H., Melchers W.J., Verweij P.E. Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles. Appl Environ Microbiol 2009, 75:4053-4057.
15. Verweij P.E., Snelders E., Kema G.H., Mellado E., Melchers W.J. Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?. Lancet Infect Dis 2009, 9:789-795.
16. Lockhart S.R., Frade J.P., Etienne K.A., Pfaller M.A., Diekema D.J., Balajee S.A. Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene. Antimicrob Agents Chemother 2011, 55:4465-4468.
17. Chowdhary A., Kathuria S., Xu J., Meis J.F. Emergence of azole-resistant Aspergillus fumigatus strains due to agricultural azole use creates an increasing threat to human health. PLoS Pathog 2013, 9:e1003633.
18. Seyedmousavi S., Hashemi S.J., Zibafar E., Zoll J., Hedayati M.T., Mouton J.W., et al. Azole-resistant Aspergillus fumigatus. Iran Emerg Infect Dis 2013, 19:832-833.
19. Verweij P.E., van der Lee H.A.L., Rijs A.J.M.M. The role of conventional diagnostic tools. Diagnosis of fungal infections 2007, 19-40. Informa Healthcare, New York. J.A. Maertens, K.A. Marr (Eds.).
20. Howard S.J., Cerar D., Anderson M.J., Albarrag A., Fisher M.C., Pasqualatto A.C., et al. Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure. Emerg Infect Dis 2009, 15:1068-1076.
21. Snelders E., van der Lee H.A.L., Kuijpers J., Rijs A.J.M., Varga J., Samson R.A., et al. Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism. Plos Med 2008, 5. e1629-37.
22. Clinical and Laboratory Standards Institute Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard M38-A2 2008, CLSI, Wayne, PA, USA.
23. Espinel-Ingroff A., Diekema D.J., Fothergill A., Johnson E., Palaez T., Pfaller M.A., et al. Wild-type MIC distributions and epidemiological cut-off values for the triazoles and six Aspergillus spp. for the CLSI broth microdilution method (M38-A2 Document). JClin Microbiol 2010, 48:3251-3257.
24. Hall T.A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl Acids Symp Ser 1999, 41:95-98.
25. Ağca H., Ener B., Yilmaz E., Ursavaş A., Kazak E., Özkocaman V., et al. Comparative evaluation of galactomannan optical density indices and culture results in bronchoscopic specimens obtained from neutropenic and non-neutropenic patients. Mycoses 2014, 57:169-175.
26. Akdağli S.A., Azap A., Demirkazik F.B., Ener B., Hayran S.A., Kumbasar ÖÖ, et al. Diagnosis of invasive fungal diseases in hematological malignancies: a critical review of evidence and Turkish expert opinion (TEO-2). Turk J Hematol 2014, 31:342-356.
27. Alanio A., Sitterlé E., Liance M., Farrugia C., Foulet F., Botterel F., et al. Low prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies. JAntimicrob Chemother 2011, 66:371-374.
28. Chowdhary A., Kathuria S., Randhawa H.S., Arfanis E., Buer J., Steinmann J. Isolation of multipletriazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India. JAntimicrob Chemother 2012, 67:362-366.
29. Rath P.M., Buchheidt D., Spiess B., Arfanis E., Buer J., Steinmann J. First reported case of azole resistant Aspergillus fumigatus due to the TR/L98H mutation in Germany. Antimicrob Agents Chemother 2012, 56:6060-6061.
30. Stensvold C.N., Jørgensen L.N., Arendrup M.C. Azole-resistant invasive aspergillosis: relationship to agriculture. Fungal Infect Rep 2012, 6:178-191.
31. Denning D.W., Venkateswarlu K., Oakley K.L., Anderson M.J., Stevens D.A., Warnock D.W., et al. Itraconazole resistance in Aspergillus fumigatus. Antimicrob Agents Chemother 1997, 41:1364-1368.
32. Warris A., Voss A., Verweij P.E. Hospital sources of Aspergillus species: new routes of transmission?. Rev Iberoam Micol 2001, 18:156-162.
33. Patterson T.F. Aspergillus species. Principles and practice of infectious diseases 2010, 3241-3256. Churchill Livingstone, London. G.L. Mandell, R.G. Douglas, J.E. Bennet (Eds.).
34. Denning D.W. Invasive aspergillosis. Clin Infect Dis 1998, 26:781-803.
35. Diaz-Guerra T.M., Mellado E., Cuenca-Estrella M., Rodriguez-Tudela J.L. Apoint mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus. Antimicrob Agents Chemother 2003, 47:1120-1124.
36. Mellado E., Garcia-Effron G., Alcazar-Fuoli L., Cuenca-Estrella M., Rodriguez-Tudela J.L. Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus is responsible for resistance invitro to azole antifungal drugs. Antimicrob Agents Chemother 2004, 48:2747-2750.
37. Chen J., Li H., Li R., Bu D., Wan Z. Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma. JAntimicrob Chemother 2005, 55:31-37.
38. Dannaoui E., Garcia-Hermoso D., Naccache J.M., Meneau I., Sanglard D., Bouges- Michel J., et al. Use of voriconazole in a patient with aspergilloma caused by an itraconazole-resistant strain of Aspergillus fumigatus. JMed Microbiol 2006, 55:1457-1459.
39. Hodiamont C.J., Dolman K.M., Ten B.I., Melchers W.J., Verwij P.E., Pajkrt D. Multiple-azole resistant Aspergillus fumigatus osteomyelitis in a patient with chronic granulomatous disease successfully treated with long-term oral posaconazole and surgery. Med Mycol 2009, 47:217-220.
40. Xu H., Chen W., Li L., Wan Z., Li R., Liu W. Clinical itraconazole-resistant strains of Aspergillus fumigatus, isolated serially from a lung aspergilloma patient with pulmonary tuberculosis, can be detected with real-time PCR method. Mycopatologia 2010, 169:193-199.
41. Latge J.P. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev 1999, 12:310-350.