Microfluidic device for sheathless particle focusing and separation using a viscoelastic fluid

Journal of Chromatography A

Volumn 1406, Issue , 2015, Pages 244-250

  Nam, Jeonghun ^a   Namgung, Bumseok ^a   Lim, Chwee Teck ^a,b   Bae, Jung Eun ^c   Leo, Hwa Liang ^a   Cho, Kwang Soo ^c   Kim, Sangho ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c Kyungpook National University   (South Korea)

Author keywords

Blood component separation; Microfluidics; Non Newtonian fluid; Viscoelastic separation

Indexed keywords

BLOOD; DIAGNOSIS; FLOW MEASUREMENT; FLUIDIC DEVICES; NON NEWTONIAN FLOW; NON NEWTONIAN LIQUIDS; PARTICLE SEPARATORS; PARTICLE SIZE; RHEOLOGY; VISCOELASTICITY; VISCOUS FLOW;

BIOCHEMICAL ANALYSIS; BLOOD COMPONENT; MICRO-FLUIDIC DEVICES; NON-NEWTONIAN FLUIDS; PARTICLE SEPARATION; THREE DIMENSIONAL FOCUSING; VIS-COELASTIC FLUIDS; VISCOELASTIC PROPERTIES;

MICROFLUIDICS;

POLYSTYRENE; VISCOELASTIC SUBSTANCE;

ARTICLE; ERYTHROCYTE; FLOW RATE; FRACTIONATION; LEUKOCYTE; MICROFLUIDICS; MICROTECHNOLOGY; PARTICLE SIZE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; SHEAR RATE; THROMBOCYTE; VISCOELASTICITY; BLOOD CELL; CELL SEPARATION; CHEMICAL ANALYSIS; CYTOLOGY; DEVICES; ELASTICITY; HUMAN; MICROFLUIDIC ANALYSIS; PROCEDURES; VISCOSITY;

BLOOD CELLS; CELL SEPARATION; CHEMISTRY TECHNIQUES, ANALYTICAL; ELASTICITY; HUMANS; MICROFLUIDIC ANALYTICAL TECHNIQUES; PARTICLE SIZE; VISCOSITY;

EID: 84937632396     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2015.06.029     Document Type: Article

References (43)

1. Gossett D.R., Weaver W.M., Mach A.J., Hur S.C., Tse H.T.K., Lee W., Amini H., Di Carlo D. Label-free cell separation and sorting in microfluidic systems. Anal. Bioanal. Chem. 2010, 397:3249-3267.
2. Osborne G.W. Chapter 21 - Recent advances in flow cytometric cell sorting. Methods Cell Biol. 2010, 102:533-556.
3. Pamme N. Continuous flow separations in microfluidic devices. Lab on a Chip 2007, 7:1644-1659.
4. Paterlini-Brechot P., Benali N.L. Circulating tumor cells (CTC) detection: clinical impact and future directions. Cancer Lett. 2007, 253:180-204.
5. Steeg P.S. Tumor metastasis: mechanistic insights and clinical challenges. Nat. Med. 2006, 12:895-904.
6. M. Toner, D. Irimia, Blood-on-a-chip, Ann. Rev. Biomed. Eng. 7 (2005) 77-103.
7. Hur S.C., Tse H.T.K., Di Carlo D. Sheathless inertial cell ordering for extreme throughput flow cytometry. Lab on a Chip 2010, 10:274-280.
8. Lee W.C., Bhagat A.A.S., Huang S., Van Vliet K.J., Han J., Lim C.T. High-throughput cell cycle synchronization using inertial forces in spiral microchannels. Lab on a Chip 2011, 11:1359-1367.
9. Nagrath S., Sequist L.V., Maheswaran S., Bell D.W., Irimia D., Ulkus L., Smith M.R., Kwak E.L., Digumarthy S., Muzikansky A. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 2007, 450:1235-1239.
10. Zhou Y., Wang Y., Lin Q. A microfluidic device for continuous-flow magnetically controlled capture and isolation of microparticles. J. Microelectromech. Syst. 2010, 19:743-751.
11. Shendruk T.N., Tahvildari R., Catafard N., Andzejewski L., Gigault C., Todd A., Gagne-Dumais L., Slater G.W., Godin M. Field-flow fractionation and hydrodynamic chromatography on a microfluidic chip. Anal. Chem. 2013, 85:5981-5988.
12. Holm S.H., Beech J.P., Barrett M.P., Tegenfeldt J.O. Separation of parasites from human blood using deterministic lateral displacement. Lab on a Chip 2011, 11:1326-1332.
13. Huang L.R., Cox E.C., Austin R.H., Sturm J.C. Continuous particle separation through deterministic lateral displacement. Science 2004, 304:987-990.
14. Zhou J., Giridhar P.V., Kasper S., Papautsky I. Modulation of aspect ratio for complete separation in an inertial microfluidic channel. Lab on a Chip 2013, 13:1919-1929.
15. D'Avino G., Maffettone P.L., Greco F., Hulsen M. Viscoelasticity-induced migration of a rigid sphere in confined shear flow. J. Non-Newtonian Fluid Mech. 2010, 165:466-474.
16. A. Leshansky, A. Bransky, N. Korin, U. Dinnar, Tunable nonlinear viscoelastic focusing in a microfluidic device, Phys. Rev. Lett. 98 (2007) 234501-1-234501-4.
17. Cha S., Kang K., You J.B., Im S.G., Kim Y., Kim J.M. Hoop stress-assisted three-dimensional particle focusing under viscoelastic flow. Rheol. Acta 2014, 53:927-933.
18. G. D'Avino, G. Romeo, M.M. Villone, F. Greco, P.A. Netti, P.L. Maffettone, Single line particle focusing induced by viscoelasticity of the suspending liquid: theory, experiments and simulations to design a micropipe flow-focuser, Lab on a Chip 12 (2012) 1638-1645.
19. Kang K., Lee S.S., Hyun K., Lee S.J., Kim J.M. DNA-based highly tunable particle focuser. Nat. Commun. 2013, 4:1-8. 2567.
20. Lim E.J., Ober T.J., Edd J.F., Desai S.P., Neal D., Bong K.W., Doyle P.S., McKinley G.H., Toner M. Inertio-elastic focusing of bioparticles in microchannels at high throughput. Nat. Commun. 2014, 5:1-9. 4120.
21. Romeo G., D'Avino G., Greco F., Netti P.A., Maffettone P.L. Viscoelastic flow-focusing in microchannels: scaling properties of the particle radial distributions. Lab on a Chip 2013, 13:2802-2807.
22. K.W. Seo, Y.R. Ha, S.J. Lee, Vertical focusing and cell ordering in a microchannel via viscoelasticity: applications for cell monitoring using a digital holographic microscopy, Appl. Phys. Lett. 104 (2014) 213702-1-213702-4.
23. Ahn S.W., Lee S.S., Lee S.J., Kim J.M. Microfluidic particle separator utilizing sheathless elasto-inertial focusing. Chem. Eng. Sci. 2015, 126:237-243.
24. Yang S., Kim J.Y., Lee S.J., Lee S.S., Kim J.M. Sheathless elasto-inertial particle focusing and continuous separation in a straight rectangular microchannel. Lab on a Chip 2011, 11:266-273.
25. Yang S., Lee S.S., Ahn S.W., Kang K., Shim W., Lee G., Hyun K., Kim J.M. Deformability-selective particle entrainment and separation in a rectangular microchannel using medium viscoelasticity. Soft Matter 2012, 8:5011-5019.
26. Lim H., Nam J., Shin S. Lateral migration of particles suspended in viscoelastic fluids in a microchannel flow. Microfluid. Nanofluid. 2014, 17:683-692.
27. Nam J., Lim H., Kim D., Jung H., Shin S. Continuous separation of microparticles in a microfluidic channel via the elasto-inertial effect of non-Newtonian fluid. Lab on a Chip 2012, 12:1347-1354.
28. Hatch A.C., Patel A., Beer N.R., Lee A.P. Passive droplet sorting using viscoelastic flow focusing. Lab on a Chip 2013, 13:1308-1315.
29. Choi S., Ku T., Song S., Choi C., Park J.-K. Hydrophoretic high-throughput selection of platelets in physiological shear-stress range. Lab on a Chip 2011, 11:413-418.
30. Abdelgawad M., Wu C., Chien W.-Y., Geddie W.R., Jewett M.A., Sun Y. A fast and simple method to fabricate circular microchannels in polydimethylsiloxane (PDMS). Lab on a Chip 2011, 11:545-551.
31. Yang X., Forouzan O., Burns J.M., Shevkoplyas S.S. Traffic of leukocytes in microfluidic channels with rectangular and rounded cross-sections. Lab on a Chip 2011, 11:3231-3240.
32. J. Kuncová-Kallio, PDMS and its suitability for analytical microfluidic devices, in: Proceedings of the 28th IEEE EMBS Annual International Conference, New York City, USA, Aug 30-Sept 3, 2006.
33. Sia S.K., Whitesides G.M. Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies. Electrophoresis 2003, 24:3563-3576.
34. Lee J.N., Park C., Whitesides G.M. Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices. Anal. Chem. 2003, 75:6544-6554.
35. Cha S., Shin T., Lee S.S., Shim W., Lee G., Lee S.J., Kim Y., Kim J.M. Cell stretching measurement utilizing viscoelastic particle focusing. Anal. Chem. 2012, 84:10471-10477.
36. Dobbe J., Streekstra G., Hardeman M., Ince C., Grimbergen C. Measurement of the distribution of red blood cell deformability using an automated rheoscope. Cytometry 2002, 50:313-325.
37. Hou H.W., Bhagat A.A.S., Chong A.G.L., Mao P., Tan K.S.W., Han J., Lim C.T. Deformability based cell margination-a simple microfluidic design for malaria-infected erythrocyte separation. Lab on a Chip 2010, 10:2605-2613.
38. Shen F., Hwang H., Hahn Y.K., Park J.-K. Label-free cell separation using a tunable magnetophoretic repulsion force. Anal. Chem. 2012, 84:3075-3081.
39. Shankaran H., Alexandridis P., Neelamegham S. Aspects of hydrodynamic shear regulating shear-induced platelet activation and '-association of von Willebrand factor in suspension. Blood 2003, 101:2637-2645.
40. Hellums J.D. 1993 Whitaker Lecture: biorheology in thrombosis research. Ann. Biomed. Eng. 1994, 22:445-455.
41. Inglis D.W., Morton K.J., Davis J.A., Zieziulewicz T.J., Lawrence D.A., Austin R.H., Sturm J.C. Microfluidic device for label-free measurement of platelet activation. Lab on a Chip 2008, 8:925-931.
42. Park J.-M., Kim M.S., Moon H.-S., Yoo C.E., Park D., Kim Y.J., Han K.-Y., Lee J.-Y., Oh J.H., Kim S.S., Park W.-Y., Lee W.-Y., Huh N. Fully automated circulating tumor cell isolation platform with large-volume capacity based on lab-on-a-disc. Anal. Chem. 2014, 6(8):3735-3742.
43. Lee W., Kwon D., Choi W., Jung G.Y., Jeon S. 3D-printed microfluidic device for the detection of pathogenic bacteria using size-based separation in helical channel with trapezoid cross-section. Sci. Rep. 2015, 5:1-6. 7717.